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Deciphering the Ori...
Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses
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- Lauber, Chris (författare)
- Tech Univ Dresden, Inst Med Informat & Biometry, D-01307 Dresden, Germany.
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- Seitz, Stefan (författare)
- Heidelberg Univ, Dept Infect Dis, Mol Virol, D-69120 Heidelberg, Germany.
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- Mattei, Simone (författare)
- European Mol Biol Lab, Struct & Computat Biol Unit, D-69117 Heidelberg, Germany.
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- Suh, Alexander (författare)
- Uppsala universitet,Evolutionsbiologi
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- Beck, Juergen (författare)
- Univ Hosp Freiburg, Dept Internal Med Mol Biol 2, D-79106 Freiburg, Germany.
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- Herstein, Jennifer (författare)
- Univ Southern Calif, Keck Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90033 USA.
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- Boerold, Jacob (författare)
- Heidelberg Univ, Dept Infect Dis, Mol Virol, D-69120 Heidelberg, Germany.
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- Salzburger, Walter (författare)
- Univ Basel, Inst Zool, CH-4051 Basel, Switzerland.
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- Kaderali, Lars (författare)
- Tech Univ Dresden, Inst Med Informat & Biometry, D-01307 Dresden, Germany.;Univ Med Greifswald, Inst Bioinformat, D-17487 Greifswald, Germany.
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- Briggs, John A. G. (författare)
- European Mol Biol Lab, Struct & Computat Biol Unit, D-69117 Heidelberg, Germany.
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- Bartenschlager, Ralf (författare)
- Heidelberg Univ, Dept Infect Dis, Mol Virol, D-69120 Heidelberg, Germany.;German Canc Res Ctr, Div Virus Associated Carcinogenesis, D-69120 Heidelberg, Germany.
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Tech Univ Dresden, Inst Med Informat & Biometry, D-01307 Dresden, Germany Heidelberg Univ, Dept Infect Dis, Mol Virol, D-69120 Heidelberg, Germany. (creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: Cell Host and Microbe. - : Elsevier BV. - 1931-3128 .- 1934-6069. ; 22:3, s. 387-399,e1-e6
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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Abstract
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- Hepatitis B viruses (HBVs), which are enveloped viruses with reverse-transcribed DNA genomes, constitute the family Hepadnaviridae. An outstanding feature of HBVs is their streamlined genome organization with extensive gene overlap. Remarkably, the similar to 1,100 bp open reading frame (ORF) encoding the envelope proteins is fully nested within the ORF of the viral replicase P. Here, we report the discovery of a diversified family of fish viruses, designated nackednaviruses, which lack the envelope protein gene, but otherwise exhibit key characteristics of HBVs including genome replication via proteinprimed reverse-transcription and utilization of structurally related capsids. Phylogenetic reconstruction indicates that these two virus families separated more than 400 million years ago before the rise of tetrapods. We show that HBVs are of ancient origin, descending from non-enveloped progenitors in fishes. Their envelope protein gene emerged de novo, leading to a major transition in viral lifestyle, followed by co-evolution with their hosts over geologic eras.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
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Lauber, Chris
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Seitz, Stefan
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Mattei, Simone
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Suh, Alexander
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Beck, Juergen
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Herstein, Jennif ...
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visa fler...
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Boerold, Jacob
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Salzburger, Walt ...
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Kaderali, Lars
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Briggs, John A. ...
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Bartenschlager, ...
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Cell Host and Mi ...
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Uppsala universitet