| 1. |
- Aad, G., et al.
(författare)
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- 2012
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swepub:Mat__t (refereegranskat)
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| 2. |
- Shulman, L M, et al.
(författare)
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Antibodies to islet cell autoantigens, rotaviruses and/or enteroviruses in cord blood and healthy mothers in relation to the 2010-2011 winter viral seasons in Israel : a pilot study
- 2014
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Ingår i: Diabetic Medicine. - : Wiley-Blackwell. - 0742-3071 .- 1464-5491. ; 31:6, s. 681-685
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Tidskriftsartikel (refereegranskat)abstract
- AimsTo determine whether antivirus and/or islet cell antibodies can be detected in healthy pregnant mothers without diabetes and/or their offspring at birth in two winter viral seasons.MethodsMaternal and cord blood sera from 107 healthy pregnant women were tested for islet cell autoantibodies using radioligand binding assays and for anti-rotavirus and anti-CoxB3 antibody using an enzyme-linked immunosorbent assay.ResultsGlutamic acid decarboxylase (GAD)65 autoantibodies and rotavirus antibodies, present in both maternal and cord blood sera, correlated with an odds ratio of 6.89 (95% CI: 1.01-46.78). For five, 22 and 17 pregnancies, antibodies to GAD65, rotavirus and CoxB3, respectively, were detected in cord blood only and not in the corresponding maternal serum. In 10 pregnancies, rotavirus antibody titres in the cord blood exceeded those in the corresponding maternal serum by 2.5-5-fold. Increased antibody titres after the 20(th) week of gestation suggested CoxB3 infection in one of the 20 pregnancies and rotavirus in another.ConclusionThe concurrent presence of GAD65 antibodies in cord blood and their mothers may indicate autoimmune damage to islet cells during gestation, possibly caused by cross-placental transmission of viral infections and/or antivirus antibodies. Cord blood antibody titres that exceed those of the corresponding maternal sample by >2.5-fold, or antibody-positive cord blood samples with antibody-negative maternal samples, may imply an active in utero immune response by the fetus. What's new? It has been hypothesized that viral infections initiate islet cell autoimmunity. Previous research suggests an association of viral infection in utero and islet autoimmunity. We found a significant correlation between glutamic acid decarboxylase 65 autoantibodies and anti-rotavirus in healthy mothers at delivery and in cord blood. The presence of antibodies in cord blood with antibody-negative mothers suggests an independent fetal immune response. Our findings support the hypothesis that viral infections during pregnancy damage fetal islet cells, triggering islet autoimmunity.
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| 3. |
- Andersson, C, et al.
(författare)
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The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes
- 2011
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Ingår i: Autoimmunity. - : Taylor & Francis. - 0891-6934 .- 1607-842X. ; 44:5, s. 394-405
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Tidskriftsartikel (refereegranskat)abstract
- Aims: We tested whether autoantibodies to all three ZnT8RWQ variants, GAD65, insulinoma-associated protein 2 (IA-2), insulin and autoantibodies to islet cell cytoplasm (ICA) in combination with human leukocyte antigen (HLA) would improve the diagnostic sensitivity of childhood type 1 diabetes by detecting the children who otherwise would have been autoantibody-negative.Methods: A total of 686 patients diagnosed in 1996–2005 in Skåne were analyzed for all the seven autoantibodies [arginin 325 zinc transporter 8 autoantibody (ZnT8RA), tryptophan 325 zinc transporter 8 autoantibody (ZnT8WA), glutamine 325 Zinc transporter 8 autoantibody (ZnT8QA), autoantibodies to glutamic acid decarboxylase (GADA), Autoantibodies to islet-antigen-2 (IA-2A), insulin autoantibodies (IAA) and ICA] in addition to HLA-DQ genotypes.Results: Zinc transporter 8 autoantibody to either one or all three amino acid variants at position 325 (ZnT8RWQA) was found in 65% (449/686) of the patients. The frequency was independent of age at diagnosis. The ZnT8RWQA reduced the frequency of autoantibody-negative patients from 7.5 to 5.4%—a reduction by 28%. Only 2 of 108 (2%) patients who are below 5 years of age had no autoantibody at diagnosis. Diagnosis without any islet autoantibody increased with increasing age at onset. DQA1-B1*X-0604 was associated with both ZnT8RA (p = 0.002) and ZnT8WA (p = 0.01) but not with ZnT8QA (p = 0.07). Kappa agreement analysis showed moderate (>0.40) to fair (>0.20) agreement between pairs of autoantibodies for all combinations of GADA, IA-2A, ZnT8RWQA and ICA but only slight ( < 0.19) agreement for any combination with IAA.Conclusions: This study revealed that (1) the ZnT8RWQA was common, independent of age; (2) multiple autoantibodies were common among the young; (3) DQA1-B1*X-0604 increased the risk for ZnT8RA and ZnT8WA; (4) agreement between autoantibody pairs was common for all combinations except IAA. These results suggest that ZnT8RWQA is a necessary complement to the classification and prediction of childhood type 1 diabetes as well as to randomize the subjects in the prevention and intervention of clinical trials.
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| 4. |
- Flannick, Jason, et al.
(författare)
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Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.
- 2014
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 46:4, s. 357-357
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Tidskriftsartikel (refereegranskat)abstract
- Loss-of-function mutations protective against human disease provide in vivo validation of therapeutic targets, but none have yet been described for type 2 diabetes (T2D). Through sequencing or genotyping of ∼150,000 individuals across 5 ancestry groups, we identified 12 rare protein-truncating variants in SLC30A8, which encodes an islet zinc transporter (ZnT8) and harbors a common variant (p.Trp325Arg) associated with T2D risk and glucose and proinsulin levels. Collectively, carriers of protein-truncating variants had 65% reduced T2D risk (P = 1.7 × 10(-6)), and non-diabetic Icelandic carriers of a frameshift variant (p.Lys34Serfs*50) demonstrated reduced glucose levels (-0.17 s.d., P = 4.6 × 10(-4)). The two most common protein-truncating variants (p.Arg138* and p.Lys34Serfs*50) individually associate with T2D protection and encode unstable ZnT8 proteins. Previous functional study of SLC30A8 suggested that reduced zinc transport increases T2D risk, and phenotypic heterogeneity was observed in mouse Slc30a8 knockouts. In contrast, loss-of-function mutations in humans provide strong evidence that SLC30A8 haploinsufficiency protects against T2D, suggesting ZnT8 inhibition as a therapeutic strategy in T2D prevention.
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| 5. |
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| 6. |
- Persson, Johan, et al.
(författare)
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Spin-Torque Oscillator in an Electromagnet Package
- 2012
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Ingår i: IEEE Transactions on Magnetics. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9464 .- 1941-0069. ; 48:11, s. 4378-4381
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Tidskriftsartikel (refereegranskat)abstract
- Spin-torque oscillators (STO) hold promise for multi-octave frequency operation at very high frequencies and modulation speeds. STO operation is typically demonstrated using large electromagnets and probe stations, and has so far not been packaged with a portable form factor. For STOs to be utilized in real applications, a smaller packaging solution is needed. We integrate STOs with packages originally developed for YIG oscillators, modified to incorporate permanent magnets and to achieve a compact portable oscillator based on the STO.
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| 7. |
- Qejvanaj, Fatjon, et al.
(författare)
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Thick Double-Biased IrMn/NiFe/IrMn Planar Hall Effect Bridge Sensors
- 2014
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Ingår i: IEEE transactions on magnetics. - 0018-9464 .- 1941-0069. ; 50:11
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we present a new material stack for planar Hall effect bridge (PHEB) sensors and a detailed investigation of the sensitivity and noise properties of PHEB sensors made from these. The sputter deposited material stack was based on a ferromagnetic (FM) NiFe sensing layer surrounded by two layers of anti-FM IrMn. This material stack enables implementation of a thick NiFe layer without loss of sensitivity. We present an improvement in detectivity in the PHEB by changing the shape and the materials of the corners between the sensors in a meander shape. A significant reduction of noise also comes from the thick NiFe layer, due to the reduced resistance of the sensor.
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| 8. |
- Salami, F, et al.
(författare)
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DETECTION OF LACTOBACILLI IN MONTHLY MAIL-IN STOOL SAMPLES FROM 3-18 MONTHS OLD INFANTS AT GENETIC RISK FOR TYPE 1 DIABETES
- 2012
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Ingår i: International journal of probiotics & prebiotics. - 1555-1431. ; 7:3-4, s. 135-144
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Tidskriftsartikel (refereegranskat)abstract
- The feasibility to detect lactobacilli in mail-in infant stools collected monthly from 3-18 months old children was investigated. The aim was to determine total lactobacilli and Lactobacillus plantarum (L. plantarum) content (ng/g feces) in 50 infants each from Colorado (648 samples), Finland (624 samples) and Sweden (685 samples) who participated in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. Total lactobacilli content varied markedly between 5 and 16,800 ng/g feces in the three clinical sites within and between individuals especially in infants. L.plantarum also varied markedly intra- and inter-individually from <0.5 - 736 ng/g feces. A higher variability of total lactobacilli was found before 10 months of age than after in the three different clinical sites. Sweden had the lowest total lactobacilli content compared to Colorado and Finland while the L.plantarum content was higher in Sweden. Mail-in stool samples from infants should prove useful in analyzing probiotics in childhood.
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| 9. |
- Andersen, Marie Louise M., et al.
(författare)
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Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes
- 2012
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Ingår i: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X .- 1399-5448. ; 13:6, s. 454-462
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Tidskriftsartikel (refereegranskat)abstract
- Background The zinc transporter 8 (ZnT8) was recently identified as a common autoantigen in type 1 diabetes (T1D) and inclusion of ZnT8 autoantibodies (ZnT8Ab) was found to increase the diagnostic specificity of T1D. Objectives The main aims were to determine whether ZnT8Ab vary during follow-up 1 year after diagnosis, and to relate the reactivity of three types of ZnT8Ab to the residual stimulated C-peptide levels during the first year after diagnosis. Subjects A total of 129 newly diagnosed T1D patients <15 years was followed prospectively 1, 3, 6, and 12 months after diagnosis. Methods Hemoglobin A1c, meal-stimulated C-peptide, ZnT8Ab, and other pancreatic autoantibodies were measured at each visit. Patients were genotyped for the rs13266634 variant at the SLC30A8 gene and HLA-DQ alleles. Results The levels of all ZnT8Ab [ZnT8Arg (arginine), ZnT8Trp (tryptophan), ZnT8Gln (glutamine)] tended to decrease during disease progression. A twofold higher level of ZnT8Arg and ZnT8Gln was associated with 4.6%/5.2% (p = 0.02), 5.3%/8.2% (p = 0.02) and 8.9%/9.7% (p = 0.004) higher concentrations of stimulated C-peptide 3, 6, and 12 months after diagnosis. The TT genotype carriers of the SLC30A8 gene had 45.8% (p = 0.01) and 60.1% (p = 0.002) lower stimulated C-peptide 6 and 12 months after diagnosis compared to the CC and the CT genotype carriers in a recessive model. Conclusions The levels of the Arg variant of the ZnT8 autoantibodies are associated with higher levels of stimulated C-peptide after diagnosis of T1D and during follow-up. Carriers of the TT genotype of the SLC30A8 gene predict lower stimulated C-peptide levels 12 months after diagnosis.
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| 10. |
- Chung, Sunjae, et al.
(författare)
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Spin transfer torque generated magnetic droplet solitons (invited)
- 2014
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Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 115:17
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Tidskriftsartikel (refereegranskat)abstract
- We present recent experimental and numerical advancements in the understanding of spin transfer torque generated magnetic droplet solitons. The experimental work focuses on nano-contact spin torque oscillators (NC-STOs) based on orthogonal (pseudo) spin valves where the Co fixed layer has an easy-plane anisotropy, and the [Co/Ni] free layer has a strong perpendicular magnetic anisotropy. The NC-STO resistance and microwave signal generation are measured simultaneously as a function of drive current and applied perpendicular magnetic field. Both exhibit dramatic transitions at a certain current dependent critical field value, where the microwave frequency drops 10 GHz, modulation sidebands appear, and the resistance exhibits a jump, while the magnetoresistance changes sign. We interpret these observations as the nucleation of a magnetic droplet soliton with a large fraction of its magnetization processing with an angle greater than 90 degrees, i.e., around a direction opposite that of the applied field. This interpretation is corroborated by numerical simulations. When the field is further increased, we find that the droplet eventually collapses under the pressure from the Zeeman energy. (C) 2014 AIP Publishing LLC.
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| 11. |
- Dumas, Randy K., et al.
(författare)
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Recent Advances in Nanocontact Spin-Torque Oscillators
- 2014
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Ingår i: Ieee Transactions on Magnetics. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9464 .- 1941-0069. ; 50:6
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Tidskriftsartikel (refereegranskat)abstract
- We present a comprehensive review of the most recent advances in nanocontact spin torque oscillators (NC-STOs). NC-STOs are highly tunable, with both applied magnetic field and dc, broadband microwave signal generators. As opposed to the nanopillar geometry, where the lateral cross section of the entire device has been confined to a typically <100 nm diameter, in NC-STOs, it is only the current injection site that has been laterally confined on top of an extended magnetic film stack. Three distinct material combinations will be discussed: 1) a Co/Cu/NiFe pseudospin valve (PSV) where both the Co and NiFe have a dominant in-plane anisotropy; 2) a Co/Cu/[Co/Ni](4) orthogonal PSV where the Co/Ni multilayer has a strong perpendicular anisotropy; and 3) a single NiFe layer with asymmetric non-magnetic Cu leads. We explore the rich and diverse magnetodynamic modes that can be generated in these three distinct sample geometries.
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| 12. |
- Houshang, A., et al.
(författare)
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Effect of Excitation Fatigue on the Synchronization of Multiple Nanocontact Spin-Torque Oscillators
- 2014
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Ingår i: IEEE Magnetics Letters. - 1949-307X .- 1949-3088. ; 5, s. 3000404-
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Tidskriftsartikel (refereegranskat)abstract
- Nanocontact spin-torque oscillators (NC-STOs) act as intrinsically nanoscale and highly current and magnetic field tunable, ultrawide band microwave signal generators. However, their low output power and high phase noise remain critical obstacles toward actual applications. Mutual synchronization of multiple NCs is one possibility to overcome these shortcomings. This letter presents a detailed study of the mutual synchronization in a NC-STO with two NCs. In particular, the effect of repeated measurements on the synchronization behavior is explored. Repeated measurements at high drive currents are shown to significantly degrade the performance of the devices with the most striking consequence being that the devices can no longer be synchronized. Ferromagnetic resonance measurements reveal a decrease in the saturation magnetization and an increase in the damping coefficient in annealed NiFe films, consistent with Cu diffusion into the NiFe from the adjacent Cu layers. This increase in damping will act to sever the spin wave-mediated communication channel between the NCs necessary for synchronization. These results highlight an important consideration when studying the synchronization behavior of multi-NC devices where Joule heating is expected to scale unfavorably with the number of NCs.
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| 13. |
- Mohseni, Seyed Majid, et al.
(författare)
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Spin Torque-Generated Magnetic Droplet Solitons
- 2013
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 339:6125, s. 1295-1298
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Tidskriftsartikel (refereegranskat)abstract
- Dissipative solitons have been reported in a wide range of nonlinear systems, but the observation of their magnetic analog has been experimentally challenging. Using spin transfer torque underneath a nanocontact on a magnetic thin film with perpendicular magnetic anisotropy (PMA), we have observed the generation of dissipative magnetic droplet solitons and report on their rich dynamical properties. Micromagnetic simulations identify a wide range of automodulation frequencies, including droplet oscillatory motion, droplet "spinning," and droplet "breather" states. The droplet can be controlled by using both current and magnetic fields and is expected to have applications in spintronics, magnonics, and PMA-based domain-wall devices.
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| 14. |
- Mohseni, S. M., et al.
(författare)
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Temperature-dependent interlayer coupling in Ni/Co perpendicular pseudo-spin-valve structures
- 2011
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 84:17, s. 174432-
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Tidskriftsartikel (refereegranskat)abstract
- The temperature-dependent coupling mechanisms in perpendicular pseudo-spin valves based on the following structure, [Ni/Co](5)/Cu(t(Cu))/[Ni/Co](2), are investigated. Despite a thick (t(Cu) >= 3 nm) Cu spacer, room-temperature measurements reveal complete coupling of the [Ni/Co](5) and [Ni/Co](2) multilayers. This coupling can be attributed to strong long range magnetostatic stray fields that penetrate the spacer layer. This results in magnetic domain imprinting and vertically correlated domains throughout the reversal process. Surprisingly, when the temperature is reduced, a complete decoupling is observed. This somewhat counterintuitive result can be explained by a large difference in the [Ni/Co](5) and [Ni/Co](2) multilayer coercivities at reduced temperatures, which then impedes domain imprinting and promotes decoupling. Finally, the decoupling temperature is found to increase with spacer thickness.
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| 15. |
- Nielsen, Lotte B., et al.
(författare)
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Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes
- 2011
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Ingår i: Autoimmunity. - : Informa UK Limited. - 0891-6934 .- 1607-842X. ; 44:8, s. 616-623
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Tidskriftsartikel (refereegranskat)abstract
- Autoantibodies against the newly established autoantigen in type 1 diabetes, zinc transporter 8, ZnT8, are presented as two types, ZnT8RAb and ZnT8WAb. The rs13266634 variant of the SLC30A8 gene has recently been found to determine the type of ZnT8Ab. The aim of this study was to explore the impact of this genetic variant and the ZnT8Ab on the residual beta-cell function during disease progression the first year after disease diagnosis in children with newly diagnosed type 1 diabetes. This cohort consists of 257 children aged < 16 years, all patients were newly diagnosed with type 1 diabetes. A Boost-test was carried out at 1, 6, and 12 months to characterize the residual beta-cell function. Carriers of the CC and CT genotype groups of the rs13266634 SNP of the SLC30A8 gene had higher stimulated C-peptide levels the first year after onset compared with those of the TT genotype group (29%, p = 0.034). CC genotype carriers were highly associated with the presence of ZnT8RAb subtype during disease progression (compared with TT, p < 0.0001). On the other hand, the TT genotype was associated with the presence of ZnT8WAb subtype during disease progression (compared with CC, p < 0.0001). The C allele of the SLC30A8 gene is associated with preserved beta-cell function in type 1 diabetes patients. The genetic determination of the rs13266634 variant on the ZnT8Ab specificity is sustained the first 12 months after the diagnosis of type 1 diabetes in a pediatric cohort.
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| 16. |
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| 17. |
- Sani, Sohrab R, et al.
(författare)
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Current induced vortices in multi-nanocontact spin-torque devices
- 2011
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Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 109:7, s. 07C913-
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate spin transfer torque (STT) switching in multi-nanocontact STT devices fabricated using hole mask colloidal lithography. We also study the STT device resistance and switching properties as a function of applied magnetic field and nanocontact current. At low nanocontact current, magnetoresistance measurements show sharp, single-step switching at low switching fields. When the current is increased, the switching becomes multistep, and the switching field increases dramatically. We explain these results as arising from a transition from a predominantly single domain like switching to switching involving a vortex state. Micromagnetic simulations corroborate this picture, indicating that a single magnetic vortex nucleates in between the nanocontacts through the influence from the total Oersted field generated by the nanocontact ensemble.
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| 18. |
- Sani, S. R., et al.
(författare)
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Microwave Signal Generation in Single-Layer Nano-Contact Spin Torque Oscillators
- 2013
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Ingår i: Ieee Transactions on Magnetics. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9464 .- 1941-0069. ; 49:7, s. 4331-4334
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate spin transfer torque (STT) driven microwave signal generation, from about 250 MHz to above 3 GHz, in single perm alloy layers underneath a nano-contact with diameter of 100 nm. The threshold current for signal generation is found to be strongly hysteretic, the microwave signal shows a number of harmonics, zero-field operation is straightforward, and the microwave frequency increases quasi-linearly with drive current. All observations are consistent with STT driven motion of a vortex-antivortex pair nucleated by the Oersted field underneath the nano-contact. While the generated power is about 10 dB smaller than the best GMR based nano-contact spin torque oscillators, the linewidth of 6-100 MHz is of the same order.
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| 19. |
- Shulman, L. M., et al.
(författare)
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Antibodies to islet cell autoantigens, rotaviruses and/or enteroviruses in cord blood and healthy mothers in relation to the 2010-2011 winter viral seasons in Israel: a pilot study
- 2014
-
Ingår i: Diabetic Medicine. - : Wiley. - 1464-5491 .- 0742-3071. ; 31:6, s. 681-685
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Tidskriftsartikel (refereegranskat)abstract
- AimsTo determine whether antivirus and/or islet cell antibodies can be detected in healthy pregnant mothers without diabetes and/or their offspring at birth in two winter viral seasons. MethodsMaternal and cord blood sera from 107 healthy pregnant women were tested for islet cell autoantibodies using radioligand binding assays and for anti-rotavirus and anti-CoxB3 antibody using an enzyme-linked immunosorbent assay. ResultsGlutamic acid decarboxylase (GAD)65 autoantibodies and rotavirus antibodies, present in both maternal and cord blood sera, correlated with an odds ratio of 6.89 (95% CI: 1.01-46.78). For five, 22 and 17 pregnancies, antibodies to GAD65, rotavirus and CoxB3, respectively, were detected in cord blood only and not in the corresponding maternal serum. In 10 pregnancies, rotavirus antibody titres in the cord blood exceeded those in the corresponding maternal serum by 2.5-5-fold. Increased antibody titres after the 20(th) week of gestation suggested CoxB3 infection in one of the 20 pregnancies and rotavirus in another. ConclusionThe concurrent presence of GAD65 antibodies in cord blood and their mothers may indicate autoimmune damage to islet cells during gestation, possibly caused by cross-placental transmission of viral infections and/or antivirus antibodies. Cord blood antibody titres that exceed those of the corresponding maternal sample by >2.5-fold, or antibody-positive cord blood samples with antibody-negative maternal samples, may imply an active in utero immune response by the fetus. What's new? It has been hypothesized that viral infections initiate islet cell autoimmunity. Previous research suggests an association of viral infection in utero and islet autoimmunity. We found a significant correlation between glutamic acid decarboxylase 65 autoantibodies and anti-rotavirus in healthy mothers at delivery and in cord blood. The presence of antibodies in cord blood with antibody-negative mothers suggests an independent fetal immune response. Our findings support the hypothesis that viral infections during pregnancy damage fetal islet cells, triggering islet autoimmunity.
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| 20. |
- Sorensen, J. S., et al.
(författare)
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Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3-6 years
- 2012
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Ingår i: Diabetes Research and Clinical Practice. - : Elsevier BV. - 1872-8227 .- 0168-8227. ; 96:2, s. 204-210
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Tidskriftsartikel (refereegranskat)abstract
- Aims: To test if islet autoantibodies at diagnosis of type 1 diabetes (T1DM) and after 3-6 years with T1D predict residual beta-cell function (RBF) after 3-6 years with T1D. Methods: T1D children (n = 260, median age at diagnosis 9.4, range 0.9-14.7 years) were tested for GAD65, IA-2, ZnT8R, ZnT8W and ZnT8Q autoantibodies (A) at diagnosis, and 3-6 years after diagnosis when also fasting and stimulated RBF were determined. Results: For every 1-year increase in age at diagnosis of TID, the odds of detectable C-peptide increased 1.21 (1.09, 1.34) times for fasting C-peptide and 1.28 (1.15, 1.42) times for stimulated C-peptide. Based on a linear model for subjects with no change in IA-2A levels, the odds of detectable C-peptide were 35% higher than for subjects whose IA-2A levels decreased by half (OR = 1.35 (1.09, 1.67), p = 0.006); similarly for ZnT8WA (OR = 1.39 (1.09, 1.77), p = 0.008) and ZnT8QA (OR = 1.55 (1.06, 2.26) p = 0.024). Such relationship was not detected for GADA or ZnT8RA. All OR adjusted for confounders. Conclusions: Age at diagnosis with T1D was the major predictor of detectable C-peptide 3-6 years post-diagnosis. Decreases in IA-2A, and possibly ZnT8A, levels between diagnosis and post-diagnosis were associated with a reduction in RBF post-diagnosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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