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Träfflista för sökning "WFRF:(Schachter J) srt2:(2015-2019)"

Sökning: WFRF:(Schachter J) > (2015-2019)

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  • Hadfield, James, et al. (författare)
  • Comprehensive global genome dynamics of Chlamydia trachomatis show ancient diversification followed by contemporary mixing and recent lineage expansion
  • 2017
  • Ingår i: Genome Research. - : Cold Spring Harbor Laboratory Press. - 1088-9051 .- 1549-5469. ; 27:7, s. 1220-1229
  • Tidskriftsartikel (refereegranskat)abstract
    • Chlamydia trachomatis is the world's most prevalent bacterial sexually transmitted infection and leading infectious cause of blindness, yet it is one of the least understood human pathogens, in part due to the difficulties of in vitro culturing and the lack of available tools for genetic manipulation. Genome sequencing has reinvigorated this field, shedding light on the contemporary history of this pathogen. Here, we analyze 563 full genomes, 455 of which are novel, to show that the history of the species comprises two phases, and conclude that the currently circulating lineages are the result of evolution in different genomic ecotypes. Temporal analysis indicates these lineages have recently expanded in the space of thousands of years, rather than the millions of years as previously thought, a finding that dramatically changes our understanding of this pathogen's history. Finally, at a time when almost every pathogen is becoming increasingly resistant to antimicrobials, we show that there is no evidence of circulating genomic resistance in C. trachomatis.
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  • Azagra-Caro, J. M., et al. (författare)
  • Dynamic interactions between university-industry knowledge transfer channels: A case study of the most highly cited academic patent
  • 2017
  • Ingår i: Research Policy. - : Elsevier BV. - 0048-7333. ; 46:2, s. 463-474
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper examines the succession of formal and informal channels of university-industry knowledge transfer, and the local economic impact of their dynamic interaction. To do so, we investigate a highly cited university patent over an extended period of time through a case study methodology. Our work provides three fundamental insights. First, local economic impact can be achieved only after a complex, temporally unfolding sequence of interactions between formal and informal channels of knowledge transfer. Second, in the course of this dynamic interaction, knowledge generated during formal transfer activities may be transferred via informal channels. Third, the method developed can provide information on the variety of knowledge transfer channels related to highly cited patents. (C) 2016 Elsevier B.V. All rights reserved.
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