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Differentiating Dru...
Differentiating Drug-related and State-related Effects of Dexmedetomidine and Propofol on the Electroencephalogram
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- Scheinin, Annalotta (författare)
- University of Turku, Finland / Hospital District of Southwest Finland, Turku, Finland / Turku University Hospital, Finland
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- Kallionpää, Roosa E. (författare)
- Turku University Hospital, Finland / University of Turku, Finland
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- Li, Duan (författare)
- University of Michigan Medical School, Ann Arbor, Michigan
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- Kallioinen, Minna (författare)
- Turku University Hospital, Finland
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- Kaisti, Kaike (författare)
- University of Turku, Finland / Hospital District of Southwest Finland, Turku, Finland / Oulu University Hospital, Finland
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- Långsjö, Jaakko (författare)
- University of Turku, Finland / Hospital District of Southwest Finland, Turku, Finland / Tampere University Hospital, Finland
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- Maksimow, Anu (författare)
- University of Turku, Finland / Hospital District of Southwest Finland, Turku, Finland / Turku University Hospital, Finland
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- Vahlberg, Tero (författare)
- University of Turku, Finland / Turku University Hospital, Finland
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- Valli, Katja, 1973- (författare)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,University of Turku, Finland,Consciousness and Cognitive Neuroscience
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- Mashour, George A. (författare)
- University of Michigan Medical School, Ann Arbor, Michigan
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- Revonsuo, Antti (författare)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,University of Turku, Finland,Consciousness and Cognitive Neurosciece
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- Scheinin, Harry (författare)
- University of Turku, Finland / Hospital District of Southwest Finland, Turku, Finland / Turku University Hospital, Finland
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2018
- 2018
- Engelska.
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Ingår i: Anesthesiology. - : Lippincott Williams & Wilkins. - 0003-3022 .- 1528-1175. ; 129:1, s. 22-36
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUNDDifferentiating drug-related changes and state-related changes on the electroencephalogram during anesthetic-induced unconsciousness has remained a challenge. To distinguish these, we designed a rigorous experimental protocol with two drugs known to have distinct molecular mechanisms of action. We hypothesized that drug- and state-related changes can be separated.METHODS: Forty-seven healthy participants were randomized to receive dexmedetomidine (n = 23) or propofol (n = 24) as target-controlled infusions until loss of responsiveness. Then, an attempt was made to arouse the participant to regain responsiveness while keeping the drug infusion constant. Finally, the concentration was increased 1.5-fold to achieve presumable loss of consciousness. We conducted statistical comparisons between the drugs and different states of consciousness for spectral bandwidths, and observed how drug-induced electroencephalogram patterns reversed upon awakening. Cross-frequency coupling was also analyzed between slow-wave phase and alpha power.RESULTS: Eighteen (78%) and 10 (42%) subjects were arousable during the constant drug infusion in the dexmedetomidine and propofol groups, respectively (P = 0.011 between the drugs). Corresponding with deepening anesthetic level, slow-wave power increased, and a state-dependent alpha anteriorization was detected with both drugs, especially with propofol. Negative phase-amplitude coupling before and during loss of responsiveness frontally and positive coupling during the highest drug concentration posteriorly were observed in the propofol but not in the dexmedetomidine group.CONCLUSIONS: Electroencephalogram effects of dexmedetomidine and propofol are strongly drug- and state-dependent. Changes in slow-wave and alpha activity seemed to best detect different states of consciousness.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Consciousness and Cognitive Neuroscience
- Kognitiv neurovetenskap och filosofi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Scheinin, Annalo ...
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Kallionpää, Roos ...
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Li, Duan
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Kallioinen, Minn ...
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Kaisti, Kaike
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Långsjö, Jaakko
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visa fler...
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Maksimow, Anu
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Vahlberg, Tero
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Valli, Katja, 19 ...
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Mashour, George ...
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Revonsuo, Antti
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Scheinin, Harry
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visa färre...
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