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- Schuler, T. V., et al.
(författare)
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Distribution of snow accumulation on the Svartisen ice cap, Norway, assessed by a model of orographic precipitation
- 2008
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Ingår i: Hydrological Processes. - : Wiley. - 0885-6087 .- 1099-1085. ; 22:19, s. 3998-4008
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Tidskriftsartikel (refereegranskat)abstract
- We apply a linear model of orographic precipitation (LT model) to estimate snow accumulation on the western Svartisen ice cap (220 km2) in northern Norway. This model combines 3D airflow dynamics with simple parameterizations of cloud physics. The model is forced by large-scale atmospheric input variables taken from the ECMWF Re-analysis (ERA-40) of the European Center for Medium Range Weather Forecast (ECMWF), and the model parameters are kept constant for the entire simulation period, after optimization. The domain covers a 120 × 125 km area surrounding the ice cap. The model is run using a 1-km resolution digital elevation model, and 6-h time steps over the period from 1958 to 2002. Precipitation data from surrounding meteorological stations and winter glacier mass balance measurements on several glaciers within the region are used to evaluate the model results. Precipitation obtained from the LT model agrees well with observations from precipitation gauges and there is also fair agreement between model results and specific winter mass balance observations on the ice cap if these are corrected for winter rain. The LT model reproduces well the spatial pattern of winter accumulation across the ice cap as well as the area-averaged winter mass balances of several other glaciers in the region. This indicates that it is a useful tool in providing high-resolution, deterministic estimates of precipitation in complex terrain as required for distributed hydrological and/or glacier mass balance modelling of unmeasured areas
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- Bekou, V, et al.
(författare)
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Detection of laminin 5-specific auto-antibodies in mucous membrane and bullous pemphigoid sera by ELISA
- 2005
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Ingår i: Journal of Investigative Dermatology. - 1523-1747. ; 124:4, s. 732-740
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Tidskriftsartikel (refereegranskat)abstract
- Mucous membrane pemphigoid (MMP) is an autoimmune bullous disease that primarily affects mucous membranes leading to a scarring phenotype. MMP patients produce auto-antibodies (auto-ab) that preferentially recognize two components of the dermoepidermal basement membrane zone (BMZ): bullous pemphigoid (BP)180 and laminin 5 (LN5). Since detection of disease-specific auto-ab may be critical for diagnosis of MMP, we developed an ELISA with affinity-purified native human LN5. A total of 24 MMP, 72 BP, and 51 control sera were analyzed for LN5-specific auto-ab: 18/24 (75.0%) MMP and 29/72 (40.3%) BP sera were LN5 reactive. Sensitivity and specificity of the LN5 ELISA for MMP were 75% and 84.3%, respectively, and 40.3% and 88.2% for BP, respectively. The LN5 ELISA was more sensitive than a dot blot assay with native LN5, which detected LN5-reactive IgG in 14/24 (58.3%) MMP and 16/72 (22.2%) BP sera. In MMP, but not BP, levels of LN5-reactive IgG correlated with disease severity. Furthermore, IgG reactivity to LN5 of the MMP and BP sera was not significantly associated with IgG reactivity against other autoantigens of the BMZ, such as BP180 or BP230. Thus, the established LN5 ELISA holds great promise as a novel diagnostic and prognostic parameter for MMP.
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