| 1. |
- Connolly, L. J., et al.
(författare)
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Effects of small-volume soccer and vibration training on body composition, aerobic fitness, and muscular PCr kinetics for inactive women aged 20-45
- 2014
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Ingår i: Journal of Sport and Health Science. - : Elsevier BV. - 2095-2546. ; 3:4, s. 284-292
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The present study investigated the effects of 16 weeks of small-volume, small-sided soccer training soccer group (SG, n = 13) and oscillating whole-body vibration training vibration group (VG, n = 17) on body composition, aerobic fitness, and muscle PCr kinetics in healthy inactive premenopausal women in comparison with an inactive control group (CO, n = 14). Methods: Training for SG and VG consisted of twice-weekly 15-min sessions with average heart rates (HRs) of similar to 155 and 90 bpm respectively. Pre- and post-measurements of body composition (DXA), phosphocreatine (PCr) on-and off-kinetics, and HR measurements during standardised submaximal exercise were performed. Results: After 16 weeks of training in SG, fat percentage was lowered (p = 0.03) by 1.7% +/- 2.4% from 37.5% +/- 6.9% to 35.8% +/- 6.2% and the PCr decrease in the quadriceps during knee-extension ramp exercise was attenuated (4% +/- 8%, p = 0.04), with no changes in VG or CO (time-group effect: p = 0.03 and p = 0.03). Submaximal exercise HR was also reduced in SG after 16 weeks of training (6% +/- 5% of HRmax, p = 0.01). Conclusion: Short duration soccer training for 16 weeks appears to be sufficient to induce favourable changes in body composition and indicators of aerobic fitness and muscle oxidative capacity in untrained premenopausal women. Copyright (C) 2014, Shanghai University of Sport. Production and hosting by Elsevier B.V. All rights reserved.
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| 3. |
- Drouart, Guillaume, 1987, et al.
(författare)
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Rapidly growing black holes and host galaxies in the distant Universe from the Herschel Radio Galaxy Evolution Project
- 2014
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 566
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Tidskriftsartikel (refereegranskat)abstract
- We present results from a comprehensive survey of 70 radio galaxies at redshifts 1 10(12) L-circle dot) or hyper-luminous (L-tot(IR) > 10(13) L-circle dot) infrared galaxies. We fit the infrared SEDs with a set of empirical templates which represent dust heated by a variety of starbursts (SB) and by an active galactic nucleus (AGN). We find that the SEDs of radio galaxies require the dust to be heated by both AGN and SB, but the luminosities of these two components are not strongly correlated. Assuming empirical relations and simple physical assumptions, we calculate the star formation rate (SFR), the black hole mass accretion rate ((M) over dot(BH)), and the black hole mass (M-BH) for each radio galaxy. We find that the host galaxies and their black holes are growing extremely rapidly, having SFR approximate to 100-5000 M-circle dot yr(-1) and. (M) over dot(BH) approximate to 1-100 M(circle dot)yr(-1). The mean specific SFRs (sSFR) of radio galaxies at z > 2 : 5 are higher than the sSFR of typical star forming galaxies over the same redshift range, but are similar or perhaps lower than the galaxy population for radio galaxies at z
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| 4. |
- Huynh, M. T., et al.
(författare)
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Physical conditions of the gas in an ALMA C II -identified submillimetre galaxy at z=4.44
- 2013
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966 .- 1745-3933 .- 1745-3925. ; 431:1, s. L88-L92
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Tidskriftsartikel (refereegranskat)abstract
- We present (CO)-C-12(2-1) observations of the submillimetre galaxy ALESS65.1 performed with the Australia Telescope Compact Array (ATCA) at 42.3 GHz. A previous Atacama Large Millimeter Array study of submillimetre galaxies (SMGs) in the Extended Chandra Deep Field South detected [C II] 157.74 mu m emission from this galaxy at a redshift of z= 4.44. No (CO)-C-12(21) emission was detected but we derive a firm upper limit to the cold gas mass in ALESS65.1 of M-gas 4 SMGs being the likely progenitors of massive red-and-dead galaxies at z > 2. The ratio of the [CII], (CO)-C-12 and far-infrared luminosities implies a strong far-ultraviolet field of G(0) greater than or similar to 103, as seen in Galactic star-forming regions or local ultraluminous infrared galaxies (ULIRGs). The observed L-[C II]/L-FIR = 2.3 x 10(-3) is high compared to local ULIRGs and, combined withLL([CII])/L-CO greater than or similar to 2700, it is consistent with ALESS65.1 either having an extended (several kpc) [C II] emitting region or lower than solar metallicity.
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| 5. |
- Maneval, J. E., et al.
(författare)
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Magnetic resonance analysis of capillary formation reaction front dynamics in alginate gels
- 2011
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Ingår i: Magnetic Resonance in Chemistry. - : Wiley. - 1097-458X .- 0749-1581. ; 49:10, s. 627-640
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Tidskriftsartikel (refereegranskat)abstract
- The formation of heterogeneous structures in biopolymer gels is of current interest for biomedical applications and is of fundamental interest to understanding the molecular level origins of structures generated from disordered solutions by reactions. The cation-mediated physical gelation of alginate by calcium and copper is analyzed using magnetic resonance measurements of spatially resolved molecular dynamics during gel front propagation. Relaxation time and pulse-field gradient methods are applied to determine the impact of ion front motion on molecular translational dynamics. The formation of capillaries in alginate copper gels is correlated to changes in translational dynamics.
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| 9. |
- Fridjonsson, E. O., et al.
(författare)
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Hydrodynamic dispersion in beta-lactoglobulin gels measured by PGSE NMR
- 2011
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Ingår i: European Physical Journal E. - : Springer Science and Business Media LLC. - 1292-8941 .- 1292-895X. ; 34:2
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Tidskriftsartikel (refereegranskat)abstract
- The displacement scale dependent molecular dynamics of solvent water molecules flowing through beta-lactoglobulin gels are measured by pulse gradient spin echo (PGSE) nuclear magnetic resonance (NMR). Gels formed under different pH conditions generate structures which are characterized by magnetic resonance imaging (MRI) and PGSE NMR measured dynamics as homogeneous and heterogeneous. The data presented clearly demonstrate the applicability of the theoretical framework for modeling hydrodynamic dispersion to the analysis of protein gels.
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| 10. |
- Kajko-Mattsson, Mira, et al.
(författare)
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Refounding software engineering : The Semat initiative (Invited presentation)
- 2012
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Ingår i: Software Engineering (ICSE), 2012 34th International Conference on. - : IEEE Computer Society. - 9781467310673 ; , s. 1649-1650
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Konferensbidrag (refereegranskat)abstract
- The new software engineering initiative, Semat, is in the process of developing a kernel for software engineering that stands on a solid theoretical basis. So far, it has suggested a set of kernel elements for software engineering and basic language constructs for defining the elements and their usage. This paper describes a session during which Semat results and status will be presented. The presentation will be followed by a discussion panel.
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| 11. |
- Lupo, Philip J., et al.
(författare)
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Allergies, atopy, immune-related factors and childhood rhabdomyosarcoma : a report from the Children's Oncology Group
- 2014
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Ingår i: International Journal of Cancer. - : Wiley-Blackwell. - 0020-7136 .- 1097-0215. ; 134:2, s. 431-436
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Tidskriftsartikel (refereegranskat)abstract
- Rhabdomyosarcoma (RMS) is a highly malignant tumor of developing muscle that can occur anywhere in the body. Due to its rarity, relatively little is known about the epidemiology of RMS. Atopic disease is hypothesized to be protective against several malignancies; however, to our knowledge, there have been no assessments of atopy and childhood RMS. Therefore, we explored this association in a case-control study of 322 childhood RMS cases and 322 pair-matched controls. Cases were enrolled in a trial run by the Intergroup Rhabdomyosarcoma Study Group. Controls were matched to cases on race, sex and age. The following atopic conditions were assessed: allergies, asthma, eczema and hives; in addition, we examined other immune-related factors: birth order, day-care attendance and breastfeeding. Conditional logistic-regression models were used to calculate an odds ratio (OR) and 95% confidence interval (CI) for each exposure, adjusted for age, race, sex, household income and parental education. As the two most common histologic types of RMS are embryonal (n=215) and alveolar (n=66), we evaluated effect heterogeneity of these exposures. Allergies (OR=0.60, 95% CI: 0.41-0.87), hives (OR=0.61, 95% CI: 0.38-0.97), day-care attendance (OR=0.48, 95% CI: 0.32-0.71) and breastfeeding for12 months (OR=0.36, 95% CI: 0.18-0.70) were inversely associated with childhood RMS. These exposures did not display significant effect heterogeneity between histologic types (p>0.52 for all exposures). This is the first study indicating that atopic exposures may be protective against childhood RMS, suggesting additional studies are needed to evaluate the immune system's role in the development of this tumor.
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| 13. |
- Lupo, Philip J., et al.
(författare)
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Maternal and birth characteristics and childhood rhabdomyosarcoma : a report from the Children's Oncology Group
- 2014
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Ingår i: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 0957-5243 .- 1573-7225. ; 25:7, s. 905-913
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Tidskriftsartikel (refereegranskat)abstract
- Previous assessments of childhood rhabdomyosarcoma have indicated maternal and birth characteristics may be associated with tumor development; however, much work remains to identify novel and confirm suspected risk factors. Our objective was to evaluate the associations between maternal and birth characteristics and childhood rhabdomyosarcoma. This case-control study included 322 cases and 322 pair-matched controls. Cases were enrolled in a trial run by the Intergroup Rhabdomyosarcoma Study Group. Population-based controls were identified using random digit dialing and were individually matched to cases on race, sex, and age. Families of the case and control subjects participated in a telephone interview, which captured information on maternal characteristics (birth control use, number of prenatal visits, anemia, and abnormal bleeding during pregnancy) and birth characteristics [birth weight, preterm birth, and type of delivery (vaginal vs. cesarean)]. Conditional logistic regression models were used to calculate an odds ratio (OR) and 95 % confidence interval (CI) for each exposure, adjusted for age, race, sex, household income, and parental education. As the two most common histologic types of rhabdomyosarcoma are embryonal (n = 215) and alveolar (n = 66), we evaluated effect heterogeneity of these exposures. The only characteristic that was associated with childhood rhabdomyosarcoma, and statistically significant, was abnormal vaginal bleeding during pregnancy (OR 1.75, 95 % CI 1.12-2.74). Birth control use (OR 1.45, 95 % CI 0.96-2.18), anemia during pregnancy (OR 1.27, 95 % CI 0.81-1.99), and preterm birth (OR 2.51, 95 % CI 0.74-8.49) were positively associated with childhood rhabdomyosarcoma, but were not statistically significant. Low birth weight [adjusted odds ratios (aOR) 4.46, 95 % CI 1.41-14.1] and high birth weight (aOR 2.41, 95 % CI 1.09-5.35) were strongly associated with alveolar rhabdomyosarcoma. However, these factors did not display significant effect heterogeneity between histologic types (p > 0.15 for all characteristics). Overall, we found little evidence that these maternal and birth characteristics are strongly associated with childhood rhabdomyosarcoma.
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| 14. |
- Morschhauser, F., et al.
(författare)
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Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma
- 2010
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Ingår i: Annals of Oncology. - : Elsevier BV. - 1569-8041 .- 0923-7534. ; 21:9, s. 1870-1876
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Tidskriftsartikel (refereegranskat)abstract
- Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3 weeks: cohort A, 200 mg/m(2) (n = 15); cohort B, 375 mg/m(2) (n = 16); cohort C, first dose 375 mg/m(2), seven subsequent doses of 750 mg/m(2) (n = 16). Patients were assessed for safety, efficacy, pharmacodynamics and pharmacokinetics. Results: The median patient age was 58 years, the majority had Ann Arbor stage III/IV disease and had received a median of 2 (range 1-6) prior regimens. Ocrelizumab was well tolerated with grade 3/4 toxicity occurring in 9% of patients. The most common toxicity was infusion-related reactions (74% patients), all grade 1/2 except one grade 3 event. The objective response rate was 38% and was similar in patients with low-affinity and high-affinity variants of the Fc gamma receptor IIIa (Fc gamma RIIIa). With follow-up of similar to 28 months, the median progression-free survival was 11.4 months. Conclusion: Ocrelizumab demonstrated activity in patients with relapsed/refractory FL following prior rituximab treatment, with safety similar to rituximab although adverse events appeared milder.
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| 15. |
- Quirke, Phil, et al.
(författare)
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Evidence-based medicine : the time has come to set standards for staging
- 2010
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Ingår i: Journal of Pathology. - : Wiley. - 0022-3417 .- 1096-9896. ; 221:4, s. 357-360
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Tidskriftsartikel (refereegranskat)abstract
- For international communication in cancer, staging systems such as TNM are essential; however, the principles and processes used to decide about changes in every new edition of TNM need to be subject to debate. Changes with major impact for patient treatment are introduced without evidence. We think that TNM should be a continual reactive process, rather than a proactive process. Changes should only occur after extensive discussion within the community, and before the introduction of any changes these should be tested for reproducibility and compared to the currently used gold standard. TNM should not be used to test hypotheses. It should introduce established facts that are beneficial to predicting patient prognosis. TNM should thus be restructured on a basis equivalent to evidence-based guidelines. The strength of the evidence should be explicitly stated and the evidence base given. It is time for the principles of staging to be widely debated and new principles and processes to be introduced to ensure that we are not in the same situation in the future. The disparity between therapeutic decision making and TNM staging is marked and we would appeal for the radical overhaul of TNM staging to make it fit for the twenty-first century. TNM is central to the management of cancer patients and we must protect and enhance its reputation.
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