| 1. |
|
|
| 2. |
- Clark, Andrew G., et al.
(författare)
-
Evolution of genes and genomes on the Drosophila phylogeny
- 2007
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
-
Tidskriftsartikel (refereegranskat)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
|
|
| 3. |
|
|
| 4. |
- Alkhomashi, N., et al.
(författare)
-
beta(-)-delayed spectroscopy of neutron-rich tantalum nuclei: Shape evolution in neutron-rich tungsten isotopes
- 2009
-
Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 80:6
-
Tidskriftsartikel (refereegranskat)abstract
- The low-lying structure of W-188,W-190,W-192 has been studied following beta decays of the neutron-rich mother nuclei Ta-188,Ta-190,Ta-192 produced following the projectile fragmentation of a 1-GeV-per-nucleon Pb-208 primary beam on a natural beryllium target at the GSI Fragment Separator. The beta-decay half-lives of Ta-188, Ta-190, and Ta-192 have been measured, with gamma-ray decays of low-lying states in their respective W daughter nuclei, using heavy-ion beta-gamma correlations and a position-sensitive silicon detector setup. The data provide information on the low-lying excited states in W-188, W-190, and W-192, which highlight a change in nuclear shape at W-190 compared with that of lighter W isotopes. This evolution of ground-state structure along the W isotopic chain is discussed as evidence for a possible proton subshell effect for the A similar to 190 region and is consistent with maximization of the gamma-softness of the nuclear potential around N similar to 116.
|
|
| 5. |
- Berman, F., et al.
(författare)
-
New grid scheduling and rescheduling methods in the GrADS Project
- 2005
-
Ingår i: International journal of parallel programming. - : Springer Science and Business Media LLC. - 0885-7458 .- 1573-7640. ; 33:3-Feb, s. 209-229
-
Tidskriftsartikel (refereegranskat)abstract
- The goal of the Grid Application Development Software (GrADS) Project is to provide programming tools and an execution environment to ease program development for the Grid. This paper presents recent extensions to the GrADS software framework: a new approach to scheduling workflow computations, applied to a 3-D image reconstruction application; a simple stop/migrate/restart approach to rescheduling Grid applications, applied to a QR factorization benchmark; and a process-swapping approach to rescheduling, applied to an N-body simulation. Experiments validating these methods were carried out on both the GrADS MacroGrid (a small but functional Grid) and the MicroGrid (a controlled emulation of the Grid).
|
|
| 6. |
|
|
| 7. |
- Singh, Umashankar, et al.
(författare)
-
Expression and Functional Analysis of Genes Deregulated in Mouse Placental Overgrowth Models: Car2 and Ncam1
- 2005
-
Ingår i: Developmental Dynamics. - : Wiley. - 1058-8388 .- 1097-0177. ; 234:4, s. 1034-1045
-
Tidskriftsartikel (refereegranskat)abstract
- Different causes, such as maternal diabetes, cloning by nuclear transfer, interspecific hybridization, and deletion of some genes such as Esx1, Ipl, or Cdkn1c, may underlie placental overgrowth. In a previous study, we carried out comparative gene expression analysis in three models of placental hyperplasias, cloning, interspecies hybridization (IHPD), and Esx1 deletion. This study identified a large number of genes that exhibited differential expression between normal and enlarged placentas; however, it remained unclear how altered expression of any specific gene was related to any specific placental phenotype. In the present study, we focused on two genes, Car2 and Ncam1, which both exhibited increased expression in interspecies and cloned hyperplastic placentas. Apart from a detailed expression analysis of both genes during normal murine placentation, we also assessed morphology of placentas that were null for Car2 or Ncam1. Finally, we attempted to rescue placental hyperplasia in a congenic model of IHPD by decreasing transcript levels of Car2 or Ncam1. In situ analysis showed that both genes are expressed mainly in the spongiotrophoblast, however, expression patterns exhibited significant variability during development. Contrary to expectations, homozygous deletion of either Car2 or Ncam1 did not result in placental phenotypes. However, expression analysis of Car3 and Ncam2, which can take over the function of Car2 and Ncam1, respectively, indicated a possible rescue mechanism, as Car3 and Ncam2 were expressed in spongiotrophoblast of Car2 and Ncam1 mutant placentas. On the other hand, downregulation of either Car2 or Ncam1 did not rescue any of the placental phenotypes of AT24 placentas, a congenic model for interspecies hybrid placentas. This strongly suggested that altered expression of Car2 and Ncam1 is a downstream event in placental hyperplasia.
|
|
| 8. |
- Zhang, W., et al.
(författare)
-
3D treatment planning and simulating for craniofacial skeleton
- 2005
-
Ingår i: The International Journal of Advanced Manufacturing Technology. - : Springer Science and Business Media LLC. - 0268-3768 .- 1433-3015. ; 26:10-sep, s. 1043-1047
-
Tidskriftsartikel (refereegranskat)abstract
- In surgery of the craniofacial skeleton, the current simulation planning systems extrapolate 3D surgical movements and outcomes based on 2D radiographs, which are inadequate for complex surgical movements. This paper presents a 3D treatment-planning system based on computerized tomography (CT) data. Based upon MedGraphics software, a 3D data field is constructed out of the sectional image stack through linear interpolation, and a seeded region-growing algorithm is adopted for the objective tissue segmentation. With the marching cubes algorithm, the triangular mesh model and 3D geometric model of diseased facial skeleton are reconstructed. Then the model is cut, the segments are moved or rotated to their predicted positions, and angles and distances are measured. After the triangular mesh model is decimated, an RP model is manufactured for surgical simulation and a prosthesis is designed. The system has been clinically used for more than 50 cases and technically validated with success.
|
|
