Mycoplasma genitalium prevalence, antimicrobial resistance-associated mutations, and coinfections with non-viral sexually transmitted infections in high-risk populations in Guatemala, Malta, Morocco, Peru and South Africa, 2019-2021

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Mycoplasma genitalium prevalence, antimicrobial resistance-associated mutations, and coinfections with non-viral sexually transmitted infections in high-risk populations in Guatemala, Malta, Morocco, Peru and South Africa, 2019-2021

Shipitsyna, Elena (författare): World Health Organization Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Department of Medical Microbiology, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russia

Kularatne, Ranmini (författare): Labtests Laboratory and Head Office, Mt Wellington, Auckland, New Zealand; Department of Clinical Microbiology & Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Golparian, Daniel, 1984- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,World Health Organization Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

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Müller, Etienne E. (författare): Centre for HIV and STIs, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa

Vargas, Silver K. (författare): School of Public Health and Administration, Centre for Interdisciplinary Investigation in Sexuality, AIDS, Society and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Universidad Peruana Cayetano Heredia, Lima, Peru

Hadad, Ronza, 1984- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,World Health Organization Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology

Padovese, Valeska (författare): Genitourinary Clinic, Department of Dermatology and Venereology, Mater Dei Hospital, Msida, Malta

Hancali, Amina (författare): STIs Laboratory, National Institute of Hygiene, Ministry of Health, Rabat, Morocco

Alvarez, Christian S. (författare): Sida y Sociedad ONG (SISO), Escuintla, Guatemala

Oumzil, Hicham (författare): STIs Laboratory, National Institute of Hygiene, Ministry of Health, Rabat, Morocco; Faculty of Medicine and Pharmacy, University Mohamed V, Rabat, Morocco

Camey, Elsy (författare): Sida y Sociedad ONG (SISO), Escuintla, Guatemala

Blondeel, Karel (författare): Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland; Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium

Toskin, Igor (författare): Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland

Unemo, Magnus, 1970- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,World Health Organization Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Institute for Global Health, University College London (UCL), London, United Kingdom

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World Health Organization Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Department of Medical Microbiology, DO. Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russia Labtests Laboratory and Head Office, Mt Wellington, Auckland, New Zealand; Department of Clinical Microbiology & Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (creator_code:org_t)

2023-02-22
2023
Engelska.
Ingår i: Frontiers in Microbiology. - : Frontiers Media S.A.. - 1664-302X. ; 14

Relaterad länk:: https://doi.org/10.3...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.3...; visa färre...

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The prevalence of Mycoplasma genitalium (MG) and MG antimicrobial resistance (AMR) appear to be high internationally, however, prevalence data remain lacking globally. We evaluated the prevalence of MG and MG AMR-associated mutations in men who have sex with men (MSM) in Malta and Peru and women at-risk for sexually transmitted infections in Guatemala, South Africa, and Morocco; five countries in four WHO regions mostly lacking MG prevalence and AMR data, and estimated MG coinfections with Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV). Male urine and anorectal samples, and vaginal samples were tested for MG, CT, NG, and TV (only vaginal samples) using Aptima assays (Hologic). AMR-associated mutations in the MG 23S rRNA gene and parC gene were identified using ResistancePlus MG kit (SpeeDx) or Sanger sequencing. In total, 1,425 MSM and 1,398 women at-risk were recruited. MG was detected in 14.7% of MSM (10.0% in Malta and 20.0% Peru) and in 19.1% of women at-risk (12.4% in Guatemala, 16.0% Morocco, 22.1% South Africa). The prevalence of 23S rRNA and parC mutations among MSM was 68.1 and 29.0% (Malta), and 65.9 and 5.6% (Peru), respectively. Among women at-risk, 23S rRNA and parC mutations were revealed in 4.8 and 0% (Guatemala), 11.6 and 6.7% (Morocco), and 2.4 and 3.7% (South Africa), respectively. CT was the most frequent single coinfection with MG (in 2.6% of MSM and 4.5% of women at-risk), compared to NG + MG found in 1.3 and 1.0%, respectively, and TV + MG detected in 2.8% of women at-risk. In conclusion, MG is prevalent worldwide and enhanced aetiological MG diagnosis, linked to clinical routine detection of 23S rRNA mutations, in symptomatic patients should be implemented, where feasible. Surveillance of MG AMR and treatment outcome would be exceedingly valuable, nationally and internationally. High levels of AMR in MSM support avoiding screening for and treatment of MG in asymptomatic MSM and general population. Ultimately, novel therapeutic antimicrobials and/or strategies, such as resistance-guided sequential therapy, and ideally an effective MG vaccine are essential.

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Av författaren/redakt...: Shipitsyna, Elen ...; Kularatne, Ranmi ...; Golparian, Danie ...; Müller, Etienne ...; Vargas, Silver K ...; Hadad, Ronza, 19 ...; visa fler...; Padovese, Valesk ...; Hancali, Amina; Alvarez, Christi ...; Oumzil, Hicham; Camey, Elsy; Blondeel, Karel; Toskin, Igor; Unemo, Magnus, 1 ...; visa färre...

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Mycoplasma genitalium prevalence, antimicrobial resistance-associated mutations, and coinfections with non-viral sexually transmitted infections in high-risk populations in Guatemala, Malta, Morocco, Peru and South Africa, 2019-2021

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