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Träfflista för sökning "WFRF:(Shulman E) srt2:(2011-2014)"

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1.	Abbasi, R., et al. (author) IceTop : The surface component of IceCube 2013 In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 700, s. 188-220 Journal article (peer-reviewed)abstract IceTop, the surface component of the IceCube Neutrino Observatory at the South Pole, is an air shower array with an area of 1 km(2). The detector allows a detailed exploration of the mass composition of primary cosmic rays in the energy range from about 100 TeV to 1 EeV by exploiting the correlation between the shower energy measured in IceTop and the energy deposited by muons in the deep ice. In this paper we report on the technical design, construction and installation, the trigger and data acquisition systems as well as the software framework for calibration, reconstruction and simulation. Finally the first experience from commissioning and operating the detector and the performance as an air shower detector will be discussed.
2.	Treusch, Sebastian, et al. (author) Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast 2011 In: Science. - Washington : American association of advancement in science. - 0036-8075 .- 1095-9203. ; 334:6060, s. 1241-1245 Journal article (peer-reviewed)abstract Aβ (beta amyloid peptide) is an important contributor to Alzheimer's disease (AD). We modeled Aβ toxicity in yeast by directing the peptide to the secretory pathway. A genome-wide screen for toxicity modifiers identified the yeast homolog of phosphatidylinositol binding clathrin assembly protein (PICALM) and other endocytic factors connected to AD whose relationship to Aβ was previously unknown. The factors identified in yeast modified Aβ toxicity in glutamatergic neurons of Caenorhabditis elegans and in primary rat cortical neurons. In yeast, Aβ impaired the endocytic trafficking of a plasma membrane receptor, which was ameliorated by endocytic pathway factors identified in the yeast screen. Thus, links between Aβ, endocytosis, and human AD risk factors can be ascertained using yeast as a model system.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Bohm, Christian (1); Kolanoski, H. (1); Sander, H. G. (1); Koepke, L. (1); Xu, C. (1); Schmitz, M. (1); show more...; Boeser, S. (1); Zarzhitsky, P. (1); Bai, X. (1); Beattie, K. (1); Benabderrahmane, M. ... (1); Landsman, H. (1); Kowalski, M. (1); Van Eijndhoven, N. (1); Ackermann, M. (1); Adams, J. (1); Aguilar, J. A. (1); Altmann, D. (1); Auffenberg, J. (1); Barwick, S. W. (1); Baum, V. (1); Bay, R. (1); Beatty, J. J. (1); Tjus, J. Becker (1); Hultqvist, Klas (1); BenZvi, S. (1); Berghaus, P. (1); Berley, D. (1); Bernardini, E. (1); Besson, D. Z. (1); Bindig, D. (1); Bissok, M. (1); Blaufuss, E. (1); Blumenthal, J. (1); Bose, D. (1); Botner, Olga (1); Brayeur, L. (1); Brown, A. M. (1); Casey, J. (1); Casier, M. (1); Chirkin, D. (1); Christy, B. (1); Cowen, D. F. (1); Daughhetee, J. (1); Davis, J. C. (1); De Clercq, C. (1); Desiati, P. (1); DeYoung, T. (1); Diaz-Velez, J. C. (1); Dunkman, M. (1); show less...

University: Umeå University (1); Uppsala University (1); Stockholm University (1)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

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