| 1. |
- Abazov, V. M., et al.
(författare)
-
Search for CP violation in B-s(0) -> mu(+) D-s(-) X decays in p(p)over-bar collisions at root s=1.96 TeV
- 2010
-
Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998 .- 1550-2368. ; 82:1, s. 012003-
-
Tidskriftsartikel (refereegranskat)abstract
- We have performed a search for CP violation in a sample of B-s(0) -> mu+Ds-X decays corresponding to 5 fb(-1) of proton-antiproton collisions collected by the D0 detector in Run II at the Fermilab Tevatron Collider. New physics in B-s(0) mixing could contribute a significant CP violating weak phase, which would be observed as a difference in the decay-time distribution for B-s(0) -> (B) over bar (0)(s) oscillated states versus that for (B) over bar (0)(s) -> B-s(0). A fit to the decay-time distributions of the B-s(0)/(B) over bar (0)(s) candidates yields the flavor-specific asymmetry as a(fs)(s) = [-1.7 +/- 9.1(stat)(-1.5)(+1.4)(syst) x 10(-3), which excludes CP violation due to new physics within the experimental sensitivity.
|
|
| 2. |
- Abazov, V. M., et al.
(författare)
-
Measurement of the t-channel single top quark production cross section
- 2010
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 682:4-5, s. 363-369
-
Tidskriftsartikel (refereegranskat)abstract
- The DO Collaboration reports direct evidence for electroweak production of single top quarks through the t-channel exchange of a virtual W boson. This is the first analysis to isolate an individual single top quark production channel. We select events containing an isolated electron or muon, missing transverse energy, and two, three or four jets from 2.3 fb(-1) of p (p) over bar collisions at the Fermilab Tevatron Collider. One or two of the jets are identified as containing a b hadron. We combine three multivariate techniques optimized for the t-channel process to measure the t- and s-channel cross sections simultaneously. We measure cross sections of 3.14(-0.80)(+0.94) pb for the t-channel and 1.05 +/- 0.81 pb for the s-channel. The measured t-channel result is found to have a significance of 4.8 standard deviations and is consistent with the standard model prediction.
|
|
| 3. |
- Abazov, V. M., et al.
(författare)
-
Measurement of Z/gamma* plus jet plus X angular distributions in p(p)over-bar collisions at root s=1.96 TeV
- 2010
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 682:4-5, s. 370-380
-
Tidskriftsartikel (refereegranskat)abstract
- We present the first measurements at a hadron collider of differential cross sections for Z/gamma* + jet + X production in Delta phi(Z. jet), vertical bar Delta y(Z, jet)vertical bar and vertical bar y(boost)(Z + jet)vertical bar. Vector boson production in association with jets is an excellent probe of QCD and constitutes the main background to many small cross section processes, such as associated Higgs production. These measurements are crucial tests of the predictions of perturbative QCD and current event generators, which have varied success in describing the data. Using these measurements as inputs in tuning event generators will increase the experimental sensitivity to rare signals.
|
|
| 4. |
- Calcagno, A., et al.
(författare)
-
Determinants of darunavir cerebrospinal fluid concentrations: impact of once-daily dosing and pharmacogenetics
- 2012
-
Ingår i: Aids. - 0269-9370. ; 26:12, s. 1529-1533
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: To compare cerebrospinal fluid (CSF) darunavir and ritonavir concentrations in patients receiving darunavir/ritonavir 800/100 mg once daily or 600/100 mg twice daily. To determine the influence of single-nucleotide polymorphisms in the genes encoding for blood-brain barrier transporters (ABCB1 3435 C>T, ABCB1 1236 C>T, ABCB1 2677 G>T, SLCO1A2 38 A>G, SLCO1A2 516 A>C, ABCC2-24 G>A) on darunavir and ritonavir penetration into CSF. Design: Comparative pharmacokinetics study in patients. Methods: Plasma and CSF darunavir and ritonavir concentrations (2-26 h after drug intake) were determined by a validated HPLC coupled with mass spectrometry method in adults on darunavir-based combination antiretroviral therapy undergoing a lumbar puncture. Results: HIV-infected patients on once-daily darunavir/ritonavir had significantly lower CSF darunavir trough concentrations and CSF-to-plasma ratios than patients on darunavir/ritonavir twice-daily (10.7 versus 38.2 ng/ml and 0.32 versus 0.90%; P < 0.05). No significant effect of single-nucleotide polymorphisms in the genes encoding for blood-brain barrier transporters was noted apart from slightly higher CSF darunavir penetration in patients carrying OATP1A2 uncommon variants. Conclusions: This is the first study to compare darunavir CSF concentrations in patients taking the once-daily or the twice-daily dosage: our data show that darunavir and ritonavir dosing significantly affects not only CSF concentrations but also the extent of drug penetration into the CSF. Furthermore a minority of patients in the once-daily arm presented very low CSF concentration of potential concern for HIV control in the central nervous system. The relative importance of pharmacogenetics in influencing CSF darunavir pharmacokinetics deserves further clinical investigation. (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
|
|
