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Sökning: WFRF:(Sierra Rodrigo) > (2015-2019)

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1.
  • Afram, Gabriel, et al. (författare)
  • Reduced intensity conditioning increases risk of severe cGVHD : identification of risk factors for cGVHD in a multicenter setting
  • 2018
  • Ingår i: Medical Oncology. - : Springer Science and Business Media LLC. - 1357-0560 .- 1559-131X. ; 35:6
  • Tidskriftsartikel (refereegranskat)abstract
    • Chronic graft-versus-host disease (cGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Aim is to identify risk factors for the development of cGVHD in a multicenter setting. Patients transplanted between 2000 and 2006 were analyzed (n = 820). Donors were HLA-identical siblings (57%), matched unrelated donors (30%), and HLA-A, B or DR antigen mismatched (13%). Reduced intensity conditioning (RIC) was given to 65% of patients. Overall incidence of cGVHD was 46% for patients surviving more than 100 days after HSCT (n = 747). Older patient age [HR 1.15, p < 0.001], prior acute GVHD [1.30, p = 0.024], and RIC [1.36, p = 0.028] increased overall cGVHD. In addition, RIC [4.85, p < 0.001], prior aGVHD [2.14, p = 0.001] and female donor to male recipient [1.80, p = 0.008] increased the risk of severe cGVHD. ATG had a protective effect for both overall [0.41, p < 0.001] and severe cGVHD [0.20, p < 0.001]. Relapse-free survival (RFS) was impaired in patients with severe cGVHD. RIC, prior aGVHD, and female-to-male donation increase the risk of severe cGVHD. ATG reduces the risk of all grades of cGVHD without hampering RFS. GVHD prophylaxis may be tailored according to the risk profile of patients.
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3.
  • Poveda-Reyes, Sara, et al. (författare)
  • Injectable composites of loose microfibers and gelatin with improved interfacial interaction for soft tissue engineering
  • 2015
  • Ingår i: Polymer. - : Elsevier BV. - 0032-3861 .- 1873-2291. ; 74, s. 224-234
  • Tidskriftsartikel (refereegranskat)abstract
    • Poly(L-lactic acid) (PLLA) microfibers were surface functionalized by graft photopolymerization of 2-hydroxyethyl methacrylate (HEMA) onto the fiber surface. Grafted fibers were easily dispersed in enzymatically gelling tyramine-substituted gelatin, forming a homogeneous dispersion without hindering subsequent gelatin crosslinking. The obtained injectable hydrogels showed improved mechanical properties compared to analogues based on non-modified fibers. The composite with 1% (w/v) of surface modified fibers had a three-fold higher shear storage modulus (535.2 +/- 90 Pa) than pure gelatin (184.9 +/- 32 Pa) while no significant increase was observed in the case of non-grafted fiber composites. Moreover, PHEMA grafting on PLLA fibers did not compromise cell viability and proliferation within the hydrogel. The new injectable hydrogels offer improved potential as substrates for the regeneration of soft tissues.
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