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Potential risk of b...
Potential risk of beta-blockade withdrawal in congestive heart failure due to abrupt autonomic changes.
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Tygesen, H (författare)
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- Andersson, Bert, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Hjärt-kärlinstitutionen,Wallenberg Laboratory,Cardiovascular Institute
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Di Lenarda, A (författare)
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visa fler...
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- Rundqvist, Bengt, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
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Sinagra, G (författare)
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- Hjalmarson, Åke, 1937 (författare)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Wallenberglaboratoriet,Cardiovascular Institute,Wallenberg Laboratory
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- Waagstein, Finn, 1938 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Hjärt-kärlinstitutionen,Wallenberg Laboratory,Cardiovascular Institute
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- Wennerblom, Bertil, 1940 (författare)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
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visa färre...
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(creator_code:org_t)
- 1999
- 1999
- Engelska.
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Ingår i: International journal of cardiology. - 0167-5273. ; 68:2, s. 171-7
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- Beta-Blockers reduce mortality in patients with congestive heart failure and a proposed mechanism has been changes of autonomic tone. Heart rate variability is a non-invasive tool to estimate cardiac autonomic tone. The aim was to study changes of heart rate variability in patients with congestive heart failure on placebo, on the beta1-selective antagonist metoprolol or 24 h after metoprolol withdrawal. Forty-five patients with congestive heart failure were studied with Holter recordings. Heart rate variability measurements were performed before, after 6-12 months of treatment with 150 mg metoprolol/placebo, or 24 h after discontinued metoprolol. After treatment, patients on beta-blockade had a significantly longer mean RR interval and changes of heart rate variability, suggesting elevated vagal tone. Patients monitored in the rebound phase of beta-blocker withdrawal had a significant vagal reduction to the level of the placebo group. There was also a nonsignificant trend towards increased sympathetic tone (LF/HF over 24 h), compared with the beta-blockade group. Heart rate variability indicates an elevated vagal tone during treatment with metoprolol but beta-blockade withdrawal shifts the autonomic balance towards lower vagal and higher sympathetic tone within 24 h. These results could imply a potential risk when abruptly discontinuing beta-blockade medication in these patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Adolescent
- Adrenergic beta-Antagonists
- adverse effects
- Adult
- Aged
- Electrocardiography
- Ambulatory
- drug effects
- Female
- Follow-Up Studies
- Heart Failure
- drug therapy
- physiopathology
- Heart Rate
- drug effects
- Humans
- Male
- Metoprolol
- adverse effects
- Middle Aged
- Myocardial Ischemia
- chemically induced
- physiopathology
- Prognosis
- Retrospective Studies
- Risk Factors
- Substance Withdrawal Syndrome
- physiopathology
- Vagus Nerve
- drug effects
- physiopathology
- Ventricular Fibrillation
- chemically induced
- physiopathology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Tygesen, H
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Andersson, Bert, ...
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Di Lenarda, A
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Rundqvist, Bengt ...
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Sinagra, G
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Hjalmarson, Åke, ...
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visa fler...
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Waagstein, Finn, ...
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Wennerblom, Bert ...
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Göteborgs universitet