| 1. |
- Andersson, Michael, et al.
(författare)
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Stabilization of Evanescent Wave Propagation Operators
- 2023
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Ingår i: Progress In Electromagnetics Research B. - 1937-6472. ; 101, s. 17-44
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a stabilized scheme that solves the wave propagation problem in a general bianisotropic, stratified medium. The method utilizes the concept of propagators, i.e., the wave propagation operators that map the total tangential electric and magnetic fields from one plane in the slab to another. The scheme transforms the propagator approach into a scattering matrix form, where a spectral decomposition of the propagator enables separation of the exponentially growing and decaying terms in order to obtain a well-conditioned formulation. Multilayer structures can be handled in a stable manner using the dissipative property of the Redheffer star product for cascading scattering matrices. The re ection and transmission dyadics for a general bianisotropic medium with an isotropic half space on both sides of the slab are presented in a coordinate-independent dyadic notation, as well as the re ection dyadic for a bianisotropic slab with perfect electric conductor backing (PEC). Several numerical examples that illustrate the performance of the stabilized algorithm are presented.
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| 2. |
- Cho, Nathan H., et al.
(författare)
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OpenCell : Endogenous tagging for the cartography of human cellular organization
- 2022
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 375:6585, s. 1143-
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Tidskriftsartikel (refereegranskat)abstract
- Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates functional communities that facilitate biological discovery. We found that remarkably precise functional information can be derived from protein localization patterns, which often contain enough information to identify molecular interactions, and that RNA binding proteins form a specific subgroup defined by unique interaction and localization properties. Paired with a fully interactive website (opencell.czbiohub.org), our work constitutes a resource for the quantitative cartography of human cellular organization.
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| 3. |
- Erestam, Sofia, et al.
(författare)
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Associations between intraoperative factors and surgeons' self-assessed operative satisfaction.
- 2020
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Ingår i: Surgical endoscopy. - : Springer Science and Business Media LLC. - 1432-2218 .- 0930-2794. ; 34:1, s. 61-68
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Tidskriftsartikel (refereegranskat)abstract
- Little is known concerning what may influence surgeon satisfaction with a surgical procedure and its associations with intraoperative factors. The objective was to explore the relationships between surgeons' self-assessed satisfaction with performed radical prostatectomies and intraoperative factors such as technical difficulties and intraoperative complications as reported by the surgeon subsequent to the operation.We utilized prospectively collected data from the controlled LAPPRO trial where 4003 patients with prostate cancer underwent open (ORP) or robot-assisted laparoscopic (RALP) radical prostatectomy. Patients were included from fourteen centers in Sweden during 2008-2011. Surgeon satisfaction was assessed by questionnaires at the end of each operation. Intraoperative factors included time for the surgical procedure as well as difficulties and complications in various steps of the operation. To model surgeon satisfaction, a mixed effect logistic regression was used. Results were presented as odds ratios (OR) with 95% confidence intervals (CI).The surgeons were satisfied in 2905 (81%) and dissatisfied in 702 (19%) of the surgical procedures. Surgeon satisfaction was not statistically associated with type of surgical technique (ORP vs. RALP) (OR 1.36, CI 0.76; 2.43). Intraoperative factors such as technical difficulties or complications, for example, suturing of the anastomosis was negatively associated with surgeon satisfaction (OR 0.24, CI 0.19; 0.30).Our data indicate that technical difficulties and/or intraoperative complications were associated with a surgeon's level of satisfaction with an operation.
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| 4. |
- Helander, Jakob, et al.
(författare)
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Reflection-Based Source Inversion for Sparse Imaging of Low-Loss Composite Panels
- 2020
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Ingår i: IEEE Transactions on Antennas and Propagation. - 0018-926X. ; 68:6, s. 4860-4870
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Tidskriftsartikel (refereegranskat)abstract
- This article presents a bistatic reflection-based imaging technique for electromagnetic testing of conductor-backed composite panels, which is based on an inverse formulation of the numerical problem at hand, and technically extends a previously demonstrated transmission-based system. The technique exploits the a priori assumption of pixel-based sparsity and retrieves the final image using data from only a single measurement, thereby removing the necessity of a reference measurement to be conducted. To demonstrate the capability of the technique, retrieved images are presented for a synthetic proof-of-concept device under test and an industrially manufactured composite panel. The presented technique can be considered as the initial model in the development of more complex bistatic imaging systems and has been developed for the purpose of extending the opportunities to conduct reflection-based electromagnetic nondestructive testing on aircraft structural components.
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| 5. |
- Hörberg, Mikael, 1972, et al.
(författare)
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A W-band, 92-114 GHz, real-time spectral efficient radio link demonstrating 10 Gbps peak rate in field trial
- 2022
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Ingår i: IEEE MTT-S International Microwave Symposium Digest. - 0149-645X. ; 2022-June, s. 545-548
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Konferensbidrag (refereegranskat)abstract
- This paper reports on a real-time radio-link at W-band (92-114 GHz). 10 Gbps peak rate is reached for a 2000 MHz carrier bandwidth, and 5.7 Gbps is demonstrated over a link-hop of 1.5 km for a 1500 MHz-carrier, running at 128 QAM and 32 QAM, respectively. High integrated radio front-end SIP modules using GaAs technology, achieves a linear TX channel power of +8 dBm, and RX NF of 8 dB from the radio. It is configured to achieve 5.7 Gbps in a radio link with 149 dB system gain.
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| 6. |
- Li, Weiqiang, et al.
(författare)
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Genome-wide association study identifies novel single nucleotide polymorphisms having age-specific effect on prostate-specific antigen levels
- 2020
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Ingår i: Prostate. - : Wiley. - 0270-4137. ; 80:16, s. 1405-1412
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Tidskriftsartikel (refereegranskat)abstract
- Background: Testing for prostate-specific antigen (PSA) levels in blood are widely used and associated with prostate cancer risk and outcome. After puberty, PSA levels increase by age and multiple single nucleotide polymorphisms (SNPs) have been found to be associated with PSA levels. However, the relationship between the effects of SNPs and age on PSA remains unknown. Methods: To test for SNP × age interaction, we conducted a genome-wide association study using 2394 men without prostate cancer diagnosis from Malmö, Sweden as a discovery set and 2137 men from the eMERGE study (USA) for validation. Linear regression was used to identify significant interactions between SNP and age (p < 1 × 10−4 for discovery, p <.05 for validation). Results: The 15 SNPs from three different loci (8p11.22, 8p12, 3q25.31) are found to have age-specific effect on PSA levels. Expression quantitative trait loci (eQTLs) analysis shows that 12 SNPs from 3q25.31 locus affect the expression level of three genes: KCNAB1, SLC33A1, PLCH1. Conclusions: Our results suggest that SNPs may have age-specific effect on PSA levels, which provides new direction to study genetic markers for PSA.
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| 7. |
- Lonergan, Peter E., et al.
(författare)
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Prospective validation of microseminoprotein-β added to the 4Kscore in predicting high-grade prostate cancer in an international multicentre cohort
- 2021
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Ingår i: BJU International. - : Wiley. - 1464-4096 .- 1464-410X. ; 128:2, s. 218-224
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To prospectively evaluate the performance of a pre-specified statistical model based on four kallikrein markers in blood (total prostate-specific antigen [PSA], free PSA, intact PSA, and human kallikrein-related peptidase 2), commercially available as the 4Kscore, in predicting Gleason Grade Group (GG) ≥2 prostate cancer at biopsy in an international multicentre study at three academic medical centres, and whether microseminoprotein-β (MSP) adds predictive value. Patients and Methods: A total of 984 men were prospectively enrolled at three academic centres. The primary outcome was GG ≥2 on prostate biopsy. Three pre-specified statistical models were used: a base model including PSA, age, digital rectal examination and prior negative biopsy; a model that added free PSA to the base model; and the 4Kscore. Results: A total of 947 men were included in the final analysis and 273 (29%) had GG ≥2 on prostate biopsy. The base model area under the receiver operating characteristic curve of 0.775 increased to 0.802 with the addition of free PSA, and to 0.824 for the 4Kscore. Adding MSP to the 4Kscore model yielded an increase (0.014–0.019) in discrimination. In decision-curve analysis of clinical utility, the 4Kscore showed a benefit starting at a 7.5% threshold. Conclusion: A prospective multicentre evaluation of a pre-specified model based on four kallikrein markers (4Kscore) with the addition of MSP improves the predictive discrimination for GG ≥2 prostate cancer on biopsy and could be used to inform biopsy decision-making.
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| 8. |
- Ludvig-Osipov, Andrei, et al.
(författare)
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Fundamental Bounds on Transmission Through Periodically Perforated Metal Screens With Experimental Validation
- 2020
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Ingår i: IEEE Transactions on Antennas and Propagation. - : IEEE. - 0018-926X .- 1558-2221. ; 68:2, s. 773-782
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Tidskriftsartikel (refereegranskat)abstract
- This article presents a study of transmission through arrays of periodic sub-wavelength apertures. Fundamental limitations for this phenomenon are formulated as a sum rule, relating the transmission coefficient over a bandwidth to the static polarizability. The sum rule is rigorously derived for arbitrary periodic apertures in thin screens. By this sum rule we establish a physical bound on the transmission bandwidth which is verified numerically for a number of aperture array designs. We utilize the sum rule to design and optimize sub-wavelength frequency selective surfaces with a bandwidth close to the physically attainable. Finally, we verify the sum rule and simulations by measurements of an array of horseshoe-shaped slots milled in aluminum foil.
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| 9. |
- Lundgren, Johan, et al.
(författare)
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A Near-Field Measurement and Calibration Technique : Radio-Frequency Electromagnetic Field Exposure Assessment of Millimeter-Wave 5G Devices
- 2021
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Ingår i: IEEE Antennas & Propagation Magazine. - : Institute of Electrical and Electronics Engineers (IEEE). - 1045-9243 .- 1558-4143. ; 63:3, s. 77-88
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Tidskriftsartikel (refereegranskat)abstract
- Accurate and efficient measurement techniques are needed for an exposure assessment of 5G portable devices, which are expected to utilize frequencies beyond 6 GHz with respect to radio-frequency (RF) electromagnetic field (EMF) exposure limits. At above 6 GHz, these limits are expressed in terms of the incident power density, thus requiring the EMFs to be evaluated with high precision in close vicinity to the device under test (DUT), i.e., in the near-field region of the radiating antenna. This article presents a cutting-edge near-field measurement technique suited for these needs. The technique, based on source reconstruction on a predefined surface representing the radiating aperture of the antenna, requires two sets of measurements: one of the DUT and one of a small aperture. This second measurement functions as a calibration of both the measurement probe impact on the received signal and the experimental setup in terms of the relative distance between the probe and the DUT. Results are presented for a 28- and a 60-GHz antenna array, both of which were developed for 5G applications. The computed power density is compared with simulations at evaluation planes residing as close as one fifth of a wavelength (lambda/5) away from the DUT.
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| 10. |
- Pellegrino, Francesco, et al.
(författare)
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Predictive value of kallikrein forms and β-microseminoprotein in blood from patients with evidence of detectable levels of PSA after radical prostatectomy
- 2023
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Ingår i: World Journal of Urology. - 1433-8726. ; 41, s. 1489-1495
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To determine whether β-microseminoprotein or any of the kallikrein forms in blood-free, total or intact PSA or total hK2-predict metastasis in patients with evidence of detectable levels of PSA in blood after radical prostatectomy.METHOD: We determined marker concentrations in blood from 173 men treated with radical prostatectomy and evidence of detectable levels of PSA in the blood (PSA ≥ 0.05) after surgery between 2014 and 2015 and at least 1 year after any adjuvant therapy. We used Cox regression to determine whether any marker was associated with metastasis using both univariate and multivariable models that included standard clinical predictors.RESULTS: Overall, 42 patients had metastasis, with a median follow-up of 67 months among patients without an event. The levels of intact and free PSA and free-to-total PSA ratio were significantly associated with metastasis. Discrimination was highest for free PSA (c-index: 0.645) and free-to-total PSA ratio (0.625). Only free-to-total PSA ratio remained associated with overall metastasis (either regional or distant) after including standard clinical predictors (p = 0.025) and increased discrimination from 0.686 to 0.697. Similar results were found using distant metastasis as an outcome (p = 0.011; c-index increased from 0.658 to 0.723).CONCLUSION: Our results provide evidence that free-to-total PSA ratio can risk stratifying patients with evidence of detectable levels of PSA in blood after RP. Further research is warranted on the biology of prostate cancer markers in patients with evidence of detectable levels of PSA in blood after radical prostatectomy. Our findings on the free-to-total ratio for predicting adverse oncologic outcomes need to be validated in other cohorts.
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| 11. |
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| 12. |
- Vertosick, Emily A, et al.
(författare)
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Prespecified Four Kallikrein Marker Model (4Kscore) at Age 50 or 60 for Early Detection of Lethal Prostate Cancer in a Large Population-Based Cohort of Asymptomatic Men Followed for 20 Years.
- 2020
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Ingår i: Journal of Urology. - : Lippincott Williams & Wilkins. - 0022-5347 .- 1527-3792. ; 204:2, s. 281-288
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: A prespecified statistical model based on 4 kallikrein markers in blood, commercially available as the 4Kscore®, has been shown to accurately detect high grade (greater than Grade Group 2) prostate cancer in men with moderately elevated prostate specific antigen. We assessed whether the model predicted prostate cancer metastasis or death in men not subject to prostate specific antigen screening.Materials and Methods: The cohort includes 43,692 unscreened prostate cancer-free men from a Swedish population based cohort with low rates of prostate specific antigen screening (Västerbotten Intervention Project). Using cryopreserved blood collected at ages 50 and 60 years from men in this cohort we analyzed the association between prostate specific antigen and other kallikrein marker levels in blood and risk of prostate cancer metastasis or death.Results: There were 308 with metastases and 172 prostate cancer deaths. Baseline prostate specific antigen was strongly associated with 20-year risk of prostate cancer death (c-index at age 50, 0.859, 95% CI 0.799–0.916; age 60, 0.840, 95% CI 0.799–0.878). Men 60 years old with prostate specific antigen below median (less than 1.2 ng/ml) had 0.4% risk of prostate cancer death at 20 years. Among men with moderately elevated prostate specific antigen (2.0 ng/ml or greater) the 4Kscore markedly improved discrimination (c-index 0.767 vs 0.828 and 0.774 vs 0.862 in men age 50 and 60, respectively). Long-term risk of prostate cancer death or metastasis in men with low 4Kscores was very low.Conclusions: Screening should focus on men in top prostate specific antigen quartile at age 60 years. Men with elevated prostate specific antigen but a low 4Kscore can safely be monitored with repeated blood markers in place of immediate biopsy.
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| 13. |
- Vertosick, Emily A., et al.
(författare)
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Reply by Authors
- 2020
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Ingår i: The Journal of urology. - 1527-3792. ; 204:2, s. 287-288
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Tidskriftsartikel (refereegranskat)
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| 14. |
- Wingren, Niklas, et al.
(författare)
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Analytical Modeling and Multiphysics Simulation of Acousto-Electromagnetic Interaction
- 2020
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Ingår i: 14th European Conference on Antennas and Propagation, EuCAP 2020. - 9788831299008
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Konferensbidrag (refereegranskat)abstract
- A model for interaction between acoustic and elec- tromagnetic waves based on photoelasticity is presented. A radar equation based on physical, geometric and system parameters is shown, as well as a condition for maximizing interaction (equivalent to the Bragg condition in acousto-optics). The photoelastic model is used to implement a multiphysics simulation of the problem. The Bragg condition is shown to hold for the simulated case. Additionally, simulations are used to show how a contrast in material properties in a small inclusion affects the interaction.
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| 15. |
- Wingren, Niklas, et al.
(författare)
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Finite Element-Boundary Integral Simulation of Icing Effects on a Marine Radar Reflector
- 2022
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Ingår i: 2022 3rd URSI Atlantic and Asia Pacific Radio Science Meeting (AT-AP-RASC). - 9789463968058
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Konferensbidrag (refereegranskat)abstract
- This paper presents simulations of the radar cross section for a marine corner reflector affected by icing as it is illuminated by 3 GHz marine radar. This is compared to the radar cross section for an unaffected reflector, and the consequences for radar range are investigated. To perform the simulations, a finite element-boundary integral hybrid method is used. The simulation code is based on several open-source packages, of which the most important are FEniCSx and Bempp-cl. Simulations show a large reduction in maximum radar range due to icing, with a maximum reduction by 60 % found near boresight.
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| 16. |
- Wingren, Niklas, et al.
(författare)
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Simulating Magnetized Plasma using an Accelerated Finite Element-Boundary Integral Code
- 2023
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Ingår i: 2023 35th General Assembly and Scientific Symposium of the International Union of Radio Science, URSI GASS 2023. - 9789463968096 - 9798350309973
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Konferensbidrag (refereegranskat)abstract
- This paper describes an accelerated finite element-boundary integral code with support for complex media. The code is implemented in Python using several open source packages, and uses Numba just-in-time compilation for improved performance. To accelerate the boundary integral part of the code, a multilevel implementation of the adaptive cross approximation is used. As a numerical example, scattering against a magnetized plasma is demonstrated. For this example, compression of boundary integral matrices is achieved to 9 % of the memory required for full matrices.
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