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- van de Sande-Bruinsma, Nienke, et al.
(författare)
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Antimicrobial drug use and resistance in Europe
- 2008
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Ingår i: Emerging Infectious Diseases. - : Centers for Disease Control and Prevention (CDC). - 1080-6040 .- 1080-6059. ; 14:11, s. 1722-30
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Tidskriftsartikel (refereegranskat)abstract
- Our study confronts the use of antimicrobial agents in ambulatory care with the resistance trends of 2 major pathogens, Streptococcus pneumoniae and Escherichia coli, in 21 European countries in 2000-2005 and explores whether the notion that antimicrobial drug use determines resistance can be supported by surveillance data at national aggregation levels. The data obtained from the European Surveillance of Antimicrobial Consumption and the European Antimicrobial Resistance Surveillance System suggest that variation of consumption coincides with the occurrence of resistance at the country level. Linear regression analysis showed that the association between antimicrobial drug use and resistance was specific and robust for 2 of 3 compound pathogen combinations, stable over time, but not sensitive enough to explain all of the observed variations. Ecologic studies based on routine surveillance data indicate a relation between use and resistance and support interventions designed to reduce antimicrobial drug consumption at a national level in Europe.
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- Hicks, J, et al.
(författare)
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Novel patterns of genome rearrangement and their association with survival in breast cancer
- 2006
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Ingår i: Genome research. - : Cold Spring Harbor Laboratory. - 1088-9051. ; 16:12, s. 1465-1479
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Tidskriftsartikel (refereegranskat)abstract
- Representational Oligonucleotide Microarray Analysis (ROMA) detects genomic amplifications and deletions with boundaries defined at a resolution of ∼50 kb. We have used this technique to examine 243 breast tumors from two separate studies for which detailed clinical data were available. The very high resolution of this technology has enabled us to identify three characteristic patterns of genomic copy number variation in diploid tumors and to measure correlations with patient survival. One of these patterns is characterized by multiple closely spaced amplicons, or “firestorms,” limited to single chromosome arms. These multiple amplifications are highly correlated with aggressive disease and poor survival even when the rest of the genome is relatively quiet. Analysis of a selected subset of clinical material suggests that a simple genomic calculation, based on the number and proximity of genomic alterations, correlates with life-table estimates of the probability of overall survival in patients with primary breast cancer. Based on this sample, we generate the working hypothesis that copy number profiling might provide information useful in making clinical decisions, especially regarding the use or not of systemic therapies (hormonal therapy, chemotherapy), in the management of operable primary breast cancer with ostensibly good prognosis, for example, small, node-negative, hormone-receptor-positive diploid cases.
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- Rockwood, Kenneth, et al.
(författare)
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The inclusion of cognition in vascular risk factor clinical practice guidelines.
- 2009
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Ingår i: Clinical interventions in aging. - 1176-9092. ; 4, s. 425-33
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Forskningsöversikt (refereegranskat)abstract
- BACKGROUND: People with vascular risk factors are at increased risk for cognitive impairment as well as vascular disease. The objective of this study was to evaluate whether vascular risk factor clinical practice guidelines consider cognition as an outcome or in connection with treatment compliance. METHODS: ARTICLES FROM PUBMED, EMBASE, AND THE COCHRANE LIBRARY WERE ASSESSED BY AT LEAST TWO REVIEWERS AND WERE INCLUDED IF: (1) Either hypertension, high cholesterol, diabetes, or atrial fibrillation was targeted; (2) The guideline was directed at physicians; (3) Adult patients (aged 19 years or older) were targeted; and (4) The guideline was published in English. Of 91 guidelines, most were excluded because they were duplicates, older versions, or focused on single outcomes. RESULTS: Of the 20 clinical practice guidelines that met inclusion criteria, five mentioned cognition. Of these five, four described potential treatment benefits but only two mentioned that cognition may affect compliance. No guidelines adequately described how to screen for cognitive impairment. CONCLUSION: Despite evidence that links cognitive impairment to vascular risk factors, only a minority of clinical practice guidelines for the treatment of vascular risk factors consider cognition as either an adverse outcome or as a factor to consider in treatment.
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- Skoog, L, et al.
(författare)
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B cell neoplasms
- 2009
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Ingår i: Monographs in clinical cytology. - Basel : KARGER. - 0077-0809. ; 18, s. 19-37
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Tidskriftsartikel (refereegranskat)
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| 22. |
- Skoog, L, et al.
(författare)
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Extranodal lymphomas
- 2009
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Ingår i: Monographs in clinical cytology. - Basel : KARGER. - 0077-0809. ; 18, s. 60-3
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Tidskriftsartikel (refereegranskat)
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- Skoog, L, et al.
(författare)
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Histiocytic and dendritic neoplasms
- 2009
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Ingår i: Monographs in clinical cytology. - Basel : KARGER. - 0077-0809. ; 18, s. 56-9
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Tidskriftsartikel (refereegranskat)
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| 25. |
- Skoog, L, et al.
(författare)
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Historical aspects
- 2009
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Ingår i: Monographs in clinical cytology. - Basel : KARGER. - 0077-0809. ; 18, s. 1-4
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Tidskriftsartikel (refereegranskat)
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| 26. |
- Skoog, L, et al.
(författare)
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Hodgkin lymphoma
- 2009
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Ingår i: Monographs in clinical cytology. - Basel : KARGER. - 0077-0809. ; 18, s. 49-52
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Tidskriftsartikel (refereegranskat)
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- Skoog, L, et al.
(författare)
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Lymphoma look-alike
- 2009
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Ingår i: Monographs in clinical cytology. - Basel : KARGER. - 0077-0809. ; 18, s. 64-75
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Tidskriftsartikel (refereegranskat)
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| 29. |
- Skoog, L, et al.
(författare)
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T cell neoplasms
- 2009
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Ingår i: Monographs in clinical cytology. - Basel : KARGER. - 0077-0809. ; 18, s. 38-48
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Tidskriftsartikel (refereegranskat)
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| 30. |
- Skoog, L, et al.
(författare)
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Techniques
- 2009
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Ingår i: Monographs in clinical cytology. - Basel : KARGER. - 0077-0809. ; 18, s. 5-10
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Tidskriftsartikel (refereegranskat)
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- Zetterberg, Madeleine, 1969, et al.
(författare)
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Association of complement factor HY402H gene polymorphism with Alzheimer's disease
- 2008
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Ingår i: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. - : Wiley. - 1552-4841. ; 147B:6, s. 720-6
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Tidskriftsartikel (refereegranskat)abstract
- Alzheimer's disease (AD) and age-related macular degeneration (AMD) share several epidemiological and biochemical features. The present study aimed to assess the possible influence of the AMD-associated complement factor H (CFH) Y402H (1277T > C) polymorphism on the risk of AD. Caucasian subjects (n=800) meeting the criteria for probable (n = 717) or definite (n = 83) AD and Caucasian non-demented controls (n 1265) were included in this multi-center case-control study, in which genotype and allele frequencies of the CFH 1277T > C polymorphism were determined and related to diagnosis, APOE genotype, Mini-Mental State Examination score (MMSE) and the cerebrospinal fluid (CSF) biomarkers total-tau (T-tau), phospho-tau(181), (P-tau(181)), and beta-amyloid(1-42) (A beta(1-42)). The AMD-associated CFH genotypes (1277CC and 1277TC) were overrepresented in subjects with AD as compared to control individuals (P = 0.029). Positive C carrier status was associated with an odds ratio (OR) for AD of 1.24 (95% confidence interval [CI] 1.02-1.50). When APOE 4 carrier status was included in the regression model, this association was even stronger (OR 1.34, 95% CI: 1.08-1.65, P=0.007). Subgroup analysis showed that the association between CFH C allele positivity and AD was only evident for individuals carrying the APOE epsilon 4 allele. Positive C carrier status was also associated with lower levels of CSF A beta(1-42) selectively in the control group in an APOE epsilon 4-independent manner (P=0.003). In conclusion, the CFH 1277T > C polymorphism seems to influence the risk of AD and there appears to be an interaction between CFH 1277C and APOE epsilon 4 alleles. The CFH 1277C allele may predispose patients for co-morbidity in AD and AMD. (c) 2007 Wiley-Liss, Inc.
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