| 1. |
- Aaltonen, T., et al.
(författare)
-
Tevatron Combination of Single-Top-Quark Cross Sections and Determination of the Magnitude of the Cabibbo-Kobayashi-Maskawa Matrix Element V-tb
- 2015
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:15
-
Tidskriftsartikel (refereegranskat)abstract
- We present the final combination of CDF and D0 measurements of cross sections for single-top-quark production in proton-antiproton collisions at a center-of-mass energy of 1.96 TeV. The data correspond to total integrated luminosities of up to 9.7 fb(-1) per experiment. The t-channel cross section is measured to be sigma(t) = 2.25(-0.31)(+0.29) pb. We also present the combinations of the two-dimensional measurements of the s- vs t-channel cross section. In addition, we give the combination of the s + t channel cross section measurement resulting in sigma(s+t) = 3.30(-0.40)(+0.52) pb, without assuming the standard model value for the ratio sigma(s)/sigma(t). The resulting value of the magnitude of the top-to-bottom quark coupling is vertical bar V-tb vertical bar = 1.02(-0.05)(+0.06), corresponding to vertical bar V-tb vertical bar > 0.92 at the 95% C. L.
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| 2. |
- Aaltonen, T., et al.
(författare)
-
Tevatron Constraints on Models of the Higgs Boson with Exotic Spin and Parity Using Decays to Bottom-Antibottom Quark Pairs
- 2015
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 114:15
-
Tidskriftsartikel (refereegranskat)abstract
- Combined constraints from the CDF and D0 Collaborations on models of the Higgs boson with exotic spin J and parity P are presented and compared with results obtained assuming the standard model value J(P) = 0(+). Both collaborations analyzed approximately 10 fb(-1) of proton-antiproton collisions with a center-of-mass energy of 1.96 TeV collected at the Fermilab Tevatron. Two models predicting exotic Higgs bosons with J(P) = 0(-) and J(P) = 2(+) are tested. The kinematic properties of exotic Higgs boson production in association with a vector boson differ from those predicted for the standard model Higgs boson. Upper limits at the 95% credibility level on the production rates of the exotic Higgs bosons, expressed as fractions of the standard model Higgs boson production rate, are set at 0.36 for both the J(P) = 0(-) hypothesis and the J(P) = 2(+) hypothesis. If the production rate times the branching ratio to a bottom-antibottom pair is the same as that predicted for the standard model Higgs boson, then the exotic bosons are excluded with significances of 5.0 standard deviations and 4.9 standard deviations for the J(P) = 0(-) and J(P) = 2(+) hypotheses, respectively.
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| 3. |
- Aaltonen, T., et al.
(författare)
-
Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron
- 2018
-
Ingår i: Physical Review Letters. - : AMER PHYSICAL SOC. - 0031-9007 .- 1079-7114. ; 120:4
-
Tidskriftsartikel (refereegranskat)abstract
- The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of root s = 1.96 TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is A(FB)(t (t) over bar) = 0.128 +/- 0.025. The combined inclusive and differential asymmetries are consistent with recent standard model predictions.
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| 4. |
- Aaltonen, T., et al.
(författare)
-
Tevatron Run II combination of the effective leptonic electroweak mixing angle
- 2018
-
Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 97:11
-
Tidskriftsartikel (refereegranskat)abstract
- Drell-Yan lepton pairs produced in the process p (p) over bar -> l(+)l(-) + X through an intermediate gamma*/Z boson have an asymmetry in their angular distribution related to the spontaneous symmetry breaking of the electroweak force and the associated mixing of its neutral gauge bosons. The CDF and D0 experiments have measured the effective-leptonic electroweak mixing parameter sin(2) theta(lept)(eff) using electron and muon pairs selected from the full Tevatron proton-antiproton data sets collected in 2001-2011, corresponding to 9-10 fb(-1) of integrated luminosity. The combination of these measurements yields the most precise result from hadron colliders, sin(2)theta(lept)(eff) = 0.23148 +/- 0.00033. This result is consistent with, and approaches in precision, the best measurements from electron-positron colliders. The standard model inference of the on-shell electroweak mixing parameter sin(2) theta(W), or equivalently the W-boson mass M-W, using the ZFITTER software package yields sin(2) theta(W) = 0.22324 +/- 0.00033 or equivalently, M-W = 80.367 +/- 0.017 GeV/c(2).
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| 5. |
- Abazov, V. M., et al.
(författare)
-
B-s(0) lifetime measurement in the CP-odd decay channel B-s(0) -> J/Psi f(0)(980)
- 2016
-
Ingår i: PHYSICAL REVIEW D. - 2470-0010. ; 94:1
-
Tidskriftsartikel (refereegranskat)abstract
- The lifetime of the B-s(0) meson is measured in the decay channel B-s(0) -> J/Psi pi(+)pi(-) with 880 <= M pi+pi- <= 1080 MeV/c(2), which is mainly a CP-odd state and dominated by the f(0)(980) resonance. In 10.4 fb(-1) of data collected with the D0 detector in Run II of the Tevatron, the lifetime of the B-s(0) meson is measured to be tau(B-s(0)) = 1.70 +/- 0.14(stat) +/- 0.05(syst) ps. Neglecting CP violation in B-s(0)/(B) over bar (0)(s) mixing, the measurement can be translated into the width of the heavy mass eigenstate of the B-s(0), Gamma(H) = 0.59 +/- 0.05(stat) +/- 0.02(syst) ps(-1).
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| 6. |
- Abazov, V. M., et al.
(författare)
-
Combination of D0 measurements of the top quark mass
- 2017
-
Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 95:11
-
Tidskriftsartikel (refereegranskat)abstract
- We present a combination of measurements of the top quark mass by the D0 experiment in the lepton + jets and dilepton channels. We use all the data collected in Run I (1992-1996) at root s = 1.8 TeV and Run II (2001-2011) at root s = 1.96 TeV of the Tevatron p (p) over bar collider, corresponding to integrated luminosities of 0.1 fb(-1) and 9.7 fb(-1), respectively. The combined result is: m(t) = 174.95 +/- 0.40(stat)+/- 0.64(syst) GeV = 174.95 +/- 0.75 GeV.
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| 7. |
- Abazov, V. M., et al.
(författare)
-
Evidence for a B-s(0)pi(+/-) State
- 2016
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 117:2
-
Tidskriftsartikel (refereegranskat)abstract
- We report evidence for a narrow structure, X(5568), in the decay sequence X(5568) -> B-s(0)pi(+/-), B-s(0) -> J/psi phi, J/psi -> mu(+)mu(-), phi -> K+K-. This is evidence for the first instance of a hadronic state with valence quarks of four different flavors. The mass and natural width of this state are measured to be m = 5567.8 +/- 2.9(stat)(-1.9)(+0.9) (syst) MeV/c(2) and Gamma = 21.9 +/- 6.4(stat)(-2.5)(+5.0) (syst) MeV/c(2). If the decay is X(5568) -> B-s*pi(+/-). B-s(0)gamma pi(+/-) with an unseen gamma, m(X(5568)) will be shifted up by m(B-s*) - m(B-s(0)) similar to 49 MeV/c(2). This measurement is based on 10.4 fb(-1) of p (p) over bar collision data at root s = 1.96 TeV collected by the D0 experiment at the Fermilab Tevatron collider.
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| 8. |
- Abazov, V. M., et al.
(författare)
-
Evidence for Simultaneous Production of J/psi and Upsilon Mesons
- 2016
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 116:8
-
Tidskriftsartikel (refereegranskat)abstract
- We report evidence for the simultaneous production of J/psi and Upsilon mesons in 8.1 fb(-1) of data collected at root s = 1.96 TeV by the D0 experiment at the Fermilab p (p) over bar Tevatron Collider. Events with these characteristics are expected to be produced predominantly by gluon-gluon interactions. In this analysis, we extract the effective cross section characterizing the initial parton spatial distribution, sigma(eff) = 2.2 +/- 0.7(stat) +/- 0.9(syst) mb.
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| 9. |
- Abazov, V. M., et al.
(författare)
-
Evidence for Z(c)(+/-)(3900) in semi-inclusive decays of b-flavored hadrons
- 2018
-
Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 98:5
-
Tidskriftsartikel (refereegranskat)abstract
- We present evidence for the exotic charged charmoniumlike state Z(c)(+/-)(3900) decaying to J/psi pi(+/-) in semi-inclusive weak decays of b-flavored hadrons. The signal is correlated with a parent J/psi pi(+)pi(-) system in the invariant-mass range 4.2-4.7 GeV that would include the exotic structure Y(4260). The study is based on 10.4 fb(-1) of p (p) over bar collision data collected by the D0 experiment at the Fermilab Tevatron collider.
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| 10. |
- Abazov, V. M., et al.
(författare)
-
Inclusive Production of the X(4140) State in p(p)over-bar Collisions at D0
- 2015
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:23
-
Tidskriftsartikel (refereegranskat)abstract
- We present a study of the inclusive production of the X(4140) state with the decay to the J/psi phi final state in hadronic collisions. Based on 10.4 fb(-1) of p (p) over bar collision data collected by the D0 experiment at the Fermilab Tevatron collider, we report the first evidence for the prompt production of an X(4140) state and find the fraction of X(4140) events originating from b hadrons to be f(b) = 0.39 +/- 0.07 (stat) +/- 0.10 (syst). The ratio of the nonprompt X(4140) production rate to the B-s(0) yield in the same channel is R = 0.19 +/- 0.05 (stat) +/- 0.07 (syst). The values of the mass M = 4152.5 +/- 1.7 (stat)(-5.4)(+/- 6.2)(syst) MeV and width Gamma = 16.3 +/- 5.6 (stat) +/- 11.4 (syst) MeV are consistent with previous measurements.
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| 11. |
- Abazov, V. M., et al.
(författare)
-
Measurement of spin correlation between top and antitop quarks produced in p(p)over-bar collisions at root s=1.96 TeV
- 2016
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 757, s. 199-206
-
Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the correlation between the spins of t and (t) over bar quarks produced in proton-antiproton collisions at the Tevatron Collider at a center-of-mass energy of 1.96 TeV. We apply a matrix element technique to dilepton and single-lepton+jets final states in data accumulated with the DO detector that correspond to an integrated luminosity of 9.7 fb(-1). The measured value of the correlation coefficient in the off-diagonal basis, O-off = 0.89 +/- 0.22 (stat + syst), is in agreement with the standard model prediction, and represents evidence for a top-antitop quark spin correlation difference from zero at a level of 4.2 standard deviations.
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| 12. |
- Abazov, V. M., et al.
(författare)
-
Measurement of the B-s(0) Lifetime in the Flavor-Specific Decay Channel B-s(0)-> D-s(-)mu(+)nu X
- 2015
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 114:6
-
Tidskriftsartikel (refereegranskat)abstract
- We present an updated measurement of the B-s(0) lifetime using the semileptonic decays B-s(0) -> D-s(-)mu(+)nu X, with D-s(-) -> phi pi(-) and phi -> K+K- (and the charge conjugate process). This measurement uses the full Tevatron Run II sample of proton-antiproton collisions at root s = 1.96 TeV, comprising an integrated luminosity of 10.4 fb(-1). We find a flavor-specific lifetime tau(fs)(B-s(0)) = 1.479 +/- 0.010(stat) +/- 0.021(syst) ps. This technique is also used to determine the B-0 lifetime using the analogous B-0 -> D- mu(+)nu X decay with D- -> phi pi(-) and phi -> K+K-, yielding tau(B-0) = 1.534 +/- 0.019(stat) +/- 0.021(syst) ps. Both measurements are consistent with the current world averages, and the B-s(0) lifetime measurement is one of the most precise to date. Taking advantage of the cancellation of systematic uncertainties, we determine the lifetime ratio tau(fs)(B-s(0))/tau(B-0) = 0.964 +/- 0.013(stat) +/- 0.007(syst).
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| 13. |
- Abazov, V. M., et al.
(författare)
-
Measurement of the direct CP violating charge asymmetry in B-+/- -> mu(+/-)nu D-mu(0) decays
- 2017
-
Ingår i: Physical Review D. - 2470-0010 .- 2470-0029. ; 95:3
-
Tidskriftsartikel (refereegranskat)abstract
- We present the first measurement of the CP violating charge asymmetry in B-+/- -> mu(+/-)nu D-mu(0) decays using the full Run II integrated luminosity of 10.4 fb(-1) in proton-antiproton collisions collected with the D0 detector at the Fermilab Tevatron Collider. We measure a difference in the yield of B- and B+ mesons in these decays by fitting the reconstructed invariant mass distributions. This results in an asymmetry of A(mu D0) = [-0.14 +/- 0.20] %, which is consistent with standard model predictions.
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| 14. |
- Abazov, V. M., et al.
(författare)
-
Measurement of the Effective Weak Mixing Angle in p(p)over-bar -> Z/gamma* -> e(+)e(-) Events
- 2015
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:4
-
Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the fundamental parameter of the standard model, the weak mixing angle sin(2)theta(l)(eff) which determines the relative strength of weak and electromagnetic interactions, in p (p) over bar -> Z/gamma* -> e(+)e(-) events at a center of mass energy of 1.96 TeV, using data corresponding to 9.7 fb(-1) of integrated luminosity collected by the D0 detector at the Fermilab Tevatron. The effective weak mixing angle is extracted from the forward-backward charge asymmetry as a function of the invariant mass around the Z boson pole. The measured value of sin(2)theta(l)(eff) = 0.23147 +/- 0.00047 is the most precise measurement from light quark interactions to date, with a precision close to the best LEP and SLD results.
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| 15. |
- Abazov, V. M., et al.
(författare)
-
Measurement of the Effective Weak Mixing Angle in p¯p→Z/γ∗→ℓ+ℓ− Events
- 2018
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 120:24
-
Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the effective weak mixing angle parameter sin(2)theta(l)(eff) in p (p) over bar -> Z/gamma* -> mu(+)mu(-) events at a center-of-mass energy of 1.96 TeV, collected by the D0 detector at the Fermilab Tevatron Collider and corresponding to 8.6 fb(-1) of integrated luminosity. The measured value of sin(2)theta(l)(eff)[mu mu] = 0.23016 +/- 0.00064 is further combined with the result from the D0 measurement in p (p) over bar -> Z/gamma* -> e(+)e(-) events, resulting in sin(2)theta(l)(eff)[comb] = 0.23095 +/- 0.00040. This combined result is the most precise measurement from a single experiment at a hadron collider and is the most precise determination using the coupling of the Z/gamma* to light quarks.
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| 16. |
- Abazov, V. M., et al.
(författare)
-
Measurement of the electron charge asymmetry in p(p)over-bar -> W + X -> ev plus X decays in p(p)over-bar collisions at root S=1.96 TeV
- 2015
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 91:3
-
Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the electron charge asymmetry in p (p) over bar -> W + X -> ev + X events at a center-of-mass energy of 1.96 TeV, using data corresponding to 9.7 fb(-1) of integrated luminosity collected with the D0 detector at the Fermilab Tevatron Collider. The asymmetry is measured as a function of the electron pseudorapidity and is presented in five kinematic bins based on the electron transverse energy and the missing transverse energy in the event. The measured asymmetry is compared with next-to-leading-order predictions in perturbative quantum chromodynamics and provides accurate information for the determination of parton distribution functions of the proton. This is the most precise lepton charge asymmetry measurement to date.
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| 17. |
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| 18. |
- Abazov, V. M., et al.
(författare)
-
Measurement of the forward-backward asymmetry in Lambda(0)(b) and (Lambda)over-bar(b)(0) baryon production in p(p)over-bar collisions at root s=1.96 TeV
- 2015
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 91:7
-
Tidskriftsartikel (refereegranskat)abstract
- We measure the forward-backward asymmetry in the production of Lambda(0)(b) and (Lambda) over bar (0)(b) baryons as a function of rapidity in p (p) over bar collisions at root s = 1.96 TeV using 10.4 fb(-1) of data collected with the D0 detector at the Fermilab Tevatron collider. The asymmetry is determined by the preference of Lambda(0)(b) or (Lambda) over bar (0)(b) particles to be produced in the direction of the beam protons or antiprotons, respectively. The measured asymmetry integrated over rapidity y in the range 0.1 < vertical bar y vertical bar < 2.0 is A = 0.04 +/- 0.07(stat) +/- 0.02(syst).
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| 19. |
- Abazov, V. M., et al.
(författare)
-
Measurement of the Forward-Backward Asymmetry in the Production lof B-+/- Mesons in p(p)over-bar Collisions at root s=1.96 TeV
- 2015
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 114:5
-
Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the forward-backward asymmetry in the production of B-+/- mesons, A(FB)(B-+/-) using B-+/- -> J/ Psi K-+/- decays in 10.4 fb(-1) of p (p) over bar collisions at root s = 1.96 TeV collected by the D0 experiment during Run II of the Tevatron collider. A nonzero asymmetry would indicate a preference for a particular flavor, i.e., b quark or (b) over bar antiquark, to be produced in the direction of the proton beam. We extract A(FB) (B-+/-) from a maximum likelihood fit to the difference between the numbers of forward-and backward-produced B-+/- mesons. We measure an asymmetry consistent with zero: A(FB) (B-+/-) = [-0.24 +/- 0.41 (stat) +/- 0.19 (syst)] %.
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| 20. |
- Abazov, V. M., et al.
(författare)
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Measurement of the forward-backward asymmetry of Lambda and (Lambda)over-bar production in p(p)over-bar collisions
- 2016
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Ingår i: PHYSICAL REVIEW D. - 2470-0010. ; 93:3
-
Tidskriftsartikel (refereegranskat)abstract
- We study Lambda and (Lambda) over bar production asymmetries in p (p) over bar -> Lambda((Lambda) over bar )X, p (p) over bar -> J/psi Lambda((Lambda) over bar )X, and p (p) over bar -> mu(+/-)Lambda((Lambda) over bar )X events recorded by the D0 detector at the Fermilab Tevatron collider at root s = 1.96 TeV. We find an excess of Lambda's ((Lambda) over bar 's) produced in the proton (antiproton) direction. This forward-backward asymmetry is measured as a function of rapidity. We confirm that the (Lambda) over bar/Lambda production ratio, measured by several experiments with various targets and a wide range of energies, is a universal function of "rapidity loss," i.e., the rapidity difference of the beam proton and the lambda.
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| 21. |
- Abazov, V. M., et al.
(författare)
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Measurement of the inclusive t(t)over-bar production cross section in p(p)over-bar collisions at root s=1.96 TeV and determination of the top quark pole mass
- 2016
-
Ingår i: PHYSICAL REVIEW D. - 2470-0010. ; 94:9
-
Tidskriftsartikel (refereegranskat)abstract
- The inclusive cross section of top quark-antiquark pairs produced in p (p) over bar collisions at root s = 1.96 TeV is measured in the lepton + jets and dilepton decay channels. The data sample corresponds to 9.7 fb(-1) of integrated luminosity recorded with the D0 detector during Run II of the Fermilab Tevatron Collider. Employing multivariate analysis techniques we measure the cross section in the two decay channels and we perform a combined cross section measurement. For a top quark mass of 172.5 GeV, we measure a combined inclusive top quark-antiquark pair production cross section of sigma(t<(t)over bar) = 7.26 +/- 0.13(stat)(-0.50)(+0.57) (syst) pb which is consistent with standard model predictions. We also perform a likelihood fit to the measured and predicted top quark mass dependence of the inclusive cross section, which yields a measurement of the pole mass of the top quark. The extracted value is m(t) = 172.8 +/- 1.1(theo)(-3.1)(+3.3) (exp) GeV.
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| 22. |
- Abazov, V. M., et al.
(författare)
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Measurement of the phi(eta)* distribution of muon pairs with masses between 30 and 500 GeV in 10.4 fb(-1) of p(p)over-bar collisions
- 2015
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 91:7
-
Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the distribution of the variable phi(eta)* for muon pairs with masses between 30 and 500 GeV, using the complete run II data set collected by the D0 detector at the Fermilab Tevatron proton-antiproton collider. This corresponds to an integrated luminosity of 10.4 fb(-1) at root s = 1.96 TeV. The data are corrected for detector effects and presented in bins of dimuon rapidity and mass. The variable phi(eta)* probes the same physical effects as the Z/gamma* boson transverse momentum, but is less susceptible to the effects of experimental resolution and efficiency. These are the first measurements at any collider of the phi(eta)* distributions for dilepton masses away from the Z --> l(+)l(-) boson mass peak. The data are compared to QCD predictions based on the resummation of multiple soft gluons.
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| 23. |
- Abazov, V. M., et al.
(författare)
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Measurement of the ratio of inclusive cross sections sigma(p(p)over-bar) -> Z+2b jets/sigma(p((p)over-bar) -> Z+2 jets) in p((p)over-bar) collisions at root s=1.96 TeV
- 2015
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 91:5
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Tidskriftsartikel (refereegranskat)abstract
- We measure the ratio of cross sections, σ(pp¯→Z+2b jets)/σ(pp¯→Z+2 jets), for associated production of a Z boson with at least two jets with transverse momentum pjetT>20 GeV and pseudorapidity |ηjet|<2.5. This measurement uses data corresponding to an integrated luminosity of 9.7 fb−1 collected by the D0 experiment in Run II of Fermilab’s Tevatron pp¯ Collider at a center-of-mass energy of 1.96 TeV. The measured integrated ratio of 0.0236±0.0032 (stat)±0.0035 (syst) is in agreement with predictions from next-to-leading-order perturbative QCD and the Monte Carlo event generators pythia and alpgen.
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| 24. |
- Abazov, V. M., et al.
(författare)
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Measurement of the top quark mass using the matrix element technique in dilepton final states
- 2016
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Ingår i: PHYSICAL REVIEW D. - 2470-0010. ; 94:3
-
Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the top quark mass in p (p) over bar collisions at a center-of-mass energy of 1.96 TeV at the Fermilab Tevatron collider. The data were collected by the D0 experiment corresponding to an integrated luminosity of 9.7 fb(-1). The matrix element technique is applied to t (t) over bar events in the final state containing leptons (electrons or muons) with high transverse momenta and at least two jets. The calibration of the jet energy scale determined in the lepton + jets final state of t (t) over bar decays is applied to jet energies. This correction provides a substantial reduction in systematic uncertainties. We obtain a top quark mass of m(t) = 173.93 +/- 1.84 GeV.
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| 25. |
- Abazov, V. M., et al.
(författare)
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Measurement of the W plus b-jet and W plus c-jet differential production cross sections in p (p)over-bar collisions at root s=1.96 TeV
- 2015
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 743, s. 6-14
-
Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the cross sections for the associated production of a W boson with at least one heavy quark jet, b or c, in proton-antiproton collisions. Data corresponding to an integrated luminosity of 8.7 fb(-1) recorded with the D0 detector at the Fermilab Tevatron p (p) over bar Collider at root s = 1.96 TeV are used to measure the cross sections differentially as a function of the jet transverse momenta in the range 20 to 150 GeV. These results are compared to calculations of perturbative QCD theory as well as predictions from Monte Carlo generators.
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| 26. |
- Abazov, V. M., et al.
(författare)
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Measurement of top quark polarization in t(t)over-bar lepton+jets final states
- 2017
-
Ingår i: PHYSICAL REVIEW D. - 2470-0010. ; 95:1
-
Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of top quark polarization in t (t) over bar pair production in p (p) over bar collisions at root s = 1.96 TeV using data corresponding to 9.7 fb(-1) of integrated luminosity recorded with the D0 detector at the Fermilab Tevatron Collider. We consider final states containing a lepton and at least three jets. The polarization is measured through the distribution of lepton angles along three axes: the beam axis, the helicity axis, and the transverse axis normal to the t (t) over bar production plane. This is the first measurement of top quark polarization at the Tevatron using lepton + jet final states and the first measurement of the transverse polarization in t (t) over bar production. The observed distributions are consistent with standard model predictions of nearly no polarization.
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| 27. |
- Abazov, V. M., et al.
(författare)
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Precise measurement of the top quark mass in dilepton decays using optimized neutrino weighting
- 2016
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 752, s. 18-26
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Tidskriftsartikel (refereegranskat)abstract
- We measure the top quark mass in dilepton final states of t (t) over bar events in p (p) over bar collisions at root s = 1.96 TeV, using data corresponding to an integrated luminosity of 9.7 fb(-1) at the Fermilab Tevatron Collider. The analysis features a comprehensive optimization of the neutrino weighting method to minimize the statistical uncertainties. We also improve the calibration of jet energies using the calibration determined in t (t) over bar -> lepton + jets events, which reduces the otherwise limiting systematic uncertainty from the jet energy scale. The measured top quark mass is m(t) = 173.32 +/- 1.36(stat) +/- 0.85(syst) GeV.
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| 28. |
- Abazov, V. M., et al.
(författare)
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Precision measurement of the top-quark mass in lepton plus jets final states
- 2015
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 91:11
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Tidskriftsartikel (refereegranskat)abstract
- We measure the mass of the top quark in lepton + jets final states using the full sample of p (p) over bar collision data collected by the D0 experiment in Run II of the Fermilab Tevatron Collider at root s = 1.96 TeV, corresponding to 9.7 fb(-1) of integrated luminosity. We use a matrix element technique that calculates the probabilities for each event to result from t (t) over bar production or background. The overall jet energy scale is constrained in situ by the mass of the W boson. We measure m(t) = 174.98 +/- 0.76 GeV. This constitutes the most precise single measurement of the top-quark mass.
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| 29. |
- Abazov, V. M., et al.
(författare)
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Search for Violation of CPT and Lorentz Invariance in B-s(0) Meson Oscillations
- 2015
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:16
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Tidskriftsartikel (refereegranskat)abstract
- We present the first search for CPT-violating effects in the mixing of B-s(0) mesons using the full Run II data set with an integrated luminosity of 10.4 fb(-1) of proton-antiproton collisions collected using the D0 detector at the Fermilab Tevatron Collider. We measure the CPT-violating asymmetry in the decay B-s(0) -> mu D-+/-(s)+/- as a function of celestial direction and sidereal phase. We find no evidence for CPT-violating effects and place limits on the direction and magnitude of flavor-dependent CPT- and Lorentz-invariance violating coupling coefficients. We find 95% confidence intervals of Delta a(perpendicular to) < 1.2 x 10(-12) GeV and (-0.8 < Delta a(T) - 0.396 Delta a(Z) < 3.9) x 10(-13) GeV.
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| 30. |
- Abazov, V. M., et al.
(författare)
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Simultaneous measurement of forward-backward asymmetry and top polarization in dilepton final states from t(t)over-bar production at the Tevatron
- 2015
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 92:5
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Tidskriftsartikel (refereegranskat)abstract
- We present a simultaneous measurement of the forward-backward asymmetry and the top-quark polarization in t (t) over bar production in dilepton final states using 9.7 fb(-1) of proton-antiproton collisions at root s = 1.96 TeV with the D0 detector. To reconstruct the distributions of kinematic observables we employ a matrix element technique that calculates the likelihood of the possible t (t) over bar kinematic configurations. After accounting for the presence of background events and for calibration effects, we obtain a forward-backward asymmetry of A(t (t) over bar) = (15.0 +/- 6.4(stat) +/- 4.9(syst)) % and a top-quark polarization times spin analyzing power in the beam basis of kappa P = (7.2 +/- 10.5(stat) +/- 4.2(syst)) %, with a correlation of -56% between the measurements. If we constrain the forward-backward asymmetry to its expected standard model value, we obtain a measurement of the top polarization of kappa P = (11.3 +/- 9.1(stat) +/- 1.9(syst)) %. If we constrain the top polarization to its expected standard model value, we measure a forward-backward asymmetry of A(t (t) over bar) = (17.5 +/- 5.6(stat) +/- 3.1(syst)) %. A combination with the D0 A(t (t) over bar) measurement in the lepton + jets final state yields an asymmetry of A(t (t) over bar) = (11.8 +/- 2.5(stat) +/- 1.3(syst)) %. Within their respective uncertainties, all these results are consistent with the standard model expectations.
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| 31. |
- Abazov, V. M., et al.
(författare)
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Study of double parton interactions in diphoton plus dijet events in p<(p)over bar> collisions at root s = 1.96 TeV
- 2016
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Ingår i: PHYSICAL REVIEW D. - 2470-0010. ; 93:5
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Tidskriftsartikel (refereegranskat)abstract
- We use a sample of diphoton + dijet events to measure the effective cross section of double parton interactions, which characterizes the area containing the interacting partons in proton-antiproton collisions, and find it to be sigma(eff) = 19.3 +/- 1.4(stat) +/- 7.8(syst) mb. The sample was collected by the D0 detector at the Fermilab Tevatron collider in p (p) over bar collisions at root s = 1.96 TeV and corresponds to an integrated luminosity of 8.7 fb(-1).
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| 32. |
- Abazov, V. M., et al.
(författare)
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Study of the X-+/-(5568) state with semileptonic decays of the B-s(0) meson
- 2018
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Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 97:9
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Tidskriftsartikel (refereegranskat)abstract
- We present a study of the X-+/-(5568) using semileptonic decays of the B-s(0) meson using the full run II integrated luminosity of 10.4 fb(-1) in proton-antiproton collisions at a center of mass energy of 1.96 TeV collected with the DO detector at the Fermilab Tevatron Collider. We report evidence for a narrow structure, X-+/-(5568), in the decay sequence X-+/-(5568) -> B-s(0) pi(+/-) where B-s(0)-> mu(-/+) (DsX)-X-+/-, D-s(+/-)-> phi pi(+/-)which is consistent with the previous measurement by the DO Collaboration in the hadronic decay mode, X-+/-(5568) -> B-s(0)pi(+/-) where B-s(0 )-> J/psi phi. The mass and width of this state are measured using a combined fit of the hadronic and semileptonic data, yielding m = 5566.9(-3.1)(+3.2)(stat)(-1.2)(+0.6)(syst) MeV/c(2), Gamma = 18.6(-6.1)(+7.9)(stat)(-3.8)(+3.5) (syst) McV/c(2) with a significance of 6.7 sigma.
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| 33. |
- Jiang, X., et al.
(författare)
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Shared heritability and functional enrichment across six solid cancers
- 2019
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
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| 34. |
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| 35. |
- Huyghe, Jeroen R., et al.
(författare)
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Discovery of common and rare genetic risk variants for colorectal cancer
- 2019
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:1, s. 76-
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Tidskriftsartikel (refereegranskat)abstract
- To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 x 10(-8), bringing the number of known independent signals for CRC to similar to 100. New signals implicate lower-frequency variants, Kruppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs and somatic drivers, and support a role for immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of biology underlying this risk and influence personalized screening strategies and drug development.
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| 36. |
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| 37. |
- Schmit, Stephanie L, et al.
(författare)
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Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
- 2019
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 111:2, s. 146-157
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Tidskriftsartikel (refereegranskat)abstract
- Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery of additional susceptibility loci may capture unexplained familial risk.Methods: We conducted a GWAS in European descent CRC cases and control subjects using a discovery-replication design, followed by examination of novel findings in a multiethnic sample (cumulative n = 163 315). In the discovery stage (36 948 case subjects/30 864 control subjects), we identified genetic variants with a minor allele frequency of 1% or greater associated with risk of CRC using logistic regression followed by a fixed-effects inverse variance weighted meta-analysis. All novel independent variants reaching genome-wide statistical significance (two-sided P < 5 × 10-8) were tested for replication in separate European ancestry samples (12 952 case subjects/48 383 control subjects). Next, we examined the generalizability of discovered variants in East Asians, African Americans, and Hispanics (12 085 case subjects/22 083 control subjects). Finally, we examined the contributions of novel risk variants to familial relative risk and examined the prediction capabilities of a polygenic risk score. All statistical tests were two-sided.Results: The discovery GWAS identified 11 variants associated with CRC at P < 5 × 10-8, of which nine (at 4q22.2/5p15.33/5p13.1/6p21.31/6p12.1/10q11.23/12q24.21/16q24.1/20q13.13) independently replicated at a P value of less than .05. Multiethnic follow-up supported the generalizability of discovery findings. These results demonstrated a 14.7% increase in familial relative risk explained by common risk alleles from 10.3% (95% confidence interval [CI] = 7.9% to 13.7%; known variants) to 11.9% (95% CI = 9.2% to 15.5%; known and novel variants). A polygenic risk score identified 4.3% of the population at an odds ratio for developing CRC of at least 2.0.Conclusions: This study provides insight into the architecture of common genetic variation contributing to CRC etiology and improves risk prediction for individualized screening.
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| 38. |
- Bien, Stephanie A., et al.
(författare)
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Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer
- 2019
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Ingår i: Human Genetics. - : Springer. - 0340-6717 .- 1432-1203. ; 138:4, s. 307-326
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies have reported 56 independently associated colorectal cancer (CRC) risk variants, most of which are non-coding and believed to exert their effects by modulating gene expression. The computational method PrediXcan uses cis-regulatory variant predictors to impute expression and perform gene-level association tests in GWAS without directly measured transcriptomes. In this study, we used reference datasets from colon (n=169) and whole blood (n=922) transcriptomes to test CRC association with genetically determined expression levels in a genome-wide analysis of 12,186 cases and 14,718 controls. Three novel associations were discovered from colon transverse models at FDR0.2 and further evaluated in an independent replication including 32,825 cases and 39,933 controls. After adjusting for multiple comparisons, we found statistically significant associations using colon transcriptome models with TRIM4 (discovery P=2.2x10(-4), replication P=0.01), and PYGL (discovery P=2.3x10(-4), replication P=6.7x10(-4)). Interestingly, both genes encode proteins that influence redox homeostasis and are related to cellular metabolic reprogramming in tumors, implicating a novel CRC pathway linked to cell growth and proliferation. Defining CRC risk regions as one megabase up- and downstream of one of the 56 independent risk variants, we defined 44 non-overlapping CRC-risk regions. Among these risk regions, we identified genes associated with CRC (P<0.05) in 34/44 CRC-risk regions. Importantly, CRC association was found for two genes in the previously reported 2q25 locus, CXCR1 and CXCR2, which are potential cancer therapeutic targets. These findings provide strong candidate genes to prioritize for subsequent laboratory follow-up of GWAS loci. This study is the first to implement PrediXcan in a large colorectal cancer study and findings highlight the utility of integrating transcriptome data in GWAS for discovery of, and biological insight into, risk loci.
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| 39. |
- Drews, A., et al.
(författare)
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Inhibiting the Ca2+ Influx Induced by Human CSF
- 2017
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Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 21:11, s. 3310-3316
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Tidskriftsartikel (refereegranskat)abstract
- One potential therapeutic strategy for Alzheimer's disease (AD) is to use antibodies that bind to small soluble protein aggregates to reduce their toxic effects. However, these therapies are rarely tested in human CSF before clinical trials because of the lack of sensitive methods that enable the measurement of aggregate-induced toxicity at low concentrations. We have developed highly sensitive single vesicle and single-cell-based assays that detect the Ca2+ influx caused by the CSF of individuals affected with AD and healthy controls, and we have found comparable effects for both types of samples. We also show that an extracellular chaperone clusterin; a nanobody specific to the amyloid-beta peptide (A beta); and bapineuzumab, a humanized monoclonal antibody raised against A beta, could all reduce the Ca2+ influx caused by synthetic A beta oligomers but are less effective in CSF. These assays could be used to characterize potential therapeutic agents in CSF before clinical trials.
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| 40. |
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| 41. |
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| 42. |
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| 43. |
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| 44. |
- Doody, A., et al.
(författare)
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Validating the association between plasma tumour necrosis factor receptor 1 levels and the presence of renal injury and functional decline in patients with Type 2 diabetes
- 2018
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Ingår i: Journal of Diabetes and Its Complications. - : Elsevier BV. - 1056-8727. ; 32:1, s. 95-99
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Tidskriftsartikel (refereegranskat)abstract
- Aims: Elevated plasma soluble tumour necrosis factor receptor 1 (TNFR1) predicts long-term progression of chronic kidney disease. We investigated the association between elevated TNFR1 and the presence of renal disease in patients with Type 2 diabetes mellitus registering a haemoglobin Mc (HbA1c) >48 mmol/mol despite medical therapy. Methods: Using sensitivity, specificity and regression analyses we interrogated the association between plasma TNFR1 and presence of chronic kidney disease as assessed by the presence of microalbuminuria and/or an estimated glomerular filtration rate of less than 60 ml/min/1.73 m(2) (stages 3-5 chronic kidney disease). The association of TNFR1 with C-reactive protein and leptin-adiponectin ratio as plasma markers of systemic inflammation and adipose stress respectively was also investigated. Results: Upper quartile TNFR1 is independently associated with elevated urinary albumin-creatinine ratios, reductions in eGFR and strongly predicts the presence of stages 3-5 chronic kidney disease in regression modelling. Elevated TNFR1 levels are associated with increased plasma C-reactive protein and augmented leptin-adiponectin ratio. Conclusions: Our study confirms plasma TNFR1 as a surrogate of renal structural and functional impairment in patients with type 2 diabetes mellitus. Association of TNFR1 with markers of systemic inflammation and adipose stress indicates that TNFR1 may be a biomarker of these processes as components of the pathogenesis of diabetic kidney disease. (C) 2017 Elsevier Inc. All rights reserved.
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| 45. |
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| 46. |
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| 47. |
- Paterson, R W, et al.
(författare)
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A targeted proteomic multiplex CSF assay identifies increased malate dehydrogenase and other neurodegenerative biomarkers in individuals with Alzheimer's disease pathology.
- 2016
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Ingår i: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 6:11
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Tidskriftsartikel (refereegranskat)abstract
- Alzheimer's disease (AD) is the most common cause of dementia. Biomarkers are required to identify individuals in the preclinical phase, explain phenotypic diversity, measure progression and estimate prognosis. The development of assays to validate candidate biomarkers is costly and time-consuming. Targeted proteomics is an attractive means of quantifying novel proteins in cerebrospinal and other fluids, and has potential to help overcome this bottleneck in biomarker development. We used a previously validated multiplexed 10-min, targeted proteomic assay to assess 54 candidate cerebrospinal fluid (CSF) biomarkers in two independent cohorts comprising individuals with neurodegenerative dementias and healthy controls. Individuals were classified as 'AD' or 'non-AD' on the basis of their CSF T-tau and amyloid Aβ1-42 profile measured using enzyme-linked immunosorbent assay; biomarkers of interest were compared using univariate and multivariate analyses. In all, 35/31 individuals in Cohort 1 and 46/36 in Cohort 2 fulfilled criteria for AD/non-AD profile CSF, respectively. After adjustment for multiple comparisons, five proteins were elevated significantly in AD CSF compared with non-AD CSF in both cohorts: malate dehydrogenase; total APOE; chitinase-3-like protein 1 (YKL-40); osteopontin and cystatin C. In an independent multivariate orthogonal projection to latent structures discriminant analysis (OPLS-DA), these proteins were also identified as major contributors to the separation between AD and non-AD in both cohorts. Independent of CSF Aβ1-42 and tau, a combination of these biomarkers differentiated AD and non-AD with an area under curve (AUC)=0.88. This targeted proteomic multiple reaction monitoring (MRM)-based assay can simultaneously and rapidly measure multiple candidate CSF biomarkers. Applying this technique to AD we demonstrate differences in proteins involved in glucose metabolism and neuroinflammation that collectively have potential clinical diagnostic utility.
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| 48. |
- Paterson, R. W., et al.
(författare)
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Do cerebrospinal fluid transfer methods affect measured amyloid β42, total tau, and phosphorylated tau in clinical practice?
- 2015
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Ingår i: Alzheimer's & Dementia. - : Elsevier Inc.. - 1552-5260 .- 1552-5279. ; 1:3, s. 380-384
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Cerebrospinal fluid (CSF) neurodegenerative markers are measured clinically to support a diagnosis of Alzheimer's disease. Several preanalytical factors may alter the CSF concentrations of amyloid β 1-42 (Aβ1-42) in particular with the potential to influence diagnosis. We aimed to determine whether routine handling of samples alters measured biomarker concentration compared with that of prompt delivery to the laboratory. Methods: Forty individuals with suspected neurodegenerative diseases underwent diagnostic lumbar punctures using a standardized technique. A sample of each patient's CSF was sent to the laboratory by four different delivery methods: (1) by courier at room temperature; (2) by courier, on ice; (3) using standard hospital portering; and (4) after quarantining for >24 hours. Aβ1-42, total tau (t-tau), and phosphorylated tau (p-tau) levels measured using standard enzyme-linked immunosorbent assay techniques were compared between transfer methods. Results: There were no significant differences in Aβ1-42, t-tau, or p-tau concentrations measured in samples transported via the different delivery methods despite significant differences in time taken to deliver samples. Discussion: When CSF is collected in appropriate tubes, transferred at room temperature, and processed within 24 hours, neurodegenerative markers can be reliably determined. © 2015 The Authors.
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| 49. |
- Thrift, Aaron P., et al.
(författare)
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Mendelian randomization study of height and risk of colorectal cancer
- 2015
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Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 44:2, s. 662-672
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Tidskriftsartikel (refereegranskat)abstract
- Background: For men and women, taller height is associated with increased risk of all cancers combined. For colorectal cancer (CRC), it is unclear whether the differential association of height by sex is real or is due to confounding or bias inherent in observational studies. We performed a Mendelian randomization study to examine the association between height and CRC risk. Methods: To minimize confounding and bias, we derived a weighted genetic risk score predicting height (using 696 genetic variants associated with height) in 10 226 CRC cases and 10 286 controls. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for associations between height, genetically predicted height and CRC. Results: Using conventional methods, increased height (per 10-cm increment) was associated with increased CRC risk (OR = 1.08, 95% CI = 1.02-1.15). In sex-specific analyses, height was associated with CRC risk for women (OR = 1.15, 95% CI = 1.05-1.26), but not men (OR = 0.98, 95% CI = 0.92-1.05). Consistent with these results, carrying greater numbers of (weighted) height-increasing alleles (per 1-unit increase) was associated with higher CRC risk for women and men combined (OR = 1.07, 95% CI = 1.01-1.14) and for women (OR = 1.09, 95% CI = 1.01-1.19). There was weaker evidence of an association for men (OR = 1.05, 95% CI = 0.96-1.15). Conclusion: We provide evidence for a causal association between height and CRC for women. The CRC-height association for men remains unclear and warrants further investigation in other large studies.
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| 50. |
- Wellington, H., et al.
(författare)
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CSF neurogranin or tau distinguish typical and atypical Alzheimer disease
- 2018
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Ingår i: Annals of Clinical and Translational Neurology. - : Wiley. - 2328-9503. ; 5:2, s. 162-171
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To assess whether high levels of cerebrospinal fluid neurogranin are found in atypical as well as typical Alzheimer's disease. Methods: Immunoassays were used to measure cerebrospinal fluid neurogranin in 114 participants including healthy controls (n=27), biomarker-proven amnestic Alzheimer's disease (n=68), and the atypical visual variant of Alzheimer's (n=19) according to international criteria. CSF total-tau, A beta 42, and neurofilament light concentrations were investigated using commercially available assays. All affected individuals had T1-weighted volumetric MR images available for analysis of whole and regional brain volumes. Associations between neurogranin, brain volumes, total-tau, A beta 42, and neurofilament light were assessed. Results: Median cerebrospinal fluid neurogranin concentrations were higher in typical and atypical Alzheimer's compared to controls (P<0.001 and P=0.005). Both neurogranin and total-tau concentrations, but not neurofilament light and A beta 42, were higher in typical Alzheimer's compared to atypical patients (P=0.004 and P=0.03). There were significant differences in the left hippocampus and right and left superior parietal lobules in atypical patients, which were larger (P=0.03) and smaller (P=0.001 and P<0.001), respectively, compared to typical patients. We found no evidence of associations between neurogranin and brain volumes but a strong association with total-tau (P<0.001) and a weaker association with neurofilament light (P=0.005). Interpretation: These results show significant differences in neurogranin and total-tau between typical and atypical patients, which may relate to factors other than disease topography. The differential relationships between neurogranin, total-tau and neurofilament light in the Alzheimer's variants, provide evidence for mechanistically distinct and coupled markers of neurodegeneration.
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