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Träfflista för sökning "WFRF:(Smith RL) srt2:(1995-1999)"

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1.	COLEMAN, RA, et al. (author) Prostanoid and leukotriene receptors: a progress report from the IUPHAR working parties on classification and nomenclature 1995 In: Advances in prostaglandin, thromboxane, and leukotriene research. - 0732-8141. ; 23, s. 283-285 Journal article (peer-reviewed)
2.	Salim, K, et al. (author) Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase 1996 In: The EMBO journal. - : Wiley. - 0261-4189. ; 15:22, s. 6241-6250 Journal article (peer-reviewed)
3.	Zhang, B, et al. (author) Discovery of a small molecule insulin mimetic with antidiabetic activity in mice 1999 In: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 284:5416, s. 974-977 Journal article (peer-reviewed)abstract Insulin elicits a spectrum of biological responses by binding to its cell surface receptor. In a screen for small molecules that activate the human insulin receptor tyrosine kinase, a nonpeptidyl fungal metabolite (L-783,281) was identified that acted as an insulin mimetic in several biochemical and cellular assays. The compound was selective for insulin receptor versus insulin-like growth factor I (IGFI) receptor and other receptor tyrosine kinases. Oral administration of L-783,281 to two mouse models of diabetes resulted in significant lowering in blood glucose levels. These results demonstrate the feasibility of discovering novel insulin receptor activators that may lead to new therapies for diabetes.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Nicosia, S (2); Zhang, Y. (1); Paoletti, R. (1); Zhang, B. (1); Dahlen, SE (1); Zierath, JR (1); show more...; Shimizu, T (1); Jones, RL (1); Smith, CIE (1); Samuelsson, B (1); Ramwell, PW (1); Folco, G (1); Granstrom, E (1); Drazen, JM (1); Jones, TR (1); COLEMAN, RA (1); EGLEN, RM (1); NARUMIYA, S (1); SMITH, WL (1); GARDINER, PJ (1); JACKSON, WT (1); KRELL, RD (1); Driscoll, PC (1); Mao, XZ (1); Li, ZH (1); Moller, DE (1); Salituro, G (1); Smith, RG (1); Salim, K (1); Bottomley, MJ (1); Querfurth, E (1); Zvelebil, MJ (1); Gout, I (1); Scaife, R (1); Margolis, RL (1); Gigg, R (1); Waterfield, MD (1); Panayotou, G (1); Griffin, P (1); Szalkowski, D (1); Royo, I (1); Vilella, D (1); Diez, MT (1); Pelaez, F (1); Ruby, C (1); Kendall, RL (1); Calaycay, J (1); Heck, JV (1); show less...

University: Karolinska Institutet (3)

Language: English (3)

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