Microbial-gut interactions in health and disease. Progress in enteric vaccine development.

• Enteric infections resulting in diarrhoea are among the most important causes of morbidity and mortality, particularly in children in developing countries. They are also a common cause of disease among travellers to Africa, Asia and Latin America. Recently, effective, live and inactivated oral and parenteral vaccines against some of the most severe enteric infections-cholera and typhoid fever-have been licensed in several countries. Different candidate vaccines against rotavirus, Shigella and ETEC diarrhoea have also been developed and tested for safety and immunogenicity in developed as well as in developing countries. The protective efficacy of several of these vaccines has also been tested, either in human volunteer challenge studies or in field trials. In this chapter we describe the properties and availability of the recently licensed vaccines and present an update on the diverse efforts being made to achieve new or improved vaccines against the most prevalent enteropathogens.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Nyckelord

Cholera

complications

prevention & control

Diarrhea

microbiology

prevention & control

virology

Dysentery

Bacillary

complications

prevention & control

Enterobacteriaceae

drug effects

Escherichia coli Infections

complications

prevention & control

Humans

Rotavirus Infections

complications

prevention & control

Typhoid Fever

complications

prevention & control

Vaccines

administration & dosage

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)