| 1. |
- Modin, H, et al.
(author)
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Genome-wide linkage screen of a consanguineous multiple sclerosis kinship
- 2003
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In: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 9:2, s. 128-134
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Journal article (peer-reviewed)abstract
- Multiple sclerosis (MS), like A lzheimer’s disease (A D) and Parkinson’s disease (PD), is a common neurological disorder thought to be caused by the interaction of several genes with unknown environmental factors. In both A D and PD the identification of disease forms inherited in a classic Mendelian fashion has helped investigators elucidate pathogenetic mechanisms. In this study a whole-genome screen, with an average of 608 successful genotypes per person, was performed on nine members of a consanguineous family: the index case, three of her siblings and her daughter, all of whom have been diagnosed with definite MS; as well as the parents of the index case (first cousins), one of her five healthy siblings and her husband (who is also her first cousin). Nonparametric linkage analysis was performed on genotyping data. Based on the presence of consanguinity, the a priori hypothesis was that the disease is transmitted in an autosomal recessive fashion in the pedigree. Linkage analysis revealed a suggestive logarithm of odds (LO D) score of 2.29 on the long arm of chromosome 9. Four of five affected family members were identically homozygous for a haplotype under this peak, spanning approximately 43 cM, while the fifth affected subject and all unaffected family members were hetero zygous for the haplotype.
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| 2. |
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| 3. |
- Handeland, S. O., et al.
(author)
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Seawater adaptation and growth of post-smolt Atlantic salmon (Salmo salarnext term) of wild and farmed strains
- 2004
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In: Aquaculture. - 0044-8486. ; 220:1-4, s. 367-384
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Journal article (peer-reviewed)abstract
- previous termAtlantic salmon smolts (Salmo salarnext term L.) of wild (Namsen) and farmed (AquaGen) strains were transferred to full-strength previous termseawaternext term (33‰) for 0 (initial control group), 0.5, 1, 2, 4, 8, 14, 30, 42 and 60 days at three different temperatures (4.3, 9.4 and 14.3 °C). Freshwater temperature in each tank was adjusted to test conditions 10 days prior to transfer. Physiological previous termadaptationnext term was monitored as changes in plasma previous termgrowthnext term hormone levels, gill Na+,K+-ATPase activity, plasma chloride levels and survival in previous termseawater.next term Overall, previous termsmoltsnext term from the wild strain were better able to tolerate transfer to previous termseawater than smoltsnext term from the hatchery strain. A delay in the osmotic disturbance and a prolonged period of osmotic stress were observed at the low temperature. Circulating GH levels increased transiently in all groups during the first 12–48 h in previous termseawaternext term and long-term GH levels were positively correlated with previous termseawaternext term temperature. previous termGrowthnext term rates were influenced by temperature and strain, with the farmed previous termsmoltsnext term showing a higher previous termgrowthnext term than the wild previous termsmolts.next term Food Conversion Efficiency (FCE) was higher in previous termsmoltsnext term from the farmed strain, whereas no differences in daily food consumption were observed. Optimum temperature for FCE was calculated to be 10.5 °C, whereas the optimal temperature for previous termgrowthnext term in previous termseawaternext term was calculated to be 13.0 °C. We suggest that the observed differences in previous termseawaternext term tolerance, previous termgrowthnext term and food conversion probably are genetic and may reflect the fact that the hatchery fish have been bred for rapid previous termgrowthnext term for several generations.
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| 4. |
- Stefansson, Gunnar, 1963, et al.
(author)
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Clisme, Functional Requirements Analysis
- 2000
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In: Paper presented and published in Deliverable D2 of Client Service System For SME’s, CLISME. European Commission, Directorate-General XIII, TEN-Telecom, 2000..
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Conference paper (other academic/artistic)
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| 5. |
- Stefansson, Gunnar, 1963, et al.
(author)
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CLISME, System Specification
- 2000
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In: Paper presented and published in Deliverable D3 of Client Service System. For SME’s, CLISME. European Commission, Directorate-General XIII, TEN-Telecom, 2000..
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Conference paper (other academic/artistic)
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