| 1. |
- Steffenburg, Suzanne, et al.
(författare)
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Autism in Angelman syndrome: a population-based study.
- 1996
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Ingår i: Pediatric Neurolgy. - 0887-8994. ; 14:2, s. 131-136
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to examine the prevalence of angelman syndrome in prepubertal school-aged children and analyze its comorbidity with autistic disorder. A clinical/psychiatric evaluation of a population-based sample of 6- to 13-year-old mentally retarded children with active epilepsy was performed. Four individuals in a total population of almost 49,000 children conformed to the clinical diagnosis of Angelman syndrome. Two of these had a typical microdeletion at chromosome 15q11-13. The minimum prevalence of Angelman syndrome was estimated at 0.008% (1: 12,000) in the examined age group. All 4 children with Angelman syndrome met full behavioral criteria for the diagnosis of autistic disorder/childhood autism. It is concluded that Angelman syndrome is uncommon, but more frequent than previously estimated. The diagnosis should be considered in all patients with combined autistic disorder, severe mental retardation, and epilepsy. The implications of the possible association of Angelman syndrome and autism are discussed
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| 2. |
- Steffenburg, Suzanne, et al.
(författare)
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Psychiatric disorders in children and adolescents with mental retardation and active epilepsy.
- 1996
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Ingår i: Archives of Neurology. - 0003-9942. ; 53:9, s. 904-912
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To assess the prevalence and types of psychiatric disorders in a representative sample of school-age children with the combination of mental retardation (MR) and active epilepsy. SUBJECTS AND METHODS: Ninety-eight children were identified with MR and active epilepsy in a population-based study from Göteborg, Sweden, which has a general population at risk of 48873 children. They were born between 1975 and 1986 and were 8 to 16 years old at the time of psychiatric examination. Five children had died, 3 had parents who declined participation, and 90 were clinically examined. RESULTS: Fifty-three children (59%) had at least 1 psychiatric diagnosis, and the conditions in 30 (33%) could not be classified because of profound severe MR. Twenty-four children (27%) had autistic disorder, and another 10 (11%) had an autisticlike condition. The combination of MR, active epilepsy, and autism or an autisticlike condition occurred at a rate of 0.07% in the general population. The most common seizure types in the group with autism or an autisiclike condition were complex partial, atypical absence, myoclonic, and tonic-clonic. CONCLUSIONS: Children with MR and active epilepsy suffered from a psychiatric disorder in a majority of those cases in which the children had enough skills and mobility to exhibit behavioral and emotional problems. Many such problems had been undiagnosed despite parental concern and the conviction that the psychiatric problems were the most burdensome in many cases. Neurologists and psychiatrists need to develop better programs for the adequate management of psychiatric disorders in this population.
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| 3. |
- Gillberg, Christopher, 1950, et al.
(författare)
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Auditory Integration Training in Children with Autism : Brief Report of an Open Pilot Study
- 1997
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Ingår i: Autism. - : SAGE Publications. - 1362-3613 .- 1461-7005. ; 1:1, s. 97-100
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Tidskriftsartikel (refereegranskat)abstract
- Nine children aged 3-I 6 years with an autistic disorder were given auditory integration training for half-hour sessions during 10 days according to guidelines suggested by Guy Berard. No significant change in overall autistic symptom level could be documented 9 months later. However a small but non-significant reduction of 'sensory problems' as rated by the Autism Behaviour Checklist was noted.
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