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Early Life Wheeze a...
Early Life Wheeze and Risk Factors for Asthma-A Revisit at Age 7 in the GEWAC-Cohort
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- Holmdahl, Idun (author)
- Karolinska Univ Hosp, Astrid Lindgrens Childrens Hosp, S-17164 Stockholm, Sweden.;Karolinska Inst, Dept Womens & Childrens Hlth, S-17177 Stockholm, Sweden.
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- Filiou, Anastasia (author)
- Karolinska Institutet
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- Stenberg Hammar, Katarina (author)
- Karolinska Univ Hosp, Astrid Lindgrens Childrens Hosp, S-17164 Stockholm, Sweden.;Karolinska Inst, Dept Womens & Childrens Hlth, S-17177 Stockholm, Sweden.
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- Asarnoj, Anna (author)
- Karolinska Institutet
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- Borres, Magnus P, 1956- (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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- van Hage, Marianne (author)
- Karolinska Inst, Div Immunol & Allergy, Dept Med Solna, S-17176 Stockholm, Sweden.;Karolinska Univ Hosp, S-17176 Stockholm, Sweden.
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- Hedlin, Gunilla (author)
- Karolinska Institutet
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- Söderhäll, Cilla (author)
- Karolinska Institutet
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- Konradsen, Jon R. (author)
- Karolinska Institutet
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Karolinska Institutet Karolinska Univ Hosp, Astrid Lindgrens Childrens Hosp, S-17164 Stockholm, Sweden;Karolinska Inst, Dept Womens & Childrens Hlth, S-17177 Stockholm, Sweden. (creator_code:org_t)
- 2021-06-08
- 2021
- English.
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In: Children. - : MDPI. - 2227-9067. ; 8:6
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Abstract
Subject headings
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- One third of all toddlers are in need of medical care because of acute wheeze and many of these children have persistent asthma at school age. Our aims were to assess risk factors for and the prevalence of asthma at age 7 in a cohort of children suffering from an acute wheezing episode as toddlers. A total of 113 children, included during an acute wheezing episode (cases), and 54 healthy controls were followed prospectively from early pre-school age to 7 years. The protocol included questionnaires, ACT, FeNO, nasopharyngeal virus samples, blood sampling for cell count, vitamin D levels, and IgE to food and airborne allergens. The prevalence of asthma at age 7 was 70.8% among cases and 1.9% among controls (p < 0.001). Acute wheeze caused by rhinovirus (RV) infection at inclusion was more common among cases with asthma at age 7 compared to cases without asthma (p = 0.011) and this association remained significant following adjustment for infection with other viruses (OR 3.8, 95% CI 1.4-10.5). Cases with asthma at age 7 had been admitted to hospital more often (p = 0.024) and spent more days admitted (p = 0.01) during the year following inclusion compared to cases without asthma. RV infection stands out as the main associated factor for wheeze evolving to persistent asthma. Cases who developed asthma also had an increased need of hospital time and care for wheeze during the year after inclusion.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- preschool wheeze
- rhinovirus
- allergic sensitization
- asthma
- wheeze
Publication and Content Type
- ref (subject category)
- art (subject category)
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