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Photodynamic therap...
Photodynamic therapy with methyl aminolevulinate for prevention of new skin lesions in transplant recipients: a randomized study
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- Wennberg, Ann-Marie, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Stenquist, Bo, 1937 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Stockfleth, E (författare)
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Keohane, S. (författare)
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- Lear, J.T (författare)
- Karolinska Institutet
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Jemec, G. (författare)
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Mork, C. (författare)
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Christensen, E. (författare)
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Kapp, A. (författare)
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Solvsten, H. (författare)
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Talme, T. (författare)
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- Berne, Berit (författare)
- Uppsala universitet,Dermatologi och venereologi
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Forschner, T. (författare)
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(creator_code:org_t)
- 2008
- 2008
- Engelska.
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Ingår i: Transplantation. - 0041-1337 .- 1534-6080. ; 86:3, s. 423-9
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Organ transplant recipients on long-term immunosuppressive therapy are at increased risk of non-melanoma skin lesions. Repeated field photodynamic therapy using topical methyl aminolevulinate (MAL) may have potential as a preventive treatment. METHODS: This open randomized, intrapatient, comparative, multicenter study included 81 transplant recipients with 889 lesions (90% actinic keratoses (AK)]. In each patient, the study treatment was initially administered to one 50 cm area on the face, scalp, neck, trunk, or extremities (n=476 lesions) twice (1 week apart), with additional single treatments at 3, 9, and 15 months. On each occasion, the area was debrided gently and MAL cream (160 mg/g) applied for 3 hr, before illumination with noncoherent red light (630 nm, 37 J/cm2). The control, 50 cm2 area (n=413 lesions) received lesion-specific treatment (83% cryotherapy) at baseline and 3, 9, and 15 months. Additionally, all visible lesions were given lesion-specific treatment 21 and 27 months in both treatment and control areas. RESULTS: At 3 months, MAL photodynamic therapy significantly reduced the occurrence of new lesions (65 vs. 103 lesions in the control area; P=0.01), mainly AK (46% reduction; 43 vs. 80; P=0.006). This effect was not significant at 27 months (253 vs. 312; P=0.06). Hypopigmentation, as assessed by the investigator, was less evident in the treatment than control areas (16% vs. 51% of patients; P<0.001) at 27 months. CONCLUSION: Our results suggest that repeated field photodynamic therapy using topical MAL may prevent new AK in transplant recipients although further studies are needed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- Administration
- Topical
- Adult
- Aged
- derivatives/therapeutic use
- Cryotherapy
- Europe
- Female
- Humans
- Immunosuppressive Agents/*adverse effects
- Keratosis/chemically induced/pathology/*prevention & control
- Male
- Middle Aged
- *Organ Transplantation
- *Photochemotherapy/adverse effects
- Photosensitizing Agents/administration & dosage/adverse
- effects/*therapeutic use
- Treatment Outcome
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Wennberg, Ann-Ma ...
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Stenquist, Bo, 1 ...
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Stockfleth, E
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Keohane, S.
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Lear, J.T
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Jemec, G.
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visa fler...
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Mork, C.
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Christensen, E.
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Kapp, A.
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Solvsten, H.
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Talme, T.
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Berne, Berit
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Forschner, T.
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visa färre...
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Transplantation
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Göteborgs universitet
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Uppsala universitet
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Karolinska Institutet