| 1. |
- Schunkert, Heribert, et al.
(författare)
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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
- 2011
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:4, s. 153-333
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Tidskriftsartikel (refereegranskat)abstract
- We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.
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| 2. |
- Assimes, Themistocles L., et al.
(författare)
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Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
- 2010
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Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097. ; 56:19, s. 1552-1563
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Tidskriftsartikel (refereegranskat)abstract
- Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports. Results A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of >= 2% in the risk of CAD among European 719Arg carriers. We also observed no increase in the risk of CAD among 719Arg carriers in the subset of Europeans with early-onset disease (younger than 50 years of age for men and younger than 60 years of age for women) compared with similarly aged controls as well as all non-European subgroups. Conclusions The KIF6 Trp719Arg polymorphism was not associated with the risk of clinical CAD in this large replication study. (J Am Coll Cardiol 2010;56:1552-63) (C) 2010 by the American College of Cardiology Foundation
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| 3. |
- Love, David C., et al.
(författare)
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Emerging COVID-19 impacts, responses, and lessons for building resilience in the seafood system
- 2021
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Ingår i: Global food security. - : Elsevier BV. - 2211-9124. ; 28
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Tidskriftsartikel (refereegranskat)abstract
- The COVID-19 pandemic and subsequent lockdowns are creating health and economic crises that threaten food and nutrition security. The seafood sector provides important sources of nutrition and employment, especially in low-income countries, and is highly globalized allowing shocks to propagate. We studied COVID-19-related disruptions, impacts, and responses to the seafood sector from January through May 2020, using a food system resilience ‘action cycle’ framework as a guide. We find that some supply chains, market segments, companies, small-scale actors and civil society have shown initial signs of greater resilience than others. COVID-19 has also highlighted the vulnerability of certain groups working in- or dependent on the seafood sector. We discuss early coping and adaptive responses combined with lessons from past shocks that could be considered when building resilience in the sector. We end with strategic research needs to support learning from COVID-19 impacts and responses.
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| 4. |
- Partelow, Stefan, et al.
(författare)
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Aquaculture governance : five engagement arenas for sustainability transformation
- 2023
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Ingår i: Current Opinion in Environmental Sustainability. - 1877-3435 .- 1877-3443. ; 65
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Tidskriftsartikel (refereegranskat)abstract
- A greater focus on governance is needed to facilitate effective and substantive progress toward sustainability transformations in the aquaculture sector. Concerted governance efforts can help move the sector beyond fragmented technical questions associated with intensification and expansion, social and environmental impacts, and toward system-based approaches that address interconnected sustainability issues. Through a review and expert-elicitation process, we identify five engagement arenas to advance a governance agenda for aquaculture sustainability transformation: (1) setting sustainability transformation goals, (2) cross-sectoral linkages, (3) land–water–sea connectivity, (4) knowledge and innovation, and (5) value chains. We then outline the roles different actors and modes of governance can play in fostering sustainability transformations, and discuss action items for researchers, practitioners, and policymakers to operationalize activities within their engagement arenas.
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| 5. |
- Stoll, Joshua S., et al.
(författare)
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Alternative pathways to sustainable seafood
- 2020
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Ingår i: Conservation Letters. - : Wiley. - 1755-263X. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Seafood certifications are a prominent tool being used to encourage sustainability in marine fisheries worldwide. However, questions about their efficacy remain the subject of ongoing debate. A main criticism is that they are not well suited for small-scale fisheries or those in developing nations. This represents a dilemma because a significant share of global fishing activity occurs in these sectors. To overcome this shortcoming and others, a range of fixes have been implemented, including reduced payment structures, development of fisheries improvement projects, and head-start programs that prepare fisheries for certification. These adaptations have not fully solved incompatibilities, instead creating new challenges that have necessitated additional fixes. We argue that this dynamic is emblematic of a common tendency in natural resource management where particular tools and strategies are emphasized over the conservation outcomes they seek to achieve. This can lead to the creation of hammers in management and conservation. We use seafood certifications as an illustrative case to highlight the importance of diverse approaches to sustainability that do not require certification. Focusing on alternative models that address sustainability problems at the local level and increase fishers' adaptive capacity, social capital, and agency through relational supply chains may be a useful starting point.
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| 6. |
- Stoll, Joshua S., et al.
(författare)
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Seafood Trade Routes for Lobster Obscure Teleconnected Vulnerabilities
- 2018
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Ingår i: Frontiers in Marine Science. - : Frontiers Media SA. - 2296-7745. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Reliance on international seafood markets leaves small-scale fishers and fishing economies vulnerable to distant disturbances that can negatively affect market prices and trigger social, economic, and environmental crises at local levels. This paper examines the role of seafood trade routes and re-exports in masking such market linkages. We employ a network approach to map the global trade routes of lobster (Homarus spp.) from small-scale producers in North America to terminal markets and evaluate the extent to which intermediary nations act to obscure producer-market relationships. In taking this approach, we provide a method for systematically measuring teleconnectivity created through seafood trade routes, and thus making explicit vulnerabilities to small-scale fisheries from this teleconnectivity. Our empirical analysis shows that the perceived trade diversification of lobster producers is masking increased dependencies on a reduced number of end-markets, particularly in Asia. These results suggest, paradoxically, that the apparent diversification of trade partnerships may actually amplify, rather than reduce, the vulnerabilities of small-scale fishers associated with international trade by making risk harder to identify and anticipate. We discuss our results in the context of local fisheries and global seafood trade and describe key impediments to being able to monitor market dependencies and exposure to potential vulnerabilities.
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| 7. |
- Stoll, Joshua S., et al.
(författare)
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Uneven adaptive capacity among fishers in a sea of change
- 2017
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 12:6
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Tidskriftsartikel (refereegranskat)abstract
- Fishers worldwide operate in an environment of uncertainty and constant change. Their ability to manage risk associated with such uncertainty and subsequently adapt to change is largely a function of individual circumstances, including their access to different fisheries. However, explicit attention to the heterogeneity of fishers' connections to fisheries at the level of the individual has been largely ignored. We illustrate the ubiquitous nature of these connections by constructing a typology of commercial fishers in the state of Maine based on the different fisheries that fishers rely on to sustain their livelihoods and find that there are over 600 combinations. We evaluate the adaptive potential of each strategy, using a set of attributes identified by fisheries experts in the state, and find that only 12% of fishers can be classified as being well positioned to adapt in the face of changing socioeconomic and ecological conditions. Sensitivity to the uneven and heterogeneous capacity of fishers to manage risk and adapt to change is critical to devising effective management strategies that broadly support fishers. This will require greater attention to the social-ecological connectivity of fishers across different jurisdictions.
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| 8. |
- Young, William J., et al.
(författare)
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Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
- 2022
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovascular disease. The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for cell growth and extracellular matrix interactions are significantly enriched. We demonstrate polygenic risk score associations with atrial fibrillation, conduction disease and sudden cardiac death. Prioritization of druggable genes highlight potential therapeutic targets for arrhythmia. Together, these results substantially advance our understanding of the genetic architecture of ventricular depolarization and repolarization.
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