| 1. |
- Gad, Helge, et al.
(författare)
-
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
- 2014
-
Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221
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Tidskriftsartikel (refereegranskat)abstract
- Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
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| 2. |
- Carlbring, Per, et al.
(författare)
-
The effects on depression of Internet-administered behavioural activation and physical exercise with treatment rationale and relapse prevention : study protocol for a randomised controlled trial
- 2013
-
Ingår i: Trials. - : Springer Science and Business Media LLC. - 1745-6215. ; 14, s. 35-
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Despite their potential as low-threshold, low-cost and high-flexibility treatments of depression, behavioural activation and physical exercise have not yet been directly compared. This study will examine the effects of these interventions, administered via the Internet. The added effect of providing a treatment rationale will also be studied, as well as a relapse prevention program featuring cognitive behavioural therapy components.Methods/Design: This randomised controlled trial will include 500 participants meeting the diagnostic criteria for major depression, recruited in multiple cycles and randomised to either a waiting list control group with delayed treatment, or one of the four treatment groups: (1) physical exercise without a clear treatment rationale; (2) physical exercise with treatment rationale; (3) behavioural activation with treatment rationale; or (4) behavioural activation without a clear treatment rationale. Post treatment, half of the participants will be offered a relapse prevention program. Primary outcome measure will be the Patient Health Questionnaire 9-item. Secondary measures include diagnostic criteria for depression, as well as self-reported anxiety, physical activity and quality of life. Measurements - done via telephone and the Internet - will be collected pre-treatment, weekly during treatment period, immediately post treatment and then monthly during a 24-month follow-up period.Discussion: The results of this study will constitute an important contribution to the body of knowledge of the respective interventions. Limitations are discussed.
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| 3. |
- Athley, Karin, et al.
(författare)
-
Mechanical retention - Influence of filler floc size and grammage of the fibre web
- 2012
-
Ingår i: Nordic Pulp & Paper Research Journal. - 0283-2631 .- 2000-0669. ; 27:2, s. 202-207
-
Tidskriftsartikel (refereegranskat)abstract
- An investigation of the impact of particle size on the mechanical retention of particles in a fibre network has been conducted. The particles used were five sets of quartz particle fractions having fairly narrow particle size distributions with average particle size ranging from a few μm to around 100 μm. The particles were used to model flocculated filler aggregates as part of a larger study of the effect of pre-flocculation on mechanical retention. Pre-flocculation of the filler is a possible strategy to increase the filler content of paper without deterioration of strength properties. A modified laboratory hand sheet former, known as the Rapid Drainage Device (RDD) was used. The major modification consisted of a long pipe that acted as a suction leg, which provides a dewatering vacuum at the same level as on a paper machine. The experimental results showed that mechanical filler retention increased linearly with particle size and grammage of the fibre layer above a critical grammage which depended on particle size. The linear relation was also seen in a pilot scale trial on the FEX pilot-paper machine at Innventia. During this trial fine paper was produced using pre-flocculated filler where the mean particle size of the flocs and fibres was measured in the flow to the headbox. The results from this pilot trial show that mechanical retention is an important part of the total filler retention. Drainage time and therefore drainage resistance increased with the grammage of the fibre layer and amount of quartz particle added. Drainage time, compared at total grammage (i.e. the sum of fibre and quartz particle grammage) was lowest for a fraction of medium-sized particles, with a median size of 35 μm. There was no obvious effect on retention or drainage resistance of a change in the dewatering pressure from 27.5 to 41.5 kPa.
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| 4. |
- Athley, Karin, et al.
(författare)
-
Optimizing the benefit of retention chemicals
- 2014
-
Konferensbidrag (refereegranskat)abstract
- Pre-flocculation of filler has been tested as a concept for improving the retention of filler and the strength properties of the sheet. The impact of the size of the filler floes on the mechanical retentionin a fibre network was investigated using a modified laboratory hand sheet former. The mechanical retention was found to increase linearly with both particle size and grammage of the fibre web. These results were confirmed in a full scale production trial on the FEX pilot paper machine at Innventia. Here different filler floe sizes were created through different chemical pre-flocculation strategies. The particle size in the flow to the headbox was measured with FBRM, and a linear relation between particle size and filler retention was found. Corresponding linear relation was seen in a pilot trial when adding filler and retention aid conventionally. This implies that mechanical retention constitute an important part of the filler retention not only upon pre-flocculation but also with conventional addition of filler and retention aid. Thus, the particle size before the headbox can be a good indicator of the retention level. For the conventional application of a two component retention aid system, the increased filler retention correlated to impaired formation and decreased sheet strength. On the contrary, pre-flocculation led to an increase in both sheet strength and filler retention, demonstrating the advantage of pre-flocculating filler.
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| 5. |
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| 6. |
- Bollen, Math, et al.
(författare)
-
Guidelines for good practice on voltage quality monitoring
- 2013
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Ingår i: 22nd International Conference and Exhibition on Electricity Distribution (CIRED 2013). - Red Hook, NY : Curran Associates, Inc.. - 9781849197328
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Konferensbidrag (refereegranskat)abstract
- Guidelines are given for setting up and running a voltage quality monitoring programme. These guidelines are published jointly by CEER and ECRB and contain among others recommendations on the number and location of monitors, on disturbances to be monitored and indices to be calculated, on reporting of the results and on financing of the programme. It is concluded that voltage quality monitoring programs are important tools for voltage quality regulation and that all other possible applications should be kept in mind when setting up such a programme. It is also concluded that such programmes should be funded through the network tariffs; that the results should be made available regularly and that diversification of indices and methods is to be avoided.
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| 7. |
- Bondelind, Mia, 1980, et al.
(författare)
-
Eulerian modelling of the formation and flow of aggregates in dissolved air flotation
- 2012
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Ingår i: Proceedings of the conference on Modelling Fluid Flow, Budapest Hungary 2012. - 9789630845878 ; 2, s. 650-657
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Konferensbidrag (refereegranskat)abstract
- Dissolved Air Flotation (DAF) is a well-established process within the drinking water treatment community. The process is driven by density differences caused by injection of air bubbles into the main water flow. Particulate matter in the water is flocculated into larger particles (termed flocs). The water, together with flocs, is thereafter mixed with the injected air bubbles. Buoyant aggregates are formed by adhesion of bubbles to the flocs. The aggregates rise to the surface of the unit where they are removed from the water phase. The objective of this paper is to conduct simulations of fluid dynamics of a DAF unit, with a specific aim to capture the formation and flow of aggregates. For that purpose, a model has been developed that explains the mechanisms that lead to creation of aggregates and results in estimation of their size. Details on the implementation of the aggregation model into an Eulerian framework are given in the paper. We show in the paper that the modelling framework can describe the dynamics of flotation by capturing the formation, change in size and movements of the aggregates through the contact zone of a pilot DAF unit as a function of the properties of the flocs.
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| 8. |
- Bondelind, Mia, 1980, et al.
(författare)
-
Modelling of formation and flow of aggregates in Dissolved Air Flotation: Comparison between 2D and 3D
- 2013
-
Ingår i: Proceedings of the International Conference on Multiphase Flow 2013 (ICMF2013), Jeju, South Korea.
-
Konferensbidrag (refereegranskat)abstract
- In this paper a framework is proposed for capturing the flow and formation of aggregates in Dissolved Air Flotation (DAF). DAF is a well-established process within the drinking water treatment community. The process is driven by density differences caused by injection of air bubbles into the main water flow. By adhesion of bubbles to solid particles (to be removed from the water) buoyant aggregates are formed. The objective of this paper is to demonstrate a modelling framework, with a specific aim to capture the formation and flow of these aggregates in two- and three-dimensional computational setups. For that purpose, a model has been developed that explains the mechanisms that lead to creation of aggregates and results in estimation of their size. Details on the implementation of the aggregation model into an Eulerian framework are given in the paper. We show here that the modelling framework can describe the dynamics of flotation by capturing the formation, change in size and movements of the aggregates through a pilot DAF unit as a function of the properties of the flocs. The differences between a two- and a three-dimensional setup, in terms of the predicted aggregate sizes, are investigated. The framework is demonstrated to be applicable for both two-dimensional and three-dimensional computational setups.
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| 9. |
- Buhrman, Monica, et al.
(författare)
-
Guided internet-based cognitive behavioural treatment for chronic back pain reduces pain catastrophizing : a randomized controlled trial
- 2011
-
Ingår i: Journal of Rehabilitation Medicine. - : Medical Journals Sweden AB. - 1650-1977 .- 1651-2081. ; 43:6, s. 500-505
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this study was to investigate whether an Internet-based cognitive behavioural intervention would have an effect on the symptoms of chronic back pain. Design: Experimental design with a treatment group and a control group measured before and after a treatment period. Subjects: Participants who met the criteria for chronic back pain (n = 54). Methods: All participants were screened in a live, structured interview before inclusion. The study period was 12 weeks and the treatment consisted of education, cognitive skills acquisition, behavioural rehearsal, generalization and maintenance. The main outcome of interest was the catastrophizing subscale of the Coping Strategies Questionnaire. Results: There were statistically significant reductions from pre- to post-treatment in catastrophizing in the treatment group, and an improvement in quality of life for the treatment group. However, most outcome measures did not indicate a positive treatment outcome. On a scale measuring pain catastrophizing, 58% (15/26) of the treated participants showed reliable improvement, compared with 18% (5/28) of the control group. Conclusion: Internet-based cognitive behavioural therapy can serve as a complement for individuals with chronic pain who prefer this treatment and have difficulties accessing specialist treatment facilities.
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| 10. |
- Faxälv, Lars, et al.
(författare)
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Putting polyphosphates to the test: evidence against platelet-induced activation of factor XII
- 2013
-
Ingår i: Blood. - Washington, USA : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 122:23, s. 3818-3824
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Tidskriftsartikel (refereegranskat)abstract
- The recent claim that stimulated platelets activate the intrinsic pathway of coagulation by the release of polyphosphates has been considered a breakthrough in hemostasis research. In little more than 3 years, the original publication by Muller et al has been cited greater than100 times. However, none of the citing articles has sought to independently validate this potentially paradigm-shifting concept. To this end, we performed extensive experimentation in vitro and in vivo in an attempt to verify the claim that factor XII (FXII) is primarily activated by stimulated platelets. In contrast to the original assertion, platelet-derived polyphosphates were found to be weak activators of FXII, with a FXIIa-generating activity of less than10% compared with equivalent concentrations of kaolin. Using different coagulation assays, it was shown that platelet contribution to whole blood coagulation was unrelated to the generation of activated FXII in vitro. Additionally, key results used to verify the hypothesis in the original study in vivo were found to be irreproducible. We conclude that platelet-derived polyphosphates are not physiologically relevant activators of FXII.
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| 11. |
- Fujita, S., et al.
(författare)
-
Spatial and temporal variability of snow accumulation rate on the East Antarctic ice divide between Dome Fuji and EPICA DML
- 2011
-
Ingår i: The Cryosphere. - : Copernicus GmbH. - 1994-0416 .- 1994-0424. ; 5:4, s. 1057-1081
-
Tidskriftsartikel (refereegranskat)abstract
- To better understand the spatio-temporal variability of the glaciological environment in Dronning Maud Land (DML), East Antarctica, a 2800-km-long Japanese-Swedish traverse was carried out. The route includes ice divides between two ice-coring sites at Dome Fuji and EPICA DML. We determined the surface mass balance (SMB) averaged over various time scales in the late Holocene based on studies of snow pits and firn cores, in addition to radar data. We find that the large-scale distribution of the SMB depends on the surface elevation and continentality, and that the SMB differs between the windward and leeward sides of ice divides for strong-wind events. We suggest that the SMB is highly influenced by interactions between the large-scale surface topography of ice divides and the wind field of strong-wind events that are often associated with high-precipitation events. Local variations in the SMB are governed by the local surface topography, which is influenced by the bedrock topography. In the eastern part of DML, the accumulation rate in the second half of the 20th century is found to be higher by similar to 15% than averages over longer periods of 722 a or 7.9 ka before AD 2008. A similar increasing trend has been reported for many inland plateau sites in Antarctica with the exception of several sites on the leeward side of the ice divides.
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| 12. |
- Galland, Sylvain, 1987-, et al.
(författare)
-
Cellulose nanofibers decorated with magnetic nanoparticles : synthesis, structure and use in magnetized high toughness membranes for a prototype loudspeaker
- 2013
-
Ingår i: Journal of Materials Chemistry C. - 2050-7526. ; 1:47, s. 7963-7972
-
Tidskriftsartikel (refereegranskat)abstract
- Magnetic nanoparticles are the functional component for magnetic membranes, but they are difficult to disperse and process into tough membranes. Here, cellulose nanofibers are decorated with magnetic ferrite nanoparticles formed in situ which ensures a uniform particle distribution, thereby avoiding the traditional mixing stage with the potential risk of particle agglomeration. The attachment of the particles to the nanofibrils is achieved via aqueous in situ hydrolysis of metal precursors onto the fibrils at temperatures below 100 °C. Metal adsorption and precursor quantification were carried out using Induction Coupled Plasma-Optical Emission Spectroscopy (ICP-OES). FE-SEM was used for high resolution characterization of the decorated nanofibers and hybrid membranes, and TEM was used for nanoparticle size distribution studies. The decorated nanofibers form a hydrocolloid. Large (200 mm diameter) hybrid cellulose/ferrite membranes were prepared by simple filtration and drying of the colloidal suspension. The low-density, flexible and permanently magnetized membranes contain as much as 60 wt% uniformly dispersed nanoparticles (thermogravimetric analysis data). Hysteresis magnetization was measured by a Vibrating Sample Magnetometer; the inorganic phase was characterized by XRD. Membrane mechanical properties were measured in uniaxial tension. An ultrathin prototype loudspeaker was made and its acoustic performance in terms of output sound pressure was characterized. A full spectrum of audible frequencies was resolved.
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| 13. |
- Galland, Sylvain, 1987-, et al.
(författare)
-
Strong and Moldable Cellulose Magnets with High Ferrite Nanoparticle Content
- 2014
-
Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 6:22, s. 20524-20534
-
Tidskriftsartikel (refereegranskat)abstract
- A major limitation in the development of highly functional hybrid nanocomposites is brittleness and low tensile strength at high inorganic nanoparticle content. Herein, cellulose nanofibers were extracted from wood and individually decorated with cobalt-ferrite nanoparticles and then for the first time molded at low temperature (<120 degrees C) into magnetic nanocomposites with up to 93 wt % inorganic content. The material structure was characterized by TEM and FE-SEM and mechanically tested as compression molded samples. The obtained porous magnetic sheets were further impregnated with a thermosetting epoxy resin, which improved the load-bearing functions of ferrite and cellulose material. A nanocomposite with 70 wt % ferrite, 20 wt % cellulose nanofibers, and 10 wt % epoxy showed a modulus of 12.6 GPa, a tensile strength of 97 MPa, and a strain at failure of ca. 4%. Magnetic characterization was performed in a vibrating sample magnetometer, which showed that the coercivity was unaffected and that the saturation magnetization was in proportion with the ferrite content. The used ferrite, CoFe2O4 is a magnetically hard material, demonstrated by that the composite material behaved as a traditional permanent magnet. The presented processing route is easily adaptable to prepare millimeter-thick and moldable magnetic objects. This suggests that the processing method has the potential to be scaled-up for industrial use for the preparation of a new subcategory of magnetic, low-cost, and moldable objects based on cellulose nanofibers.
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| 14. |
- Gertsovich, Irina, et al.
(författare)
-
A novel methodology for the interoperability evaluation of an iris segmentation algorithm
- 2013
-
Konferensbidrag (refereegranskat)abstract
- The performance of an iris recognition system depends greatly on how well the iris segmentation part of the system performs its task. The performance of an iris segmentation algorithm can be evaluated using different criteria and methods. Some of the methods evaluate the performance of the segmentation algorithm based on the performance of the whole iris recognition system. Other methods evaluate the performance of an iris segmentation subsystem independent of the performance of the system's other subsystems. To our knowledge there do not exist a generally accepted method or criteria for the evaluation of the standalone iris segmentation subsystem. This paper proposes a novel methodology to compare the performance of different iris segmentation algorithms, applied to different image datasets in a consistent way. The methodology employs the F1 score and an empirical cumulative distribution function. The implementation of the F1 score estimation, adapted to the iris segmentation task is described. Finally the application of the proposed methodology is demonstrated and discussed.
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| 15. |
- Grythe, Henrik, 1980-
(författare)
-
Primary Marine Aerosol : Validation of sea spray source functions using observations and transport modeling
- 2014
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Sea spray aerosols (SSA) are an important part of the climate system through their effects on the global radiative budget, both directly as scatterers and absorbers of solar and terrestrial radiation, and indirectly as cloud condensation nuclei (CCN) influencing cloud formation, lifetime and precipitation. In terms of their global mass, SSA is the largest source and has the largest uncertainty of all aerosols. In this study I have reviewed 21 SSA source functions from the literature, several of which are used in current climate models, and as a result of this work a new source function is proposed.The model FLEXPART was run in backward mode utilizing a large global set of observed SSA concentrations, comprised of several station networks and ship cruise measurement campaigns. FLEXPART backward calculations produce gridded emission sensitivity fields, which can subsequently be multiplied with gridded SSA production fluxes to obtain modeled SSA concentrations. This allows to efficiently evaluate all 21 source functions at the same time. Another advantage of this method is that source-region information on wind speed and sea surface temperatures (SSTs) could be stored and used for evaluating their influence on SSA production.The main driver of SSA production is wind, and the best fit to the observation data could be obtained when the SSA production is proportional to U103.5. A strong influence of SST on the production could be detected as well, although the underlying physical mechanisms of the SST influence remains unclear. For SST we obtain the best fit to the measurement data when SSA concentration is proportional to 0.031×T+0.39, where T is the source average SST. Based on the model source region average temperature and wind, an empirical fit was made to the data and a new source function obtained. The fit was made by using the model concentrations, observational data, ECMWF winds and the existing source function volume fluxes. Our new source function gives a global SSA production for particles smaller than 10μm of 9Pg yr-1 and is the best fit to the observed concentrations. The existing source functions display the large uncertainties, spanning from a global emitted mass of 1.9 to 100’s of Pg yr-1. Wind dependencies also range strongly and those far from U103.5, have poor correlation with observed values. It is also possible to add temperature dependence to an existing source function to come further towards observed values with the model results. Sea spray aerosols (SSA) are an important part of the climate system through their effects on the global radiative budget, both directly as scatterers and absorbers of solar and terrestrial radiation, and indirectly as cloud condensation nuclei (CCN) influencing cloud formation, lifetime and precipitation. In terms of their global mass, SSA is the largest source and has the largest uncertainty of all aerosols. In this study I have reviewed 21 SSA source functions from the literature, several of which are used in current climate models, and as a result of this work a new source function is proposed.The model FLEXPART was run in backward mode utilizing a large global set of observed SSA concentrations, comprised of several station networks and ship cruise measurement campaigns. FLEXPART backward calculations produce gridded emission sensitivity fields, which can subsequently be multiplied with gridded SSA production fluxes to obtain modeled SSA concentrations. This allows to efficiently evaluate all 21 source functions at the same time. Another advantage of this method is that source-region information on wind speed and sea surface temperatures (SSTs) could be stored and used for evaluating their influence on SSA production.The main driver of SSA production is wind, and the best fit to the observation data could be obtained when the SSA production is proportional to U103.5. A strong influence of SST on the production could be detected as well, although the underlying physical mechanisms of the SST influence remains unclear. For SST we obtain the best fit to the measurement data when SSA concentration is proportional to 0.031×T+0.39, where T is the source average SST. Based on the model source region average temperature and wind, an empirical fit was made to the data and a new source function obtained. The fit was made by using the model concentrations, observational data, ECMWF winds and the existing source function volume fluxes. Our new source function gives a global SSA production for particles smaller than 10μm of 9Pg yr-1 and is the best fit to the observed concentrations. The existing source functions display the large uncertainties, spanning from a global emitted mass of 1.9 to 100’s of Pg yr-1. Wind dependencies also range strongly and those far from U103.5, have poor correlation with observed values. It is also possible to add temperature dependence to an existing source function to come further towards observed values with the model results.Sea spray aerosols (SSA) are an important part of the climate system through their effects on the global radiative budget, both directly as scatterers and absorbers of solar and terrestrial radiation, and indirectly as cloud condensation nuclei (CCN) influencing cloud formation, lifetime and precipitation. In terms of their global mass, SSA is the largest source and has the largest uncertainty of all aerosols. In this study I have reviewed 21 SSA source functions from the literature, several of which are used in current climate models, and as a result of this work a new source function is proposed.The model FLEXPART was run in backward mode utilizing a large global set of observed SSA concentrations, comprised of several station networks and ship cruise measurement campaigns. FLEXPART backward calculations produce gridded emission sensitivity fields, which can subsequently be multiplied with gridded SSA production fluxes to obtain modeled SSA concentrations. This allows to efficiently evaluate all 21 source functions at the same time. Another advantage of this method is that source-region information on wind speed and sea surface temperatures (SSTs) could be stored and used for evaluating their influence on SSA production.The main driver of SSA production is wind, and the best fit to the observation data could be obtained when the SSA production is proportional to U103.5. A strong influence of SST on the production could be detected as well, although the underlying physical mechanisms of the SST influence remains unclear. For SST we obtain the best fit to the measurement data when SSA concentration is proportional to 0.031×T+0.39, where T is the source average SST. Based on the model source region average temperature and wind, an empirical fit was made to the data and a new source function obtained. The fit was made by using the model concentrations, observational data, ECMWF winds and the existing source function volume fluxes. Our new source function gives a global SSA production for particles smaller than 10μm of 9Pg yr-1 and is the best fit to the observed concentrations. The existing source functions display the large uncertainties, spanning from a global emitted mass of 1.9 to 100’s of Pg yr-1. Wind dependencies also range strongly and those far from U103.5, have poor correlation with observed values. It is also possible to add temperature dependence to an existing source function to come further towards observed values with the model results.
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| 16. |
- Gustavsson, Ingvar, et al.
(författare)
-
Chapter 15 – The VISIR Open Lab Platform
- 2011
-
Ingår i: InternetAccessible Remote Laboratories. - : IGI Global. - 9781613501863 - 9781613501870 ; , s. 294-317
-
Bokkapitel (refereegranskat)abstract
- The VISIR Open Lab Platform designed at the Department of Electrical Engineering (AET), the Blekinge Institute of Technology (BTH), Sweden, is a platform for opening instructional laboratories for remote access 24/7 with preserved context. VISIR is an acronym for Virtual Instrument Systems in Reality. In VISIR laboratories, students perform physical experiments and laboratory work remotely. A unique interface gives them the feeling of “being there.” The platform software is published under a GPL license, and other universities, schools, et cetera, are invited use it to open their laboratories and to participate in further research and development. Apart from BTH, five universities in Europe have set up VISIR online laboratories for electrical experiments and the Indian Institute of Technology Madras in India will set up one soon. A VISIR community has been established. Common projects are initiated, and the sharing of learning material is being discussed. This chapter is a general introduction to VISIR and its possibilities.
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| 17. |
- Gustavsson, Ingvar, et al.
(författare)
-
The VISIR Open Lab Platform
- 2011
-
Ingår i: Internet Accessible Remote Laboratories. - : IGI Global. - 9781613501863 ; , s. 294-317
-
Bokkapitel (refereegranskat)abstract
- The VISIR Open Lab Platform designed at the Department of Electrical Engineering (AET), the Blekinge Institute of Technology (BTH), Sweden, is a platform for opening instructional laboratories for remote access 24/7 with preserved context. VISIR is an acronym for Virtual Instrument Systems in Reality. In VISIR laboratories, students perform physical experiments and laboratory work remotely. A unique interface gives them the feeling of “being there.” The platform software is published under a GPL license, and other universities, schools, etc., are invited use it to open their laboratories and to participate in further research and development. Apart from BTH, five universities in Europe have set up VISIR online laboratories for electrical experiments and the Indian Institute of Technology Madras in India will set up one soon. A VISIR community has been established. Common projects are initiated, and the sharing of learning material is being discussed. This chapter is a general introduction to VISIR and its possibilities.
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| 18. |
- Olsson, Richard T., et al.
(författare)
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Making flexible magnetic aerogels and stiff magnetic nanopaper using cellulose nanofibrils as templates
- 2010
-
Ingår i: Nature Nanotechnology. - 1748-3387. ; 5:8, s. 584-588
-
Tidskriftsartikel (refereegranskat)abstract
- Nanostructured biological materials inspire the creation of materials with tunable mechanical properties(1-3). Strong cellulose nanofibrils derived from bacteria(4) or wood(5,6) can form ductile or tough networks(7,8) that are suitable as functional materials(9,10). Here, we show that freeze-dried bacterial cellulose nanofibril aerogels can be used as templates for making lightweight porous magnetic aerogels, which can be compacted into a stiff magnetic nanopaper. The 20-70-nm-thick cellulose nanofibrils act as templates for the non-agglomerated growth of ferromagnetic cobalt ferrite nanoparticles(11) (diameter, 40-120 nm). Unlike solvent-swollen gels(12) and ferrogels(13-15), our magnetic aerogel is dry, lightweight, porous (98%), flexible, and can be actuated by a small household magnet. Moreover, it can absorb water and release it upon compression. Owing to their flexibility, high porosity and surface area, these aerogels are expected to be useful in microfluidics devices and as electronic actuators.
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| 19. |
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| 20. |
- Schubert, Per, et al.
(författare)
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Impact of nutrients on peatland GPP estimations using MODIS time series data
- 2010
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Ingår i: Remote Sensing of Environment. - : Elsevier BV. - 0034-4257. ; 114:10, s. 2137-2145
-
Tidskriftsartikel (refereegranskat)abstract
- Time series of satellite sensor-derived data can be used in the light use efficiency (LUE) model for gross primary productivity (GPP). The LUE model and a closely related linear regression model were studied at an ombrotrophic peatland in southern Sweden. Eddy covariance and chamber GPP, incoming and reflected photosynthetic photon flux density (PPFD), field-measured spectral reflectance, and data from the Moderate Resolution Imaging Spectroradiometer (MODIS) were used in this study. The chamber and spectral reflectance measurements were made on four experimental treatments: unfertilized control (Ctrl). nitrogen fertilized (N), phosphorus fertilized (P), and nitrogen plus phosphorus fertilized (NP). For Ctrl, a strong linear relationship was found between GPP and the photosynthetically active radiation absorbed by vegetation (APAR) (R-2=0.90). The slope coefficient (epsilon(s), where s stands for "slope") for the linear relationship between seasonal time series of GPP and the product of the normalized difference vegetation index (NDVI) and PPFD was used as a proxy for the light use efficiency factor (epsilon). There were differences in epsilon(s) depending on the treatments with a significant effect for N compared to Ctrl (ANOVA: p = 0.042, Tukey's: p <= 0.05). Also. epsilon(s) was linearly related to the cover degree of vascular plants (R-2= 0.66). As a sensitivity test, the regression coefficients (epsilon(s) and intercept) for each treatment were used to model time series of 16-day GPP from the product of MODIS NDVI and PPFD. Seasonal averages of GPP were calculated for 2005, 2006. and 2007, which resulted in up to 19% higher average GPP for the fertilization treatments compared to Ctrl. The main conclusion is that the LUE model and the regression model can be applied in peatlands but also that temporal and spatial changes in epsilon or the regression coefficients should be considered. (C) 2010 Elsevier Inc. All rights reserved.
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| 21. |
- Sjöberg, Mats, 1965-, et al.
(författare)
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Infliximab or cyclosporine as rescue therapy in hospitalized patients with steroid-refractory ulcerative colitis : a retrospective observational study
- 2012
-
Ingår i: Inflammatory Bowel Diseases. - : John Wiley & Sons. - 1078-0998 .- 1536-4844. ; 18:2, s. 212-218
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Tidskriftsartikel (refereegranskat)abstract
- Background: Cyclosporine (CsA) or infliximab (IFX) are used as rescue therapies in steroid-refractory, severe attacks of ulcerative colitis (UC). There are no data comparing the efficacy of these two alternatives. Methods: Outcome of rescue therapy was retrospectively studied in two cohorts of patients hospitalized due to steroid-refractory moderate to severe UC: 1) a Swedish-Danish cohort (n 49) treated with a single infusion of IFX; 2) an Austrian cohort (n 43) treated with intravenous CsA. After successful rescue therapy, maintenance immunomodulator treatment was given to 27/33 (82%) of IFX patients and to 31/40 (78%) of CsA patients. Endpoints were colectomy-free survival at 3 and 12 months. Kaplan-Meier and Cox regression models were used to evaluate the association between treatment groups and colectomy. Results: At 15 days, colectomy-free survival in the IFX cohort was 36/49 (73%) versus 41/43 (95%) in the CsA cohort (P = 0.005), at 3 months 33/49 (67%) versus 40/43 (93%) (P = 0.002), and at 12 months 28/49 (57%) versus 33/43 (77%) (P = 0.034). After adjusting for potential confounding factors, Cox regression analysis yielded adjusted hazard ratios for risk of colectomy in IFX-treated patients of 11.2 (95% confidence interval [CI] 2.4-53.1, P = 0.002) at 3 months and of 3.0 (95% CI 1.1-8.2, P = 0.030) at 12 months in comparison with CsA-treated patients. There were no opportunistic infections or mortality. Conclusions: Colectomy frequencies were significantly lower after rescue therapy with CsA than with a single infusion of IFX both at 3 and 12 months' follow-up. The superiority of CsA was seen principally during the first 15 days.
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| 22. |
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| 23. |
- Ström, Lars, et al.
(författare)
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Handbok för oglada : Vetenskapligt förankrade metoder för ökad glädje och harmoni
- 2014. - 1
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Är du deprimerad, nedstämd eller bara oglad i största allmänhet? Då är du långt ifrån ensam! Idag räknar man med att uppemot 25 procent av kvinnorna och 10 procent av männen någon gång kommer att vara kliniskt deprimerade. Till det kommer ett mycket stort antal människor som "bara" är nedstämda eller oglada! Även om det är skrämmande siffror kan man samtidigt konstatera att det inte behöver vara på det viset! Idag finns nämligen många verktyg som effektivt påverkar ens mående på ett postivt sätt. I denna bok får du tillgång till en lång rad av dessa metoder och strategier. De flesta har sin utgångspunkt i kognitiv beteendeterapi (KBT), och alla är sådana som i forskning har visat sig ge en tydlig effekt för att minska nedstämdhet och depression - och skapa ökad livsglädje! Boken är förhoppningsvis även användbar för dig som arbetar med vård av människor, och innehåller både förklaringsmodeller och arbetsformulär som kan användas i den egna verksamheten. Alla bokens formulär kan också laddas ner från www.kbtakademin.se och användas fritt.
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| 24. |
- Ström, Lars, et al.
(författare)
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Voltage quality regulation in Sweden
- 2011
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Ingår i: Proceedings of CIRED 21st International Conference on Electricity Distribution.
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Konferensbidrag (refereegranskat)abstract
- This paper presents the voltage-quality requirements set by the Swedish energy regulator. Requirements have been set for harmonics, unbalance, slow voltage variations, voltage dips, voltage swells and rapid voltage changes, which are all discussed in this paper. This paper further discusses recommended measurement methods for verification of compliance with the requirements and the way in which voltage-quality regulation takes place in practice.
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| 25. |
- Tagesson, Torbern, et al.
(författare)
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High-resolution satellite data reveal an increase in peak growing season gross primary production in a high-Arctic wet tundra ecosystem 1992-2008
- 2012
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Ingår i: International Journal of Applied Earth Observation and Geoinformation. - : Elsevier BV. - 1569-8432. ; 18, s. 407-416
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Tidskriftsartikel (refereegranskat)abstract
- Arctic ecosystems play a key role in the terrestrial carbon cycle. Our aim was to combine satellite-based normalized difference vegetation index (NDVI) with field measurements of CO2 fluxes to investigate changes in gross primary production (GPP) for the peak growing seasons 1992-2008 in Rylekaerene, a wet tundra ecosystem in the Zackenberg valley, north-eastern Greenland. A method to incorporate controls on GPP through satellite data is the light use efficiency (LUE) model, here expressed as GPP = epsilon(peak) x PAR(in) x FAPAR(green_peak); where epsilon(peak) was peak growing season light use efficiency of the vegetation, PARin was incoming photosynthetically active radiation, and FAPAR(green_peak) was peak growing season fraction of PAR absorbed by the green vegetation. The Speak was measured for seven different high-Arctic plant communities in the field, and it was on average 1.63 g CO2 MJ(-1). We found a significant linear relationship between FAPARgreen_peak measured in the field and satellite-based NDVI. The linear regression was applied to peak growing season NDVI 1992-2008 and derived FAPAR(green_peak) was entered into the LUE-model. It was shown that when several empirical models are combined, propagation errors are introduced, which results in considerable model uncertainties. The LUE-model was evaluated against field-measured GPP and the model captured field-measured GPP well (RMSE was 192 mg CO2 m(-2) h(-1)). The model showed an increase in peak growing season GPP of 42 mg CO2 m(-2) h(-1) y(-1) in Rylekaerene 1992-2008. There was also a strong increase in air temperature (0.15 degrees C y(-1)), indicating that the GPP trend may have been climate driven. (C) 2012 Elsevier B.V. All rights reserved.
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| 26. |
- Tagesson, Torbern, et al.
(författare)
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Modelling of growing season methane fluxes in a high-Arctic wet tundra ecosystem 1997-2010 using in situ and high-resolution satellite data
- 2013
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Ingår i: Tellus. Series B: Chemical and Physical Meteorology. - : Stockholm University Press. - 0280-6509 .- 1600-0889. ; 65
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Tidskriftsartikel (refereegranskat)abstract
- Methane (CH4) fluxes 1997-2010 were studied by combining remotely sensed normalised difference water index (NDWI) with in situ CH4 fluxes from Rylekaerene, a high-Arctic wet tundra ecosystem in the Zackenberg valley, north-eastern Greenland. In situ CH4 fluxes were measured using the closed-chamber technique. Regression models between in situ CH4 fluxes and environmental variables [soil temperature (T-soil), water table depth (WtD) and active layer (AL) thickness] were established for different temporal and spatial scales. The relationship between in situ WtD and remotely sensed NDWI was also studied. The regression models were combined and evaluated against in situ CH4 fluxes. The models including NDWI as the input data performed on average slightly better [root mean square error (RMSE) = 1.56] than the models without NDWI (RMSE = 1.67), and they were better in reproducing CH4 flux variability. The CH4 flux model that performed the best included exponential relationships against temporal variation in T-soil and AL, an exponential relationship against spatial variation in WtD and a linear relationship between WtD and remotely sensed NDWI (RMSE = 1.50). There were no trends in modelled CH4 flux budgets between 1997 and 2010. Hence, during this period there were no trends in the soil temperature at 10 cm depth and NDWI.
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| 27. |
- Toft, Palle, et al.
(författare)
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Non-sedation versus sedation with a daily wake-up trial in critically ill patients receiving mechanical ventilation (NONSEDA Trial) : study protocol for a randomised controlled trial
- 2014
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Ingår i: Trials. - : Springer Science and Business Media LLC. - 1745-6215. ; 15:499, s. 1-11
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Through many years, the standard care has been to use continuous sedation of critically ill patients during mechanical ventilation. However, preliminary randomised clinical trials indicate that it is beneficial to reduce the sedation level. No randomised trial has been conducted comparing sedation with no sedation, a priori powered to have all-cause mortality as primary outcome.The objective is to assess the benefits and harms of non-sedation versus sedation with a daily wake-up trial in critically ill patients.METHODS/DESIGN: The non-sedation (NONSEDA) trial is an investigator-initiated, randomised, clinical, parallel-group, multinational trial designed to include 700 patients from at least six ICUs in Denmark, Norway and Sweden.Inclusion criteria are mechanically ventilated patients with expected duration of mechanical ventilation >24 hours.Exclusion criteria are non-intubated patients, patients with severe head trauma, coma at admission or status epilepticus, patients treated with therapeutic hypothermia, patients with PaO2/FiO2 < 9 where sedation might be necessary to ensure sufficient oxygenation or place the patient in prone position.Experimental intervention is non-sedation supplemented with pain management during mechanical ventilation.Control intervention is sedation with a daily wake-up trial.The primary outcome will be all cause mortality at 90 days after randomization. Secondary outcomes will be: days until death throughout the total observation period; coma- and delirium-free days; highest RIFLE score; days until discharge from the intensive care unit (within 28 days); days until the participant is without mechanical ventilation (within 28 days); and proportion of patients with a major cardiovascular outcome. Explorative outcomes will be: all cause mortality at 28 days after randomisation; days until discharge from the intensive care unit; days until the participant is without mechanical ventilation; days until discharge from the hospital; organ failure.Trial size: we will include 700 participants (2 × 350) in order to detect or reject 25% relative risk reduction in mortality with a type I error risk of 5% and a type II error risk of 20% (power at 80%).DISCUSSION: The trial investigates potential benefits of non-sedation. This might have large impact on the future treatment of mechanically ventilated critically ill patients.TRIAL REGISTER: ClinicalTrials.gov NCT0196768, 09.01.2014.
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| 28. |
- Trey, Stacy, et al.
(författare)
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Controlled deposition of magnetic particles within the 3-D template of wood : making use of the natural hierarchical structure of wood
- 2014
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Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 4:67, s. 35678-35685
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Tidskriftsartikel (refereegranskat)abstract
- This study presents a promising method to make three-dimensional lattices of structured nanomaterials by using wood templates for in situ (confined) directed growth of inorganic material in the ordered cell walls. The wood was impregnated by transition metal ion precursors (iron, manganese and cobalt) at 5 bars pressure that were further transformed into magnetic particles (Fe3O4, MnFe2O4 and CoFe2O4) by addition of alkaline solutions. It was found that by this method, it was possible to produce lightweight ferromagnetic functionalized wood materials in an inexpensive and environmentally friendly way. It was possible to functionalise the wood throughout the structure with a high weight percent of particles from 15-20 wt% as observed by TGA. These were not only adsorbed to the surface of the lumen, but also found by SEM-EDX throughout the cell wall and middle lamella and in higher amounts in early wood. The magnetic properties were nearly unaffected by the incorporation into the wood samples as compared to powder compacts obtained as particles that precipitated separately in the impregnation solution, both for soft and hard magnetic materials. Whereas the hard magnetic phase CoFe2O4 showed insignificant leaching, the soft magnetic Fe3O4, MnFe2O4 lost around 50 wt% during repeated washing in deionized water, suggesting that the CoFe2O4 particles were more readily attached in the structure of the wood. The crystal structure of the magnetic particles was determined to be the same in the wood structure as those formed in solution.
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| 29. |
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