| 1. |
- Kjellberg, Emma, et al.
(författare)
-
Serum n-6 and n-9 Fatty Acids Correlate with Serum IGF-1 and Growth Up to Four Months of Age in Healthy Infants.
- 2018
-
Ingår i: Journal of pediatric gastroenterology and nutrition. - 1536-4801. ; 66:1, s. 141-146
-
Tidskriftsartikel (refereegranskat)abstract
- To study the relationship between insulin-like growth factor 1 (IGF-1), serum phospholipid fatty acids and growth in healthy full-term newborns during infancy.Prospective observational study of a population-based Swedish cohort comprising 126 healthy, term infants investigating cord blood and serum at two days and four months of age for IGF-1 and phospholipid fatty acid profile and breast milk for fatty acids at two days and four months, compared to anthropometric measurements (SDS).At all time-points arachidonic acid (AA) was negatively associated with IGF-1. IGF-1 had positive associations with Linoleic acid (LA) at two days and four months and Mead acid (MA) showed positive associations in cord blood. Multiple regression analyses adjusted for maternal factors (BMI, weight gain, smoking, education), gender, birth weight and feeding modality confirmed a negative association for the ratio AA/LA to IGF-1. MA in cord blood correlated to birth size. Changes in the ratios of n-6/n-3 and AA/docosahexaenoic acid from day two to four months together with infants' weight and feeding modality determined 55% of the variability of delta-IGF-1. Breastfed infants at four months had lower IGF-1 correlating with lower LA and higher AA concentrations, which in girls correlated with lower weight gain from birth to four months of age.Our data showed interaction of n-6 fatty acids with IGF-1 during the first four months of life, and an association between MA and birth size when adjusted for confounding factors. Further follow-up might indicate if these correlations are associated with later body composition.
|
|
| 2. |
- Strandvik, Birgitta, et al.
(författare)
-
Long-chain saturated and monounsaturated fatty acids associate with development of premature infants up to 18 months of age.
- 2016
-
Ingår i: Prostaglandins, Leukotrienes and Essential Fatty Acids. - : Elsevier BV. - 0952-3278 .- 1532-2823. ; , s. 43-49
-
Tidskriftsartikel (refereegranskat)abstract
- Myelination is important perinatally and highly dependent on long-chain saturated and monounsaturated fatty acids. Long-chain polyunsaturated fatty acids, nowadays often supplemented, inhibit oleic acid synthesis. Using data from a premature cohort, we studied if nervonic, lignoceric and oleic acids correlated to growth and early development up to 18 months corrected age. Small for gestational age infants had lower concentrations than infants appropriate for gestational age. Only oleic acid was negatively correlated to long-chain polyunsaturated fatty acids. Oleic and lignoceric acids correlated to social interaction at one month, and nervonic acid to mental, psychomotor and behavioral development at 6, 10 and 18 months, also when adjusted for several confounders. Negative association between oleic acid and long-chain polyunsaturated fatty acids suggests inhibition of delta-9 desaturase, and nervonic acid´s divergent correlation to lignoceric and oleic acids suggests different metabolism in neonatal period. Our results may have implications for the supplementation of premature infants.
|
|
