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1.	Qiu, XY, et al. (author) Action of mifepristone on the expression of insulin-like growth factor binding protein-1 mRNA and protein during the early luteal phase in the human oviduct 2003 In: Fertility and sterility. - : Elsevier BV. - 0015-0282. ; 8080 Suppl 2, s. 776-782 Journal article (peer-reviewed)
2.	Qiu, XY, et al. (author) The effect of mifepristone on the expression of insulin-like growth factor binding protein-1, prolactin and progesterone receptor mRNA and protein during the implantation phase in human endometrium 2002 In: Molecular human reproduction. - : Oxford University Press (OUP). - 1360-9947 .- 1460-2407. ; 8:11, s. 998-1004 Journal article (peer-reviewed)
3.	Slatt, J, et al. (author) 2-(4-nitro-phenyl)-1-oxy-indol-3-one potentiates P2X(1) receptor mediated vascular contraction and blood pressure elevation 2002 In: DRUG DEVELOPMENT RESEARCH. - 0272-4391. ; 56:4, s. 569-569 Conference paper (other academic/artistic)
4.	Sun, XX, et al. (author) Effects of mifepristone on expression of endothelial nitric oxide synthase in human endometrium during the implantation phase 2003 In: Fertility and sterility. - : Elsevier BV. - 0015-0282. ; 80:6, s. 1454-1460 Journal article (peer-reviewed)
5.	Wihlborg, Anna-Karin, et al. (author) 2,2 '-nitrophenylisatogen potentiates P2X(1) receptor mediated vascular contraction and blood pressure elevation 2003 In: Drug Development Research (Proceedings of the Seventh International Symposium on Adenosine and Adenine Nucleotides - Part 2). - : Wiley. - 1098-2299 .- 0272-4391. ; 59:1, s. 82-87 Conference paper (peer-reviewed)abstract The objective of this research was to examine the effects of chemical compounds with possible P2 receptor modulating effects and to characterize the potentiating effects of 2,2'-nitrophenylisatogen (NPI) on P2X(1) receptors in vitro and in vivo. Chemical compounds were tested in an in vitro pharmacological assay using vascular segments from the rat mesenteric artery stimulated by P2 receptor-specific agonists. Contractions were expressed as a percentage of 60 mM K+-induced contractions. Blood pressure was evaluated in pithed rats. NPI (30 muM) added 15 min before addition of the P2X(1) receptor-specific agonist alphabeta-MeATP increased the maximum vasoconstriction from 23% to 49% (an increase of 113%). Furthermore, NPI prevented the desensitization of repeated UP-MeATP contractions. Related compounds were examined, and 2-(3-methoxy-phenyl)-1-oxy-indol-3-one (MPI) had similar effects as NPI, but several others lacked effect. NPI had no effect on ADPbetaS (P2Y(1)) or acetylcholine-mediated vasodilatation, nor on UTP (P2Y(2/4)), UDP (P2Y(6)), or noradrenaline-mediated contractions. In pithed rats, the blood pressure response to 50 nmol/kg-infusion of alphabeta-MeATP was increased from 50+/-6 to 63+/-5 mmHg (P < 0.05), but had no effect on basal blood pressure or on the cardiovascular response to preganglionic nerve stimulation. In conclusion, NPI and MPI potentiates P2X(1) receptor vascular contractions in vitro and (NPI) blood pressure effects in vivo. It is possible that the effect is mediated by an inhibition of P2X(1) receptor desensitization. Drug Dev. Res. (C) Wiley-Liss, Inc.

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Type of publication: journal article (3); conference paper (2)

Type of content: peer-reviewed (4); other academic/artistic (1)

Author/Editor: Gemzell-Danielsson, ... (3); Sun, XX (3); Qiu, XY (3); Hedner, T (2); Malmsjo, M (2); Stabi, B (2); show more...; Bergman, J. (2); Christow, A (2); Sun, XY (2); Zhao, XH (2); Erlinge, David (1); Wihlborg, Anna-Karin (1); Wihlborg, AK (1); Slätt, Johnny, 1976- (1); Slatt, J (1); Erlinger, D (1); show less...

University: Karolinska Institutet (5); Royal Institute of Technology (1); Lund University (1)

Language: English (5)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

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