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Träfflista för sökning "WFRF:(Sundkvist D.) srt2:(2005-2009)"

Sökning: WFRF:(Sundkvist D.) > (2005-2009)

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1.
  • Bakhtadze, Ekaterine, et al. (författare)
  • Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients
  • 2008
  • Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 51:12, s. 2224-2232
  • Tidskriftsartikel (refereegranskat)abstract
    • Type 1 diabetes in children is characterised by autoimmune destruction of pancreatic beta cells and the presence of certain risk genotypes. In adults the same situation is often referred to as latent autoimmune diabetes in adults (LADA). We tested whether genetic markers associated with type 1 or type 2 diabetes could help to discriminate between autoimmune and non-autoimmune diabetes in young (15-34 years) and middle-aged (40-59 years) diabetic patients. In 1,642 young and 1,619 middle-aged patients we determined: (1) HLA-DQB1 genotypes; (2) PTPN22 and INS variable-number tandem repeat (VNTR) polymorphisms; (3) two single nucleotide polymorphisms (rs7903146 and rs10885406) in the TCF7L2 gene; (4) glutamic acid decarboxylase (GAD) and IA-2-protein tyrosine phosphatase-like protein (IA-2) antibodies; and (5) fasting plasma C-peptide. Frequency of risk genotypes HLA-DQB1 (60% vs 25%, p =9.4x10(-34); 45% vs 18%, p= 1.4x10(-16)), PTPN22 CT/TT (34% vs 26%, p=0.0023; 31% vs 23%, p=0.034), INS VNTR class I/I (69% vs 53%, p=1.3x10(-8); 69% vs 51%, p=8.5x10(-5)) and INS VNTR class IIIA/IIIA (75% vs 63%, p=4.3x10(-6); 73% vs 60%, p=0.008) was increased in young and middle-aged GAD antibodies (GADA)-positive compared with GADA-negative patients. The type 2 diabetes-associated genotypes of TCF7L2 CT/TT of rs7903146 were significantly more common in young GADA-negative than in GADA-positive patients (53% vs 43%; p=0.0004). No such difference was seen in middle-aged patients, in whom the frequency of the CT/TT genotypes of TCF7L2 was similarly increased in GADA-negative and GADA-positive groups (55% vs 56%). Common variants in the TCF7L2 gene help to differentiate young but not middle-aged GADA-positive and GADA-negative diabetic patients, suggesting that young GADA-negative patients have type 2 diabetes and that middle-aged GADA-positive patients are different from their young GADA-positive counterparts and share genetic features with type 2 diabetes.
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2.
  • Yordanova, Emiliya, et al. (författare)
  • Energy input from the exterior cusp into the ionosphere : Correlated ground-based and satellite observations
  • 2007
  • Ingår i: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 34:4, s. L04102-
  • Tidskriftsartikel (refereegranskat)abstract
    • The energy transport from the exterior cusp into the ionosphere is investigated using coordinated ground-based (EISCAT and MIRACLE) and satellite ( Cluster) observations. EISCAT and MIRACLE data are used to estimate the plasma heating in the F-region and the Joule heating in the E-region. Cluster measurements are used to derive the electromagnetic and particle energy fluxes at the high altitudes. These fluxes are then compared with the energy deposition into the ionospheric cusp during a 30 minutes long time interval in which Cluster and EISCAT are nearly conjugated. It is shown that the particles seen at about 9 Re in the exterior cusp carry an earthward energy flux that corresponds to the observed heating of the F-region. The estimated earthward Poynting flux is more than enough to account for the Joule heating in the E-region.
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