| 1. |
- Ericsson, Stina, 1972, et al.
(author)
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Att analysera interaktion
- 2023
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Book (other academic/artistic)abstract
- Snart sagt alla situationer en människa befinner sig i präglas av interaktion. Människor pratar med varandra, rör sig genom ett rum, utbyter blickar, lär sig saker, arbetar, skämtar, håller i föremål ... Utmärkande för oss människor är nämligen att vi får saker och ting gjorda med vårt språk och våra kroppsliga resurser. Genom sådana handlingar påverkar vi vår omvärld och våra medmänniskor - och vi gör det tillsammans med dem. Det är studiet av denna mänskliga interaktion som boken handlar om. I första delen introduceras forskningsfältet interaktionsanalys och de arbetssätt, redskap och etiska ställningstaganden som hör till fältet. Den andra delen innehåller forskningsstudier som visar på bredden inom fältet och som pedagogiskt leder läsaren genom hela analysarbetet. Till boken hör även ett videomaterial som illustrerar några av bokens exempel, och som är tillgängligt för läsarens egna studier. Att analysera interaktion är avsedd för utbildningar inom språk vetenskap och angränsande ämnen som sociologi, utbildningsvetenskap och kommunikation.
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| 2. |
- Bergh Nestlog, Ewa, Professor, 1959-, et al.
(author)
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Flerspråkiga klassrum i Växjösskolor – ett utvecklings- ochforskningsprojekt
- 2023
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In: Språk, reflektion och vetenskap i lärarutbildningen. - Växjö : Institutionen för didaktik och lärares praktik, Linnéuniversitetet. - 9789180820714 - 9789180820721 ; , s. 51-66
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Book chapter (pop. science, debate, etc.)abstract
- En människas språkliga resurser är nära sammankopplade med vem hon är och hur hon blir uppfattad av andra. Med andra ord har en människas språkliga resurser med hennes identitet att göra (Edwards, 2009). I dagens Sverige talas fler än 150 språk (Parkvall, 2015). Dessa språk tillskrivs inte lika värde, varken officiellt i lagar och språkpolicyer eller av talare av olika språk. Hult (2017) har å ena sidan beskrivit den språkliga hierarki som råderi Sverige med svenska som huvudspråk (SFS 2009:600) och det obligatoriska skolämnet engelska som ett andraspråk (SFS 2010:800), å andra sidan de inhemska minoritetsspråken (finska, jiddisch, meänkieli, romani och samiska) och övriga fler än hundra minoritetsspråk. Denna språkliga hierarki kan ses som ett uttryck för en enspråkig, eller möjligen tvåspråkig svensk-engelsk, norm. Svenska och engelska värdesätts högst i samhället, följt av skolspråken franska, tyska och spanska. De övriga språken tillmäts snarare ett individuellt värde. Det utvecklings- och forskningsprojekt som beskrivs i denna rapport har med språkliga resurser att göra, och det är rimligt att även relatera beskrivningen till ovanstående resonemang om språkliga hierarkier.
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| 3. |
- Berghauser Pont, Meta, 1972, et al.
(author)
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Förtätning av stationsnära områden för god tillgänglighet. Utveckling av en analys - och utvärderingsmetod
- 2022
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Reports (other academic/artistic)abstract
- Det finns en vilja att förtäta i närheten av stationer för att öka användningen av kollektivtrafik och därmed minska klimatpåverkan kopplad till transpor- ter. Förtätning bidrar bland annat till att skapa levande stationssamhällen, med blandade funktioner, god tillgäng- lighet och miljöer som är trygga och vistelsevänliga där olika grupper och behov möts. Potentialerna är många men så även utmaningarna. Förtätning av stationsnära områden kan också leda till oönskade konsekven- ser för social, ekonomisk och ekologisk hållbarhet. Den här rap- porten kan förhoppningsvis ge ökad förståelse för förtätning i relation till regional tillgänglighet samt för positiva och negativa konsekvenser av förtätning i stationsnära områden. Den kan också skapa insikter om hur olika alternativ för utveckling av stations- nära områden kan värderas utifrån Agenda 2030, särskilt Mål 11: Hållbara städer och samhällen. Rapporten är framtagen inom projektet Urbana stationssamhäll- en – förtätning av stationsnära områden för god tillgänglighet (2020–2022) som finansierats av Trafikverket och bedrivits i sam- verkan mellan Urban Futures vid GMV (projektägare), Arkitektur och samhällsbyggnadsteknik vid Chalmers tekniska högskola, Gö- teborgsregionen (GR), Samhällsplanering vid Högskolan Dalarna och Samhällsplanering och miljö vid KTH.
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| 4. |
- Broberg, Karin, et al.
(author)
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Evaluation of 92 cardiovascular proteins in dried blood spots collected under field-conditions : Off-the-shelf affinity-based multiplexed assays work well, allowing for simplified sample collection
- 2021
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In: BioEssays. - : Wiley. - 0265-9247 .- 1521-1878. ; 43:9
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Journal article (peer-reviewed)abstract
- Workplace-collected blood spots deposited on filter paper were analysed with multiplexed affinity-based protein assays and found to be suitable for proteomics analysis. The protein extension assay (PEA) was used to characterize 92 proteins using 1.2 mm punches in repeated samples collected from 20 workers. Overall, 97.8% of the samples and 91.3% of the analysed proteins passed quality control. Both within and between spot correlations using six replicates from the same individual were above 0.99, suggesting that comparable levels are obtained from multiple punches from the same spot and from consecutive spots. Protein levels from dried blood and wet serum from the same individuals were compared and the majority of the analysed proteins were found to be significantly correlated. These results open up for simplified sample collection of blood in field conditions for proteomic analysis, but also highlight that not all proteins can be robustly measured from dried whole blood.
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| 5. |
- Edvardsson, Jenny, et al.
(author)
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Från sårbar till hållbar läsning
- 2020
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In: Från sårbarhet till hållbarhet i lärande och undervisning. - Lund : Studentlitteratur AB. - 9789144138824 ; , s. 207-240
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Book chapter (other academic/artistic)
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| 6. |
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| 7. |
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| 8. |
- Gullberg, Cecilia, et al.
(author)
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Institutional Complexity in Schools : Reconciling Clashing Logics Through Technology?
- 2020
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In: Scandinavian Journal of Public Administration. - : Göteborgs universitet. - 2001-7405 .- 2001-7413. ; 24:1, s. 49-71
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Journal article (peer-reviewed)abstract
- The article analyses the introduction and use of an IT platform in two Swedish schools. The aim is to examine the role of information systems in shaping institutional complexity, and the research questions addressed are: what logics are manifested through the use of the system and how do they interact with each other in relation to teachers’ emerging work practices? The article is based on a qualitative case study of how teachers and principals perceive and use the system, and it combines theoretical thinking on institutional logics and complexity with ideas on materiality and its role in organisational change. An analysis of three teacher practices that are emerging with use of the system enables a discussion of the presence and, notably, interplay of three primary logics. Logics of professionalism, bureaucracy and management are shown to interrelate in competitive but, primarily, cooperative ways. The very materiality of the IT system is shown to attenuate experiences of incompatibilities between logics and facilitate the management of different logics when they are actually perceived to be incompatible. Contrary to what much previous literature on institutional complexity in the field of education suggests, we therefore argue that institutional complexity may facilitate and enrich teachers’ practices instead of merely constituting a hindrance.
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| 9. |
- Hendrikse, Natalie, et al.
(author)
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Ancestral lysosomal enzymes with increased activity harbor therapeutic potential for treatment of Hunter syndrome
- 2021
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In: ISCIENCE. - : Elsevier BV. - 2589-0042. ; 24:3
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Journal article (peer-reviewed)abstract
- We show the successful application of ancestral sequence reconstruction to enhance the activity of iduronate-2-sulfatase (IDS), thereby increasing its therapeutic potential for the treatment of Hunter syndrome-a lysosomal storage disease caused by impaired function of IDS. Current treatment, enzyme replacement therapy with recombinant human IDS, does not alleviate all symptoms, and an unmet medical need remains. We reconstructed putative ancestral sequences of mammalian IDS and compared them with extant IDS. Some ancestral variants displayed up to 2-fold higher activity than human IDS in in vitro assays and cleared more substrate in ex vivo experiments in patient fibroblasts. This could potentially allow for lower dosage or enhanced therapeutic effect in enzyme replacement therapy, thereby improving treatment outcomes and cost efficiency, as well as reducing treatment burden. In summary, we showed that ancestral sequence reconstruction can be applied to lysosomal enzymes that function in concert with modern enzymes and receptors in cells.
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| 10. |
- Holm-Waters, Susanna, et al.
(author)
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Preclinical Pharmacology of 2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl (Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease
- 2020
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In: Journal of Pharmacology and Experimental Therapeutics. - : American Society for Pharmacology & Experimental Therapeutics (ASPET). - 0022-3565 .- 1521-0103. ; 374:1, s. 113-125
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Journal article (peer-reviewed)abstract
- IRL790 ([2-(3-fluoro-5-methanesulfonylphenoxy)ethyl](propyl)amine, mesdopetam) is a novel compound in development for the clinical management of motor and psychiatric disabilities in Parkinson disease. The discovery of IRL790 was made applying a systems pharmacology approach based on in vivo response profiling. The chemical design idea was to develop a new type of DA D3/D2 receptor type antagonist built on agonist rather than antagonist structural motifs. We hypothesized that such a dopamine antagonist with physicochemical properties similar to agonists would exert antidyskinetic and antipsychotic effects in states of dysregulated dopaminergic signaling while having little negative impact on physiologic dopamine transmission and, hence, minimal liability for side effects related to dopamine-dependent functions. At the level of in vivo pharmacology, IRL790 displays balancing effects on aberrant motor phenotypes, reducing L-DOPA-induced dyskinesias in the rodent 6-hydroxydopamine lesion model and reducing psychostimulant-induced locomotor hyperactivity elicited by pretreatment with either d-amphetamine or dizocilpine, without negatively impacting normal motor performance. Thus, IRL790 has the ability to normalize the behavioral phenotype in hyperdopaminergic as well as hypoglutamatergic states. Neurochemical and immediate early gene (IEG) response profiles suggest modulation of DA neurotransmission, with some features, such as increased DA metabolites and extracellular DA, shared by atypical antipsychotics and others, such as increased frontal cortex IEGs, unique to IRL790. IRL790 also increases extracellular levels of acetylcholine in the prefrontal cortex and ventral hippocampus. At the receptor level, IRL790 appears to act as a preferential DA D3 receptor antagonist. Computational docking studies support preferential affinity at D3 receptors with an agonist-like binding mode. SIGNIFICANCE STATEMENT This paper reports preclinical pharmacology along with molecular modeling results on IRL790, a novel compound in clinical development for the treatment of motor and psychiatric complications in advanced Parkinson disease. IRL790 is active in models of perturbed dopaminergic and glutamatergic signaling, including rodent 6-hydroxydopamine L-DOPA-induced dyskinesias and psychostimulant-induced hyperactivity, in a dose range that does not impair normal behavior. This effect profile is attributed to interactions at dopamine D2/D3 receptors, with a 6- to 8-fold preference for the D3 subtype.
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| 11. |
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| 12. |
- Khoury, Spiro, et al.
(author)
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Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases
- 2023
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In: Biomolecules. - : MDPI. - 2218-273X. ; 13:2
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Journal article (peer-reviewed)abstract
- Lipids, especially lysophosphatidylcholine LPC16:0, have been shown to be involved in chronic joint pain through the activation of acid-sensing ion channels (ASIC3). The aim of the present study was to investigate the lipid contents of the synovial fluids from controls and patients suffering from chronic joint pain in order to identify characteristic lipid signatures associated with specific joint diseases. For this purpose, lipids were extracted from the synovial fluids and analyzed by mass spectrometry. Lipidomic analyses identified certain choline-containing lipid classes and molecular species as biomarkers of chronic joint pain, regardless of the pathology, with significantly higher levels detected in the patient samples. Moreover, correlations were observed between certain lipid levels and the type of joint pathologies. Interestingly, LPC16:0 levels appeared to correlate with the metabolic status of patients while other choline-containing lipids were more specifically associated with the inflammatory state. Overall, these data point at selective lipid species in synovial fluid as being strong predictors of specific joint pathologies which could help in the selection of the most adapted treatment.
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| 13. |
- Klintö, Kristina, et al.
(author)
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Inter-centre comparison of data on surgery and speech outcomes at 5 years of age based on the Swedish quality registry for patients born with cleft palate with or without cleft lip
- 2022
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In: BMC Pediatrics. - : Springer Science and Business Media LLC. - 1471-2431. ; 22:1
-
Journal article (peer-reviewed)abstract
- BACKGROUND: The objective of the Swedish cleft lip and palate registry (CLP registry) is to promote quality control, research and improvement of treatment, by the comparison of long-term results. The aim was to compare data from the CLP registry among the six treatment centres, regarding data on surgery and speech outcomes at 5 years of age.METHODS: The participants were 430 children born in Sweden from 2009 to 2014, with cleft palate with or without cleft lip and without known syndromes and/or additional malformations. The number of primary and secondary palatal surgeries up to 5 years of age, timing of the last primary palatal surgery, percentage consonants correct, percentage non-oral speech errors and perceived velopharyngeal competence at 5 years were assessed. Multivariable binary logistic regression adjusted for sex and cleft type was used to compare results between the six centres.RESULTS: At one centre (centre 4), the palate was closed in one to three stages, and at the remaining centres in one or two stages. At centre 4, more children underwent a higher number of palatal surgeries, and the last primary palatal surgery was performed at a higher age. Children in centre 4 were also less likely to achieve ≥86% correct consonants (OR = 0.169, P = < 0.001), have no non-oral speech errors (OR = 0.347, P = < 0.001), or have competent or marginally incompetent velopharyngeal competence (OR = 0.244, P = < 0.001), compared to the average results of the other centres. No clear association between patient volume and speech outcome was observed.CONCLUSIONS: The results indicated the risk of a negative speech result if the last primary palatal surgery was performed after 25 months of age. Whether the cleft in the palate was closed in one or two stages did not affect speech outcome. The Swedish CLP registry can be used for open comparisons of treatment results to provide the basis for improvements of treatment methods. If deviating negative results are seen consistently at one centre, this information should be acted upon by further investigation and analysis, making changes to the treatment protocol as needed.
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| 14. |
- Kokkinou, Efthymia, et al.
(author)
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The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis
- 2023
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In: Cell reports medicine. - 2666-3791. ; 4:5
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Journal article (peer-reviewed)abstract
- Innate lymphoid cells (ILCs) are considered innate counterparts of adaptive T cells; however, their common and unique transcriptional signatures in pediatric inflammatory bowel disease (pIBD) are largely unknown. Here, we report a dysregulated colonic ILC composition in pIBD colitis that correlates with inflammatory ac-tivity, including accumulation of naive-like CD45RA+CD62L- ILCs. Weighted gene co-expression network analysis (WGCNA) reveals modules of genes that are shared or unique across innate and adaptive lympho-cytes. Shared modules include genes associated with activation/tissue residency, naivety/quiescence, and antigen presentation. Lastly, nearest-neighbor-based analysis facilitates the identification of most in-flamedand least inflamedlymphocytes in pIBD colon with unique transcriptional signatures. Our study reveals shared and unique transcriptional signatures of colonic ILCs and T cells in pIBD. We also provide insight into the transcriptional regulation of colonic inflammation, deepening our understanding of the poten-tial mechanisms involved in pIBD.
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| 15. |
- Kvedaraite, Egle, et al.
(author)
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Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF
- 2024
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
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Journal article (peer-reviewed)abstract
- Stromal cells support epithelial cell and immune cell homeostasis and play an important role in inflammatory bowel disease (IBD) pathogenesis. Here, we quantify the stromal response to inflammation in pediatric IBD and reveal subset-specific inflammatory responses across colon segments and intestinal layers. Using data from a murine dynamic gut injury model and human ex vivo transcriptomic, protein and spatial analyses, we report that PDGFRA+CD142−/low fibroblasts and monocytes/macrophages co-localize in the intestine. In primary human fibroblast-monocyte co-cultures, intestinal PDGFRA+CD142−/low fibroblasts foster monocyte transition to CCR2+CD206+ macrophages through granulocyte-macrophage colony-stimulating factor (GM-CSF). Monocyte-derived CCR2+CD206+ cells from co-cultures have a phenotype similar to intestinal CCR2+CD206+ macrophages from newly diagnosed pediatric IBD patients, with high levels of PD-L1 and low levels of GM-CSF receptor. The study describes subset-specific changes in stromal responses to inflammation and suggests that the intestinal stroma guides intestinal macrophage differentiation.
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| 16. |
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| 17. |
- Mattsson, Jenny, et al.
(author)
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Sequence enrichment profiles enable target-agnostic antibody generation for a broad range of antigens
- 2023
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In: Cell reports methods. - 2667-2375. ; 3:5
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Journal article (peer-reviewed)abstract
- Phenotypic drug discovery (PDD) enables the target-agnostic generation of therapeutic drugs with novel mechanisms of action. However, realizing its full potential for biologics discovery requires new technologies to produce antibodies to all, a priori unknown, disease-associated biomolecules. We present a methodology that helps achieve this by integrating computational modeling, differential antibody display selection, and massive parallel sequencing. The method uses the law of mass action-based computational modeling to optimize antibody display selection and, by matching computationally modeled and experimentally selected sequence enrichment profiles, predict which antibody sequences encode specificity for disease-associated biomolecules. Applied to a phage display antibody library and cell-based antibody selection, ∼105 antibody sequences encoding specificity for tumor cell surface receptors expressed at 103–106 receptors/cell were discovered. We anticipate that this approach will be broadly applicable to molecular libraries coupling genotype to phenotype and to the screening of complex antigen populations for identification of antibodies to unknown disease-associated targets.
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| 18. |
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| 19. |
- Nilsson, Jenny, et al.
(author)
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Influence of age and sex on disease course and treatment in rheumatoid arthritis
- 2021
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In: Open Access Rheumatology: Research and Reviews. - 1179-156X. ; 13, s. 123-138
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Journal article (peer-reviewed)abstract
- Objective: More than 50% of patients with rheumatoid arthritis (RA) are >65 years at diagnosis. Age of onset and sex may influence the disease course, outcome and treatment. This study follows a large cohort of patients with early RA to assess contributions of age and sex to disease outcomes. Methods: Patients from the BARFOT cohort, n=2837 (68% women), were followed for eight years at predefined time points to assess inflammation, function, joint destruction and treatment with disease modifying anti-rheumatic drugs (DMARDs) and glucocorticoids (GC). The patients were divided by sex and age at inclusion (<40, 40–54, 55–69 and ≥70 years). Results: For both sexes, disease activity, function and pain improved over time, significantly more in men than in women in all age groups. In men, those <40 years displayed significantly lower DAS28 compared with all other groups. This group was also the least represented group in the study. The Sharp van der Heijde Score (SHS) increased over time in both sexes and all age groups. Women ≥70 years showed less improvement in disability and the highest progression of SHS mainly due to increased joint space narrowing. Patients <40 years were more likely to receive biological DMARDs, while those ≥70 years more often received only GC treatment. Conclusion: There were significant age-and sex-dependent differences in the medical treatment and in outcome of RA 8 years after diagnosis. The differences were most pronounced in men<40 and women ≥70 years, but whether they are due to disease phenotype or treatment is unclear.
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| 20. |
- Nilsson, Jenny, et al.
(author)
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Influence of Age and Sex on Disease Course and Treatment in Rheumatoid Arthritis
- 2021
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In: Open Access Rheumatology-Research and Reviews. - 1179-156X. ; 13, s. 123-138
-
Journal article (peer-reviewed)abstract
- Objective: More than 50% of patients with rheumatoid arthritis (RA) are >65 years at diagnosis. Age of onset and sex may influence the disease course, outcome and treatment. This study follows a large cohort of patients with early RA to assess contributions of age and sex to disease outcomes. Methods: Patients from the BARFOT cohort, n=2837 (68% women), were followed for eight years at predefined time points to assess inflammation, function, joint destruction and treatment with disease modifying anti-rheumatic drugs (DMARDs) and glucocorticoids (GC). The patients were divided by sex and age at inclusion (<40, 40-54, 55-69 and >= 70 years). Results: For both sexes, disease activity, function and pain improved over time, significantly more in men than in women in all age groups. In men, those <40 years displayed significantly lower DAS28 compared with all other groups. This group was also the least represented group in the study. The Sharp van der Heijde Score (SHS) increased over time in both sexes and all age groups. Women >= 70 years showed less improvement in disability and the highest progression of SHS mainly due to increased joint space narrowing. Patients <40 years were more likely to receive biological DMARDs, while those >= 70 years more often received only GC treatment. Conclusion: There were significant age- and sex-dependent differences in the medical treatment and in outcome of RA 8 years after diagnosis. The differences were most pronounced in men<40 and women >= 70 years, but whether they are due to disease phenotype or treatment is unclear.
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| 21. |
- Norrman, Jenny, 1971, et al.
(author)
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Enriching social and economic aspects in sustainability assessments of remediation strategies – Methods and implementation
- 2020
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In: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 707
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Journal article (peer-reviewed)abstract
- Over the last decade, there has been rapid development in promoting and implementing sustainable remediation. It is now common to include at least some sustainability considerations in remediation projects. Specific challenges that have been highlighted often relate to economic and social aspects not receiving enough attention: broadening the social aspects, community and meaningful stakeholder engagement, understanding stakeholders' risk perception, and a need for better estimates of site-specific economic costs and benefits. This study presents an application of the Sustainable Choice of REmediation (SCORE) framework with special focus on (1) demonstrating the working process for a broad sustainability assessment and (2) sharing the lessons learned from its application. Specific objectives are to describe (a) the types of stakeholders involved in the assessment, (b) the methods for collection of social and economic sustainability data, (c) residents' perception of risks, (d) the use of the sustainability assessment results in the decision-making process, and (5) possibilities for improving the methods and working process. SCORE was applied and evaluated with input from, and together with, stakeholders at the BT Kemi industrial site in the village of Teckomatorp, south Sweden, a former pesticide production site associated with the most infamous Swedish environmental scandal. A questionnaire (n = 78) was used to collect input from residents regarding local acceptance and economic externalities of the remediation alternatives. Alternatives with a high degree of removal of contaminants received a high ranking in the assessment, primarily due to social and economic effects. The working process can be improved, specifically regarding workshop preparation and workshop structure. A broad representation of stakeholders and early establishment of communication channels to residents is key for robust assessment of social aspects. The information from the sustainability assessment was used in the decision-making process, not least for revising remediation options.
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| 22. |
- Selldén, Tilia, 1996, et al.
(author)
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Radiographic airway abnormalities in untreated early rheumatoid arthritis are associated with peripheral neutrophil activation
- 2023
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In: Arthritis Research & Therapy. - : Springer Science and Business Media LLC. - 1478-6362. ; 25:1
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Journal article (peer-reviewed)abstract
- Background: The role of the lung for the initiation and progression of rheumatoid arthritis (RA) is still unclear. Up to 10% of RA patients develop interstitial lung disease which remains a clinical challenge. Understanding early disease mechanisms is of great importance. The objective of this study was to determine whether there is an association between peripheral neutrophil phenotypes and presence of pulmonary abnormalities (PA) on chest high-resolution computed tomography (HRCT) in untreated early RA (ueRA).MethodsClinical data and blood were collected, and HRCT performed at diagnosis on 30 consecutive anti-citrullinated protein antibody (ACPA) and/or rheumatoid factor (RF) positive ueRA patients. HRCTs were evaluated for the presence of RA-associated parenchymal, airway and/or pleural abnormalities. Expression of phenotype markers on neutrophils were determined by flow cytometry. Levels of calprotectin, ACPA and RF were measured using immunoassays.ResultsThe frequency of having any PA was 60%. Airway abnormalities were present in 50%, parenchymal nodules in 43% and interstitial lung abnormalities (ILA) in 10%. Unsupervised multivariate data analysis showed clustering of any PA with neutrophil activation, parameters of inflammation and RF titres. In univariate analysis, the patients with PA displayed significantly increased CD11b and decreased CD62L expression on neutrophils (1.2-fold, p = 0.014; 0.8-fold, p = 0.012) indicating activation and significantly increased RF IgM titre and CRP (5.7-fold, p = 0.0025; 2.3-fold, p = 0.0035) as compared to no PA. Titres of RF, but not ACPA, correlated with expression of the neutrophil activation marker CD11b. A stratified analysis demonstrated that airway involvement was the PA subtype with the strongest association with neutrophil activation.ConclusionWe report a strong association between radiographic airway findings and activation of circulating neutrophils in early RA supporting a role of innate immunity and the lung at disease onset. Our results also indicate different contributions of RF and ACPA in the RA pathogenesis.
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| 23. |
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SPRÅK I NORDEN : Svensklärarföreningens årsskrift 2023
- 2024
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Editorial collection (pop. science, debate, etc.)abstract
- Hur kan svenskämnet bidra till att bevara och stärka den språkliga mångfalden i Sverige och språkgemenskapen i Norden? Svensklärarföreningensårsskrift 2023 fokuserar på den del av svenskämnet som berör språk, språkbruk och språkförhållanden i Sverige och Norden. I åtta artiklar skrivna av språkexperter, forskare, lärarutbildare och verksamma lärare i Sverige, Norge, Danmark och Finland får vi ta del av en mängd infallsvinklar på detta tema.
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| 24. |
- Svensson, Anette, 1972-, et al.
(author)
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Från finrummet till vardagsrummet : Transmedialt berättande som litteraturdidaktisk underhållning
- 2021
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In: Utbildning och Lärande / Education and Learning. - Falun : Högskolan Dalarna. - 2001-4554. ; 15:2, s. 149-166
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Journal article (peer-reviewed)abstract
- This study explores re-creation processes, through transmedia storytelling, that are made visible in the Swedish TV-programme Helt lyriskt (2018), where music artists transmediate Swedish poems into songs. The aim is to analyse, through a close-reading method, two episodes of Helt lyriskt in order to discuss how processes of transmedia storytelling make literary analyses visible and accessible to the general public. The analysis shows that the episodes employ pedagogical strategies to encourage the audience to partake in, and learn about, poetry and how to conduct literary analyses. One strategy is to illuminate the artists’ interpretation and analysis processes. Thus, the audience experiences the textual and musical adaptations that the artist Molly Sandén makes in her re-creation of Edith Södergran’s “Vierge moderne” (1916), in which she transfers the main theme of the poem, the early twentieth-century modern woman, to a song intended for the modern woman of today. Another strategy, brought up in relation to Annika Norlin’s re-creation of Karin Boye’s “I rörelse” (1927), is to question what liberties may be taken with a literary work, when she adopts the main theme of the poem, to always strive for more, by adding self-composed lyrics to the poem.
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| 25. |
- Svensson, Jenny, 1974-, et al.
(author)
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Nursing students' experiences of what influences achievement of learning outcomes in a problem-based learning context : A qualitative descriptive study
- 2021
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In: Nursing Open. - : John Wiley & Sons. - 2054-1058. ; 8:4, s. 1863-1869
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Journal article (peer-reviewed)abstract
- Aim: This study aimed to describe nursing students' experiences of what facilitate orimpede the achievement of learning outcomes in PBL-basednursing education.Design: A qualitative descriptive design was used.Methods: Data were collected from individual semi-structuredinterviews with 18undergraduate nursing students in Sweden and were analysed using Burnard's qualitativecontent analysis.Results: The results were organized into three categories: (a) understanding of therequired level of knowledge depth (b) tutor's engagement and (c) student base groupinteractions. These categories represent essential components of PBL that couldeither facilitate or impede students' achievement of learning outcomes in nursingeducation. To improve the students' opportunities to achieve the learning outcomes,proper introduction of and a continuous education on PBL as a pedagogical methodprovided both to students and tutors should be considered important.
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| 26. |
- Svensson, Katarina, et al.
(author)
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Adverse motor outcome after paediatric ischaemic stroke : A nationwide cohort study
- 2022
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In: Paediatric and Perinatal Epidemiology. - : Wiley. - 0269-5022 .- 1365-3016. ; 36:3, s. 412-421
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Journal article (peer-reviewed)abstract
- Background Various frequencies of adverse motor outcomes (cerebral palsy and hemiplegia) after paediatric ischaemic stroke have been reported. Few reports on the risks of adverse motor outcomes in nationwide cohorts and contributing risk factors are available. Objectives To assess risk of adverse motor outcome and potential risk factors thereof after paediatric ischaemic stroke in a nationwide cohort. Methods This nationwide matched cohort study identified 877 children <18 years of age diagnosed with ischaemic stroke through the Swedish national health registers from 1997 to 2016. These children, exposed to ischaemic stroke, alive 1 week after stroke, were matched for age, sex and county of residence with 10 unexposed children. Using Cox regression, we estimated the risk of adverse motor outcomes in children with stroke compared to that in unexposed children. Logistic regression was applied to compare the characteristics of children with and without adverse motor outcomes after stroke. Results Out of the 877 children with ischaemic stroke, 280 (31.9%) suffered adverse motor outcomes compared with 21 (0.2%) of the 8770 unexposed: adjusted hazard ratio (aHR) 167.78 (95% confidence interval (CI) 107.58, 261.66). There were no differences between risk estimates of adverse motor outcome according to age at stroke: perinatal stroke (aHR 124.11, 95% CI 30.45, 505.84) and childhood stroke (aHR 182.37, 95% CI 113.65, 292.64). An association between adverse motor outcome and childhood stroke aOR 1.56 (95% CI 1.05, 2.31) was found when analysing only children with ischaemic stroke. No associations were found between adverse motor outcome and sex, gestational age or parental age at birth. Conclusions The risk of adverse motor outcome is substantial after paediatric ischaemic stroke, especially childhood stroke, confirming results of previous smaller studies. This study found no associations between sex, gestational age or parental age and adverse motor outcome after paediatric ischaemic stroke.
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| 27. |
- Tegel, Hanna, et al.
(author)
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High throughput generation of a resource of the human secretome in mammalian cells
- 2020
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In: New Biotechnology. - : Elsevier BV. - 1871-6784 .- 1876-4347. ; 58, s. 45-54
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Journal article (peer-reviewed)abstract
- The proteins secreted by human tissues and blood cells, the secretome, are important both for the basic understanding of human biology and for identification of potential targets for future diagnosis and therapy. Here, a high-throughput mammalian cell factory is presented that was established to create a resource of recombinant full-length proteins covering the majority of those annotated as 'secreted' in humans. The full-length DNA sequences of each of the predicted secreted proteins were generated by gene synthesis, the constructs were transfected into Chinese hamster ovary (CHO) cells and the recombinant proteins were produced, purified and analyzed. Almost 1,300 proteins were successfully generated and proteins predicted to be secreted into the blood were produced with a success rate of 65%, while the success rates for the other categories of secreted proteins were somewhat lower giving an overall one-pass success rate of ca. 58%. The proteins were used to generate targeted proteomics assays and several of the proteins were shown to be active in a phenotypic assay involving pancreatic beta-cell dedifferentiation. Many of the proteins that failed during production in CHO cells could be rescued in human embryonic kidney (HEK 293) cells suggesting that a cell factory of human origin can be an attractive alternative for production in mammalian cells. In conclusion, a high-throughput protein production and purification system has been successfully established to create a unique resource of the human secretome.
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| 28. |
- Uddling, Jenny, 1972-, et al.
(author)
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Flerspråkighet som villkorad resurs : en studie om hur mellanstadielärare talar om flerspråkande i skolarbete
- 2024
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In: Pedagogisk forskning i Sverige. - : Linnéuniversitetet. - 1401-6788 .- 2001-3345. ; 29:1-2
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Journal article (peer-reviewed)abstract
- I denna studie undersöks hur två mellanstadielärare i intervjuer talar om flerspråkande i skolarbetet före och efter en intervention. Materialet är insamlat inom ett samverkansprojekt mellan Linnéuniversitetet och två olika F–6-skolor på initiativ av en kommuns utbildningsförvaltning. Själva interventionen pågick i två språkligt heterogena klasser under 14 veckor i syfte att ge stöd till respektive lärare att i större utsträckning tillvarata flerspråkiga resurser i skolarbetet. Intervjuerna analyseras med hjälp av kvalitativ innehållsanalys, som i sin tur tolkas och diskuteras med hjälp av Ruíz (1984) tre olika förhållningssätt till språk och språkanvändning som problem, rättighet eller resurs. Studiens resultat diskuteras också utifrån begreppen epistemisk rättvisa (Fricker, 2007, 2017) och inkluderande undervisning (Ainscow & Messiou, 2018; Kugelmass, 2006). Resultatet visar att lärarna efter interventionen uttrycker att de i högre grad erbjuder flerspråkande i skolarbetet, vilket kan tolkas som ett exempel på inkluderande undervisning som ökar den epistemiska rättvisan för såväl elever som vårdnadshavare med migrationsbakgrund. Emellertid ger båda lärarna fortsatt uttryck för flerspråkigheten som en villkorad resurs, något som tillfälligt kan användas av de elever som ännu inte lärt sig tillräckligt med svenska.
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| 29. |
- Uddling, Jenny, 1972-, et al.
(author)
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Flerspråkighet som villkorad resurs : en studie om hur mellanstadielärare talar om flerspråkande i skolarbete
- 2024
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In: Pedagogisk forskning i Sverige. - : Linnaeus University Press. - 1401-6788 .- 2001-3345. ; 29:1-2, s. 97-121
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Journal article (peer-reviewed)abstract
- I denna studie undersöks hur två mellanstadielärare i intervjuer talar om flerspråkande i skolarbetet före och efter en intervention. Materialet är insamlat inom ett samverkansprojekt mellan Linnéuniversitetet och två olika F–6-skolor på initiativ av en kommuns utbildningsförvaltning. Själva interventionen pågick i två språkligt heterogena klasser under 14 veckor i syfte att ge stöd till respektive lärare att i större utsträckning tillvarata flerspråkiga resurser i skolarbetet. Intervjuerna analyseras med hjälp av kvalitativ innehållsanalys, som i sin tur tolkas och disku-teras med hjälp av Ruíz (1984) tre olika förhållningssätt till språk och språkan-vändning som problem, rättighet eller resurs. Studiens resultat diskuteras också utifrån begreppen epistemisk rättvisa (Fricker, 2007, 2017) och inkluderande undervisning (Ainscow & Messiou, 2018; Kugelmass, 2006). Resultatet visar att lärarna efter interventionen uttrycker att de i högre grad erbjuder flerspråkande i skolarbetet, vilket kan tolkas som ett exempel på inkluderande undervisning som ökar den epistemiska rättvisan för såväl elever som vårdnadshavare med migrationsbakgrund. Emellertid ger båda lärarna fortsatt uttryck för flerspråkigheten som en villkorad resurs, något som tillfälligt kan användas av de elever som ännu inte lärt sig tillräckligt med svenska.
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