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- Sjöholm, Kajsa, 1971, et al.
(författare)
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A microarray search for genes predominantly expressed in human omental adipocytes: adipose tissue as a major production site of serum amyloid A.
- 2005
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Ingår i: Journal of Clinical Endocrinology & Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 90:4, s. 2233-9
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Tidskriftsartikel (refereegranskat)abstract
- To identify genes predominantly expressed in omental adipocytes, microarray expression profiles from 33 human tissues or cell types were analyzed, using an algorithm developed for identification of transcripts predominantly expressed in a certain tissue. Both known adipocyte-specific and more unexpected genes were among the 28 genes identified. To validate the approach, adipocyte expression of three of these genes, acute-phase serum amyloid A (A-SAA), aquaporin 7, and transport secretion protein-2.2, was compared with 17 other human tissues by real-time PCR. The unexpectedly high expression of A-SAA in adipocytes was further verified by Northern blot and immunohistochemistry. The liver, reported to be the main production site for A-SAA, displayed the second highest expression using microarray and real-time PCR. In obese subjects, adipose tissue mRNA and serum A-SAA levels were down-regulated during an 18-wk diet regime (P < 0.05 and P < 0.0001, respectively). A-SAA serum levels were highly correlated to adipose tissue mRNA levels (P < 0.001) and to the total (P < 0.0001) and sc (P < 0.0001) adipose tissue areas, as analyzed by computed tomography. We show that adipose tissue is a major expression site of A-SAA during the nonacute-phase reaction condition. This provides a direct link between adipose tissue mass and a marker for low-grade inflammation and cardiovascular risk.
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| 2. |
- Svensson, Jenny, 1977-
(författare)
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The Regulation of Rule-Following : Imitation and Soft Regulation in the European Union
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Present times are sometimes referred to as "the golden era of regulation", as more and more areas of social life are regulated. But regulation is not only increasing; it is also changing. New regulators are emerging, and they are issuing new kinds of rules. These new kinds of regulation are frequently not legally binding, and are therefore labelled soft regulation as opposed to hard law. It is not compulsory to follow soft rules but many actors - including sovereign states - still do, and the thesis asks the question why this is so. Why do even states, which are powerful regulators themselves, abide by soft regulation, and wherein lies the regulative power of soft rules? Through an in-depth study of the European Union's pre-accession instrument Twinning an answer to the question of the power of soft regulation has been arrived at. Treating Twinning as a critical case of soft regulation, and using theories of imitation to grasp the meaning and evolution of Twinning projects, makes it possible to define three regulative elements involved in soft regulation. These are the combinative, co-productive and constitutive elements of soft regulation, from which the thesis suggests that it derives its power. First of all, soft regulation combines different kinds of rules, the regulation of identity and the regulation of activity, and a variety of sources of legitimacy. Second, it depends on regulators and regulatees interacting to co-produce regulation. And third, as its main result, it constitutes the rule-followers as formal, rational, and modern organisations. Accordingly, soft regulation has rather impressive regulative capabilities, builds on complex, dynamic, and social interactions, and embodies as well as promotes some of Western society's most strongly institutionalised ideas. The thesis argues that it is through these characteristics that actors, including states, are compelled to follow soft rules.
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