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| 2. |
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| 3. |
- Andersson, Marica, et al.
(författare)
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Increased noise levels cause behavioural and distributional changes in Atlantic cod and saithe in a large public aquarium—A case study
- 2023
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Ingår i: Aquaculture, Fish and Fisheries. - : John Wiley & Sons. - 2693-8847.
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Investigating the effects of underwater noise on aquatic animals is a research field that is receiving rapidly increasing attention. Despite this, surprisingly few studies have addressed the potential impacts of noise in a marine animal husbandry setting. In this regard, the behaviour of fish in public aquariums can be used as an indicator of well-being, and noise is known to cause behavioural changes. This case study investigates the behaviour of cod (Gadus morhua) and saithe (Pollachius virens) in a large public aquarium when exposed to increased noise levels originating from an aquarium renovation carried out by construction divers. Swimming behaviour, group formation and vertical distribution, along with yawning and scratching frequencies of the fish, were analysed from video recordings made before, during and after the exposure to increased noise levels. The same parameters were also analysed to evaluate potential effects of the presence of divers when not making renovation noise, compared to fish behaviour prior to the renovation. There was a slight change in the depth distribution of both species and a decrease in the number of scratches in cod due to the presence of divers that were not making renovation noise. In the presence of construction noises in the tank, however, both cod and saithe showed a wider array of behavioural changes, including increased swimming speed, changes in depth distribution and increased yawning frequencies. The results from this case study demonstrate that an underwater renovation with increased noise levels impacts fish behaviour and suggests that underwater noise should be considered during the management of aquatic environments, including public aquaria.
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| 4. |
- Blom, Eva-Lotta, et al.
(författare)
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Anthropogenic noise disrupts early-life development in a fish with paternal care
- 2024
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Ingår i: Science of the Total Environment. - 0048-9697 .- 1879-1026. ; 935
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Tidskriftsartikel (refereegranskat)abstract
- Anthropogenic noise is a global pollutant but its potential impacts on early life-stages in fishes are largely unknown. Here, using controlled laboratory experiments, we tested for impacts of continuous or intermittent exposure to low-frequency broadband noise on early life-stages of the common goby (Pomatoschistus microps), a marine fish with exclusive paternal care. Neither continuous nor intermittent noise exposure had an effect on filial cannibalism, showing that males were capable and willing to care for their broods. However, broods reared in continuous noise covered a smaller area and contained fewer eggs than control broods. Moreover, although developmental rate was the same in all treatments, larvae reared by males in continuous noise had, on average, a smaller yolk sac at hatching than those reared in the intermittent noise and control treatments, while larvae body length did not differ. Thus, it appears that the increased consumption of the yolk sac reserve was not utilised for increased growth. This suggests that exposure to noise in early life-stages affects fitness-related traits of surviving offspring, given the crucial importance of the yolk sac reserve during the early life of pelagic larvae. More broadly, our findings highlight the wide-ranging impacts of anthropogenic noise on aquatic wildlife living in an increasingly noisy world.
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| 5. |
- Blom, Eva-Lotta, et al.
(författare)
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Continuous and intermittent noise has a negative impact on reproductive success and early life survival in marine fish
- 2022
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Konferensbidrag (refereegranskat)abstract
- Anthropogenic underwater noise is a global pollutant of increasing concern and its effect on marine organisms is largely unknown. Importantly, direct assessments of fitness consequences are lacking especially in fish. The effect of noise pattern with continuous or intermittent noise are poorly understood and the few existing studies investigating the effect highlight contradictory responses in fish. Working in aquaria, we experimentally tested the impact of broadband noise exposure (similar frequency range as anthropogenic boat noise; added either continuously or intermittently) on the behaviour and reproductive success, assessed by the number of obtained eggs, of the common goby (Pomatoschistus microps), a vocal fish with exclusive paternal care. The continuous noise treatment had the most detrimental effect by reducing spawning probability and females took longer to spawn under continuous noise. Males exposed to continuous noise got significantly fewer egg clutches (4 compared to 11 and 15 in the intermittent noise and silence treatments). Clutch area did not differ among treatments but clutches in the intermittent and continuous noise treatment had significantly more eggs per cm2. In addition, eggs in the control tanks hatched earlier than in the intermittent and noisy treatments. Larvae reared in continuous noise treatment were larger and had a smaller yolk-sac at hatching than larvae in the intermittent noise treatment and the control. Taken together, we show that noise, particularly a continuous noise exposure, negatively affects reproductive success and early life survival in fish larvae.
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| 6. |
- Blom, Eva-Lotta, 1973, et al.
(författare)
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Male acoustic display in the sand goby – Essential cue in female choice, but unaffected by supplemental feeding
- 2022
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Ingår i: Journal of Experimental Marine Biology and Ecology. - : Elsevier. - 0022-0981 .- 1879-1697. ; 556
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Tidskriftsartikel (refereegranskat)abstract
- Many teleost fishes use acoustic and visual signalling during courtship. Such displays may convey information about body condition. Here we experimentally altered body condition of sand goby (Pomatoschistus minutus) males to examine effects on acoustic and visual courtship and subsequent spawning decisions. Over two weeks, males fed in excess were fed daily, whereas food-deprived males were fed once a week. Females only spawned with males that produced courtship sound. However, there were no treatment effects on the occurrence of spawning and males fed in excess did not invest more in visual or acoustic courtship than food-deprived males. That said, males fed in excess built more well-covered nests, with more sand piled on top, compared to food-deprived males. Male condition measured as lipid content differed significantly between treatments. However, only males fed in excess differed in lipid content from wild caught males, indicating that in nature, males are of similar condition to males in the low condition treatment group. Apart from the importance of courtship sound, the only male or female behaviour predicting reproductive success was if male displayed in the nest opening. Males often produce courtship sounds together with a visual display in this position. A female dark-eye display did not associate with reproductive success which, together with previous results, suggest a non-ornamental function of this trait. We conclude that male courtship sounds appear to be crucial in female mate choice, but the information content of the courtship sounds and how it relates to male condition remains elusive.
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| 7. |
- Jakobsson, Lotta, 1967, et al.
(författare)
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ASSESSMENT OF PASSENGER SAFETY IN FUTURE CARS - IDENTIFYING THE REAL-WORLD NEEDS TOWARDS SAFETY SYSTEM DEVELOPMENT
- 2023
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Ingår i: 27th ESV Conference Proceedings.
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Konferensbidrag (refereegranskat)abstract
- Future cars will likely include further collision mitigation systems, seat positions and seating configurations compared to current cars, in addition to an increased degree of shared mobility solutions. At the same time the population is becoming older and the diversity in car passenger dimensions is growing. This calls for assessment tools and evaluation methods beyond the current standardized crash test methods. This paper summarizes the results of a Swedish research project on how to assess the protection of the heterogeneous population of passengers (i.e., nondrivers) in future car crashes, focusing on restraint interaction. With the overall purpose of further improving passenger protection, the specific aims were to achieve method developments based on the enhancement of tools (physical and virtual human substitutes) as well as to create knowledge on passenger protection needs. This comprehensive research project combined multiple competencies and international collaborations, and a large number of studies have been performed using different methods. The applied methods include real-world crash data analyses to identify scenarios and situations, crash testing and simulation, and additionally user-studies conducted in cars to evaluate sitting posture, beltfit, kinematics, comfort, experiences and attitudes. Furthermore, the project included studies on crash test dummies (ATDs) and Human Body Models (HBM). Moreover, adult morphed HBMs were developed in various sizes, ages and sexes, for investigating various protection principles. In novel studies, crash interventions strategies were applied to predicted residual crash configurations. User-studies provided evidence of self-selected passenger postures in real car settings and, thus, deviations from standardized ATD positions. The importance of body shape was highlighted in a beltfit user-study including older adults. Essential booster design parameters were identified for children in upright and reclined seat positions. Restraint principles were investigated for adults in reclined seat positions and with the seat in rearward positions, away from the frontal airbag and knee bolster, along with an evaluation of the capabilities of the assessment tools. The adult HBM morphed to various sizes, ages and sexes were validated for prediction of in-crash kinematics in different impact scenarios, and provided enhanced insights in passenger protection assessment compared to the three standardized sizes of ATDs. Simulations with PIPER6y, a child-sized HBM, emphasized the importance of vehiclebooster-user system interaction. The results from the research project provided input to safety system development, ATD/HBM design, assessment methods development, and a number of identified research challenges for future work. Specifically, there is a need to further explore car passenger interaction with the restraint system in terms of seat positions and variations in body sizes, shapes and postures. The inclusions of the heterogeneous population into more advanced tools such as HBMs are essential, acknowledging that when moving closer to “zero injuries”, the situations to address are more unique and specific. Although a large range of studies using different methods was conducted, many challenges still remain to cover the entire scope of passenger safety in future cars.
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| 8. |
- Lindgren, Cecilia, et al.
(författare)
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Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase
- 2022
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Ingår i: Chemistry - A European Journal. - : John Wiley & Sons. - 0947-6539 .- 1521-3765. ; 28:40
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Tidskriftsartikel (refereegranskat)abstract
- Reactivators are vital for the treatment of organophosphorus nerve agent (OPNA) intoxication but new alternatives are needed due to their limited clinical applicability. The toxicity of OPNAs stems from covalent inhibition of the essential enzyme acetylcholinesterase (AChE), which reactivators relieve via a chemical reaction with the inactivated enzyme. Here, we present new strategies and tools for developing reactivators. We discover suitable inhibitor scaffolds by using an activity-independent competition assay to study non-covalent interactions with OPNA-AChEs and transform these inhibitors into broad-spectrum reactivators. Moreover, we identify determinants of reactivation efficiency by analysing reactivation and pre-reactivation kinetics together with structural data. Our results show that new OPNA reactivators can be discovered rationally by exploiting detailed knowledge of the reactivation mechanism of OPNA-inhibited AChE.
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| 9. |
- Lumbers, R. T., et al.
(författare)
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The genomics of heart failure: design and rationale of the HERMES consortium
- 2021
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Ingår i: Esc Heart Failure. - : Wiley. - 2055-5822. ; 8:6, s. 5531-5541
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Tidskriftsartikel (refereegranskat)abstract
- Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targets) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of >1.10 for common variants (allele frequency > 0.05) and >1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 x 10(-8) under an additive genetic model. Conclusions HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.
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| 10. |
- Manderstedt, Eric, et al.
(författare)
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Classic Thrombophilias and Thrombotic Risk Among Middle-Aged and Older Adults : A Population-Based Cohort Study
- 2022
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Ingår i: Journal of the American Heart Association. - : Wiley-Blackwell Publishing Ltd. - 2047-9980. ; 11:4
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Five classic thrombophilias have been recognized: factor V Leiden (rs6025), the prothrombin G20210A variant (rs1799963), and protein C, protein S, and antithrombin deficiencies. This study aimed to determine the thrombotic risk of classic thrombophilias in a cohort of middle-aged and older adults. METHODS AND RESULTS: Factor V Leiden, prothrombin G20210A and protein-coding variants in the PROC (protein C), PROS1 (protein S), and SERPINC1 (antithrombin) anticoagulant genes were determined in 29 387 subjects (born 1923–1950, 60% women) who participated in the Malmö Diet and Cancer study (1991–1996). The Human Gene Mutation Database was used to define 68 disease-causing mutations. Patients were followed up from baseline until the first event of venous thromboembolism (VTE), death, or Dec 31, 2018. Carriership (n=908, 3.1%) for disease-causing mutations in the PROC, PROS1, and SERPINC1 genes was associated with incident VTE: Hazard ratio (HR) was 1.6 (95% CI, 1.3–1.9). Variants not in Human Gene Mutation Database were not linked to VTE (HR, 1.1; 95% CI, 0.8–1.5). Heterozygosity for rs6025 and rs1799963 was associated with incident VTE: HR, 1.8 (95% CI, 1.6–2.0) and HR, 1.6 (95% CI, 1.3–2.0), respectively. The HR for carrying 1 classical thrombophilia variant was 1.7 (95% CI, 1.6–1.9). HR was 3.9 (95% CI, 3.1–5.0) for carriers of ≥2 thrombophilia variants. CONCLUSIONS: The 5 classic thrombophilias are associated with a dose-graded risk of VTE in middle-aged and older adults. Disease-causing variants in the PROC, PROS1, and SERPINC1 genes were more common than the rs1799963 variant but the conferred genetic risk was comparable with the rs6025 and rs1799963 variants.
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| 11. |
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| 12. |
- Manderstedt, Eric, et al.
(författare)
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Thrombomodulin (THBD) gene variants and thrombotic risk in a population-based cohort study
- 2022
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Ingår i: Journal of Thrombosis and Haemostasis. - : Elsevier BV. - 1538-7933 .- 1538-7836. ; 20:4, s. 929-935
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Tidskriftsartikel (refereegranskat)abstract
- Background: The protein C anticoagulant system plays a key role in maintaining the hemostatic balance. Although several studies have identified thrombomodulin gene (THBD) variants among venous thromboembolism (VTE) patients, the role of THBD in relation to VTE in humans remains to be clarified. Objectives: This study aimed to determine the thrombotic risk of rare and common THBD variants in a large population-based cohort of middle-aged and older adults. Patients/Methods: The exome sequence of THBD was analyzed for qualifying variants in 28,794 subjects (born 1923–1950, 60% women), who participated in the Malmö Diet and Cancer study (1991–1996). Patients were followed from baseline until the first event of VTE, death, or 2018. Qualifying variants were defined as loss-of-function or non-benign (PolyPhen-2) missense variants with minor allele frequency <0.1%. Results: The single common coding variant rs1042579 was not associated with incident VTE. Sixteen rare variants were classified as qualifying and included in collapsing analysis. Seven individuals with VTE compared to 24 individuals without VTE carried one qualifying variant. Cox multivariate regression analysis adjusted for age, sex, body mass index, systolic blood pressure, smoking and alcohol consumption, rs6025, rs1799963, and the top two eigenvectors from a principal components analysis showed a hazard ratio of 3.0 (95% confidence interval 1.4–6.3) for the rare qualifying variants. The distributions of qualifying variants in THBD showed a difference for individuals with and without incident VTE indicating a possible position effect. Conclusions: Rare qualifying THBD variants were associated with VTE, suggesting that rare variants in THBD contribute to development of VTE.
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| 13. |
- Manderstedt, Eric, et al.
(författare)
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Thrombotic Risk Determined by Protein C Receptor (PROCR) Variants among Middle-Aged and Older Adults : A Population-Based Cohort Study
- 2022
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Ingår i: Thrombosis and Haemostasis. - : Georg Thieme Verlag KG. - 0340-6245 .- 2567-689X. ; 122:8, s. 1326-1332
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Tidskriftsartikel (refereegranskat)abstract
- Background The protein C (PC) anticoagulant system has a key role in maintaining hemostatic balance. One missense (Ser219Gly) variant in the PC receptor (PROCR) was associated with venous thromboembolism (VTE) in genome-wide association studies. Objectives This study aimed to determine the thrombotic risk of rare and common PROCR variants in a large population-based cohort of middle-aged and older adults. Methods The exonic sequence of PROCR was analyzed for the Ser219Gly variant and other qualifying variants in 28,794 subjects (born 1923-1950, 60% women) without previous VTE, who participated in the Malmö Diet and Cancer study (1991-1996). Incidence of VTE was followed up until 2018. Qualifying variants were defined as loss-of-function or nonbenign (PolyPhen-2) missense variants with minor allele frequencies (MAFs) <0.1%. Results Re-sequencing identified 36 PROCR variants in the study population (26,210 non-VTE exomes and 2,584 VTE exomes), 11 synonymous, 22 missense, and three loss-of-function variants. Kaplan-Meier analysis of the known Ser219Gly variant (rs867186) showed that homozygosity for this variant increased the risk of disease, whereas heterozygosity showed no effect. Cox multivariate regression analysis revealed an adjusted hazard ratio (HR) of 1.5 (95% confidence interval [CI]: 1.1-2.0). Fifteen rare variants were classified as qualifying and were included in collapsing analysis (burden test and SKAT-O). They did not contribute to risk. However, a Arg113Cys missense variant (rs146420040; MAF = 0.004) showed an increased VTE risk (HR = 1.3; 95% CI: 1.0-1.9). Conclusion Homozygosity for the Ser219Gly variant and a previously identified functional PROCR variant (Arg113Cys) was associated with VTE. Other variants did not contribute to VTE.
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| 14. |
- Manderstedt, Eric, et al.
(författare)
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Thrombotic risk determined by rare and common SERPINA1 variants in a population-based cohort study
- 2022
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Ingår i: Journal of Thrombosis and Haemostasis. - : Elsevier BV. - 1538-7933 .- 1538-7836. ; 20:6
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Tidskriftsartikel (refereegranskat)abstract
- Background: Severe alpha-1-antitrypsin deficiency (AATD), phenotype PiZZ, was associated with venous thromboembolism (VTE) in a case-control study. Objectives: This study aimed to determine the genetic variation in the SERPINA1 gene and a possible thrombotic risk of these variants in a population-based cohort study. Patients/Methods: The coding sequence of SERPINA1 was analyzed for the Z (rs28929474), S (rs17580), and other qualifying variants in 28,794 subjects without previous VTE (born 1923–1950, 60% women), who participated in the Malmö Diet and Cancer study (1991–1996). Individuals were followed from baseline until the first event of VTE, death, or 2018. Results: Resequencing the coding sequence of SERPINA1 identified 84 variants in the total study population, 21 synonymous, 62 missense, and 1 loss-of-function variant. Kaplan-Meier analysis showed that homozygosity for the Z allele increased the risk of VTE whereas heterozygosity showed no effect. The S (rs17580) variant was not associated with VTE. Thirty-one rare variants were qualifying and included in collapsing analysis using the following selection criteria, loss of function, in frame deletion or non-benign (PolyPhen-2) missense variants with minor allele frequency (MAF)
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| 15. |
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| 16. |
- Moilanen, Johanna, et al.
(författare)
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Being, becoming and belonging in constructing children’s lived citizenship with contact persons and contact families
- 2023
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Ingår i: Barn. - Trondheim : Norsk senter for barneforskning. - 0800-1669 .- 2535-5449. ; 41:2–3, s. 74-89
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Tidskriftsartikel (refereegranskat)abstract
- The article discusses children’s citizenship by linking the dimensions of being, becoming and belonging to the concept of lived citizenship in the context of contact person and contact family interventions. Drawing on empirical research from Finland and Sweden, the article elaborates on how to identify if, and if so, how, children’s lived citizenship is constructed in contact person and contact family interventions and to what extent these constructions leave room for children’s perspectives. The results of the study indicate that contact person and contact family interventions contribute to the construction of children’s citizenship in various ways that include the perspectives on children and childhood of being, becoming and belonging. However, children’s active participation often seems to be governed by adults. Thus, giving greater attention to children’s intergenerational connections, i.e., adults’ roles in forming children’s citizenship, is needed.
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| 17. |
- Nilsson, Eva-Lotta, et al.
(författare)
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The association between number of siblings and delinquent behaviour
- 2024
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Ingår i: Journal of Crime and Justice. - : Taylor & Francis. - 0735-648X.
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Tidskriftsartikel (refereegranskat)abstract
- This study examines the association between number of siblings and delinquency, adjusting for family relations and demographic variables. Data is based on a nationally representative school survey in Sweden consisting of approximately 25,000 youths. The results show a positive association for those having five or more siblings (IRR = 1.533, p = < .001), whereas one or two siblings is negatively associated with delinquency compared to those having no siblings. These results remain stable after adjusting for family relations. This study underscores the importance of further exploring the variation and direction of the association between the number of siblings and delinquency, as well as deepening our understanding of the various theoretical mechanisms through which the number of siblings is associated with delinquent behaviour.
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| 18. |
- Shah, S, et al.
(författare)
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Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 163-
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Tidskriftsartikel (refereegranskat)abstract
- Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies.
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| 19. |
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| 20. |
- Svensson, Ola, 1971-, et al.
(författare)
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Sand goby females do not spawn with silent males - but do males sing out their condition and can female hear the song in a noisy environment?
- 2022
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Konferensbidrag (refereegranskat)abstract
- Males of sand gobies (Pomatoschistus spp.) spawn in shallow water and produce a courtship sound to entice females to spawn. Previous work on field-caught males shows that courtship sounds differ between males of different body condition and between species suggesting that females use acoustic information in mate choice. Here, we manipulated male body condition via feeding regimes and measured courtship and subsequent spawning decisions. Although male condition measured as lipid content differed significantly between feeding regimes, neither male visual courtship, acoustic courtship nor spawning success were affected. However, comparing the lipid content of the experimental males to field-caught males show that in nature, males are of similar condition to males in the low condition treatment group. Acoustic signals might be masked by anthropogenic noise. Thus, to test if noise may affect spawning success we exposed courting males to experimental noise, resembling boat noise. We found that females only spawned with males that produced courtship sounds and significantly less often when exposed to noise. We conclude that the information content of male courtship sound and how it relates to male condition remains elusive, but that acoustic courtship is essential for mating success, making sand gobies potentially vulnerable to noise pollution. These results will be discussed in the light of preliminary data from a field experiment using the same noise set-up where male mating success was unaffected by treatment, and a pond experiment where variation in male mating success was affected by low levels of playback noise.
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| 21. |
- Vallström, Maria, et al.
(författare)
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Introduktion - den urbana normen
- 2022
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Ingår i: Kulturella perspektiv - Svensk etnologisk tidskrift. - : Föreningen Kulturella Perspektiv. - 1102-7908 .- 2004-0288. ; 30, s. 1-5
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 22. |
- Vasiljevic, Zoran, et al.
(författare)
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Do Moral Values Moderate the Relationship Between Immigrant-School Concentration and Violent Offending? : A Cross-Level Interaction Analysis of Self-Reported Violence in Sweden
- 2024
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Ingår i: Deviant behavior. - : Taylor & Francis. - 0163-9625 .- 1521-0456. ; 45:6, s. 836-846
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Tidskriftsartikel (refereegranskat)abstract
- The study examines whether school-level immigrant concentration is related to students' involvement in violence, and whether students' moral values moderate the relationship between immigrant concentration and violence. The study is based on six nationally representative school surveys conducted by the Swedish National Council for Crime Prevention between 1999 and 2011, with a combined sample of 38,711 adolescents. We have combined different surveys to create one large pooled data set to evaluate segregation effects at the school level. Multilevel linear probability models are used to examine cross-level interaction effects. This study shows that contextual effects impact students differently, and that the relationship between immigrant concentration and violence is considerably stronger for adolescents with weak personal moral values. The paper provides empirical support for the differential vulnerability hypothesis. Policy and practice would benefit from a focus on the further development of programs and interventions that target personal moral values, not least in schools.
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| 23. |
- Velin, Lotta, et al.
(författare)
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What is the role of global health and sustainable development in Swedish medical education? A qualitative study of key stakeholders’ perspectives
- 2023
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Ingår i: BMC Medical Education. - : BMC. - 1472-6920. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Global health and sustainable development have increasingly been recognised as important parts of medical education, yet education on these issues remains fragmented and scarce. In 2020, a bill to reform the national medical curricula across all Swedish medical schools was introduced, including a greater emphasis on global health and sustainable development. This study aimed to explore the perspectives of key stakeholders in medical education on the role of global health and sustainable development in Swedish medical education. Methods: This was a qualitative study based on semi-structured interviews with 11 key stakeholders in medical education, broadly defined as faculty board members (dean and/or vice-deans for medical education) and/or programme chairs representing six universities. Data were analysed using qualitative content analyis (QCA). The study was conducted according to the Consolidated Criteria for Reporting Qualitative research (COREQ) guidelines. Results: Stakeholders discussed the challenges and opportunities associated with the modification of medical education, which was seen as necessary modernisation to fit the changing societal perception of the role of medical doctors. The anchoring process of redesigning the curriculum and integrating global health and sustainable development was discussed, with emphasis on ownership and mandate and the role of teachers and students in the process. Finding a shared understanding of global health and sustainable development was perceived as a challenge, associated with resistance due to fear of curriculum overload. To overcome this, integrating global health and sustainable development with other topics and developing existing components of the curricula were seen as important. Additionally, it was stressed that fostering capacity building and developing infrastructure, including utilization of digital tools and collaborations, were essential to ensure successful implementation. Conclusions: Medical institutions should prepare future doctors to respond to the needs of a globalised world, which include knowledge of global health and sustainable development. However, conceptual uncertainties and questions about ownership remain among key stakeholders in medical education. Yet, key stakeholders also highlight that the inclusion of global health and sustainable development in the new curricula represents multiple overarching educational opportunities that can bring about necessary improvement.
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