Search: WFRF:(Theofilopoulos Argyrios N.)
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The lupus-related L...
The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.
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- Haraldsson, M Katarina (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Immunologi/immunkemi
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Louis-Dit-Sully, Christine A (author)
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Lawson, Brian R (author)
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Sternik, Gabriel (author)
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Santiago-Raber, Marie-Laure (author)
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Gascoigne, Nicholas R J (author)
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Theofilopoulos, Argyrios N (author)
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Kono, Dwight H (author)
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
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In: Immunity. - : Elsevier BV. - 1074-7613 .- 1097-4180. ; 28:1, s. 40-51
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Here, we show that a lupus-suppressing locus is caused by a nonsense mutation of the filamentous actin-inhibiting Coronin-1A gene. This mutation was associated with developmental and functional alterations in T cells including reduced migration, survival, activation, and Ca2+ flux. T-dependent humoral responses were impaired, but no intrinsic B cell defects were detected. By transfer of T cells, it was shown that suppression of autoimmunity could be accounted for by the presence of the Coro1a(Lmb3) mutation in T cells. Our results demonstrate that Coronin-1A is required for the development of systemic lupus and identify actin-cytoskeleton regulatory proteins as potential targets for modulating autoimmune diseases.
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