| 1. |
|
|
| 2. |
- Axelsson, L., et al.
(författare)
-
Study of the unbound nucleus 11N by elastic resonance scattering
- 1996
-
Ingår i: Physical Review C (Nuclear Physics). - 0556-2813 .- 2469-9985 .- 2469-9993. ; 54:4, s. 1511-1514
-
Tidskriftsartikel (refereegranskat)abstract
- Resonances in the unbound nucleus 11N have been studied, using the resonance scattering reaction 10C+p. The data give evidence for three states above the 10C+p threshold with energies 1.30, 2.04, and 3.72 MeV. These states can be interpreted, in a potential-model analysis, as the ground state and the first two excited states with spin-parity 1 / 2+, 1 / 2-, and 5 / 2+ arising from the shell-model orbitals 1s1 / 2, 0p1 / 2, and 0d5 / 2. A narrow state superposed on a broad structure found at higher energy could be interpreted as the mirror state of the 3 / 2- in 11Be shifted down in energy. This shift would suggest a large radius of the potential.
|
|
| 3. |
- Clarke, Robert, et al.
(författare)
-
Lowering blood homocysteine with folic acid based supplements : Meta-analysis of randomised trials
- 1998
-
Ingår i: British Medical Journal. - : BMJ. - 0959-8146. ; 316:7135, s. 894-898
-
Forskningsöversikt (refereegranskat)abstract
- Objective: To determine the size of reduction in homocysteine concentrations produced by dietary supplementation with folic acid and with vitamins B-12 or B-6. Design: Meta-analysis of randomised controlled trials that assessed the effects of folic acid based supplements on blood homocysteine concentration. Multivariate regression analysis was used to determine the effects on homocysteine concentrations of different doses of folic acid and of the addition of vitamin B-12 or B-6. Subjects: Individual data on 1114 people included in 12 trials. Findings: The proportional and absolute reductions in blood homocysteine produced by folic acid supplements were greater at higher pretreatment blood homocysteine concentrations (P < 0.001) and at lower pretreatment blood folate concentrations (P < 0.001). After standardisation to pretreatment blood concentrations of homocysteine of 12 μmol/l and of folate of 12 nmol/l (approximate average concentrations for Western populations), dietary folic acid reduced blood homocysteine concentrations by 25% (95% confidence interval 23% to 28%; P < 0.001), with similar effects in the range of 0.5-5 mg folic acid daily. Vitamin B-12 (mean 0.5 mg daily) produced an additional 7% (3% to 10%) reduction in blood homocysteine. Vitamin B-6 (mean 16.5 mg daily) did not have a significant additional effect. Conclusions: Typically in Western populations, daily supplementation with both 0.5-5 mg folic acid and about 0.5 mg vitamin B-12 would be expected to reduce blood homocysteine concentrations by about a quarter to a third (for example, from about 12 μmol/l to 8-9 μmol/l). Large scale randomised trials of such regimens in high risk populations are now needed to determine whether lowering blood homocysteine concentrations reduces the risk of vascular disease.
|
|
| 4. |
- Axelsson, L., et al.
(författare)
-
Beta decay of Ar-31
- 1998
-
Ingår i: Nuclear Physics A. - 0375-9474. ; 634:4, s. 475-496
-
Tidskriftsartikel (refereegranskat)abstract
- A complete study of Ar-31 beta decay has been made by high-resolution charged-particle and gamma-ray spectroscopy. Beta-delayed radiation was detected by an array of three charged-particle detectors and a large-volume germanium detector. Fifteen new energy levels were discovered in Cl-31. The beta-strength distribution, measured to 14.5 MeV, is compared with a shell-model calculation in the full sd space. The quenching of the Gamow-Teller strength and the isospin impurity of the IAS in Cl-31 are discussed. (C) 1998 Published by Elsevier Science B.V.
|
|
| 5. |
- Axelsson, L., et al.
(författare)
-
Two-proton emission in the decay of Ar-31
- 1998
-
Ingår i: Nuclear Physics A. - 0375-9474. ; 628:3, s. 345-362
-
Tidskriftsartikel (refereegranskat)abstract
- Several beta-delayed two-proton branches were observed in the decay of Ar-31, the most intense ones proceeding through the isobaric analogue state (IAS) in Cl-31. The mechanism of the two-proton emission is studied via the energy and angular distributions of the two protons, Simultaneous emission of the two protons fits the present data well, sequential decays might also describe them. Independent of the decay mechanism, a spin of 5/2 for the IAS is suggested, An improved limit on the direct two-proton emission fi om the ground state of Ar-31 is presented, (C) 1998 Elsevier Science B.V.
|
|
| 6. |
- Fynbo, H. O. U., et al.
(författare)
-
Ar-31 examined: New limit on the beta-delayed three-proton branch
- 1999
-
Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 59:4, s. 2275-2277
-
Tidskriftsartikel (refereegranskat)abstract
- We have remeasured the decay of Ar-31 with a setup sensitive to multiparticle decay branches and obtained. a new limit of 1.1 x 10(-3) (99% C.L.) on the beta-delayed three-proton branch between the isobaric analog state in Cl-31 and the ground state of Si-28. This a factor of 17 below the previously reported first observation of beta-delayed three-proton emission in Ar-31. The limit on a possible beta 3p branch to the first excited state in Si-28 is 2.9 x 10(-4). [S0556-2813(99)04404-0].
|
|
| 7. |
- Honkanen, A., et al.
(författare)
-
Fine structure in the beta-delayed proton decay of Ar-33
- 1996
-
Ingår i: Nuclear Physics A. - 0375-9474. ; 611:1, s. 47-55
-
Tidskriftsartikel (refereegranskat)abstract
- Low-energy beta-delayed protons from Ar-33 have been measured for the first time, The data reveal states, which, despite unfavourable barrier penetrability values, strongly decay to the first excited 2(+) state in S-32. The observation is discussed in terms of the standard shell model, A natural explanation is provided by the large spectroscopic amplitudes, involving s(1/2) and d(3/2) orbitals, as well as the l = 0 barrier penetrability, favouring the decay to the 2(+) state.
|
|
| 8. |
- Aleksandrov, D., et al.
(författare)
-
Invariant mass spectrum and alpha-n correlation function studied in the fragmentation of He-6 on a carbon target
- 1998
-
Ingår i: Nuclear Physics A. - 0375-9474. ; 633:2, s. 234-246
-
Tidskriftsartikel (refereegranskat)abstract
- Momentum distributions and invariant mass spectra from the breakup of He-6 ions with an energy of 240 MeV/u interacting with a carbon target have been studied. The data were used to extract information about the reaction mechanism which is influenced by the structure of He-6. It is found that the dominant reaction mechanism is a two-step process: knock out of one neutron followed by the decay of the He-5 resonance. The shape of the (alpha+n) two-body invariant mass spectrum is interpreted as mainly reflecting the 5He ground state which is a J(pi) = 3/2(-) resonance. However, no evidence for correlations between cu particles and neutrons is observed in the momentum widths of the distributions. It is demonstrated that a combined analysis of the two-body invariant mass spectrum and an appropriate correlation function may be used to determine the properties of the intermediate resonance. (C) 1998 Elsevier Science B.V.
|
|
| 9. |
- Arvidsson, Thomas, et al.
(författare)
-
Autism in 3-6-Year-Old Children in a Suburb of Goteborg, Sweden
- 1997
-
Ingår i: Autism. - : SAGE Publications. - 1362-3613 .- 1461-7005. ; 1:2, s. 163-173
-
Tidskriftsartikel (refereegranskat)abstract
- 1941 ofthe 3-6-year-old children living in a community outside Gbteborg on the Swedish west coast were screened with a view to identifying all individuals with severe degrees of autistic behaviour. All children in the population were known to well baby clinic staff, and any child suspected of suffering from autism was referred to a specialized clinical research team. The nurses and doctors working in the well baby clinics were well informed about autism. Clinical and ADI-R diagnoses of autism were established after thorough clinical assessments of each suspected case. All children were seen at least twice, and all were over the age of 3 years at the time of diagnosis. The general population prevalence for autism was 3 I in I o,ooo children (9; percent confidence interval 7/ g;). Classic Kanner autism was found in I o in Io,ooo children (9; percent confidence interval-4/24). These rates appear to reflect higher rates than previously reported. Some reasons for the possibly higher prevalence are discussed.
|
|
| 10. |
- Bergh, Jonas C., et al.
(författare)
-
The first clinical pilot study of roquinimex (Linomide) in cancer patients with special focus on immunological effects
- 1997
-
Ingår i: Cancer Investigation. - 0735-7907 .- 1532-4192. ; 15:3, s. 204-11
-
Tidskriftsartikel (refereegranskat)abstract
- Roquinimex (Linomide) has been demonstrated to suppress tumor growth in animal models. The effect is at least in part related to enhanced numbers and activity of natural killer (NK) cells. In this clinical pilot study, roquinimex was given at increasing doses (0.05 mg/kg to 0.6 mg/kg) to 13 patients (performance status 0-3) with various malignant disorders. Immunology parameters were followed and side effects were observed during the study. The plasma pharmacokinetics of roquinimex was studied at the 0.2 mg/kg dose level. The clinical side effects were dominated by musculoskeletal discomfort, nausea, and pain. No significant hematological or biochemical toxicity was observed. Pharmacokinetic analysis at the 0.2 mg/kg dose level revealed a Cmax of 4.0 mumol/L at tmax of 1.2 hr and an elimination half-life of 42 hr. Increased numbers of phenotypic NK cells, activated T (DR+CD4+) cells, and monocytes were observed after administration of roquinimex compared with pretreatment values. Roquinimex seems to be an active immunomodulator with manageable toxicity. Further exploration of therapeutic efficacy is warranted.
|
|
| 11. |
|
|
| 12. |
- Borge, M. J. G., et al.
(författare)
-
Elucidating halo structure by beta decay: beta gamma from the Li-11 decay
- 1997
-
Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 55:1, s. R8-R11
-
Tidskriftsartikel (refereegranskat)abstract
- New values for the gamma ray intensities following the beta decay of Li-11 are presented. Special emphasis is put on the determination of the Gamow-Teller transition Li-11 --> Be-11 (1/2(-), 320 keV) to the only bound excited state in Be-11. We show that a shell-model calculation can simultaneously reproduce the half-life of Li-11 and the newly measured branching ratio to the 1/2(-) state provided the Li-11 ground state wave function contains about 50% of s-wave neutron components.
|
|
| 13. |
- Borge, M. J. G., et al.
(författare)
-
Probing the Li-11 halo structure through beta-decay into the Be-11(*) (18 MeV) state
- 1997
-
Ingår i: Nuclear Physics A. - 0375-9474. ; 613:3, s. 199-208
-
Tidskriftsartikel (refereegranskat)abstract
- An experimental study of beta-delayed charged particles (H, He, Be) from Li-11 shows a beta-feeding to an excited state at 18.15(15) MeV in Be-11 with a large Gamow-Teller strength, B-GT greater than or equal to 1.6. Branching ratios and reduced widths of 2-, 3- and 5- particle decay channels of this state are extracted, A strong suppression of the neutron branch from the 18 MeV state to the Be-10(g.s.) is observed, We suggest that the measured partial width may be sensitive to the (p(1/2))(2) component in the Li-11 halo, A rough estimate indicates that the (p(1/2))(2) component is not the dominant one in the halo wave-function.
|
|
| 14. |
- Chulkov, L. V., et al.
(författare)
-
Large spin alignment of the unbound He-5 fragment after fragmentation of 240 MeV/nucleon He-6
- 1997
-
Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 79:2, s. 201-204
-
Tidskriftsartikel (refereegranskat)abstract
- Peripheral fragmentation of a 240 MeV/nucleon beam of the halo nucleus He-6 incident on carbon target has been studied in a kinematically complete experiment. It is found that one-neutron stripping to the unbound nucleus He-5 is the dominant fragmentation mechanism and that it leads to a spin alignment of He-5 in a plane perpendicular to the He-5 momentum vector. This is expected to be a common feature for all neutron halo nuclei.
|
|
| 15. |
- Elomaa, I, et al.
(författare)
-
Chemotherapy in Ewing's sarcoma. The Scandinavian Sarcoma Group experience
- 1999
-
Ingår i: Acta Orthopaedica Scandinavica. Supplementum. - 0300-8827. ; 70:285, s. 69-73
-
Tidskriftsartikel (refereegranskat)abstract
- During the past 15 years the Scandinavian Sarcoma Group has treated 140 patients with Ewing's sarcoma. Two protocols have been used. SSG IV included 52 patients between 1984 and 1990 and SSG IX, 88 patients since 1990. After 5 years of treatment, local recurrences occurred in 19% of the patients (M0 + M1) in the SSG IV group and 10% in the SSG IX group. Distant metastases developed in 57% of the M0-patients in the SSG IV group and in 33% in the SSG IX group. Tumor-related survival (overall) of M0-patients was 49% in SSG IV and 70% in SSG IX, and the metastasis-free survival rate 45% and 58%, respectively. Patients having a localized extremity tumor had a survival rate of 90% (SSG IX). In both treatment groups, good responders to chemotherapy had a better survival rate than poor ones (SSG IV, p < 0.02, GI-II vs. G II-IV and SSG IX, p < 0.003, GI-III vs. G IV). In conclusions local control and survival rates were better with SSG IX than SSG IV.
|
|
| 16. |
|
|
| 17. |
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
- Kjellgren, Karin I, 1950, et al.
(författare)
-
Patients' and physicians' assessment of risks associated with hypertension and benefits from treatment.
- 1998
-
Ingår i: Journal of cardiovascular risk. - 1350-6277. ; 5:3, s. 161-6
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Perceptions of effects of a medical regimen may affect patients' adherence to therapy. OBJECTIVE: To assess concordance between patients' and physicians' estimations of the risks of hypertension and benefits of treatment during a regular follow-up appointment. DESIGN: A population-based Swedish multicentre study. Patients were included consecutively from a randomized selection of centres (55 primary health care centres and 11 clinics of internal medicine). METHODS: A questionnaire was given to 1013 patients undergoing their individually prescribed antihypertensive therapy and 212 physicians who were caring for these patients. RESULTS: Without therapy, patients perceived the risks of cardiovascular complications to be higher than did their physicians. Patients were not aware that an increasing number of risk factors has an impact on the risk of complications. Patients furthermore rated the benefits of treatment higher than did their physicians (P<0.001). Of the patients, 14% had blood pressures < or = 140/90 mmHg. Most of the patients (61%) were not aware of their target blood pressure. However, when the target pressure was communicated to patients by the physician, patients remembered it accurately. The patients were generally not willing to trade even minor side effects from antihypertensive therapy for benefits of treatment. CONCLUSIONS: There was a high degree of inconsistency between patients' and physicians' estimations of risks of hypertension. Patients estimated the effects of treatment to be more beneficial than did their physicians.
|
|
| 21. |
- Kjellgren, Karin I, 1950, et al.
(författare)
-
Perceived symptoms amongst hypertensive patients in routine clinical practice- a population-based study.
- 1998
-
Ingår i: Journal of internal medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 244:4, s. 325-32
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To compare perceived symptoms between patients undergoing antihypertensive therapy and hypertensive patients without drug treatment, and to assess reasons for change of antihypertensive medication in routine clinical practice. DESIGN: Population-based multicentre study. Consecutive patients from a randomized sample of centres were given a standardized questionnaire to assess symptoms as well as opinions about their antihypertensive drugs. SETTING: Fifty-five Swedish primary health care centres and 11 clinics of internal medicine. PATIENTS: One thousand and thirteen hypertensive patients on their individually prescribed antihypertensive medication and 13 5 without antihypertensive therapy. MAIN OUTCOME MEASURES: Prevalence and perception of symptoms with and without antihypertensive drug therapy, changes of medication and reasons for this. RESULTS: Amongst the group of patients on antihypertensive medication, 57% spontaneously reported having had symptoms of high blood pressure before they started their drug therapy. Amongst the patients without antihypertensive drugs, 52% reported having such symptoms. When answering direct questions about different symptoms related to current drug treatment or increased blood pressure, patients with and without medication reported symptoms to a similar extent: 80 and 85%, respectively. A majority of patients (64%) had changed their medication during the course of treatment (range 0-61 years). The mean number of changes was 2.4 times over 12 years. The most common reported cause for changing drug treatment was side-effects (42%). CONCLUSIONS: The study shows that patients in general perceive symptoms from hypertension. Antihypertensive medication decreases the frequency and intensity of symptoms that might be related to high blood pressure but adds other symptoms linked to the medication. Changes in medication were mostly related to side-effects. The follow-up should pay attention to patients' experience of treatment. A sign of a well-managed hypertension population would be a decrease of symptoms over time.
|
|
| 22. |
|
|
| 23. |
- Mukha, I., et al.
(författare)
-
Observation of the Li-11(beta d) decay
- 1996
-
Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 367:1-4, s. 65-69
-
Tidskriftsartikel (refereegranskat)abstract
- Experimental data from the decay of Li-11 show for the first time the presence of beta-delayed deuterons with a branching ratio larger than 10(-4). To distinguish between beta d and beta t events the decays of the daughter nuclei Li-9 and Li-8 were identified in the energy and decay time spectra. Furthermore, a time correlation analysis between the beta d events and the subsequent daughter decays was performed.
|
|
| 24. |
- Mukha, I., et al.
(författare)
-
Super-strong beta-decay of Li-11 into Be-11* (18 MeV) state: A probe for halo p-wave component?
- 1997
-
Ingår i: Nuclear Physics A. - 0375-9474. ; 616:1-2, s. C201-C207
-
Konferensbidrag (refereegranskat)abstract
- An experimental study of beta-delayed charged particles (H, He, Be), neutrons and gamma-rays that follow the Li-11 beta-decay, clearly indicates a beta-feeding to an exited state at 18.1 MeV in Be-11 with a large Gamow-Teller strength, B-GT greater than or equal to 1.0. The large strength of this beta-transition implies a broad overlap of the Be-11* state at 18.1 MeV and the ground state of Li-11. The deduced width of this resonance is similar or equal to 1 MeV. A strong suppression of the branch from 18.1 MeV state into the Be-10+n channel is observed. This branch, with the largest decay energy, has a partial width less than 1% of the total width. A centrifugal barrier consideration fails to explain this effect. A possible consequence of the observed effect for the Li-11 structure is that the admixture of (p(1/2))(2) configuration in Li-11 might be small.
|
|
| 25. |
- Nilbert, Mef, et al.
(författare)
-
Ewing's sarcoma treatment in Scandinavia 1984-1990--ten-year results of the Scandinavian Sarcoma Group Protocol SSGIV
- 1998
-
Ingår i: Acta Oncologica. - 1651-226X. ; 37:4, s. 375-378
-
Tidskriftsartikel (refereegranskat)abstract
- A report on the long-term follow up of the first cooperative Scandinavian Sarcoma Group study in Ewing's sarcoma of bone is presented. Fifty-two previously untreated patients entered the study between 1984 and 1990. Half of the tumors were located in the extremities and one quarter in the pelvis. The combined modality treatment consisted of 5 cycles of chemotherapy--including vincristine, methotrexate, doxorubicin, cyclophosphamide, bleomycin and dactinomycin. The first two cycles were followed by local resection or amputation in 35 patients and by radiotherapy alone in 17 patients. When surgery was not performed, was incomplete or yielded poor margins radiotherapy was given at a dose of 40-60 Gy. Local tumor relapses developed in 10 patients and in all but one patient were accompanied by metastatic disease. Five patients had metastasis at diagnosis and distant metastases developed after primary treatment in 27 patients after a median of 14 months. The median follow-up time for the 20 surviving patients is 10 years. At 5 years the tumor-related survival was 46% and the metastasis-free survival 43%. Late tumor relapses occurred in 4 patients, which reduced the 10-year tumor related survival to 41% and the metastasis-free survival to 38%. Histopathological tumour response correlated with survival with 5-year metastasis-free survival rates of 73% for the good responders and 35% for the poor responders.
|
|
| 26. |
|
|
| 27. |
- Saeter, G, et al.
(författare)
-
Prognostic factors in bone sarcomas
- 1997
-
Ingår i: Acta Orthopaedica Scandinavica. Supplementum. - 0300-8827. ; 68:273, s. 156-160
-
Tidskriftsartikel (refereegranskat)abstract
- Based on a literature review and the SSG experience, the most important prognostic factors in high-grade osteosarcoma appear to be the presence of detectable metastases at diagnosis, tumour volume, old age, sex, histologic response, and possibly tumoral P-glycoprotein expression. However, for an adolescent patient with non-metastatic extremity disease, there is no consensus regarding prognostic factors at initial presentation, and currently there is thus no established method for dividing them into high- and low risk groups for the purpose of treatment differentiation. It should also be remembered that available prognostic factors have been identified only in a retrospective manner, following aggressive treatment of all patients. Thus patients in "favourable" prognostic groups may simply be patients who have had a good effect from aggressive treatment, and how they would have done with reduced treatment remains to be shown. Obviously the best method for prognostication would be the direct demonstration of micrometastatic disease in the lungs or in peripheral blood. In the relatively near future, this may become possible with immunoscintigrapy or immunohistochemistry utilizing monoclonal antibodies [29-31]. In Ewing's sarcoma, the most powerful factors indicating poor prognosis are metastases at diagnosis, poor histologic response, large tumour size and possibly pelvic localisation. There appears to be a somewhat better international consensus regarding prognostic factors in Ewing's sarcoma than in osteosarcoma. Although several studies have implemented intensified treatment for poor prognostic groups [8, 32], the role (if any) of high-dose treatment with stem cell rescue remains to be proven. The same factors are prognostic both for the development of metastases and local recurrence, but in addition, surgical treatment as opposed to radiotherapy appears to reduce local failure rate [12, 17, 33, 34]. As in osteosarcoma, the near future offers promise regarding the detection and quantification of micrometastatses and minimal residual disease, by means of PCR techniques recognizing specific genetic changes in the Ewing family of tumors [35].
|
|
| 28. |
|
|
| 29. |
- Svensson, C. E., et al.
(författare)
-
Decay Out of the Doubly Magic Superdeformed Band in the N=Z Nucleus 60Zn
- 1999
-
Ingår i: Physical Review Letters. - 1079-7114. ; 82:17, s. 3400-3403
-
Tidskriftsartikel (refereegranskat)abstract
- The doubly magic superdeformed band in the N = Z nucleus Zn-60 has been identified. Linking transitions connecting this band to the yrast line provide the first spin, parity, and excitation energy measurements for superdeformed states in the A similar to 60 region. The stretched-E2 character and relatively large B(E2) values of these transitions suggest a nonstatistical decay-out process.
|
|
| 30. |
- Svensson, C. E., et al.
(författare)
-
Observation and Quadrupole Moment Measurement of the First Superdeformed Band in the A~60 Mass Region
- 1997
-
Ingår i: Physical Review Letters. - 1079-7114. ; 79:7, s. 1233-1236
-
Tidskriftsartikel (refereegranskat)abstract
- A high-spin rotational cascade of six gamma rays has been observed in Zn-62. The quadrupole moment of 2.7(-0.5)(+0.7) e b measured for this band corresponds to a deformation beta(2) = 0.45(-0.07)(+0.10). The properties of this band are in excellent agreement with calculations that predict high-spin superdeformed bands in Zn-62 with deformations beta(2) = 0.41-0.49. These results establish a new region of superdeformation for nuclei with neutron and proton numbers N, Z approximate to 30-32.
|
|
| 31. |
- Svensson, C. E., et al.
(författare)
-
Smooth Termination of Rotational Bands in 62Zn: Evidence for a Loss of Collectivity
- 1998
-
Ingår i: Physical Review Letters. - 1079-7114. ; 80:12, s. 2558-2561
-
Tidskriftsartikel (refereegranskat)abstract
- Two sets of strongly coupled rotational bands have been identified in Zn-62. These bands have been observed up to the terminating states of their respective configurations. Lifetime measurements indicate that the transition quadrupole moments in these bands decrease as termination is approached. These results establish the first terminating states of rotational bands in the A similar to 60 mass region and confirm the predicted loss of collectivity associated with smooth band termination.
|
|
| 32. |
|
|
