| 1. |
- Dasmah, Amir, et al.
(författare)
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Integration of fluoridated implants in onlay autogenous bone grafts - An experimental study in the rabbit tibia.
- 2014
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Ingår i: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. - : Elsevier BV. - 1878-4119 .- 1010-5182. ; 42:6, s. 796-800
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Tidskriftsartikel (refereegranskat)abstract
- Bone augmentation before treatment with endosseous implants is a common procedure for rehabilitation of the edentulous jaw. Both machined and surface modified implants have been used in one-stage and two-stage surgery protocols with varying results and survival rates. The influence of surface modification on the integration of implants has been documented in both non-grafted and grafted bone. The aim of this study was to compare the integration and stability of surface modified fluoridated vs. machined implants when placed simultaneously with an onlay bone graft.
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| 2. |
- Dasmah, Amir, et al.
(författare)
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Marginal Bone-Level Alterations at Implants Installed in Block versus Particulate Onlay Bone Grafts Mixed with Platelet-Rich Plasma in Atrophic Maxilla. A Prospective 5-Year Follow-Up Study of 15 Patients.
- 2013
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Ingår i: Clinical implant dentistry and related research. - : Wiley. - 1708-8208 .- 1523-0899. ; 15:1, s. 7-14
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Tidskriftsartikel (refereegranskat)abstract
- Background: Extensive atrophy of the alveolar process may require a bone-grafting procedure prior to implant treatment. Autogenous bone grafts from the iliac crest, used as onlay block and particulate bone, have been used together with sinus-lift procedure in order to rehabilitate patients with extremely resorbed maxillae. However, there are to our knowledge no 5-year follow-up studies evaluating the extent of bone-level change in patients treated with respectively block and particulate autogenous bone grafts. Purpose: The purpose of this prospective clinical study was to conduct a 5-year follow-up analysis with focus on bone-level alteration in block versus particulate onlay bone grafts. Material and Methods: Fifteen out of originally 19 patients who were treated with iliac bone grafts and oral implants in the maxilla have been followed through the first 5 postoperative years. In a first study conducted on 19 patients, the role of platelet-rich plasma in conjunction with autogenous bone was evaluated. In this 5-year follow-up study, the marginal bone alterations have been documented at base line, 1 year and 5 years of loading to the nearest 0,1mm at mesial and distal surfaces of the implants. Two implants were installed on each side of the midline in either block or particulate bone grafts giving test and control sides in each patient. Additionally, two implants on each side were installed in residual bone/grafted sinus floor. Result: Marginal bone alteration in the anterior maxilla appeared larger at the side augmented by block bone at baseline, and after 1 and 5 years of loading, but the change was not statistically significant. Moreover, there was a significantly higher degree of marginal alteration during the first year of loading, compared with the examinations after 5 years. Conclusion: The present follow-up study showed that there is no significant difference in the extension of resorption between block- and particulate autogenous bone grafts over a 5-year period. Most of the resorption occurred during the first year in function.
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| 3. |
- Dasmah, Amir, et al.
(författare)
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Particulate vs. block bone grafts : Three-dimensional changes in graft volume after reconstruction of the atrophic maxilla, a 2-year radiographic follow-up
- 2012
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Ingår i: Journal of Cranio-Maxillofacial Surgery. - : Elsevier BV. - 1010-5182 .- 1878-4119. ; 40:8, s. 654-659
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND:Extensive alveolar bone resorption in the maxilla limits the possibility of successful placement and osseointegration of endosseous implants for future prosthetic rehabilitation. Autogenous bone from the iliac crest may be used as lateral onlays in the atrophic maxilla, both as block and particulate bone. To our knowledge, there is no three-dimensional 2-year follow-up study measuring the volumetric reduction of the augmented areas comparing particulate and block bone grafts.PURPOSE:The aim of this study was to conduct a radiographic 2-year follow-up study, using computed tomographic (CT) images in order to evaluate and compare the extent of bone graft resorption in the frontal maxillae augmented by particulate (test) and block bone (control).MATERIAL AND METHODS:Eleven patients treated with iliac bone grafts and oral implants in the maxilla were followed with CT examinations directly post grafting and after 2years.RESULT:The volumetric changes after 6months were extensive. Additionally, the changes in particulate bone tended to be larger after 2years compared to block bone, using this protocol. However, the difference was not statistically significant.CONCLUSION:The present follow-up study showed that there is radiographically complete integration and embedding of implants installed in grafted bone despite extensive initial graft resorption. There was no significant difference in the amount of volumetric reduction between particulate bone and block bone grafts.
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| 4. |
- Dérand, Per, et al.
(författare)
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Glomangioma: a case presentation.
- 2010
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Ingår i: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. - : Elsevier BV. - 1531-5053 .- 0278-2391. ; 68:1, s. 204-7
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Forskningsöversikt (refereegranskat)
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| 5. |
- Erkapers, Maria, et al.
(författare)
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Patient satisfaction following dental implant treatment with immediate loading in the edentulous atrophic maxilla
- 2011
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Ingår i: International Journal of Oral & Maxillofacial Implants. - 0882-2786 .- 1942-4434. ; 26:2, s. 356-364
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The present study evaluated patient satisfaction using the Oral Health Impact Profile 49 (OHIP-49) questionnaire for patients who received six implants in the severely resorbed maxilla and an implant-supported prosthesis that was delivered within 24 hours after surgery. Materials and Methods: Fifty-one edentulous patients with severe atrophy in the maxilla were included in the study, which was performed at two centers. Six implants were placed in the maxilla and loaded within 24 hours with a provisional restoration. The definitive restorations were delivered 20 to 24 weeks later. Patients were asked to complete the OHIP-49 questionnaire (which includes seven domains representing functional limitation, physical pain, psychologic discomfort, physical disability, psychologic disability, social disability, and handicap) prior to implant placement and on three subsequent occasions. The data were collected and analyzed and OHIP scores were compared over time. Results: Baseline satisfaction scores for the two different centers displayed no statistically significant differences. Treatment resulted in improved total OHIP-49 scores in both centers, with no significant difference between centers. Furthermore, no significant differences were observed in any of the individual pretreatment and posttreatment OHIP-49 domains between centers. All seven domains showed a statistically significant improvement posttreatment. Of the seven domains, social disability and handicap showed the least improvement and had the lowest pretreatment scores, indicating lower significance for these domains compared to the other domains during implant treatment. This study also indicated that domains one to five (functional limitation, physical pain, psychologic discomfort, physical disability, and psychologic disability) are the most important domains in patient satisfaction with implant therapy. Conclusion: Measurement with the OHIP-49 questionnaire displayed that patient satisfaction increases after treatment with a fixed restoration on implants loaded within 24 hours.
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| 6. |
- Franke Stenport, Victoria, 1970, et al.
(författare)
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Onlay and inlay bone grafts with platelet-rich plasma: histologic evaluations from human biopsies.
- 2011
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Ingår i: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. - : Elsevier BV. - 1531-5053 .- 0278-2391. ; 69:4, s. 1079-85
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The aim of the present study was to histomorphometrically evaluate biopsies from 1) sinus inlay bone grafts prepared with or without platelet-rich plasma (PRP) and 2) onlay bone grafts in the anterior maxilla with particulate bone and PRP or block bone without PRP after 3 months.
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| 7. |
- Frisch, Andreas, et al.
(författare)
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Additions to the calicioid flora of Japan and Korea, with the descriptions of two new species
- 2014
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Ingår i: Annales Botanici Fennici. - : Finnish Zoological and Botanical Publishing Board. - 0003-3847 .- 1797-2442. ; 51, s. 189-194
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Tidskriftsartikel (refereegranskat)abstract
- Two new species of calicioid fungi are described, Phaeocalicium triseptatum Tibell and Sphinctrina intermedia Tibell. While P. triseptatum is only known from Hokkaido, Japan, S. intermedia is known from Hokkaido and Korea. Sphinctrina leucopoda as reported from Korea in the literature is misidentified S. intermedia. The genus Microcalicium is reported as new to Japan with one species, M. arenarium. Phaeocalicium flabelliforme is reported as new to Asia (Japan). Chaenothecopsis savonica is reported as new to Japan and Sphinctrina tubaeformis as new to Hokkaido.
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| 8. |
- Frisch, Andreas, et al.
(författare)
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Crypthonia, a new genus of byssoid Arthoniaceae (lichenised Ascomycota)
- 2010
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Ingår i: Mycological Progress. - : Springer Science and Business Media LLC. - 1617-416X .- 1861-8952. ; 9, s. 281-303
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Tidskriftsartikel (refereegranskat)abstract
- Crypthonia with 11 species is described as belonging to the Arthoniaceae. The new genus is characterised by (1) white to pale carneous, maculiform ascomata lacking a distinct exciple, (2) a weakly gelatinised, hydrophobic hymenium of paraphysoids, (3) a discontinuous layer of branched ascogenous hyphae in the hypothecium, (4) small, clavate to broadly clavate asci of the Arthonia-type lacking a hemiamyloid ring structure in the tholus, (5) eight small, hyaline, 1-3-septate, thin-walled ascospores per ascus, (6) loosely attached thalli with a byssoid, coloured hypothallus, and (7) a chemistry of mainly beta-orcinol depsidones and tridepsides including psoromic, norstictic, and gyrophoric acids. Rugulosin occurs in C. bella and C. citrina. Crypthonia athertoniensis Frisch & G. Thor, C. bella Frisch & G. Thor, C. brevispora Frisch & G. Thor, C. citrina Frisch & G. Thor, C. olivacea Frisch & G. Thor, C. palaeotropica Frisch & G. Thor, and C. vandenboomii Frisch & G. Thor are described. C. albida (F,e) Frisch & G. Thor, C. biseptata (Aptroot & Wolseley) Frisch & G. Thor, C. mycelioides (Vain.) Frisch & G. Thor, and C. polillensis (Vain.) Frisch & G. Thor are new combinations. The delimitation from similar genera and the position within the Arthoniaceae is discussed.
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| 9. |
- Frisch, Andreas, et al.
(författare)
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Four new Arthoniomycetes from Bwindi Impenetrable National Park, Uganda - supported by molecular data
- 2014
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Ingår i: Nova Hedwigia. - : Schweizerbart. - 0029-5035 .- 1438-9134. ; 98, s. 295-312
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Tidskriftsartikel (refereegranskat)abstract
- Arthonia physcidiicola Frisch & G.Thor, Chiodecton sorediatum G.Thor & Frisch, Herpothallon kigeziense Frisch & G.Thor and Reichlingia syncesioides Frisch & G.Thor are described as new to science. All species have been collected in the montane rainforests of Bwindi Impenetrable National Park in south western Uganda. The earlier monotypic genus Reichlingia with one anamorphic species is emended to include three fertile species and is newly reported to Africa. The combinations Reichlingia virginea (Mull.Arg.) Frisch for Arthothelium virgineum Mull.Arg. from the Usambara Mts. in north eastern Tanzania, and Reichlingia zwackhii (Sandst.) Frisch & G.Thor for the European Arthonia zwackhii Sandst. are made. A phylogenetic tree based on Bayesian and ML analyses of combined mtSSU, nLSU and RPB2 data showing the position of the new species in Arthoniomycetes is presented.
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| 10. |
- Frisch, Andreas, et al.
(författare)
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Herpothallon biacidum, a new lichen species from tropical Australia
- 2010
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Ingår i: Lichenologist. - 0024-2829 .- 1096-1135. ; 42, s. 285-289
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Tidskriftsartikel (refereegranskat)abstract
- Herpothallon biacidum Frisch et al. is described from Queensland, tropical Australia. The new species is characterized by a thick byssoid thallus that is loosely attached to the substratum, globular to claviform to short cylindrical pseudoisidia, a brown to brownish black hypothallus, and by the presence of gyrophoric and norstictic acids. This is the first reported co-occurrence of gyrophoric and norstictic acids in the genus. The differences between H. biacidum and other species containing either norstictic acid or gyrophoric acid are discussed. Herpothallon biacidum is also compared with Cryptothecia eungellaeae. Both occur in north Queensland and have the same chemistry, but the latter has a closely adnate thallus and lacks the dark hypothallus and pseudoisidia. The circumscription of Herpothallon and its distinction from Cryptothecia are discussed
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| 11. |
- Frisch, Andreas, et al.
(författare)
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Herpothallon inopinatum (Arthoniaceae), a new lichen species from Mexico
- 2014
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Ingår i: Annales Botanici Fennici. - : Finnish Zoological and Botanical Publishing Board. - 0003-3847 .- 1797-2442. ; 51, s. 63-68
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Tidskriftsartikel (refereegranskat)abstract
- Herpothallon inopinatum Frisch & G. Thor sp. nova (Arthoniaceae) is described from Chiapas, Mexico. It is the second species of Herpothallon known with mature ascospores besides H. fertile. It differs from H. fertile in smaller asci immersed in the thallus instead of strongly protruding barrel-shaped thallus warts, smaller bean-shaped Herpothallon inopinatum most closely resembles H. pustulatum, but differs in the absence of pustules. The closely related H. rubrocinctum has distinct bright-red pseudoisidia and a bright-red pigmentation of pro- and hypothallus, while H. inopinatum lacks pseudoisidia and has a pro- and hypothallus white mottled pale yellow to orange to purplish brown. A revised key to all 34 currently accepted species in Herpothallon is provided.
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| 12. |
- Frisch, Andreas, et al.
(författare)
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Herpothallon rubroechinatum (Arthoniaceae), a new species from tropical and subtropical America
- 2010
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Ingår i: Bryologist. - : American Bryological and Lichenological Society. - 0007-2745. ; 113, s. 144-148
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Tidskriftsartikel (refereegranskat)abstract
- Herpothallon rubroechinatum is described from the U.S.A. (Florida), Costa Rica and Peru. The new species is characterised by scattered red anthraquinone crystals being attached to hyphae projecting from the thallus, the globose to cylindrical pseudoisidia, a closely adnate thallus, and psoromic acid as the main lichen compound; pycnidia are common at the tips of the pseudoisidia. The medulla of the new species shows a patchily distributed amyloid reaction. Contrary to previous reports, the amyloidity of the medulla was observed in all Herpothallon species re-investigated during this study. H. rubroechinatum is compared to the two other red pigmented species that contain psoromic acid, H. australasicum that lacks pigment crystals on the pseudoisidia, and H. globosum that has a loosely attached thallus and a well developed red hypothallus.
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| 13. |
- Frisch, Andreas, et al.
(författare)
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The Arthonialean challenge: Restructuring Arthoniaceae
- 2014
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Ingår i: Taxon. - : Wiley. - 0040-0262 .- 1996-8175. ; 63, s. 727-744
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Tidskriftsartikel (refereegranskat)abstract
- The Arthoniales is the second-largest group of lichen-forming fungi. A new phylogeny of Arthoniales based on mtSSU, nLSU and RPB2 sequence data is presented, with a focus on crustose representatives. A total of 145 taxa are analyzed including 64 species of Arthoniaceae. We obtained 198 new sequences for 83 specimens representing 71 taxa of Arthoniales. Arthoniaceae is recovered as polyphyletic, demonstrating that previous classifications do not reflect evolutionary patterns. Three phylogenetic lineages are identified: the Arthoniaceae clade, the Bryostigma clade and the Felipes clade. The Bryostigma clade is related to Arthoniaceae, while the Felipes clade shows close affinities to Chrysotrichaceae. Cryptotheciaceae is included as a paraphyletic grouping in Arthoniaceae. Lecanographaceae and the genera Felipes and Melarthonis are described. Bryostigma and Pachnolepia are reinstated for former Arthonia species, and Myriostigma for the Cryptothecia candida complex. Fouragea is reinstated for foliicolous Opegrapha species. Arthonia eos is described and the new combination Alyxoria mougeotii is made. A lectotype is selected for Spiloma fallax. Melaspilea granitophila belongs in Arthoniaceae and Arthonia mediella in Chrysotrichaceae. According to the phylogenetic hypothesis, lichen secondary chemistry, such as pulvinic acid derivates or red pigments, does not characterize monophyletic groups above the genus level. The parasitic life style in Arthoniaceae has evolved more than once. Parasitic species are found in four lineages of the Arthoniaceae clade and in the Bryostigma clade. Arthoniomycetes with chlorococcoid photobionts are restricted to the Bryostigma clade and Chrysotrichaceae, while the only saprophytic Arthonia species in the phylogeny are related to Arthonia radiata and group with lichenized taxa. The phylogenetic data provide a coherent framework for delineating further monophyletic groups in Arthoniaceae in the future.
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| 14. |
- Hammarfjord, Oscar, et al.
(författare)
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Surgical treatment of recurring ameloblastoma, are there options?
- 2013
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Ingår i: British Journal of Oral & Maxillofacial Surgery. - : Elsevier BV. - 0266-4356 .- 1532-1940. ; 51:8, s. 762-766
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Tidskriftsartikel (refereegranskat)abstract
- Our aim was to evaluate the treatment given to patients with intraosseus ameloblastomas with special emphasis on recurrence and the outcomes of primary and secondary resection. Forty-eight patients who were treated for intraosseous ameloblastoma at 8 centres across Sweden met the inclusion criteria. They showed typical distribution of age, sex, site of lesion, and characteristic presenting features. Eleven of the 48 were initially treated with radical resection and none recurred. Twenty-two of the remaining 37 who were initially treated by conservative resection presented with recurrences. Sixteen of the 22 then had conservative secondary resections, which resulted in further recurrence in 6 patients. Initial radical resection is therefore superior to conservative management as far as recurrences are concerned. We argue, however, that a conservative surgical approach is adequate for many intraosseous ameloblastomas with limited extension, because relapse can be followed by radical resection if clinically indicated in selected cases.
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| 15. |
- Hong, Jaan, et al.
(författare)
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A Hydrophilic Dental Implant Surface Exhibit Thrombogenic Properties In Vitro
- 2013
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Ingår i: Clinical Implant Dentistry and Related Research. - : Wiley. - 1523-0899 .- 1708-8208. ; 15:1, s. 105-112
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Tidskriftsartikel (refereegranskat)abstract
- Background: Surface modifications of dental implants have gained attention during several years and the thrombotic response from blood components with these materials has become more important during recent years.Purpose:The aims of this study were to evaluate the thrombogenic response of whole blood, in contact with clinically used dental surfaces, Sandblasted Large grit Acid etched titanium (SLA) and Sandblasted Large grit Acid etched, and chemically modified titanium with hydrophilic properties (SLActive).Methods: An in vitro slide chamber model, furnished with heparin, was used in which whole blood came in contact with slides of the test surfaces. After incubation (60-minute rotation at 22 rpm in a 37°C water bath), blood was mixed with ethylenediaminetetraacetic acid (EDTA) or citrate, further centrifuged at +4°C. Finally, plasma was collected pending analysis.Results:Whole blood in contact with surfaces resulted in significantly higher binding of platelets to the hydrophilic surface, accompanied by a significant increase of contact activation of the coagulation cascade. In addition, the platelet activation showed a similar pattern with a significant elevated release of β-TG from platelet granule.Conclusions:The conclusion that can be drawn from the results in our study is that the hydrophilic modification seems to augment the thrombogenic properties of titanium with implications for healing into bone of, that is titanium dental implants.
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| 16. |
- Köttgen, Anna, et al.
(författare)
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New loci associated with kidney function and chronic kidney disease
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:5, s. 376-384
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Tidskriftsartikel (refereegranskat)abstract
- Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m2; n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide–significant loci (P < 5 × 10−8) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.
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| 17. |
- Lango Allen, Hana, et al.
(författare)
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Hundreds of variants clustered in genomic loci and biological pathways affect human height.
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 467:7317, s. 832-8
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Tidskriftsartikel (refereegranskat)abstract
- Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.
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| 18. |
- Rasmusson, Lars, 1962, et al.
(författare)
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Stability Evaluation of Implants Integrated in Grafted and Nongrafted Maxillary Bone : a Clinical Study from Implant Placement to Abutment Connection
- 2012
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Ingår i: Clinical Implant Dentistry and Related Research. - : Wiley. - 1523-0899 .- 1708-8208. ; 14:1, s. 61-66
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Tidskriftsartikel (refereegranskat)abstract
- Background: Clinical studies have shown a higher degree of implant failures in grafted bone compared with normal nongrafted maxillary bone. Additionally, a prolonged time for integration of titanium implants in grafted block bone has been shown by means of resonance frequency analysis (RFA). Purpose: The aim of this prospective study was to compare the stability of implants placed in particulate bone, onlay block bone, interpositional bone, and nongrafted maxillary bone during the early phase of osseointegration using RFA and implant failure. Material and Methods: Thirty-five patients with edentulism in the maxilla were included in the study. In all, 260 Astra Tech TiOblast™ implants (Astra Tech AB, Mölndal, Sweden) were installed. Twenty-five of these patients had severe maxillary atrophy and were treated with iliac bone grafts 5 to 6 months prior to implant placement, 19 with lateral onlay block grafts on one side (group A, 38 implants) and particulate bone for lateral augmentation on the other (group B, 38 implants). These 19 patients also got bilateral sinus floor augmentation with particulate bone (group C, 76 implants). Six patients had an unfavorable sagittal relation between the jaws and underwent a LeFort I operation with interpositional bone blocks grafted to the nasal and sinus floors (group D, 48 implants). The remaining 10 patients could be treated with implants without bone augmentation and served as control (group E, 60 implants). RFA was performed at implant placement and abutment connection 6 months later and an implant stability quotient (ISQ) value was given for each implant. Results: Four implants (1.5%) were found mobile at abutment connection and removed (two in group A and two in group D). RFA showed a slight increase in stability from installation to abutment connection but the differences were not statistically significant in any of the groups (Wilcoxon signed rank test for comparison of paired data). Implants installed in group D had a significantly lower ISQ value at both measurements compared with the other groups (Wilcoxon Rank Sum test for comparisons of independent samples, p = .05). Conclusion: It is concluded that TiO(2) -blasted implants placed in nongrafted and grafted maxillary bone using a two-staged protocol show similar stability during the early phase of osseointegration. Patients reconstructed with interpositional bone graft after a LeFort I osteotomy showed lower implant stability values than nongrafted patients and other grafting techniques.
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| 19. |
- Riben, Christopher, et al.
(författare)
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The Maxillary Sinus Membrane Elevation Procedure : Augmentation of Bone around Dental Implants without Grafts - A Review of a Surgical Technique
- 2012
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Ingår i: International journal of dentistry. - : Hindawi Limited. - 1687-8736 .- 1687-8728. ; 2012, s. 105483-
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundLong-term edentulism may in many cases result in resorption of the alveolar process. The sinus lift procedure aims to create increased bone volume in the maxillary sinus in order to enable installation of dental implants in the region. The method is over 30 years old, and initially autogenous bone grafts were used and later also different bone substitutes. Since 1997, a limited number of studies have explored the possibility of a graftless procedure where the void under the sinus membrane is filled with a blood clot that enables bone formation.AimTo describe the evolution of the sinus-lift technique and to review the literature related to the technique with a focus on long-term studies related to the graft-less technique.MethodsThe electronic database PubMed was searched, and a systematic review was conducted regarding relevant articles.ResultsA relatively few long-term studies using the described technique were found. However, the technique was described as reliable considering the outcome of the existing studies.ConclusionAll investigated studies show high implant survival rates for the graftless technique. The technique is considered to be cost-effective, less time-consuming, and related to lower morbidity since no bone harvesting is needed.
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| 20. |
- Rodriguez-Lorenzo, Andres, et al.
(författare)
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Fibula osteo-adipofascial flap for reconstruction of a cervical spine and posterior pharyngeal wall defect
- 2014
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Ingår i: Microsurgery. - : Wiley. - 0738-1085 .- 1098-2752. ; 34:4, s. 314-318
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Tidskriftsartikel (refereegranskat)abstract
- When reconstructing combined defects of the cervical spine and the posterior pharyngeal wall the goals are bone stability along with continuity of the aerodigestive tract. We present a case of a patient with a cervical spine defect, including C1 to C3, associated with a posterior pharyngeal wall defect after excision of a chordoma and postoperative radiotherapy. The situation was successfully solved with a free fibula osteo-adipofascial flap. The reconstruction with a fibula osteo-adipofascial flap provided several benefits in comparison with a fibula osteo-cutaneous flap in our case, including an easier insetting of the soft tissue component at the pharyngeal level and less bulkiness of the flap allowing our patient to resume normal deglutition.
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| 21. |
- Speliotes, Elizabeth K., et al.
(författare)
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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| 22. |
- Thor, Andreas, et al.
(författare)
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Fracture of the tympanic plate with soft tissue extension into the auditory canal resulting from an unfavorable chewing experience
- 2010
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Ingår i: Dental Traumatology. - : Wiley. - 1600-4469 .- 1600-9657. ; 26:1, s. 112-114
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Tidskriftsartikel (refereegranskat)abstract
- We present a case where a patient sustained a tympanic plate fracture of the right side while chewing a sandwich. Intense pain with temporomandibular joint (TMJ) symptoms such as restrained painful mouth opening and functional pain in full occlusion followed the incident and the fracture was diagnosed after ocular and CT-examination of the right external auditory canal. Non-ruptured soft tissue could be seen protruding into the external auditory canal and the size of the mass changed during movement of the TMJ. Treatment was not needed to resolve the situation and at 3-year follow-up the patient has no clinical symptoms.
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| 23. |
- Thor, Andreas Li, et al.
(författare)
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Correlation of Platelet Growth Factor Release in Jawbone Defect Repair - A Study in the Dog Mandible.
- 2013
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Ingår i: Clinical implant dentistry and related research. - : Wiley. - 1708-8208 .- 1523-0899. ; 15:5, s. 759-768
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Tidskriftsartikel (refereegranskat)abstract
- Background: Platelet concentrate/platelet-rich plasma (PRP) has been studied extensively in various experimental models and there is some agreement among workers to its early effect in bone regeneration and healing. We have earlier showed in vitro that titanium in whole blood activates the thrombogenic response to a higher degree than PRP and that a fluoridated test surface augmented the effect compared with control. Purpose: We designed this study to evaluate the effect of PRP and whole blood on bone regeneration in a dog implant defect model and, in addition, the effect of a test surface modified in hydrofluoric acid. A correlation attempt between platelet count, release of growth factors, and bone regeneration was made. Materials and Methods: Six dogs were used and simultaneously with the experimental surgery and implant installation, autologous PRP was prepared. Defects were prepared (6mm in diameter and 5mm deep), and implants were installed (TiO(2) gritblasted and hydrofluoric acid treated [test] or TiO(2) gritblasted [control], 5mm in diameter and 9mm long) in defects filled with either PRP or whole blood. Randomization of sides between PRP and whole blood, and sites for test and control implants were made. Blood samples were collected from PRP and whole blood. The dogs were killed after 5 weeks of healing, and samples with implants and surrounding bone were collected and processed for analysis. Enzyme linked immunosorbent assays were used for detection of growth factors in PRP. Results: The mean increase of platelet count was 424% in PRP. A correlation for platelet counts and transforming growth factor β was found in each dog (r(2) =0.857). Approximately 50% of the region of interest (ROI) in the defects was filled with new bone after 5 weeks. No difference could be observed in ROI by using PRP or whole blood in the defects regarding new bone formation, bone in contact with implant, or distance to first bone contact. However, the fluoridated implants exhibited more new bone formation (p=.03) compared with control, regardless of comparing PRP or whole blood, and also displayed a shorter distance from first bone contact to the margin of the bone envelope (p=.05). Conclusions: Platelet concentrate/PRP failed to show more new bone regeneration in a peri-implant defect model compared with whole blood. Implants treated with hydrofluoric acid displayed higher percentages of bone fill in the defect.
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| 24. |
- Thor, Andreas
(författare)
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Porous Titanium Granules and Blood for Bone Regeneration around Dental Implants : Report of Four Cases and Review of the Literature
- 2013
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Ingår i: Case Reports in Dentistry. - : Hindawi Limited. - 2090-6447 .- 2090-6455. ; 2013, s. 410515-
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Tidskriftsartikel (refereegranskat)abstract
- A regenerative procedure treating a local osseous defect around titanium dental implant using porous titanium granules is described in four patients. Porous titanium granules represent, for maxillofacial surgery, a new alternative in augmenting osseous defects. Its earliest application was in the field of orthopedics for stabilization of tibia plateau fractures and for reoperations in prosthetic fixation of femoral stems. There is emerging scientific evidence regarding titanium for its potential use in the maxillofacial area and porous titanium granules are now commercially available. The scientific background for the osteoconductive use of porous titanium granules is elucidated in this paper and the supporting literature is reviewed.
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| 25. |
- Thor, Andreas, 1979-
(författare)
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Studies on Juvencus' Language and Style
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis deals with the language and style used in the poem Evangeliorum Libri Quattuor by the fourth-century Christian poet Juvencus. The poem, a rendering of the biblical story of Jesus in dactylic poetry, initiated a literary genre, which is referred to as biblical epic.Juvencus’ language is characterized by use of different linguistic features. In parallel with aspects that are characteristic also of earlier poetry, there are many features that have rare or no counterpart in previous poetry. Thus, Juvencus’ linguistic usage is often complex, drawing influence from a wide variety of sources.The thesis deals with features of vocabulary, syntax and stylistics. The principal aim is to show how Juvencus linguistically transformed the text of the biblical model. Throughout, attempts are made to elucidate the sources, from which Juvencus drew linguistic material. Common sources include the language of epic poetry, archaically coloured language, the contemporary Late Latin language, prosaically coloured language and language influenced by the biblical model. As far as possible, attention is drawn to influence from other poets, and to Juvencus’ influence on later poets.It is shown that a number of previous statements concerning Juvencus’ linguistic usage need to be modified, and that a correct description of the Evangeliorum Libri Quattuor must take into account the full complexity of Juvencus’ language.
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| 26. |
- Thor, Andreas, et al.
(författare)
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Three-year Follow-up of Immediately Loaded Implants in the Edentulous Atrophic Maxilla : A Study in Patients with Poor Bone Quantity and Quality
- 2014
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Ingår i: International Journal of Oral & Maxillofacial Implants. - 0882-2786 .- 1942-4434. ; 29:3, s. 642-649
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Immediate loading of implants in the edentulous maxilla has previously been successfully performed and reported. Severe resorption of the maxillary alveolar crest presents a more demanding situation for the restorative team. Thus, it would be valuable to assess outcomes for this immediate loading treatment protocol in subjects with marked maxillary alveolar crest atrophy. This study evaluated the 3-year results of dental implants that were immediately restored with provisional fixed prostheses in atrophic maxillae without previous augmentation. Materials and Methods: Two centers enrolled subjects with resorbed edentulous maxillae (Lekholm and Zarb quality 3 or 4 and quantity C, D, or E). Six implants were placed in each subject and restored with screw-retained fixed provisionals within 24 hours. Impressions were taken for definitive restorations, which were placed 20 to 24 weeks later. Radiographs were used to analyze marginal bone level changes throughout the study. Results: Fifty-one patients received 306 implants. Forty-five patients remained in the study at the 3-year follow-up visit and successfully used their definitive prostheses. Sixty-two percent of the implants were placed in bone quantity C and quality 3 or 4, and 38% were placed in quantity D and quality 3 or 4 bone. Thirteen implants in six subjects were lost, resulting in a cumulative survival rate of 96% after 3 years. The mean marginal bone loss during the first year was -0.4 +/- 0.8 mm (255 implants); at 3 years it was -0.6 +/- 1.1 mm (253 implants). Conclusion: Data from the first 3 years of this study revealed good clinical outcomes. Careful selection of patients and planning by the restorative team can enable successful treatment outcomes for patients presenting with marked resorption of the edentulous maxilla.
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| 27. |
- Thor, Göran, et al.
(författare)
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Increase of Lichen Diversity in the Imperial Palace Grounds, Tokyo, Japan
- 2014
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Ingår i: Memoirs of the National Museum of Nature and Science, Tokyo. - 0082-4755. ; 49, s. 193-217
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Tidskriftsartikel (refereegranskat)abstract
- The lichen flora in the Imperial Palace Grounds, Tokyo, was investigated in 2009- 2013. A total of 98 species of lichens and related fungi were found during the investigation, which is almost doubled compared to a previous study in 1995-1996 when 57 species were discovered. Eight species found in 1995-1996 were not found again in 2009-2013. A Total of 106 species has been found during the investigations in 1995-1996 and 2009-2013. Enterographa hutchinsiae and Porina leptalea are reported as new to Japan, while Arthonia pertabescens, Aspicilia cinerea, Chaenotheca hygrophila, Coenogonium pineti, Cresponea japonica, Endocarpon petrolepideum, Graphis handelii, G. scripta, Lecanora leprosa, Lithothelium japonicum, Normandina pulchella, Pertusaria pertusa, Sculptolumina japonica, and Thelidium japonicum are new to the Imperial Palace Grounds. Forty-six species could only be determined to genus and three species are indicated as Lichen sp. for the specimens collected through both investigations in 1995-1996 and 2009- 2013. Twenty-three of the species determined only to genus and as Lichen sp. are also new to the investigated area. The increase in lichen diversity is probably caused by the reduction of air pollution due to new regulations regarding exhaust emissions from automobiles in and around Tokyo, established in 2003.
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