| 1. |
- Antonsson, Malin, 1986, et al.
(författare)
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Post-surgical effects on language in patients with presumed low-grade glioma
- 2018
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Ingår i: Acta Neurologica Scandinavica. - : Hindawi Limited. - 0001-6314. ; 137:5, s. 469-480
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Low-grade glioma (LGG) is a slow-growing brain tumour often situated in or near areas involved in language and/or cognitive functions. Thus, language impairments due to tumour growth or surgical resection are obvious risks. We aimed to investigate language outcome following surgery in patients with presumed LGG, using a comprehensive and sensitive language assessment. Materials and methods: Thirty-two consecutive patients with presumed LGG were assessed preoperative, early post-operative, and 3 months post-operative using sensitive tests including lexical retrieval, language comprehension and high-level language. The patients’ preoperative language ability was compared with a reference group, but also with performance at post-operative controls. Further, the association between tumour location and language performance pre-and post-operatively was explored. Results: Before surgery, the patients with presumed LGG performed worse on tests of lexical retrieval when compared to a reference group (BNT: LGG-group median 52, Reference-group median 54, P = .002; Animals: LGG-group mean 21.0, Reference-group mean 25, P = 001; Verbs: LGG-group mean 17.3, Reference-group mean 21.4, P = .001). At early post-operative assessment, we observed a decline in all language tests, whereas at 3 months there was only a decline on a single test of lexical retrieval (Animals: preoperative. median 20, post-op median 14, P = .001). The highest proportion of language impairment was found in the group with a tumour in language-eloquent areas at all time-points. Conclusions: Although many patients with a tumour in the left hemisphere deteriorated in their language function directly after surgery, their prognosis for recovery was good.
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| 2. |
- Antonsson, Malin, 1986, et al.
(författare)
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Pre-operative language ability in patients with presumed low-grade glioma
- 2018
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Ingår i: Journal of Neuro-Oncology. - : Springer Science and Business Media LLC. - 0167-594X .- 1573-7373. ; 137:1, s. 93-102
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Tidskriftsartikel (refereegranskat)abstract
- In patients with low-grade glioma (LGG), language deficits are usually only found and investigated after surgery. Deficits may be present before surgery but to date, studies have yielded varying results regarding the extent of this problem and in what language domains deficits may occur. This study therefore aims to explore the language ability of patients who have recently received a presumptive diagnosis of low-grade glioma, and also to see whether they reported any changes in their language ability before receiving treatment. Twenty-three patients were tested using a comprehensive test battery that consisted of standard aphasia tests and tests of lexical retrieval and high-level language functions. The patients were also asked whether they had noticed any change in their use of language or ability to communicate. The test scores were compared to a matched reference group and to clinical norms. The presumed LGG group performed significantly worse than the reference group on two tests of lexical retrieval. Since five patients after surgery were discovered to have a high-grade glioma, a separate analysis excluding them were performed. These analyses revealed comparable results; however one test of word fluency was no longer significant. Individually, the majority exhibited normal or nearly normal language ability and only a few reported subjective changes in language or ability to communicate. This study shows that patients who have been diagnosed with LGG generally show mild or no language deficits on either objective or subjective assessment.
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| 3. |
- Backman, Sofia, et al.
(författare)
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Swedish consensus reached on recording, interpretation and reporting of neonatal continuous simplified electroencephalography that is supported by amplitude-integrated trend analysis
- 2018
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Ingår i: Acta Paediatrica. - : WILEY. - 0803-5253 .- 1651-2227. ; 107:10, s. 1702-1709
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Tidskriftsartikel (refereegranskat)abstract
- Continuous monitoring of electroencephalography (EEG), with a focus on amplitude-integrated EEG (aEEG), has been used in neonatal intensive care for decades. A number of systems have been suggested for describing and quantifying aEEG patterns. Extensive full-montage EEG monitoring is used in specialised intensive care units. The American Clinical Neurophysiology Society published recommendations for defining and reporting EEG findings in critically ill adults and infants. Swedish neonatologists and clinical neurophysiologists collaborated to optimise simplified neonatal continuous aEEG and EEG recordings based on these American documents. Conclusion: This paper describes the Swedish consensus document produced by those meetings.
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| 4. |
- Gu, Irene Yu-Hua, 1953, et al.
(författare)
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3D Limb Movement Tracking and Analysis for Neurological Dysfunctions of Neonates Using Multi-Camera Videos
- 2016
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Ingår i: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. - 1557-170X. - 9781457702204 ; 2016-October, s. 2395-2398
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Konferensbidrag (refereegranskat)abstract
- Central nervous system dysfunction in infants may be manifested through inconsistent, rigid and abnormal limb movements. Detection of limb movement anomalies associated with such neurological dysfunctions in infants is the first step towards early treatment for improving infant development. This paper addresses the issue of detecting and quantifying limb movement anomalies in infants through non-invasive 3D image analysis methods using videos from multiple camera views. We propose a novel scheme for tracking 3D time trajectories of markers on infant’s limbs by video analysis techniques. The proposed scheme employ videos captured from three camera views. This enables us to detect a set of enhanced 3D markers through cross-view matching and to effectively handle marker self-occlusions by other body parts. We track a set of 3D trajectories of limb movements by a set of particle filters in parallel, enabling more robust 3D tracking of markers, and use the 3D model errors for quantifying abrupt limb movements. The proposed work makes a significant advancement to the previous work in [1] through employing tracking in 3D space, and hence overcome several main barriers that hinder real applications by using single camera-based techniques. To the best of our knowledge, applying such a multi-view video analysis approach for assessing neurological dysfunctions of infants through 3D time trajectories of markers on limbs is novel, and could lead to computer-aided tools for diagnosis of dysfunctions where early treatment may improve infant development. Experiments were conducted on multi-view neonate videos recorded in a clinical setting and results have provided further support to the proposed method.
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| 5. |
- Selassie, G. R. H., et al.
(författare)
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Navigated transcranial magnetic stimulation for preoperative cortical mapping of expressive language in children: Development of a method
- 2018
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Ingår i: Epilepsy & Behavior. - : Elsevier BV. - 1525-5050 .- 1525-5069. ; 87, s. 180-187
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Tidskriftsartikel (refereegranskat)abstract
- We adjusted an object-naming task with repetitive navigated transcranial magnetic stimulation (rnTMS) originally developed for preoperative cortical language mapping in adults in order for it to be used in children. Two series of pictures were chosen for children above and below 10 years of age, respectively. Firstly, the series of pictures and the preferred speed of presentation were assessed for their applicability in children of different ages and abilities. Secondly, these series were used with rnTMS preoperatively in five children with epilepsy. Naming errors induced by the stimulation comprised no response, delayed response, semantic error, phonological error, and self-correction. Language laterality was compared with the results of a dichotic listening test and with neuropsychological tests with respect to general laterality, and general language abilities were considered with respect to the results of stimulation. One participant had below normal general language abilities, two had below-normal rapid naming, and three had slow and indistinct articulation. Laterality was only clear in two of the participants. All children required breaks of various durations during the process, and individual adjustments of the interpicture interval and other stimulation parameters were also made. We conclude that, after adjustment, rnTMS combined with an object-naming task can be useful for preoperative language mapping in children.
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| 6. |
- Xu, Long, et al.
(författare)
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Video-based Tracking and Quantified Assessment of Spontaneous Limb Movements in Neonates
- 2015
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Ingår i: 17th IEEE Int'l conf. on E-Health, Networking, Application & Services (HealthCom'15), 2015. - 9781467383257 ; , s. 517-522
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Konferensbidrag (refereegranskat)abstract
- Central nervous system dysfunction in infants may be manifested through inconsistent, rigid and abnormal limbmovements. Detection and quantification of these movements in infants from videos are hence desirable for providing useful information to clinicians. This could lead to computer-aided diagnosis of dysfunctions where early treatment may improve infant development. In this paper, we propose a scheme for detecting and quantifying qualitative aspects of limb movement through multiple tracking and state space motion modeling on videos. The main novelties of the paper include: (a) An enhanced detection method for effectively detection small weak marker points from video; (b) Bayesian estimation and nearest neighbor searching for selecting new observation in individual tracker and for tracking marker trajectories on limbs; (c) A criterion foranomaly detection based on the frequency and duration of abrupt changes in limb movement, using window averaged prominent residual powers. The proposed method has been tested on videos of neonates, results show that the proposed method is promising for tracking and quantifying the movement of neonate limbs for helping medical diagnostics.
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