| 1. |
- Aurumskjöld, Marie-Louise, et al.
(författare)
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A PHANTOM STUDY SHOWING THE IMPORTANCE OF COMPRESSION IN CONVENTIONAL DIAGNOSTIC X-RAY EXAMINATIONS.
- 2010
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Ingår i: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 1742-3406 .- 0144-8420. ; Apr 7, s. 78-80
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Tidskriftsartikel (refereegranskat)abstract
- Compression was earlier an important and well-managed part of the clinical routine, but during the past 15-20 y the use has diminished, except for mammography, where it is a prerequisite for having images of high quality and low radiation dose. According to national and European regulations and recommendations, it is important to apply the compression technique to obtain the optimal image quality and radiation dose in common conventional diagnostic examinations. Current experience of compression technique is, however, based on studies carried out a long time ago and with analogue imaging techniques. An anthropomorphic phantom was used to show the importance of compression in conventional X-ray examinations. The patient thicknesses on volunteers with and without compression was measured. This measurement was done to investigate compression potential on patients and to select suitable phantom thicknesses. The X-ray examinations that were included in the study were abdomen overview, lumbar spine and the pelvis. The results from the phantom study showed a large dependency of the kerma-area product value on the phantom thickness. The phantom study suggests that there is a potential for significant reduction of radiation dose to the patient by using compression also with modern X-ray techniques. A dose reduction of up to 50 % or even more may be obtained.
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| 2. |
- Dustler, Magnus, et al.
(författare)
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A Study of the Feasibility of using slabbing to reduce Tomosynthesis Review Time
- 2013
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Ingår i: Medical Imaging 2013: Image Perception, Observer Performance, And Technology Assessment. - : SPIE. - 0277-786X .- 1996-756X. ; 8673, s. 86731-86731
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Konferensbidrag (refereegranskat)abstract
- This study aimed to investigate whether decreasing the amount of slices in breast tomosynthesis (BT) image volumes reduce reading time. BT slices were combined into so-called slabs, by reconstructing thin slices and merging them into thicker slabs. Sets of slabs where created from 35 clinical BT volumes with malignant or benignant findings and from 50 BT volumes drawn from screening sets (without any prior review). The image sets were reviewed in two separate sessions while the review time was recorded. A total of five experienced radiologists were employed for the image review. Additionally a VGA study was performed to compare slabbed images with the originals in order to ensure that the image quality was not significantly degraded. One set of 27 pathological cases (13 masses and 14 microcalcification clusters) and one of 22 subtle lesions that had been missed on digital mammography but detected on BT were presented to an experienced radiologist and 2 medical physicists who rated the quality of the slabbed versions relative to the originals. The study could find no significant degradation in image quality when using 2 mm slabs instead of 1 mm slices. There was no significant decrease in reading time on clinical cases (P=.133), but on screening images there was a significant decrease of 7.7 +/- 9.6 s from an average level of 32.2 +/- 14.5 s (P<.0001). This suggests that increasing slab thickness can reduce the time radiologists spend studying normal images by 20%.
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| 3. |
- Dustler, Magnus, et al.
(författare)
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Breast compression in mammography: pressure distribution patterns
- 2012
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Ingår i: Acta Radiologica. - : SAGE Publications. - 1600-0455 .- 0284-1851. ; 53:9, s. 973-980
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Tidskriftsartikel (refereegranskat)abstract
- Background: Breast compression is important in mammography in order to improve image quality, better separate tissue components, and reduce absorbed dose to the breast. In this study we use a method to measure and visualize the distribution of pressure over a compressed breast in mammography. Purpose: To measure and describe the pressure distribution over the breast as a result of applied breast compression in mammography. Material and Methods: One hundred and three women aged 40.7-74.3 years (median, 48.9 years) invited for mammographic screening consented to take part in this study. They were subjected to two additional breast compressions of the left breast (standard force and approximately 50% reduction). Pressure images of the compressed breast were obtained using force sensing resistor (FSR) sensors placed underneath the compression plate. Subjects rated their experience of pain on a visual analogue scale (VAS). Results: Four pressure patterns were identified, fitting 81 of the 103 breasts, which were grouped accordingly. The remaining 22 breasts were found to correspond to a combination of any two patterns. Two groups (43 breasts) showed pressure mainly over the juxtathoracic part of the breast, had significantly greater breast thickness (P = 0.003) and had a lower mean pressure over dense tissue (P < 0.0001) than those with more evenly distributed pressure. Reducing compression force increased average breast thickness by 1.8 mm (P < 0.0001). Conclusion: The distribution of pressure differed greatly between breasts. In a large proportion of breasts the compression plate did not provide optimal compression of the breast, the compression force being absorbed in juxtathoracic structures.
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| 4. |
- Dustler, Magnus, et al.
(författare)
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The Effect of Breast Positioning on Breast Compression in Mammography: a Pressure Distribution Perspective
- 2012
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Ingår i: Medical Imaging 2012: Physics of Medical Imaging. - : SPIE. - 0277-786X .- 1996-756X. ; 8313
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Konferensbidrag (refereegranskat)abstract
- The standard procedure at mammography is to compress the breast in order to improve image quality, better separate tissue components and reduce absorbed dose to the breast. Traditionally, compression guidelines have been based on applied force, rather than actual thickness reduction. Structures such as the pectoral muscle are stiffer than breast tissue and if compressed along with it, as in the MLO-projection, might absorb much of the applied force. This study investigated the difference in compression of breasts before and after they were repositioned to exclude 1 cm of the juxtathoracic part. Twenty-one women were included in the study. The distribution of compression pressure was measured using thin FSR (Force Sensing Resistor) pressure sensors attached to the compression paddle. Breast thickness and compression force were measured by the mammographic device. Compared to standard positioning the repositioned breasts were thinner by 4.4 +/- 2.3 mm (P < 0.001) (from 50.3 mm to 45.9 mm) and had a 12.3 +/- 24.5 cm(2) (P = 0.032) larger area over which pressure was distributed (from 97.6 cm(2) to 109.9 cm(2)), despite less of the breast being included in the projection. This indicates that the inclusion of the pectoral muscle and other juxtathoracic structures in the MLO-projection substantially affects pressure distribution and prevents proper compression of the breast. The results suggest that the exact positioning of the MLO-projection should be carefully evaluated in order to find a balance between breast compression and tissue inclusion.
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| 5. |
- Förnvik, Daniel, et al.
(författare)
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A human observer study for evaluation and optimization of reconstruction methods in breast tomosynthesis using clinical cases
- 2011
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Ingår i: Medical Imaging 2011: Physics of Medical Imaging. - : SPIE. - 0277-786X .- 1996-756X. ; 7961, s. 79615-79615
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Konferensbidrag (refereegranskat)abstract
- In breast tomosynthesis1 (BT) a number of 2D projection images are acquired from different angles along a limited arc. The imaged breast volume is reconstructed from the projection images, providing 3D information. The purpose of the study was to investigate and optimize different reconstruction methods for BT in terms of image quality using human observers viewing clinical cases. Sixty-six cases with suspected masses and calcifications were collected from 55 patients. Four different reconstructions of each image set were evaluated by four observers (two experienced radiologists, two experienced medical physicists): filtered back projection (FBP), iterative adapted FBP (iFBP) and two ML-convex iterative algorithm (MLCI) reconstructions (8 and 10 iterations) that differed in noise level and contrast of clinical details. Representation of masses and microcalcifications was evaluated. The structures were rated according to the overall appearance in a rank-order study. The differently reconstructed images of the same structure were displayed side by side in random order. The observers were forced to rank the order of the different reconstructed images and their proportions at each rank were scored. The results suggest that even though the FBP contains most noise its reconstructions are considered best overall, followed by iFBP, which contains least noise. In both FBP and iFBP methods the sharp borders and mass speculations were better represented than in iterative reconstructions while out-of-plane artifacts were better suppressed in the latter. However, in clinical practice the differences between the reconstructions may be considered negligible.
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| 6. |
- Förnvik, Daniel, et al.
(författare)
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Breast tomosynthesis: Accuracy of tumor measurement compared with digital mammography and ultrasonography.
- 2010
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Ingår i: Acta radiologica (Stockholm, Sweden : 1987). - : SAGE Publications. - 1600-0455 .- 0284-1851. ; 51, s. 240-247
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Tidskriftsartikel (refereegranskat)abstract
- Background: Mammographic tumor size measurement can be difficult because breast structures are superimposed onto a two-dimensional (2D) plane, potentially obscuring the tumor outline. Breast tomosynthesis (BT) is a 3D X-ray imaging technique in which low-dose images are acquired over a limited angular range at a total dose comparable to digital mammography (DM). These low-dose images are used to mathematically reconstruct a 3D image volume of the breast, thus reducing the problem of superimposed tissue. Purpose: To investigate whether breast cancer size can be more accurately assessed with breast tomosynthesis than with digital mammography and ultrasonography (US), by reducing the disturbance effect of the projected anatomy. Material and Methods: A prototype BT system was used. The main inclusion criterion for BT examination was subtle but suspicious findings of breast cancer on 2D mammography. Sixty-two women with 73 breast cancers were included. BT, DM, and US sizes were measured independently by experienced radiologists without knowledge of the pathology results, which were used as reference. Results: The tumor outline could be determined in significantly more cases with BT (63) and US (60) than DM (49). BT and US size correlated well with pathology (R=0.86 and R=0.85, respectively), and significantly better than DM size (R=0.71). Accordingly, staging was significantly more accurate with BT than with DM. Conclusion: The study indicates that BT is superior to DM in the assessment of breast tumor size and stage.
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| 7. |
- Förnvik, Daniel, et al.
(författare)
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No evidence for shedding of circulating tumor cells to the peripheral venous blood as a result of mammographic breast compression.
- 2013
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Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 1573-7217 .- 0167-6806. ; 141:2, s. 187-195
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Tidskriftsartikel (refereegranskat)abstract
- This pilot study aimed to investigate whether mammographic compression procedures might cause shedding of tumor cells into the circulatory system as reflected by circulating tumor cell (CTC) count in peripheral venous blood samples. From March to October 2012, 24 subjects with strong suspicion of breast malignancy were included in the study. Peripheral blood samples were acquired before and after mammography. Enumeration of CTCs in the blood samples was performed using the CellSearch(®) system. The pressure distribution over the tumor-containing breast was measured using thin pressure sensors. The median age was 66.5 years (range, 51-87 years). In 22 of the 24 subjects, breast cancer was subsequently confirmed. The difference between the average mean tumor pressure 6.8 ± 5.3 kPa (range, 1.0-22.5 kPa) and the average mean breast pressure 3.4 ± 1.6 kPa (range, 1.5-7.1 kPa) was statistically significant (p < 0.001), confirming that there was increased pressure over the tumor. The median pathological tumor size was 19 mm (range, 9-30 mm). Four subjects (17 %) were CTC positive before compression and two of these (8 %) were also CTC positive after compression. A total of seven CTCs were isolated with a mean size of 8 × 6 μm(2) (range of the longest diameter, 5-12 μm). The study supports the view that mammography is a safe procedure from the point of view of tumor cell shedding to the peripheral blood.
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| 8. |
- Förnvik, Daniel, et al.
(författare)
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Pressure distribution in mammography: compression of breasts with malignant tumor masses
- 2013
-
Ingår i: Medical Imaging 2013: Physics of Medical Imaging. - : SPIE. - 1996-756X .- 0277-786X. ; 8668, s. 86684-86684
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Konferensbidrag (refereegranskat)abstract
- The pressure distribution over a compressed breast is in general heterogeneous. In this study we investigated the pressure distribution over compressed breasts with tumor masses. Twenty-two women either recalled for work-up of findings suspicious for breast cancer in the screening program or with clinically suspected findings were included in the study. Twenty-one lesions turned out to be malignant and one benign. The distribution of compression pressure was measured using thin FSR (Force Sensing Resistor) pressure sensors attached to the compression plate. The pressure over the breast was ascertained by acquiring an x-ray image of the compressed breast with the pressure sensors present. The pressure data and the mammogram were used to create a composite image with pressure data displayed as a color overlay. The malignant tumor area generally matched an elevated pressure area and this pressure was generally higher than the pressure over surrounding parenchyma. In 11 out of 22 (50%) subjects the maximum pressure over the breast was located over the tumor. Only 4 out of 22 (18%) masses had a lower tumor mean pressure compared to the mean pressure over the breast (including one small < 10 mm tumor and one benign structure). The results suggest that tumors are stiffer, thus, absorbing more pressure compared to the surrounding parenchyma and that this property can be quantified. Refined pressure techniques could possibly be used to demonstrate the relative elasticity distribution in breast tissue, which might provide valuable differential diagnostic information.
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| 9. |
- Förnvik, Daniel, et al.
(författare)
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THE EFFECT OF REDUCED BREAST COMPRESSION IN BREAST TOMOSYNTHESIS: HUMAN OBSERVER STUDY USING CLINICAL CASES.
- 2010
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Ingår i: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 1742-3406 .- 0144-8420. ; Apr 7, s. 118-123
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate whether the compression force used with conventional mammography can be reduced with breast tomosynthesis (BT), without adversely affecting the visualisation of normal and pathological structures. Forty-five women were examined with BT using full (same as for 2D mammography) and half compression force. Both examinations were performed with the same acquisition parameters. A total of 103 paired structure images were evaluated according to specified image quality criteria. Three experienced radiologists participated in the study. They had to make a forced choice, i.e. choose the image they felt best fulfilled the image quality criteria. The results showed no evident difference in the image quality, indicating that BT may be performed with substantially less compression force compared with 2D mammography. A majority of the examined women felt that half compression was more comfortable than full compression.
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| 10. |
- Jensen, Kristin, et al.
(författare)
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Comparing five different iterative reconstruction algorithms for computed tomography in an ROC study
- 2014
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Ingår i: European Radiology. - : Springer Science and Business Media LLC. - 0938-7994 .- 1432-1084. ; 24:12, s. 2989-3002
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to evaluate lesion conspicuity achieved with five different iterative reconstruction techniques from four CT vendors at three different dose levels. Comparisons were made of iterative algorithm and filtered back projection (FBP) among and within systems. An anthropomorphic liver phantom was examined with four CT systems, each from a different vendor. CTDIvol levels of 5 mGy, 10 mGy and 15 mGy were chosen. Images were reconstructed with FBP and the iterative algorithm on the system. Images were interpreted independently by four observers, and the areas under the ROC curve (AUCs) were calculated. Noise and contrast-to-noise ratios (CNR) were measured. One iterative algorithm increased AUC (0.79, 0.95, and 0.97) compared to FBP (0.70, 0.86, and 0.93) at all dose levels (p < 0.001 and p = 0.047). Another algorithm increased AUC from 0.78 with FBP to 0.84 (p = 0.007) at 5 mGy. Differences at 10 and 15 mGy were not significant (p-values: 0.084-0.883). Three algorithms showed no difference in AUC compared to FBP (p-values: 0.008-1.000). All of the algorithms decreased noise (10-71 %) and improved CNR. Only two algorithms improved lesion detection, even though noise reduction was shown with all algorithms. aEuro cent Iterative reconstruction algorithms affected lesion detection differently at different dose levels. aEuro cent One iterative algorithm improved lesion detectability compared to filtered back projection. aEuro cent Three algorithms did not significantly improve lesion detectability. aEuro cent One algorithm improved lesion detectability at the lowest dose level.
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| 11. |
- Lång, Kristina, et al.
(författare)
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Can horizontally oriented breast tomosynthesis image volumes or the use of a systematic search strategy improve interpretation? An eye tracking and free response human observer study
- 2011
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Ingår i: Proc. SPIE. - : SPIE. ; 7966:796606
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Konferensbidrag (refereegranskat)abstract
- Our aim was to evaluate if there is a benefit in diagnostic accuracy and efficiency of viewing breast tomosynthesis (BT) image volumes presented horizontally oriented, but also to evaluate the use of a systematic search strategy where the breast is divided, and analyzed consecutively, into two sections. These image presentations were compared to regular vertical image presentation. All methods were investigated using viewing procedures consisting of free scroll volume browsing, and a combination of initial cine loops at three different frame rates (9, 14, 25 fps) terminated upon request followed by free scroll volume browsing if needed. Fifty-five normal BT image volumes in MLO view were collected. In these, simulated lesions (20 masses and 20 clusters of microcalcifications) were randomly inserted, creating four unique image sets for each procedure. Four readers interpreted the cases in a random order. Their task was to locate the lesions, mark and assign a five level confidence scale. The diagnostic accuracy was analyzed using Jackknife Free Receiver Operating Characteristics (JAFROC). Time efficiency and visual search behavior were also investigated using eye tracking. Results indicate there was no statistically significant difference in JAFROC FOM between the different image presentations, although visual search was more time efficient when viewing horizontally oriented image volumes in medium cine loops.
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| 12. |
- Lång, Kristina, et al.
(författare)
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Optimizing viewing procedures of breast tomosynthesis image volumes using eye tracking combined with a free response human observer study
- 2011
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Ingår i: Medical Imaging 2011: Image Perception, Observer Performance, and Technology Assessment / SPIE Proceedings. - : SPIE. ; 7966:796602
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Konferensbidrag (refereegranskat)abstract
- The purpose of this study was to evaluate four different viewing procedures as part of improving viewing conditions of breast tomosynthesis (BT) image volumes. The procedures consisted of free scroll volume browsing, and a combination of initial cine loops at three different frame rates (9, 14 and 25 fps) terminated upon request followed by free scroll volume browsing. Fifty-five normal BT image volumes in MLO view were collected. In these, simulated lesions (20 masses and 20 clusters of microcalcifications) were randomly inserted, creating four unique image sets for each procedure. Four readers interpreted the cases in a random order. Their task was to locate a lesion, mark and assign a five level confidence scale. The diagnostic accuracy was analyzed using Jackknife Free Receiver Operating Characteristics (JAFROC). Time efficiency and visual search behavior were also investigated using eye tracking. The results indicate that there was no statistically significant difference in JAFROC FOM between the different viewing procedures, however the medium cine loop speed seemed to be the preferred viewing procedure in terms of total analyze time and dwell time.
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| 13. |
- Mattsson, Sören, et al.
(författare)
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Special issue: Medical imaging--optimisation in X-ray and molecular imaging.
- 2010
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Ingår i: Radiation protection dosimetry. - : Oxford University Press (OUP). - 1742-3406 .- 0144-8420. ; 139:1-3, s. 1-2
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This issue of Radiation Protection Dosimetry is based on contributions to the Third Malmö Conference on Medical Imaging, which was held from 25 to 27 June 2009 at the Malmö University Hospital, Sweden. The conference was jointly organised by members of current and former research projects supported by the European Commission EURATOM-Radiation Protection Research Programme.
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| 14. |
- Precht, Helle, et al.
(författare)
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Digital radiography: optimization of image quality and dose using multi-frequency software
- 2012
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Ingår i: Pediatric Radiology. - : Springer Science and Business Media LLC. - 1432-1998 .- 0301-0449. ; 42:9, s. 1112-1118
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: New developments in processing of digital radiographs (DR), including multi-frequency processing (MFP), allow optimization of image quality and radiation dose. This is particularly promising in children as they are believed to be more sensitive to ionizing radiation than adults. OBJECTIVE: To examine whether the use of MFP software reduces the radiation dose without compromising quality at DR of the femur in 5-year-old-equivalent anthropomorphic and technical phantoms. MATERIALS AND METHODS: A total of 110 images of an anthropomorphic phantom were imaged on a DR system (Canon DR with CXDI-50 C detector and MLT[S] software) and analyzed by three pediatric radiologists using Visual Grading Analysis. In addition, 3,500 images taken of a technical contrast-detail phantom (CDRAD 2.0) provide an objective image-quality assessment. RESULTS: Optimal image-quality was maintained at a dose reduction of 61% with MLT(S) optimized images. Even for images of diagnostic quality, MLT(S) provided a dose reduction of 88% as compared to the reference image. Software impact on image quality was found significant for dose (mAs), dynamic range dark region and frequency band. CONCLUSION: By optimizing image processing parameters, a significant dose reduction is possible without significant loss of image quality.
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| 15. |
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| 16. |
- Svahn, Tony, et al.
(författare)
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THE DIAGNOSTIC ACCURACY OF DUAL-VIEW DIGITAL MAMMOGRAPHY, SINGLE-VIEW BREAST TOMOSYNTHESIS AND A DUAL-VIEW COMBINATION OF BREAST TOMOSYNTHESIS AND DIGITAL MAMMOGRAPHY IN A FREE-RESPONSE OBSERVER PERFORMANCE STUDY.
- 2010
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Ingår i: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 1742-3406 .- 0144-8420. ; 139, s. 113-117
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the present study was to compare the diagnostic accuracy of dual-view digital mammography (DM), single-view breast tomosynthesis (BT) and BT combined with the contralateral DM view. Patients with subtle lesions were selected to undergo BT examinations. Two radiologists who are non-participants in the study and have experience in using DM and BT determined the locations and extents of lesions in the images. Five expert mammographers interpreted the cases using the free-response paradigm. The task was to mark and rate clinically reportable findings suspicious for malignancy and clinically relevant benign findings. The marks were scored with reference to the outlined regions into lesion localization or non-lesion localization, and analysed by the jackknife alternative free-response receiver operating characteristic method. The analysis yielded statistically significant differences between the combined modality and dual-view DM (p < 0.05). No differences were found between single-view BT and dual-view DM or between single-view BT and the combined modality.
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| 17. |
- Timberg, Pontus, et al.
(författare)
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Investigation of viewing procedures for interpretation of breast tomosynthesis image volumes: a detection-task study with eye tracking.
- 2013
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Ingår i: European Radiology. - : Springer Science and Business Media LLC. - 0938-7994 .- 1432-1084. ; 23:4, s. 997-1005
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To evaluate the efficiency of different methods of reading breast tomosynthesis (BT) image volumes. METHODS: All viewing procedures consisted of free scroll volume browsing and three were combined with initial cine loops at three different frame rates (9, 14 and 25 fps). The presentation modes consisted of vertically and horizontally orientated BT image volumes. Fifty-five normal BT image volumes in mediolateral oblique view were collected. In these, simulated lesions were inserted, creating four unique image sets, one for each viewing procedure. Four observers interpreted the cases in a free-response task. Time efficiency, visual attention and search were investigated using eye tracking. RESULTS: Horizontally orientated BT image volumes were read faster than vertically when using free scroll browsing only and when combined with fast cine loop. Cine loops at slow frame rates were ruled out as inefficient. CONCLUSIONS: In general, horizontally oriented BT image volumes were read more efficiently. All viewing procedures except for slow frame rates were promising when assuming equivalent detection performance. KEY POINTS : • Breast tomosynthesis is increasingly used for breast cancer detection • There is a benefit in reading breast tomosynthesis image volumes presented horizontally • Align image content to visual field, especially for dynamic 3D images • Reading at slow frame rates was considered inefficient.
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| 18. |
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| 19. |
- Timberg, Pontus, et al.
(författare)
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Visibility of microcalcification clusters and masses in breast tomosynthesis image volumes and digital mammography: A 4AFC human observer study
- 2012
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Ingår i: Medical Physics. - : Wiley. - 0094-2405. ; 39:5, s. 2431-2437
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To investigate the visibility of simulated lesions in digital breast tomosynthesis (BT) image volumes compared with 2D digital mammography (DM). Methods: Simulated lesions (masses and microcalcifications) were added to images of the same women acquired on a DM system (Mammomat Novation, Siemens) and a BT prototype. The same beam quality was used for the DM and BT acquisitions. The total absorbed dose resulting from a 25-projection BT acquisition and reconstruction (BT25) was approximately twice that of a single DM view. By excluding every other projection image from the reconstruction (BT13), approximately the same dose as in DM was effected. Simulated microcalcifications were digitally added with varying contrast to the DM and BT images. Simulated masses with 8 mm diameter were also added to BT images. A series of 4-alternative forced choice (4AFC) human observer experiments were conducted. Four medical physicists participated in all experiments, each consisting of 60 trials per experimental condition. The observers interpreted the BT image volumes in cine-mode at a fixed image sequence speed. The required threshold contrast (S-t) to achieve a detectability index (d') of 2.5 (i.e., 92.5% correct decisions) was determined. Results: The St for mass detection in DM was approximately a factor of 2 higher than required in BT indicating that the detection of masses was improved under BT conditions compared to DM. St for microcalcification detection was higher for BT than for DM at both BT dose levels (BT25 and BT13), with a statistically significant difference in St between DM and BT13. These results indicate a dose-dependent decrease in detection performance in BT for detection of microcalcifications. Conclusions: In agreement with previous investigations, masses of size 8 mm can be detected with less contrast in BT than in DM indicating improved detection performance for BT. However, for the investigated microcalcifications, the results of this study indicate potentially worse performance for BT than for DM at the same dose level. (C) 2012 American Association of Physicists in Medicine. [http://dx.doi.org/10.1118/1.3694105]
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| 20. |
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| 21. |
- Tingberg, Anders, et al.
(författare)
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Breast Cancer Screening With Tomosynthesis-Initial Experiences
- 2011
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Ingår i: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 1742-3406 .- 0144-8420. ; 147:1-2, s. 180-183
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Tidskriftsartikel (refereegranskat)abstract
- Experiences gained so far using tomosynthesis for breast cancer screening will be reported. A short summary of results from preparatory studies will also be presented. The sensitivity and specificity of breast tomosynthesis (BT) will be compared with conventional two-dimensional digital mammography (DM) for breast cancer screening in a population-based study. Over 2000 women have been examined so far with BT and DM. The BT reading is significantly more time-consuming than the DM reading. Preparatory studies have shown that BT has a higher diagnostic precision and higher accuracy of size measurements and stage determination than DM. There is potential to use lower compression force with BT compared with DM, without decreasing the diagnostic accuracy. BT might play an important role in clinical as well as screening mammography. A large-scale population-based study to investigate BT as a screening modality is underway.
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| 22. |
- Tingberg, Anders, et al.
(författare)
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Digital mammography and tomosynthesis for breast cancer diagnosis
- 2011
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Ingår i: Expert Opinion on Medical Diagnostics. - : Informa Healthcare. - 1753-0059 .- 1753-0067. ; 5:6, s. 517-526
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Forskningsöversikt (refereegranskat)abstract
- Introduction: Mammography is one of the most common X-ray examinations although it is well-known that the anatomical background of the breast is the main obstacle when it comes to detection of breast lesions with this method. Tomosynthesis is a three-dimensional radiographic technique which, to a large extent, can suppress the confounding effect of the anatomical background. Tomosynthesis is a strong competitor to mammography both for screening and clinical examinations. Areas covered: This paper gives a description of digital mammography (DM) and breast tomosynthesis (BT). Relevant studies exploring the possibilities of BT from a technical and clinical point of view, in comparison with DM, are presented. The reader will learn about the concept of BT as well as its advantages compared with DM. The review highlights both diagnostic and clinical aspects of BT as well as the challenges that remain before BT can be fully incorporated in clinical breast cancer imaging and potentially in screening. Expert opinion: BT has the potential to considerably improve breast cancer diagnostics and offers advantages to the existing techniques. It has applications both for clinical breast cancer imaging as well as for screening purposes. The true potential of BT in both fields remains to be further evaluated in clinical trials.
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| 23. |
- Tingberg, Anders
(författare)
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SUSPENSION CRITERIA FOR IMAGE MONITORS AND VIEWING BOXES.
- 2013
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Ingår i: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 1742-3406 .- 0144-8420. ; 153:2, s. 230-235
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Tidskriftsartikel (refereegranskat)abstract
- Image monitors and viewing boxes have a crucial role in the diagnostic process. Modern radiology uses different modalities to produce digital images which are to be viewed in different parts of the radiology department and throughout the hospital, sometimes simultaneously, via the Picture Archiving and Communications System (PACS). Therefore, the quality of the image monitors is of great importance. IPEM notes that inadequacies in the imaging viewing area may serve to negate the benefits of other efforts made to maintain quality and consistency. Suspension criteria for diagnostic image monitors and viewing boxes are presented in RP162. These criteria are mainly based on two documents, IPEM report 91, 'Recommended standards for the routine performance testing of diagnostic x-ray imaging systems' (2005) and AAPM on-line report no. 03, 'Assessment of display performance for medical imaging systems' (2005). The development of common European suspension levels for image monitors and viewing boxes will be a valuable tool in quality assurance.
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| 24. |
- Tingberg, Anders
(författare)
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X-RAY TOMOSYNTHESIS: A REVIEW OF ITS USE FOR BREAST AND CHEST IMAGING.
- 2010
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Ingår i: Radiation Protection Dosimetry. - : Oxford University Press (OUP). - 1742-3406 .- 0144-8420. ; Apr 7, s. 100-107
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Tidskriftsartikel (refereegranskat)abstract
- Tomosynthesis is a three-dimensional imaging technique based on the reconstruction of several planar radiographs. During the image acquisition in tomosynthesis, the X-ray tube moves around the detector which is often stationary, and a number of projection images are taken from different angles. Individual slices from the reconstructed volume can be studied. With the effective reduction of the visibility of the overlapping normal tissue, the detection of pathological lesions is improved when compared with projection radiography. Up to now, tomosynthesis has mainly been used for breast and chest examinations and, to some extent, also for orthopaedic, angiographic and dental investigations. For chest, tomosynthesis is used as an alternative to computed tomography with significantly lower cost and radiation dose to the patient. Breast tomosynthesis has, in several studies, proved to be an effective tool for improving detection of breast lesions. As tomosynthesis has many properties that make it suitable as a modality for screening, including good diagnostic performance, short examination time and low radiation dose, it is a strong competitor to the current gold standard breast screening modality, i.e. mammography. In this paper, the principles of tomosynthesis will be presented as well as a few clinical studies showing the potential role of tomosynthesis in clinical routine examinations.
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