| 1. |
- Brown D., Juhlin C., Tryggvason A., Steer D., Ayarza P., Beckholmen M., Rybalka A. and Bliznetsov M.
(författare)
-
The Crustal Architecture of the Southern and Middle Urals from the URSEIS, ESRU, and Alapaev Reflection Seismic Profiles, in Orogenic Processes in the Paleozoic Uralides
- 2002
-
Ingår i: Geophysical Monograph Series, AGU. ; , s. 33-48
-
Tidskriftsartikel (refereegranskat)
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Bergman, B., et al.
(författare)
-
High resolution seismic traveltime tomography incorporating static corrections applied to a till covered bedrock environment
- 2004
-
Ingår i: Geophysics. - : Society of Exploration Geophysicists. - 0016-8033 .- 1942-2156. ; 69, s. 1082-1090
-
Tidskriftsartikel (refereegranskat)abstract
- A major obstacle in tomographic inversion is near-surface velocity variations. Such shallow velocity variations need to be known and correctly accounted for to obtain images of deeper structures with high resolution and quality. Bedrock cover in many areas consists of unconsolidated sediments and glacial till. To handle the problems associated with this cover, we present a tomographic method that solves for the 3D velocity structure and receiver static corrections simultaneously. We test the method on first-arrival picks from deep seismic reflection data acquired in the mid- late to 1980s in the Siljan Ring area, central Sweden. To use this data set successfully, one needs to handle a number of problems, including time-varying, near-surface velocities from data recorded in winter and summer, several sources and receivers within each inversion cell, varying thickness of the cover layer in each inversion cell, and complex 3D geology. Simultaneous inversion for static corrections and velocity produces a much better image than standard tomography without statics. The velocity model from the simultaneous inversion is superior to the velocity model produced using refraction statics obtained from standard reflection seismic processing prior to inversion. Best results using the simultaneous inversion are obtained when the initial top velocity layer is set to the near-surface bedrock velocity rather than the velocity of the cover. The resulting static calculations may, in the future, be compared to refraction static corrections in standard reflection seismic processing. The preferred final model shows a good correlation with the mapped geology and the airborne magnetic map.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
- Hirschberg, Daniel, et al.
(författare)
-
N-terminal acetylation in a third protein family of vertebrate alcohol dehydrogenase/retinal reductase found through a 'proteomics' approach in enzyme characterization.
- 2001
-
Ingår i: Cellular and Molecular Life Sciences (CMLS). - 1420-682X .- 1420-9071. ; 58:9
-
Tidskriftsartikel (refereegranskat)abstract
- A recent finding of a novel class of retinol-active alcohol dehydrogenase (ADH) in frog prompted analysis of this activity in other vertebrate forms. Surprisingly, yet another and still more unrelated ADH was identified in chicken tissues. It was found to be a member of the aldo-keto reductase (AKR) enzyme family, not previously known as an ADH in vertebrates. Its terminal blocking group and the N-terminal segment, not assigned by protein and cDNA structure analysis, were determined by electrospray tandem mass spectrometry after protein isolation by two-dimensional gel electrophoresis. The N terminus is Acetyl-Ala- and the N-terminal segment contains two consecutive Asn residues. The results establish the new ADH enzyme of the AKR family and show the usefulness of combined gel separation and mass spectrometry in enzyme-characterization.
|
|
| 14. |
|
|
| 15. |
- Jais, JP, et al.
(författare)
-
X-linked Alport syndrome: Natural history and genotype-phenotype correlations in girls and women belonging to 195 families: A "European community Alport syndrome concerted action" study
- 2003
-
Ingår i: Journal of the American Society of Nephrology. - 1046-6673. ; 14:10, s. 2603-2610
-
Tidskriftsartikel (refereegranskat)abstract
- Alport syndrome (AS) is a type IV collagen hereditary disease characterized by progressive hematuric nephritis, hearing loss, and ocular changes. Mutations in the COL4A5 collagen gene are responsible for the more common X-linked dominant form of the disease characterized by much less severe disease in girls and women. A "European Community Alport Syndrome Concerted Action" (ECASCA) group was established to delineate the Alport syndrome phenotype in each gender and to determine genotype-phenotype correlations in a large number of families. Data concerning 329 families, 250 of them with an X-linked transmission, were collected. Characteristics of heterozygous girls and women belonging to the 195 families with proven COL4A5 mutation are compared with those of hemizygous boys and men. Hematuria was observed in 95% of carriers and consistently absent in the others. Proteinuria, hearing loss, and ocular defects developed in 75%, 28%, and 15%, respectively. The probability of developing end-stage renal disease or deafness before the age of 40 yr was 12% and 10%, respectively, in girls and women versus 90 and 80%, respectively, in boys and men. The risk of progression to end-stage renal disease appears to increase after the age of 60 yr in women. Because of the absence of genotype-phenotype correlation and the large intrafamilial phenotypic heterogeneity, early prognosis of the disease in X-linked Alport syndrome carriers remains moot. Risk factors for developing renal failure have been identified: the occurrence and progressive increase in proteinuria, and the development of a hearing defect.
|
|
| 16. |
|
|
| 17. |
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
- Lenander, C, et al.
(författare)
-
Laminin-5 gamma 2 chain expression correlates with unfavorable prognosis in colon carcinomas
- 2001
-
Ingår i: Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology. - : Hindawi Limited. - 0921-8912. ; 22:4, s. 201-209
-
Tidskriftsartikel (refereegranskat)abstract
- Expression of the γ2 chain at the invasive front of different tumors has indicated an important role for laminin-5 in cell migration during tumor invasion and tissue remodeling. As there is considerable need for reliable invasion and prognostic markers we evaluated the correlation of laminin-5 γ2 chain expression with clinicopathologic parameters and patient survival in 93 primary colon carcinomas. Epithelial cells of normal mucosa were consistently negative for staining. In contrast, positive cytoplasmic staining was observed in 89 tumors (96%). Twenty-four (26%) cases were scored as sparse, 34 (37%) as moderate, and 31 (33%) as frequent γ2 chain expression. There was a significant association of laminin-5 γ2 chain expression and local invasiveness of colon carcinomas according to Dukes stage (A-C) (p= 0.001) and tumor budding (p< 0.001). A statistical significance could also be noted in decreasing tumor differentiation (p< 0.001) and correlation to tumor size (p= 0.032). No correlation was observed to tumor site. Univariate analysis identified laminin-5 (p= 0.010), tumor differentiation (p= 0.006) and Dukes grade (p< 0.001) as significant variables in predicting prognosis. However, by multivariate analyses, this study could not demonstrate that laminin-5 γ2 chain expression is an independent predictive factor for survival. The results indicate that laminin-5 γ2 chain expression is up-regulated during the progression of human colon cancer and that it plays a role in the aggressiveness of these tumors. Demonstration of laminin-5 γ2 chain positivity also facilitates detection of individual cells or minor cell clusters invading the surrounding stroma.
|
|
| 22. |
- Li, MH, et al.
(författare)
-
Gene therapy of canine Alport syndrome.
- 2002
-
Ingår i: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. - 1046-6673. ; 13, s. 50A-50A
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)
|
|
| 23. |
|
|
| 24. |
|
|
| 25. |
- Morgunova, E, et al.
(författare)
-
Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2
- 2002
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 99:11, s. 7414-7419
-
Tidskriftsartikel (refereegranskat)abstract
- Matrix metalloproteinases (MMPs) are a family of multidomain enzymes involved in the physiological degradation of connective tissue, as well as in pathological states such as tumor invasion and arthritis. Apart from transcriptional regulation, MMPs are controlled by proenzyme activation and a class of specific tissue inhibitors of metalloproteinases (TIMPs) that bind to the catalytic site. TIMP-2 is a potent inhibitor of MMPs, but it has also been implicated in a unique cell surface activation mechanism of latent MMP-2/gelatinase A/type IV collagenase (proMMP-2), through its binding to the hemopexin domain of proMMP-2 on the one hand and to a membrane-type MMP activator on the other. The present crystal structure of the human proMMP-2/TIMP-2 complex reveals an interaction between the hemopexin domain of proMMP-2 and the C-terminal domain of TIMP-2, leaving the catalytic site of MMP-2 and the inhibitory site of TIMP-2 distant and spatially isolated. The interfacial contact of these two proteins is characterized by two distinct binding regions composed of alternating hydrophobic and hydrophilic interactions. This unique structure provides information for how specificity for noninhibitory MMP/TIMP complex formation is achieved.
|
|
| 26. |
|
|
| 27. |
|
|
| 28. |
|
|
| 29. |
|
|
| 30. |
- Tryggvason, A, Rögnvaldsson, S.Th, and Flóvenz, Ó.G
(författare)
-
Three-dimensional imaging of the P- and S-wave velocity structure and earthquake locations beneath Southwest Iceland
- 2002
-
Ingår i: Tryggvason, A, Rögnvaldsson, S.Th, and Flóvenz, Ó.G. ; 151, s. 848-866
-
Tidskriftsartikel (refereegranskat)
|
|
| 31. |
|
|
| 32. |
|
|
| 33. |
- Yao, Z.S., et al.
(författare)
-
Comment on
- 2001
-
Ingår i: Geophysical Journal International. - 0956-540X. ; 145, s. 307-314
-
Tidskriftsartikel (refereegranskat)abstract
- When solving tomographic inversion problems, the resolution matrix is for the equation system can provide very useful information on how well the model parameters can be resolved. Recently, Nolet et NI. (1999)-referred to as NMV hereafter-proposed a onest
|
|
