| 1. |
|
|
| 2. |
- Acosta, Stefan, et al.
(författare)
-
Successful Selective Thrombolysis for Limb-Threatening Ischemia due to Bilateral Lower Extremity Emboli After Open Aortic Aneurysm Repair
- 2010
-
Ingår i: Vascular and Endovascular Surgery. - : SAGE Publications. - 1938-9116 .- 1538-5744. ; 44:6, s. 506-507
-
Tidskriftsartikel (refereegranskat)abstract
- Severe lower extremity emboli with occlusion of all 3 lower limb arteries bilaterally occurred after an elective open abdominal aortic aneurysm (AAA) repair. Selective thrombolysis with alteplase and repeated percutaneous transluminal angioplasty (PTA) along the occlusions on both side anterior and posterior tibial arteries was performed without complications. Angiography the following day showed continuous filling of the anterior tibial artery down to the dorsalis pedis artery and interrupted, but improved, flow in the medial plantar artery through collaterals. The patient recovered well. At 1 month follow-up, the right foot was unremarkable, whereas the patient experienced slight residual numbness in the medial and distal plantar aspect of his left foot where the great toe/brachial index were lowered to 0.46.
|
|
| 3. |
- Balmativola, D., et al.
(författare)
-
Pathological non-response to chemotherapy in a neoadjuvant setting of breast cancer: an inter-institutional study
- 2014
-
Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 1573-7217 .- 0167-6806. ; 148:3, s. 511-523
-
Tidskriftsartikel (refereegranskat)abstract
- To identify markers of non-response to neoadjuvant chemotherapy (NAC) that could be used in the adjuvant setting. Sixteen pathologists of the European Working Group for Breast Screening Pathology reviewed the core biopsies of breast cancers treated with NAC and recorded the clinico-pathological findings (histological type and grade; estrogen, progesterone receptors, and HER2 status; Ki67; mitotic count; tumor-infiltrating lymphocytes; necrosis) and data regarding the pathological response in corresponding surgical resection specimens. Analyses were carried out in a cohort of 490 cases by comparing the groups of patients showing pathological complete response (pCR) and partial response (pPR) with the group of non-responders (pathological non-response: pNR). Among other parameters, the lobular histotype and the absence of inflammation were significantly more common in pNR (p < 0.001). By ROC curve analyses, cut-off values of 9 mitosis/2 mm(2) and 18 % of Ki67-positive cells best discriminated the pNR and pCR + pPR categories (p = 0.018 and < 0.001, respectively). By multivariable analysis, only the cut-off value of 9 mitosis discriminated the different response categories (p = 0.036) in the entire cohort. In the Luminal B/HER2- subgroup, a mitotic count < 9, although not statistically significant, showed an OR of 2.7 of pNR. A lobular histotype and the absence of inflammation were independent predictors of pNR (p = 0.024 and < 0.001, respectively). Classical morphological parameters, such as lobular histotype and inflammation, confirmed their predictive value in response to NAC, particularly in the Luminal B/HER2- subgroup, which is a challenging breast cancer subtype from a therapeutic point of view. Mitotic count could represent an additional marker but has a poor positive predictive value.
|
|
| 4. |
- Csendes, Z., et al.
(författare)
-
Superoxide dismutase inspired Fe(III)-amino acid complexes covalently grafted onto chloropropylated silica gel - Syntheses, structural characterisation and catalytic activity
- 2013
-
Ingår i: Journal of Molecular Structure. - : Elsevier BV. - 0022-2860. ; 1044, s. 39-45
-
Tidskriftsartikel (refereegranskat)abstract
- In this work the syntheses, structure and SOD activity of covalently grafted Fe(III)-complexes formed with various N- or C-protected amino acid ligands (L-histidine and L-tyrosine) inspired by the active site of the Fe SOD enzyme are presented. Chloropropylated silica gel was used as support to mimic the proteomic skeleton of the enzyme. Anchored complexes having uniform amino acids as well as their two-component mixtures have been prepared. The products were characterised by mid and far IR and Raman spectroscopies. SOD activities of the substances were determined via the Beauchamp-Fridovich test reaction. It was found that the preparation of covalently anchored Fe(III)-amino acid complexes was successful in many cases. The structures of the anchored complexes and the coordinating groups varied upon changing the conditions of the syntheses. All the covalently immobilised complexes displayed (in some instances appreciable) SOD activity. (C) 2012 Elsevier B.V. All rights reserved.
|
|
| 5. |
- Gorlova, Olga, et al.
(författare)
-
Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy
- 2011
-
Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 7:7
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to determine, through a genome-wide association study (GWAS), the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc). We considered limited (IcSSc) and diffuse (dcSSc) cutaneous involvement, and the relationships with presence of the SSc-specific auto-antibodies, anti-centromere (ACA), and anti-topoisomerase I (ATA). Four GWAS cohorts, comprising 2,296 SSc patients and 5,171 healthy controls, were meta-analyzed looking for associations in the selected subgroups. Eighteen polymorphisms were further tested in nine independent cohorts comprising an additional 3,175 SSc patients and 4,971 controls. Conditional analysis for associated SNPs in the HLA region was performed to explore their independent association in antibody subgroups. Overall analysis showed that non-HLA polymorphism rs11642873 in IRF8 gene to be associated at GWAS level with lcSSc (P = 2.32x10(-12), OR = 0.75). Also, rs12540874 in GRB10 gene (P = 1.27 x 10(-6), OR = 1.15) and rs11047102 in SOX5 gene (P = 1.39x10(-7), OR = 1.36) showed a suggestive association with lcSSc and ACA subgroups respectively. In the HLA region, we observed highly associated allelic combinations in the HLA-DQB1 locus with ACA (P = 1.79x10(-61), OR = 2.48), in the HLA-DPA1/B1 loci with ATA (P = 4.57x10(-76), OR = 8.84), and in NOTCH4 with ACA P = 8.84x10(-21), OR = 0.55) and ATA (P = 1.14x10(-8), OR = 0.54). We have identified three new non-HLA genes (IRF8, GRB10, and SOX5) associated with SSc clinical and autoantibody subgroups. Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies. These data emphasize the differential genetic components of subphenotypes of SSc.
|
|
| 6. |
- Pham, M K, et al.
(författare)
-
A certified reference material for radionuclides in the water sample from Irish Sea (IAEA-443)
- 2011
-
Ingår i: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY. - : Springer Science Business Media. - 0236-5731 .- 1588-2780. ; 288:2, s. 603-611
-
Tidskriftsartikel (refereegranskat)abstract
- A new certified reference material (CRM) for radionuclides in sea water from the Irish sea (IAEA-443) is described and the results of the certification process are presented. Ten radionuclides (H-3, K-40, Sr-90, Cs-137, U-234, U-235, U-238, Pu-238, Pu239+240 and Am-241) have been certified, and information values on massic activities with 95% confidence intervals are given for four radionuclides (Th-230, Th-232, Pu-239 and Pu-240). Results for less frequently reported radionuclides (Tc-99, Th-228, Np-237 and Pu-241) are also reported. The CRM can be used for quality assurance/quality control of the analysis of radionuclides in water samples, for the development and validation of analytical methods and for training purposes. The material is available in 5 L units from IAEA (http://nucleus.iaea.org/rpst/index.htm).
|
|
| 7. |
- Pham, M. K., et al.
(författare)
-
A new reference material for radionuclides in the mussel sample from the Mediterranean Sea (IAEA-437)
- 2010
-
Ingår i: Journal of Radioanalytical and Nuclear Chemistry. - : Springer Science and Business Media LLC. - 0236-5731 .- 1588-2780. ; 283:3, s. 851-859
-
Tidskriftsartikel (refereegranskat)abstract
- A new Reference Material (RM) for radionuclides in mussel (Mytilus galloprovincialis) from the Mediterranean Sea (IAEA-437) is described and the results of the certification process are presented. Four radionuclides (K-40, U-234, U-238, and Pu239+240) have been certified, and information values on massic activities with 95% confidence intervals are given for nine radionuclides (Cs-137, Pb-210(Po-210), Ra-226, Ra-228, Th-228, Th-230, Th-232, U-235, and Am-241). Results for less frequently reported radionuclides (Sr-90, I-129, Pu-238, Pu-239, and Pu-240) are also reported. The RM can be used for quality assurance/quality control of the analysis of radionuclides in mussel samples, for the development and validation of analytical methods and for training purposes. The material is available in 200 g units.
|
|
| 8. |
- Radstake, Timothy R. D. J., et al.
(författare)
-
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
- 2010
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:5, s. 71-426
-
Tidskriftsartikel (refereegranskat)abstract
- Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs that leads to profound disability and premature death. To identify new SSc susceptibility loci, we conducted the first genome-wide association study in a population of European ancestry including a total of 2,296 individuals with SSc and 5,171 controls. Analysis of 279,621 autosomal SNPs followed by replication testing in an independent case-control set of European ancestry (2,753 individuals with SSc (cases) and 4,569 controls) identified a new susceptibility locus for systemic sclerosis at CD247 (1q22-23, rs2056626, P = 2.09 x 10(-7) in the discovery samples, P = 3.39 x 10(-9) in the combined analysis). Additionally, we confirm and firmly establish the role of the MHC (P = 2.31 x 10(-18)), IRF5 (P = 1.86 x 10(-13)) and STAT4 (P = 3.37 x 10(-9)) gene regions as SSc genetic risk factors.
|
|
