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1.	Watanabe, Takeshi, et al. (författare) Nocebo response in dentistry : A systematic review and meta-analysis of adverse events in analgesic trials of third molar removal 2023 Ingår i: Journal of Oral Rehabilitation. - : John Wiley & Sons. - 1365-2842 .- 0305-182X. ; 50:4, s. 332-342 Forskningsöversikt (refereegranskat)abstract BackgroundThe nocebo response refers to the phenomenon where non-specific factors, including negative verbal suggestion and treatment expectations, cause adverse events (AE) following a placebo treatment. Non-specific factors are also likely to influence AE occurrence following administration of active pharmacological treatments. ObjectiveThis meta-analysis aimed to estimate the nocebo response in dentistry by assessing the AEs prevalence in placebo- and active arms of randomised controlled trials (RCTs) assessing analgesic treatment following third molar (M3) surgery. MethodsA systematic search was performed in PubMed, Embase, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials. Eligible studies had to report the number of patients experiencing at least one drug-related AE (patients with AE >= 1) separately for the active and placebo arms. The proportion of patients with AE >= 1 and drug-related dropouts were pooled, and risk differences (RDs) between patients in the placebo- and active arm were calculated. ResultsIn 50 independent RCTs of 47 identified articles, the pooled rates of patients with AE >= 1 were 22.8% in the placebo arm and 20.6% in the active arm. The pooled rates of drug-related dropout were 0.24% in the placebo arm and 0.08% in the active arm. There were no significant RDs in patients with AE >= 1 and drug-related dropouts. ConclusionThese results show that patients in the placebo arm reported AEs to the same extent as patients receiving active treatment, suggesting that most AEs in analgesic medication following M3 surgery may be attributed to the nocebo phenomenon.
2.	Hohenschurz-Schmidt, David, et al. (författare) Recommendations for the development, implementation, and reporting of control interventions in efficacy and mechanistic trials of physical, psychological, and self-management therapies : the CoPPS Statement 2023 Ingår i: BMJ. British Medical Journal. - : BMJ Publishing Group Ltd. - 0959-8146 .- 0959-535X. ; 381, s. e072108- Tidskriftsartikel (refereegranskat)abstract Control interventions (often called "sham," "placebo," or "attention controls") are essential for studying the efficacy or mechanism of physical, psychological, and self-management interventions in clinical trials. This article presents core recommendations for designing, conducting, and reporting control interventions to establish a quality standard in non-pharmacological intervention research. A framework of additional considerations supports researchers' decision making in this context. We also provide a reporting checklist for control interventions to enhance research transparency, usefulness, and rigour.

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Typ av publikation: tidskriftsartikel (1); forskningsöversikt (1)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Vase, Lene (2); Lunde, Sigrid Juhl (2); Faria, Vanda (1); Pigg, Maria (1); Baad-Hansen, Lene (1); Scott, Whitney (1); visa fler...; Annoni, Marco (1); Palermo, Tonya M. (1); Kongsted, Alice (1); Cote, Pierre (1); Underwood, Martin (1); Hinman, Rana S. (1); Jensen, Karin (1); Berna, Chantal (1); Wartolowska, Karolin ... (1); Colloca, Luana (1); Rice, Andrew S C (1); Cerritelli, Francesc ... (1); Gerger, Heike (1); Bennell, Kim (1); Pogatzki-Zahn, Esthe ... (1); Rossettini, Giacomo (1); Williams, Amanda C. ... (1); Fabre, Laurent (1); Hohenschurz-Schmidt, ... (1); Ajayi, Oluwafemi K. (1); Barth, Juergen (1); Bialosky, Joel (1); Braithwaite, Felicit ... (1); Finnerup, Nanna B. (1); Carlino, Elisa (1); Chaibi, Aleksander (1); Cherkin, Dan (1); D Darnall, Beth (1); Evans, Roni (1); French, Simon (1); Haeuser, Winfried (1); Ho, Dien (1); Janssens, Thomas (1); Johnston, Chris (1); Keefe, Francis (1); D Kerns, Robert (1); Koechlin, Helen (1); Michener, Lori A. (1); Moerman, Daniel E. (1); Musial, Frauke (1); Newell, David (1); Nicholas, Michael (1); Palermo, Sara (1); Peerdeman, Kaya J. (1); visa färre...

Lärosäte: Uppsala universitet (1); Malmö universitet (1); Karolinska Institutet (1)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

År: 2023 (2)Ta bort avgränsningen

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