| 1. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 2. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 3. |
- Conti, David, V, et al.
(författare)
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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
- 2021
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 53:1, s. 65-75
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Tidskriftsartikel (refereegranskat)abstract
- Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.
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| 4. |
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| 5. |
- Eriksson Sörman, Daniel, 1974-, et al.
(författare)
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Relationships between Dota 2 expertise and decision-making ability
- 2022
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Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 17:3
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Tidskriftsartikel (refereegranskat)abstract
- Esports is an often time-consuming activity that has become increasingly popular with billions of players all over the world. The objective of this study was to investigate if there is a relationship between skill level in the strategy video game Dota 2, a game that places many demands on decision making to be successful, and decision making under ambiguity and experience as measured by performance in the Iowa Gambling Task (IGT), a task known to have ecological validity. Two indicators of players’ performance in Dota 2, namely match-making rating (MMR) and Medal, were used as predictors of performance in the IGT in path models. Results showed that Medal was a significant predictor of performance in IGT, while MMR score was borderline significant. The cognitive reflection task, included in the models as an indicator of the ability to engage in conscious, analytical, rational, and logical thinking, was a significant predictor of performance in IGT, and was significantly and positively related to MMR. The findings from this study give insight into the cognitive demands related to performance in Dota 2. Although results suggest that strategy video gaming may be a factor that contributes to increased decision making abilities, a reversed relationship is also possible, whereby individuals who are better at decision making are also more likely to become successful in Dota-2. More studies, preferably longitudinal, are needed to replicate the findings of this study and to establish the directionality between factors.
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| 6. |
- Mendieta-Leiva, Glenda, et al.
(författare)
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EpIG-DB: A database of vascular epiphyte assemblages in the Neotropics
- 2020
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Ingår i: Journal of Vegetation Science. - : Wiley. - 1100-9233 .- 1654-1103. ; 31, s. 518-528
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Tidskriftsartikel (refereegranskat)abstract
- Vascular epiphytes are a diverse and conspicuous component of biodiversity in tropical and subtropical forests. Yet, the patterns and drivers of epiphyte assemblages are poorly studied in comparison with soil-rooted plants. Current knowledge about diversity patterns of epiphytes mainly stems from local studies or floristic inventories, but this information has not yet been integrated to allow a better understanding of large-scale distribution patterns. EpIG-DB, the first database on epiphyte assemblages at the continental scale, resulted from an exhaustive compilation of published and unpublished inventory data from the Neotropics. The current version of EpIG-DB consists of 463,196 individual epiphytes from 3,005 species, which were collected from a total of 18,148 relevés (host trees and ‘understory’ plots). EpIG-DB reports the occurrence of ‘true’ epiphytes, hemiepiphytes and nomadic vines, including information on their cover, abundance, frequency and biomass. Most records (97%) correspond to sampled host trees, 76% of them aggregated in forest plots. The data is stored in a TURBOVEG database using the most up-to-date checklist of vascular epiphytes. A total of 18 additional fields were created for the standardization of associated data commonly used in epiphyte ecology (e.g. by considering different sampling methods). EpIG-DB currently covers six major biomes across the whole latitudinal range of epiphytes in the Neotropics but welcomes data globally. This novel database provides, for the first time, unique biodiversity data on epiphytes for the Neotropics and unified guidelines for future collection of epiphyte data. EpIG-DB will allow exploration of new ways to study the community ecology and biogeography of vascular epiphytes.
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| 7. |
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| 8. |
- Murari, A., et al.
(författare)
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A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors
- 2024
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Ingår i: Nature Communications. - 2041-1723 .- 2041-1723. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- The objective of thermonuclear fusion consists of producing electricity from the coalescence of light nuclei in high temperature plasmas. The most promising route to fusion envisages the confinement of such plasmas with magnetic fields, whose most studied configuration is the tokamak. Disruptions are catastrophic collapses affecting all tokamak devices and one of the main potential showstoppers on the route to a commercial reactor. In this work we report how, deploying innovative analysis methods on thousands of JET experiments covering the isotopic compositions from hydrogen to full tritium and including the major D-T campaign, the nature of the various forms of collapse is investigated in all phases of the discharges. An original approach to proximity detection has been developed, which allows determining both the probability of and the time interval remaining before an incoming disruption, with adaptive, from scratch, real time compatible techniques. The results indicate that physics based prediction and control tools can be developed, to deploy realistic strategies of disruption avoidance and prevention, meeting the requirements of the next generation of devices.
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| 9. |
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| 10. |
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| 11. |
- Wang, Anqi, et al.
(författare)
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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
- 2023
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:12, s. 2065-2074
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Tidskriftsartikel (refereegranskat)abstract
- The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.
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| 12. |
- Allentoft, Morten E., et al.
(författare)
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Population genomics of post-glacial western Eurasia
- 2024
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 625:7994, s. 301-311
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Tidskriftsartikel (refereegranskat)abstract
- Western Eurasia witnessed several large-scale human migrations during the Holocene1–5. Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from the Mesolithic and Neolithic periods—from across northern and western Eurasia. These were imputed alongside published data to obtain diploid genotypes from more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending from the Black Sea to the Baltic. Mesolithic hunter-gatherers were highly genetically differentiated east and west of this zone, and the effect of the neolithization was equally disparate. Large-scale ancestry shifts occurred in the west as farming was introduced, including near-total replacement of hunter-gatherers in many areas, whereas no substantial ancestry shifts happened east of the zone during the same period. Similarly, relatedness decreased in the west from the Neolithic transition onwards, whereas, east of the Urals, relatedness remained high until around 4,000 bp, consistent with the persistence of localized groups of hunter-gatherers. The boundary dissolved when Yamnaya-related ancestry spread across western Eurasia around 5,000 bp, resulting in a second major turnover that reached most parts of Europe within a 1,000-year span. The genetic origin and fate of the Yamnaya have remained elusive, but we show that hunter-gatherers from the Middle Don region contributed ancestry to them. Yamnaya groups later admixed with individuals associated with the Globular Amphora culture before expanding into Europe. Similar turnovers occurred in western Siberia, where we report new genomic data from a ‘Neolithic steppe’ cline spanning the Siberian forest steppe to Lake Baikal. These prehistoric migrations had profound and lasting effects on the genetic diversity of Eurasian populations.
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| 13. |
- Andersson, Katarina, 1963-, et al.
(författare)
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collaborative compexity in developing caring living arrangements for ageing people
- 2024
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Ingår i: Ageing in a transforming world.
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Konferensbidrag (refereegranskat)abstract
- The Swedish Social Services Act (SFS 2001:453) stipulates since 1982 that the municipal Social Committee should become well acquainted with the living conditions in the municipality. They should also participate in urban planning, and in cooperation with other public bodies, organizations, associations and individuals promote good living environments in the municipality. The development, planning and design of good living environments for older people is an endeavour of great complexity that demands collaboration between many actors. Housing and care for older people is an important area in which social servicesand urban planning could benefit from collaboration. Planning for older people has recently been indicated as urgent and necessary, especially in the light of changed demography in which the proportion of older people is increasing. A built environment that accommodates older people’s everyday needs embraces issues such as age-friendliness, care, socio-spatial inequality, inclusion, and innovation. This research program, CollAge, investigates cross-sectoral collaboration in Swedish municipalities between social eldercare, urban planning and Senior Citizens’ Councils as regards housing and care. With diverse qualitative methodologies the multidisciplinary team of scholars in social work, architecture and urban planning explore how eldercare interventions and services are managed and understood in municipal urban planning and development, and how older people’s preferences can contribute to improved quality of care in social services and housing provision. The ultimate aim of the programme is to develop a methodological tool – CollAge – to support, facilitate and structure collaboration between the three actors.
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| 14. |
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| 15. |
- Campana Barquero, Esperanza M., et al.
(författare)
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Liminalidad y comunidad: La disolución de lo urbano en la Unidad Vecinal de El Taray : [Liminality and communitas. The blurring of urban orderin the Neigbourhood Unit of El Taray]
- 2020
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Ingår i: ZARCH. - : Prensas de la Universidad de Zaragoza. - 2341-0531 .- 2387-0346. ; 14, s. 86-99
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Tidskriftsartikel (refereegranskat)abstract
- La Unidad Vecinal de El Taray (1962-1964) fue encargada por la Cooperativa Pío XII para un escarpado solar en la cara norte de la ciudadela de Segovia. Por su organización alrededor de espacios colectivos, así como por sus galerías abiertas y conexiones aéreas, el conjunto ha sido relacionado con el Neobrutalismo y las teorías del Team 10. Sin embargo, más allá de las etiquetas, puede decirse que El Taray es consecuencia de una imperiosa necesidad de adaptación a la topografía, a los requerimientos funcionales y a la escasez de recursos. Todas estas condiciones pondrán a prueba la inventiva del joven Aracil hasta producir un buen número de avanzadas soluciones que sesenta años más tarde aún dan cuenta de su frescura y pertinencia. De entre ellas destaca su esquema socioespacial, un sofisticado tejido de circulaciones y significados ambiguos que hacen que el conjunto de viviendas se difumine entre lo exterior y lo interior, lo lejano y lo cercano, lo colectivo y lo individual. El presente artículo pretende superar la tradicional lectura del caso desde la clasificación tipológica o la asimilación a corrientes arquitectónicas coetáneas para ofrecer una actualización crítica que pone el acento en su condición liminal como clave de su sostenibilidad social, material y urbana. Para ello lo vincula al presente analizándolo desde la idea de sistema habitable que extiende su influencia a la comunidad que lo habita y al contexto en el que se inserta.
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| 16. |
- Elbe, Pia, et al.
(författare)
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Computerized Cognitive Interventions for Adults With ADHD: A Systematic Review and Meta-Analysis
- 2023
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Ingår i: Neuropsychology. - : American Psychological Association (APA). - 0894-4105 .- 1931-1559. ; 37:5, s. 519-530
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Forskningsöversikt (refereegranskat)abstract
- Objective: Treatments for adults with attention-deficit hyperactivity disorder (ADHD) are understudied, compared to children and adolescents with the same condition. In this systematic review and random-effects meta-analysis, we aim to evaluate the outcomes of computerized cognitive training (CCT) interventions in randomized controlled trials (RCTs) including adults with ADHD.Method: Cognitive outcomes and ADHD symptom severity were analyzed separately. In addition, the Cattell–Horn–Carroll (CHC) theory of cognitive abilities was used to categorize outcome variables into subdomains, which were analyzed separately in a subsequent analysis.Results: The results revealed a small positive change in overall cognitive functioning, a measure of all cognitive outcomes in each study, for individuals who took part in CCT compared to controls (k = 9, Hedge’s g = 0.235, 95% CI [0.002, 0.467], p = 0.048, τ2 = 0.000, I2 = 0.000). However, neither symptom severity nor specific cognitive outcomes (executive functioning, cognitive speed, or working memory) showed a significant improvement.Conclusions: We analyzed the risk of bias in the chosen studies and discuss the findings in terms of effect size. It is concluded that CCT has a small positive effect in adults with ADHD. Due to the lack of heterogeneity in intervention designs across the included studies, increased heterogeneity in future studies could help inform clinicians about the aspects of CCT, such as training type and length, that are most beneficial for this group.
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| 17. |
- Elbe, Pia, et al.
(författare)
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Effects of auditory and tactile distraction in adults with low and high ADHD symptoms
- 2024
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Ingår i: Journal of Cognitive Psychology. - : Taylor & Francis. - 2044-5911 .- 2044-592X. ; 36:5, s. 645-656
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to investigate whether symptoms of attention deficit hyperactivity disorder (ADHD) impact distraction by unexpected deviant sounds and vibrations. The hypothesis was that there would be a difference between individuals with low and high ADHD symptom severity in deviance distraction. In a cross-modal oddball task, we measured the impact of to-be-ignored deviating auditory and vibro-tactile stimuli in 45 adults who were 18 years or older, and self-reported ADHD symptoms using the screening tool of the adult ADHD self-report scale (ASRS). Results did not show a difference between groups with low and high symptoms of ADHD in their propensity for distraction in any modality using both frequentist and Bayesian methods of analysis. The impact of the deviating sounds and vibrations on performance were similar between groups. However, the amount of missed trials, which possibly reflects mind wandering or attention away from the focal task, was higher in the high symptom group (0.5 % difference in missing data between groups). The findings indicate a difference in missed responses between groups, despite no differences in the likelihood of distraction being indicated between vibro-tactile and auditory modalities. Overall, the complexity of adult ADHD symptomatology, especially behavioral differences in attentional control is reflected in the results of this study.
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| 18. |
- Elbe, Pia
(författare)
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Exploring the Hidden Dimensions of Distraction in Adults with Atypical Attention
- 2023
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Inattention and proclivity for distraction are symptoms of adult ADHD that hamper productivity in study and work environments. The topic of this dissertation is mechanisms of distraction and facilitation of attention in ADHD. This thesis includes three studies. The following overarching questions are addressed in each study respectively: (1) Is computerized cognitive training (CCT) an intervention which improves overall cognitive outcomes in adults with ADHD, (2) Are there differences depending on ADHD symptom severity and distraction in auditory or vibro-tactile sensory modalities, and (3) Is background white noise a shield from distraction for those with ADHD during a short-term memory task?Study I is a systematic review and meta-analysis of CCT interventions for adults with ADHD, following a pre- post-test design for randomized controlled trials. Nine intervention studies are included in the systematic review, with the resulting meta-analysis for overall cognitive outcomes showing a very small benefit of the CCT intervention. Study I also included sub-analyses of three outcome categories according to the Cattell-Horn-Carol framework of cognition: cognitive speed, executive functions, and short-term memory. None of these individual meta-analyses resulted in significant improvements. Participants took part in a cross-modal visual oddball task with auditory and vibro-tactile distractors in Study II. Forty-five participants were divided into two groups for the analysis: one group with low ADHD symptoms and one group with high ADHD symptoms. Findings did not show a relationship between ADHD symptom status and distraction in either auditory or vibro-tactile modality, despite both groups showing the expected slowed reactions on deviant trials. A sensitivity analysis showed that the high symptom group exhibited 0.5 % more missed trials compared to the low symptom group, possibly due to mind wandering in this non-forced-choice task.For Study III, serial recall data was collected from sixty-six individuals with ADHD and sixty-six healthy control participants, who were tested with white background noise and no background noise conditions. The results showed that participants with ADHD were more likely to get distracted by auditory omission deviants in continuous background white noise, whereas healthy controls were more likely to get distracted by auditory addition deviants in the condition without background noise. Also, the individuals with ADHD on average did not exhibit a typical primacy effect across serial recall items. Overall, the results of the three studies in this dissertation point to some areas for improvement for adults with ADHD where targeted behavioral interventions might be useful in the future.
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| 19. |
- Eriksson Sörman, Daniel, 1974-, et al.
(författare)
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Occupational cognitive complexity and episodic memory in old age
- 2021
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Ingår i: Intelligence. - : Elsevier. - 0160-2896 .- 1873-7935. ; 89
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate occupational cognitive complexity of main lifetime occupation in relation to level and 15-year change in episodic memory recall in a sample of older adults (≥ 65 years, n = 780). We used latent growth curve modelling with occupational cognitive complexity (O*NET indicators) as independent variable. Subgroup analyses in a sample of middle-aged (mean: 49.9 years) men (n = 260) were additionally performed to investigate if a general cognitive ability (g) factor at age 18 was predictive of future occupational cognitive complexity and cognitive performance in midlife. For the older sample, a higher level of occupational cognitive complexity was related to a higher level of episodic recall (β = 0.15, p < .001), but the association with rate of change (β = 0.03, p = .64) was not statistically significant. In the middle-aged sample, g at age 18 was both directly (β = 0.19, p = .01) and indirectly (via years of education after age 18, ab = 0.19) predictive of midlife levels of occupational cognitive complexity. Cognitive ability at age 18 was also a direct predictor of midlife episodic recall (β = 0.60, p ≤ 0.001). Critically, entry of the early adult g factor attenuated the association between occupational complexity and cognitive level (from β = 0.21, p = .01 to β = 0.12, p = .14). Overall, our results support a pattern of preserved differentiation from early to late adulthood for individuals with different histories of occupational complexity.
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| 20. |
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| 21. |
- Ferrando, Carlos, et al.
(författare)
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Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy : a randomised controlled trial
- 2020
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Ingår i: British Journal of Anaesthesia. - : ELSEVIER SCI LTD. - 0007-0912 .- 1471-6771. ; 124:1, s. 110-120
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Tidskriftsartikel (refereegranskat)abstract
- Background: We aimed to examine whether using a high fraction of inspired oxygen (FIO2) in the context of an individualised intra- and postoperative open-lung ventilation approach could decrease surgical site infection (SSI) in patients scheduled for abdominal surgery. Methods: We performed a multicentre, randomised controlled clinical trial in a network of 21 university hospitals from June 6, 2017 to July 19, 2018. Patients undergoing abdominal surgery were randomly assigned to receive a high (0.80) or conventional (0.3) FIO2 during the intraoperative period and during the first 3 postoperative hours. All patients were mechanically ventilated with an open-lung strategy, which included recruitment manoeuvres and individualised positive end-expiratory pressure for the best respiratory-system compliance, and individualised continuous postoperative airway pressure for adequate peripheral oxyhaemoglobin saturation. The primary outcome was the prevalence of SSI within the first 7 postoperative days. The secondary outcomes were composites of systemic complications, length of intensive care and hospital stay, and 6-month mortality. Results: We enrolled 740 subjects: 371 in the high FIO2 group and 369 in the low FIO2 group. Data from 717 subjects were available for final analysis. The rate of SSI during the first postoperative week did not differ between high (8.9%) and low (9.4%) FIO2 groups (relative risk [RR]: 0.94; 95% confidence interval [CI]: 0.59-1.50; P=0.90]). Secondary outcomes, such as atelectasis (7.7% vs 9.8%; RR: 0.77; 95% CI: 0.48-1.25; P=0.38) and myocardial ischaemia (0.6% [n=2] vs 0% [n=0]; P=0.47) did not differ between groups. Conclusions: An oxygenation strategy using high FIO2 compared with conventional FIO2 did not reduce postoperative SSIs in abdominal surgery. No differences in secondary outcomes or adverse events were found.
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| 22. |
- Frieler, Katja, et al.
(författare)
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Scenario setup and forcing data for impact model evaluation and impact attribution within the third round of the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP3a)
- 2024
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Ingår i: Geoscientific Model Development. - : Copernicus Publications. - 1991-959X .- 1991-9603. ; 17:1, s. 1-51
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes the rationale and the protocol of the first component of the third simulation round of the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP3a, http://www.isimip.org, last access: 2 November 2023) and the associated set of climate-related and direct human forcing data (CRF and DHF, respectively). The observation-based climate-related forcings for the first time include high-resolution observational climate forcings derived by orographic downscaling, monthly to hourly coastal water levels, and wind fields associated with historical tropical cyclones. The DHFs include land use patterns, population densities, information about water and agricultural management, and fishing intensities. The ISIMIP3a impact model simulations driven by these observation-based climate-related and direct human forcings are designed to test to what degree the impact models can explain observed changes in natural and human systems. In a second set of ISIMIP3a experiments the participating impact models are forced by the same DHFs but a counterfactual set of atmospheric forcings and coastal water levels where observed trends have been removed. These experiments are designed to allow for the attribution of observed changes in natural, human, and managed systems to climate change, rising CH4 and CO2 concentrations, and sea level rise according to the definition of the Working Group II contribution to the IPCC AR6.
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| 23. |
- Garcia-Longoria, Luz, et al.
(författare)
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Diversity and host assemblage of avian haemosporidians in different terrestrial ecoregions of Peru
- 2022
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Ingår i: Current Zoology. - : Oxford University Press (OUP). - 1674-5507 .- 2396-9814. ; 68:1, s. 27-40
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Tidskriftsartikel (refereegranskat)abstract
- Characterizing the diversity and structure of host-parasite communities is crucial to understanding their eco-evolutionary dynamics. Malaria and related haemosporidian parasites are responsible for fitness loss and mortality in bird species worldwide. However, despite exhibiting the greatest ornithological biodiversity, avian haemosporidians from Neotropical regions are quite unexplored. Here, we analyze the genetic diversity of bird haemosporidian parasites (Plasmodium and Haemoproteus) in 1,336 individuals belonging to 206 bird species to explore for differences in diversity of parasite lineages and bird species across 5 well-differentiated Peruvian ecoregions. We detected 70 different haemosporidian lineages infecting 74 bird species. We showed that 25 out of the 70 haplotypes had not been previously recorded. Moreover, we also identified 81 new host-parasite interactions representing new host records for these haemosporidian parasites. Our outcomes revealed that the effective diversity (as well as the richness, abundance, and Shannon-Weaver index) for both birds and parasite lineages was higher in Amazon basin ecoregions. Furthermore, we also showed that ecoregions with greater diversity of bird species also had high parasite richness, hence suggesting that host community is crucial in explaining parasite richness. Generalist parasites were found in ecoregions with lower bird diversity, implying that the abundance and richness of hosts may shape the exploitation strategy followed by haemosporidian parasites. These outcomes reveal that Neotropical region is a major reservoir of unidentified haemosporidian lineages. Further studies analyzing host distribution and specificity of these parasites in the tropics will provide important knowledge about phylogenetic relationships, phylogeography, and patterns of evolution and distribution of haemosporidian parasites.
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| 24. |
- Gendreau, R. Michael, et al.
(författare)
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Self-guided digital behavioural therapy versus active control for fibromyalgia (PROSPER-FM) : a phase 3, multicentre, randomised controlled trial
- 2024
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Ingår i: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 404:10450, s. 364-374
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Tidskriftsartikel (refereegranskat)abstract
- Background International guidelines have recommended cognitive behavioural therapy, including acceptance and commitment therapy (ACT), as it offers validated benefits for managing fibromyalgia; however, it is inaccessible to most patients. We aimed to evaluate the effect of a 12-week, self-guided, smartphone-delivered digital ACT programme on fibromyalgia management. Methods In the PROSPER-FM randomised clinical trial conducted at 25 US community sites, adult participants aged 22-75 years with fibromyalgia were recruited and randomly assigned (1:1) to the digital ACT group or an active control group that offered daily symptom tracking and monitoring and access to health-related and fibromyalgiarelated educational materials. Randomisation was done with a web-based system in permuted blocks of four at the site level. We used a blind-to-hypothesis approach in which participants were informed they would be randomly assigned to one of two potentially effective therapies under evaluation. Research staff were not masked to group allocation, with the exception of a masked statistics group while preparing statistical programming for the interim analysis. The primary endpoint was patient global impression of change (PGIC) response rate at week 12. Analyses were by intention to treat. The trial was registered with ClinicalTrials.gov, NCT05243511 (now fully closed). Findings Between Feb 8, 2022, and Feb 2, 2023, 590 individuals were screened, of whom 275 (257 women and 18 men) were randomly assigned to the digital ACT group (n=140) and the active control group (n=135). At 12 weeks, 99 (71%) of 140 ACT participants reported improvement on PGIC versus 30 (22%) of 135 active control participants, corresponding to a difference in proportions of 484% (95% CI 379-589; p<00001). No device-related safety events were reported. Interpretation Digital ACT was safe and efficacious compared with digital symptom tracking in managing fibromyalgia in adult patients. Copyright (c) 2024 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies.
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| 25. |
- González-Bueso, Vega, et al.
(författare)
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Compulsive Sexual Behavior Online and Non-online in Adult Male Patients and Healthy Controls : Comparison in Sociodemographic, Clinical, and Personality Variables
- 2022
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Ingår i: Frontiers in Psychiatry. - : Frontiers Media SA. - 1664-0640. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- Background and Aims: Compulsive sexual behavior (CSB) is characterized by a persistent pattern of failure to control sexual impulses, resulting in repetitive sexual behavior over a prolonged period that causes marked discomfort in personal, family, social, school, work or in other functional areas. The evolution of the worldwide incidence of this disorder warrants further studies focused on examining the characteristics of the affected people. The purpose of this study was to compare online compulsive sexual behavior (when the problematic sexual practices were online) and non-online compulsive sexual behavior (when the problematic sexual practices were in-person) patients (OCSB and non-OCSB, respectively), and healthy controls in terms of sexual behavior, sociodemographic variables and psychopathology and personality characteristics. Method: A sample of 80 CSB male patients consecutively admitted to our Behavioral Addictions Unit and 25 healthy male controls, participated in the study. The CSB group was comprised by 36 online CSB patients (mean age 42.25, SD: 10.0) and 44 non-online CSB patients (mean age 43.5, SD: 11.9). Scores on the Sexual Compulsivity Scale, Temperament and Character Inventory-Revised, Symptom CheckList-90 Items-Revised, State-Trait Anxiety Index, and additional demographic, clinical, and social/family variables related to sexual behaviors between the three groups were compared. Results: When compared with healthy controls, both clinical groups showed higher psychopathology in all measures as well as higher harm avoidance and self-transcendence and lower self-directness and cooperativeness. When comparing OCSB and non-OCSB patients, results showed that non-OCSB patients exhibited higher prevalence of sexually transmitted diseases, higher percentage of homosexual and bisexual orientation and higher scores in anxiety and in sexual impulse control failure. Conclusion: Both online and non-online CSB patients may experience a variety of comorbid psychological and medical problems. Patients with non-OCSB may suffer more consequences that are negative. Therefore, these results should be considered when designing the most convenient therapeutic approach. Whether sexual orientation plays a role in treatment needs and treatment response in CSB, should be further explored in future studies.
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| 26. |
- Heyer, Mark, et al.
(författare)
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The Dense Gas Mass Fraction and the Relationship to Star Formation in M51
- 2022
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 930:2
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Tidskriftsartikel (refereegranskat)abstract
- Observations of 12CO J = 1 – 0 and HCN J = 1 – 0 emission from NGC 5194 (M51) made with the 50 m Large Millimeter Telescope and the SEQUOIA focal plane array are presented. Using the HCN-to-CO ratio, we examine the dense gas mass fraction over a range of environmental conditions within the galaxy. Within the disk, the dense gas mass fraction varies along the spiral arms but the average value over all spiral arms is comparable to the mean value of interarm regions. We suggest that the near-constant dense gas mass fraction throughout the disk arises from a population of density-stratified, self-gravitating molecular clouds and the required density threshold to detect each spectral line. The measured dense gas fraction significantly increases in the central bulge in response to the effective pressure, Pe, from the weight of the stellar and gas components. This pressure modifies the dynamical state of the molecular cloud population and, possibly, the HCN-emitting regions in the central bulge from self-gravitating to diffuse configurations in which Pe is greater than the gravitational energy density of individual clouds. Diffuse molecular clouds comprise a significant fraction of the molecular gas mass in the central bulge, which may account for the measured sublinear relationships between the surface densities of the star formation rate and molecular and dense gas.
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| 27. |
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| 28. |
- Kowal, Marta, et al.
(författare)
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Reasons for Facebook Usage : Data From 46 Countries
- 2020
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Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Seventy-nine percent of internet users use Facebook, and on average they access Facebook eight times a day (Greenwood et al., 2016). To put these numbers into perspective, according to Clement (2019), around 30% of the world's population uses this Online Social Network (OSN) site.Despite the constantly growing body of academic research on Facebook (Chou et al., 2009; Back et al., 2010; Kaplan and Haenlein, 2010; McAndrew and Jeong, 2012; Wilson et al., 2012; Krasnova et al., 2017), there remains limited research regarding the motivation behind Facebook use across different cultures. Our main goal was to collect data from a large cross-cultural sample of Facebook users to examine the roles of sex, age, and, most importantly, cultural differences underlying Facebook use.
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| 29. |
- Leray, Matthieu, et al.
(författare)
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Natural experiments and long-term monitoring are critical to understand and predict marine host–microbe ecology and evolution
- 2021
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Ingår i: PLoS biology. - : Public Library of Science (PLoS). - 1544-9173 .- 1545-7885. ; 19:8, s. e3001322-e3001322
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Tidskriftsartikel (refereegranskat)abstract
- Marine multicellular organisms host a diverse collection of bacteria, archaea, microbial eukaryotes, and viruses that form their microbiome. Such host-associated microbes can significantly influence the host’s physiological capacities; however, the identity and functional role(s) of key members of the microbiome (“core microbiome”) in most marine hosts coexisting in natural settings remain obscure. Also unclear is how dynamic interactions between hosts and the immense standing pool of microbial genetic variation will affect marine ecosystems’ capacity to adjust to environmental changes. Here, we argue that significantly advancing our understanding of how host-associated microbes shape marine hosts’ plastic and adaptive responses to environmental change requires (i) recognizing that individual host–microbe systems do not exist in an ecological or evolutionary vacuum and (ii) expanding the field toward long-term, multidisciplinary research on entire communities of hosts and microbes. Natural experiments, such as time-calibrated geological events associated with well-characterized environmental gradients, provide unique ecological and evolutionary contexts to address this challenge. We focus here particularly on mutualistic interactions between hosts and microbes, but note that many of the same lessons and approaches would apply to other types of interactions.
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| 30. |
- Medina-Vega, José A., et al.
(författare)
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Tropical tree ectomycorrhiza are distributed independently of soil nutrients
- 2024
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Ingår i: Nature Ecology and Evolution. - 2397-334X. ; 8, s. 400-410
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Tidskriftsartikel (refereegranskat)abstract
- Mycorrhizae, a form of plant–fungal symbioses, mediate vegetation impacts on ecosystem functioning. Climatic effects on decomposition and soil quality are suggested to drive mycorrhizal distributions, with arbuscular mycorrhizal plants prevailing in low-latitude/high-soil-quality areas and ectomycorrhizal (EcM) plants in high-latitude/low-soil-quality areas. However, these generalizations, based on coarse-resolution data, obscure finer-scale variations and result in high uncertainties in the predicted distributions of mycorrhizal types and their drivers. Using data from 31 lowland tropical forests, both at a coarse scale (mean-plot-level data) and fine scale (20 × 20 metres from a subset of 16 sites), we demonstrate that the distribution and abundance of EcM-associated trees are independent of soil quality. Resource exchange differences among mycorrhizal partners, stemming from diverse evolutionary origins of mycorrhizal fungi, may decouple soil fertility from the advantage provided by mycorrhizal associations. Additionally, distinct historical biogeographies and diversification patterns have led to differences in forest composition and nutrient-acquisition strategies across three major tropical regions. Notably, Africa and Asia’s lowland tropical forests have abundant EcM trees, whereas they are relatively scarce in lowland neotropical forests. A greater understanding of the functional biology of mycorrhizal symbiosis is required, especially in the lowland tropics, to overcome biases from assuming similarity to temperate and boreal regions.
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| 31. |
- Mikaeloff, Flora, et al.
(författare)
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Trans cohort metabolic reprogramming towards glutaminolysis in long-term successfully treated HIV-infection
- 2022
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 5:1
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Tidskriftsartikel (refereegranskat)abstract
- Despite successful combination antiretroviral therapy (cART), persistent low-grade immune activation together with inflammation and toxic antiretroviral drugs can lead to long-lasting metabolic flexibility and adaptation in people living with HIV (PLWH). Our study investigated alterations in the plasma metabolic profiles by comparing PLWH on long-term cART(>5 years) and matched HIV-negative controls (HC) in two cohorts from low- and middle-income countries (LMIC), Cameroon, and India, respectively, to understand the system-level dysregulation in HIV-infection. Using untargeted and targeted LC-MS/MS-based metabolic profiling and applying advanced system biology methods, an altered amino acid metabolism, more specifically to glutaminolysis in PLWH than HC were reported. A significantly lower level of neurosteroids was observed in both cohorts and could potentiate neurological impairments in PLWH. Further, modulation of cellular glutaminolysis promoted increased cell death and latency reversal in pre-monocytic HIV-1 latent cell model U1, which may be essential for the clearance of the inducible reservoir in HIV-integrated cells. Mikaeloff et al. use untargeted and targeted LC-MS/MS-based plasma metabolic profiling to discover dysregulated metabolism including that of glutaminolysis in individuals living with HIV. Furthermore, decreased levels of neurosteroids were detected suggesting a potential connection between HIV and neurological impairment.
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| 32. |
- Movilla Vega, Daniel, Associate Professor, 1984-, et al.
(författare)
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Corset and Domestic Space : Ortho-architectural Exoskeletons in the Disciplinary Era
- 2021
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Ingår i: Critic|all. - São Paulo : Criticall. - 9788409294718 ; , s. 415-423
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Konferensbidrag (refereegranskat)abstract
- Published within half a century from each other, French manual The Corset Through the Ages (1893) written by Ernest Léoty and the Swedish housing investigation The Family that Outgrows its Home (1941) led by social researcher Brita Åkerman constituted two landmarks of the sexo-political discourses for the construction of the sexualized body and the regulation of gender and family politics. While the French corsetier presented the stay as a technological and social mold of the feminine body that had its routes in antiquity, Åkerman was amassing one of the most thorough collections of knowledge on residential spaces in order to penetrate and modify daily life and social relations within the Swedish domestic realm.This article juxtaposes two apparatuses external to the body —the corset of the Victorian period and the Swedish research-based domestic space of the postwar years— that were aimed at regulating the feminine and masculine anatomy and its movements, imposed physical and sexual literacy and instigated procreative conducts. By looking into the scientific discourses governing each mechanism, their specific technologies and the instructional knowledge designed to deploy them, this study seeks to chart how orthopedic politics developed during the 19th and 20th century through disciplinary exoskeletons have helped to invent, map out and fix the somatic fictions of sexual epistemology that constituted the basis of the biopolitical modern regime.Through a close reading of garment patterns, housing plans, scientific texts, how-to manuals and usage guidelines, the article discusses Foucauldian models of biopolitical power and the administering of life as a tool for architectural analyses. Based on this proposition, it reflects on the centrality of sex and sexuality in modern ortho-architectural apparatuses and rises critical questions about their intervention into the biological and social structure of our contemporary society.
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| 33. |
- Movilla Vega, Daniel, Associate Professor, 1984-, et al.
(författare)
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Editors' notes: The housing question of tomorrow
- 2021
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Ingår i: Nordic Journal of Architectural Research. - : sintef akademisk forlag. - 1893-5281. ; 3, s. 5-12
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Tidskriftsartikel (refereegranskat)abstract
- In this theme issue authors examine contemporary housing practices that outline a new social relevance of housing in the 21st century. Editors have selected articles that provide opportunities, solutions and reflections on this challenge. The contributions bring together real-life case studies, from contexts as diverse as the Swedish, Finnish and Japanese, that reflect on alternative routes of delivery, organisation and design ideas, as well as reflections upon the main inquiry: What are the housing questions for the cities of tomorrow?
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| 34. |
- Movilla Vega, Daniel, Associate Professor, 1984-, et al.
(författare)
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Handbook, standard, room : the prescription of residential room types in Sweden between 1942 and 2023
- 2024
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Ingår i: Urban Planning. - : Cogitatio. - 2183-7635. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Norms and handbooks have played a key role in the design of residential rooms in Sweden since the 1940s. Ever since, changes in housing policies have led to varying definitions and regulations of residential rooms, allowing their existence, defining their configuration, and framing their performance. And yet, none of these rooms has been built; they are prescribed room types that belong in the pages of handbooks that validate the framework in which housing design can operate. What are these prescribed room types? What do they look like? Who and what do they include? Have they changed over time? In response to these questions, this article follows the evolution of a set of residential room types in the design handbooks that have accompanied housing policy bills in Sweden from 1942 to 2023. These manuals are not the law itself but operate as an interface for professionals and designers by reflecting the practical consequences of the norm. Diagrams, dimensions, texts, and references to housing literature vary from handbook to handbook to define the specific traits of each type of room. By studying these traits in relation to key moments of Swedish housing politics, the article reveals the role that norms and standards have played in the establishment of the regulatory regime in which housing design in Sweden operates today.
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| 35. |
- Movilla Vega, Daniel
(författare)
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Housing and Revolution : From the Dom-Kommuna to the Transitional Type of Experimental House (1926-30)
- 2020
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Ingår i: Architectural Histories. - : Ubiquity Press. - 2050-5833. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- In the USSR, against the backdrop of political change and social instability in the 1920s, the issue of housing for the masses was addressed by the Association of Contemporary Architects (OSA), under the leadership of Moisey Ginzburg. Their mission was not only to provide a solution to the lack of accommodation in the major cities of the country, but to redefine housing as a framework suited to a society transitioning towards a fully socialised life. The response was developed in three stages of design research, over a period of five years. The initial conceptual phase was formally presented by members of the OSA at the 1926 Comradely Competition, and focused on the housing question, with specific designs for communal houses. The second stage revolved around the scientific and methodological research of the Stroykom, developed in parallel with the designs for the new communal living units. The final stage took material form in six specific buildings, known as transitional-type experimental houses. One of these, the Narkomfin, gained worldwide recognition as a modern prototype of Soviet avant-garde housing, and has been widely researched as a result. However, to date no study has approached all three phases with equal scrutiny and methodology. This article offers a detailed account of the OSA's experimental design strategies for collective workers' housing between 1926 and 1930 under Ginzburg's leadership by examining original sources, as well as analysing and restoring the individual projects at each stage. It provides a new interpretation of the famous Narkomfin House and ideas on the first Soviet avant-garde housing project by reconstructing the complex research context in which the building, in tandem with other projects, was developed.
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| 36. |
- Movilla Vega, Daniel, Associate Professor, 1984-
(författare)
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Strangers at Home : An investigation on how volunteer housing support for asylum seekers in Sweden is reshaping domestic architecture
- 2022
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Konferensbidrag (refereegranskat)abstract
- This paper examines the interconnection between Swedish non-institutionalized housing provision for asylum seekers and everyday domestic practices. Though not investigated, these emergent housing modalities bridge a gap in the provision of accommodation for adolescents facing relocation orders to other municipalities. Since 2015, volunteer homes in northern Sweden multiplied and underwent major architectural transformations to provide these youths with stable housing. The spatial transformations in the affected dwellings pushed the limits of architectural design and raise critical questions about the resilience of current Swedish housing design recommendations for the construction of ‘the Swedish home’.Through an interdisciplinary examination of case studies, the paper addresses the spatial and social aspects of domestic architecture transformation. The specific research objectives are to:1. investigate the conditions that led unaccompanied asylum seekers turning 18 to face an unstable housing situation and that prompted self-organized networks to emerge;2. define the architecture of non-institutionalized accommodation for vulnerable youths provided by Swedish civil society;3. determine how the architecture of the dwelling transformations relate to everyday domestic practices; and4. understand how Swedish recommendations for housing design impact the way domestic architecture is transformed and used.The methods used are prototyping, formal analysis, interviews, site observations, and discourse analysis. The paper contributes unprecedented analysis of the implications domestic space has on everyday life, shows how housing design relates to societal circumstances, and provides an interdisciplinary framework to revise the design and regulation of domestic space.
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| 37. |
- Movilla Vega, Daniel, Associate Professor, 1984-, et al.
(författare)
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Technologies of dwelling : essays on standards, archives, and urban fictions
- 2023
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Ingår i: Symposium of Urban Design History and Theory. - 9789463844888 ; , s. 62-62
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Konferensbidrag (refereegranskat)abstract
- What constitutes the architecture of urban dwelling? What shapes its limits? What hopes is it meant to fulfill?Dwelling projects have always played a key role in the narratives surrounding urban identity. Indeed, the construction of urban identity is largely affected by a precise set of spatial configurations and material arrangements that coexist in a particular time and place. However, the architecture of dwelling in a city is not only constituted by the one that is actually built, even if the endurance of its particular aggregate of rooms, walls, and households might make it appear so. Looking into dwelling architecture through the lens of the technologies that produce it — including those that regulate it, preserve it, and validate it as a legitimate wish — reveals a whole new set of projects that overlap and enable those that visibly shape the urban environment.This paper explores three of these technologies of dwelling and their role in the construction of the Swedish urban realm. Each technology is addressed in an essay that focuses on what it is and what it does in the city. The first essay, “Standards,” investigates the sources of Swedish national housing regulations and recommendations as a semiotic technology that delimits the admissible framework in which dwelling architecture can operate. The second essay, “Archives,” surveys the aggregate of human and non-human agents involved in the practice of archiving dwelling architecture as an architectural technology for collecting, recording, and preserving what has been agreed to be built. The last essay, “Urban Fiction,” explores the programs for housing supply issued by Swedish municipalities as a discursive technology that constructs legitimate urban imaginaries. The result is a multi-layered re-interpretation of the architecture of domestic space that problematizes urban dwelling as a tangible, concrete reality.
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| 38. |
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| 39. |
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| 40. |
- Rönn, Magnus, 1950, et al.
(författare)
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EDITORS’ NOTES THE HOUSING QUESTION OF TOMORROW, 2021-3
- 2022
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Ingår i: Nordic journal of architectural research. - 1893-5281. ; 2021:3, s. 5-12
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- THE HOUSING QUESTION OF TOMORROW This theme issue on housing in architecture and urban design is made up of four scientific articles and three reviews: two reviews of dissertations and one book review. The contributions present several, complementing research perspectives on the theme.
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| 41. |
- Salloum, Fadi N., et al.
(författare)
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Priorities in Cardio-Oncology Basic and Translational Science : GCOS 2023 Symposium Proceedings: JACC: CardioOncology State-of-the-Art Review
- 2023
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Ingår i: JACC: CardioOncology. - 2666-0873. ; 5:6, s. 715-731
-
Forskningsöversikt (refereegranskat)abstract
- Despite improvements in cancer survival, cancer therapy–related cardiovascular toxicity has risen to become a prominent clinical challenge. This has led to the growth of the burgeoning field of cardio-oncology, which aims to advance the cardiovascular health of cancer patients and survivors, through actionable and translatable science. In these Global Cardio-Oncology Symposium 2023 scientific symposium proceedings, we present a focused review on the mechanisms that contribute to common cardiovascular toxicities discussed at this meeting, the ongoing international collaborative efforts to improve patient outcomes, and the bidirectional challenges of translating basic research to clinical care. We acknowledge that there are many additional therapies that are of significance but were not topics of discussion at this symposium. We hope that through this symposium-based review we can highlight the knowledge gaps and clinical priorities to inform the design of future studies that aim to prevent and mitigate cardiovascular disease in cancer patients and survivors.
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| 42. |
- Sorokowska, Agnieszka, et al.
(författare)
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Affective Interpersonal Touch in Close Relationships : A Cross-Cultural Perspective
- 2021
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Ingår i: Personality and Social Psychology Bulletin. - : Sage Publications. - 0146-1672 .- 1552-7433. ; 47:12, s. 1705-1721
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Tidskriftsartikel (refereegranskat)abstract
- Interpersonal touch behavior differs across cultures, yet no study to date has systematically tested for cultural variation in affective touch, nor examined the factors that might account for this variability. Here, over 14,000 individuals from 45 countries were asked whether they embraced, stroked, kissed, or hugged their partner, friends, and youngest child during the week preceding the study. We then examined a range of hypothesized individual-level factors (sex, age, parasitic history, conservatism, religiosity, and preferred interpersonal distance) and cultural-level factors (regional temperature, parasite stress, regional conservatism, collectivism, and religiosity) in predicting these affective-touching behaviors. Our results indicate that affective touch was most prevalent in relationships with partners and children, and its diversity was relatively higher in warmer, less conservative, and religious countries, and among younger, female, and liberal people. This research allows for a broad and integrated view of the bases of cross-cultural variability in affective touch.
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| 43. |
- Sorokowski, Piotr, et al.
(författare)
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Universality of the Triangular Theory of Love : Adaptation and Psychometric Properties of the Triangular Love Scale in 25 Countries
- 2021
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Ingår i: Journal of Sex Research. - : Informa UK Limited. - 0022-4499 .- 1559-8519. ; 58:1, s. 106-115
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Tidskriftsartikel (refereegranskat)abstract
- The Triangular Theory of Love (measured with Sternberg's Triangular Love Scale - STLS) is a prominent theoretical concept in empirical research on love. To expand the culturally homogeneous body of previous psychometric research regarding the STLS, we conducted a large-scale cross-cultural study with the use of this scale. In total, we examined more than 11,000 respondents, but as a result of applied exclusion criteria, the final analyses were based on a sample of 7332 participants from 25 countries (from all inhabited continents). We tested configural invariance, metric invariance, and scalar invariance, all of which confirmed the cultural universality of the theoretical construct of love analyzed in our study. We also observed that levels of love components differ depending on relationship duration, following the dynamics suggested in the Triangular Theory of Love. Supplementary files with all our data, including results on love intensity across different countries along with STLS versions adapted in a few dozen languages, will further enable more extensive research on the Triangular Theory of Love.
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| 44. |
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| 45. |
- Vega-Mendoza, Mariana, et al.
(författare)
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A longitudinal study of episodic memory recall in multilinguals
- 2024
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Ingår i: International Journal of Bilingualism. - : Sage Publications. - 1367-0069 .- 1756-6878. ; 28:1, s. 125-145
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Tidskriftsartikel (refereegranskat)abstract
- Aim: This study investigates the effects of degree of multilingualism on cognitive functions in adulthood, with focus on episodic memory recall and including measures of verbal fluency as well as global cognition.Design: We studied a large population-based cohort cross-sectionally, and we also assessed changes over time through longitudinal measurements on four time-points over a 15 year period. Participants were drawn from the Betula prospective cohort study in Umeå, Sweden. The participants included in this study at baseline (n = 894, mean age = 51.44, 59.4% females) were divided according to number of languages into bilinguals (n = 395), trilinguals (n = 284), quadrilinguals (n = 169), and pentalinguals (n = 46).Data and analysis: We analysed performance on tasks of episodic memory recall, verbal fluency (letter and category) and global cognition (Minimental State Examination, MMSE) both cross-sectionally and longitudinally. The control background variables were baseline age, gender, years of education, general fluid ability Gf (Wechsler Block Design Test), and socioeconomic status. We employed a linear mixed modelling approach with entropy balancing weights to assess effects of degree of multilingualism on cognitive functions.Findings and conclusions: Using bilinguals as the reference group, our results indicated that all the other multilingual groups exhibited superior performance on episodic memory recall than bilinguals at baseline. The rate of change over time did not differ for trilinguals and pentalinguals compared to bilinguals. While quadrilinguals declined more over time than bilinguals, they still scored significantly higher than bilinguals at the last test wave. For letter fluency, similarly, all language groups scored higher than bilinguals at baseline, and none of the groups differed from bilinguals in rate of change over time. With regard to category fluency, quadrilinguals scored higher than bilinguals at baseline, but trilinguals and pentalinguals did not differ from bilinguals and none of the groups differed in change over time compared to bilinguals. Finally, for global cognition (MMSE), trilinguals and quadrilinguals scored significantly higher than bilinguals at baseline with no differences in change over time for any of the groups relative to bilinguals. Our study contributes to the understanding of multilingual cognition and sheds light into an under-researched cognitive domain known to decline in normal ageing, namely episodic memory recall.Significance: Our study emphasizes the importance of researching less explored aspects of multilingualism on cognition, in particular on episodic memory recall, to aid our understanding of factors that could potentially aid cognitive decline in later adulthood.
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| 46. |
- Vega-Mendoza, Mariana, et al.
(författare)
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Testing the Foreign Language Effect on Cognitive Reflection in Older Adults
- 2021
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Ingår i: Brain Sciences. - : MDPI. - 2076-3425. ; 11:11
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Tidskriftsartikel (refereegranskat)abstract
- An increasing number of people around the world communicate in more than one language, resulting in them having to make decisions in a foreign language on a daily basis. Interestingly, a burgeoning body of literature suggests that people’s decision-making is affected by whether they are reasoning in their native language (NL) or their foreign language (FL). According to the foreign language effect (FLe), people are less susceptible to bias in many decision-making tasks and more likely to display utilitarian cost-benefit analysis in moral decision-making when reasoning in a FL. While these differences have often been attributed to a reduced emotionality in the FL, an emerging body of literature has started to test the extent to which these could be attributable to increased deliberation in the FL. The present study tests whether increased deliberation leads to a FLe on cognitive reflection in a population of older adults (Mage = 65.1), from the successful aging project in Umeå, Sweden. We explored whether performance on a 6-item version of the cognitive reflection test (CRT) adapted to Swedish would differ between participants for whom Swedish was their NL and those for whom Swedish was their FL. The CRT is a task designed to elicit an incorrect, intuitive answer. In order to override the intuitive answer, one requires engaging in deliberative, analytical thinking to determine the correct answer. Therefore, we hypothesized that if thinking in a FL increases deliberation, then those performing the task in their FL would exhibit higher accuracy rates than those performing in their NL. Our results showed that age and level of education predicted performance on the task but performance on the CRT did not differ between the NL and the FL groups. In addition, in the FL group, proficiency in the FL was not related to performance in the CRT. Our results, therefore, do not provide evidence that thinking in a FL increases deliberation in a group of older adults performing a logical reasoning task that is not typically associated with an emotional connotation.
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| 47. |
- Vega-Polanco, Mayumi, et al.
(författare)
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Reproductive strategy of an invasive buzz-pollinated plant (Solanum rostratum)
- 2023
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Ingår i: South African Journal of Botany. - : Elsevier. - 0254-6299 .- 1727-9321. ; 162, s. 342-352
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Tidskriftsartikel (refereegranskat)abstract
- Some plants that invade environments outside their native range of distribution often face reproductive challenges such as limited pollinators and mates. Thus, the capacity to reproduce autonomously in the absence of pollinators or mates can facilitate establishment and spread of invasive plants. Here, we study the capacity of Solanum rostratum to reproduce through autonomous self-pollination. Although this plant is self-compatible, it strongly depends on visitation of buzzing bees to reproduce in its native range. We compared floral morphology, pollen: ovule ratios, reproductive phenology, and capacity for autonomous self-pollination of two populations of native distribution (Mexico) and another two populations of the invasive range (USA). We found a reduction in anther-stigma distance, pollen: ovule ratio, and plant height in invasive populations, as well as a shift to increased resource allocation to floral vs. vegetative structures and faster flowering compared to native populations. Importantly, invasive populations show a marked increase in the capacity to produce fruits autonomously (without pollen vectors). Our results suggest that the northern invasion of S. rostratum could have been facilitated by a shift in reproductive strategy from outcrossing to autonomous self-pollination.
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| 48. |
- Walter, Kathryn, et al.
(författare)
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Sex Differences in Mate Preferences Across 45 Countries : A Large-Scale Replication
- 2020
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Ingår i: Psychological Science. - : SAGE Publications. - 0956-7976 .- 1467-9280. ; 31:4, s. 408-423
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Tidskriftsartikel (refereegranskat)abstract
- Considerable research has examined human mate preferences across cultures, finding universal sex differences in preferences for attractiveness and resources as well as sources of systematic cultural variation. Two competing perspectives-an evolutionary psychological perspective and a biosocial role perspective-offer alternative explanations for these findings. However, the original data on which each perspective relies are decades old, and the literature is fraught with conflicting methods, analyses, results, and conclusions. Using a new 45-country sample (N = 14,399), we attempted to replicate classic studies and test both the evolutionary and biosocial role perspectives. Support for universal sex differences in preferences remains robust: Men, more than women, prefer attractive, young mates, and women, more than men, prefer older mates with financial prospects. Cross-culturally, both sexes have mates closer to their own ages as gender equality increases. Beyond age of partner, neither pathogen prevalence nor gender equality robustly predicted sex differences or preferences across countries.
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| 49. |
- Wenger, Anna, 1990, et al.
(författare)
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DNA methylation alterations across time and space in paediatric brain tumours
- 2022
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Ingår i: Acta Neuropathologica Communications. - : Springer Science and Business Media LLC. - 2051-5960. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- DNA methylation is increasingly used for tumour classification and has expanded upon the > 100 currently known brain tumour entities. A correct diagnosis is the basis for suitable treatment for patients with brain tumours, which is the leading cause of cancer-related death in children. DNA methylation profiling is required for diagnosis of certain tumours, and used clinically for paediatric brain tumours in several countries. We therefore evaluated if the methylation-based classification is robust in different locations of the same tumour, and determined how the methylation pattern changed over time to relapse. We sampled 3-7 spatially separated biopsies per patient, and collected samples from paired primary and relapse brain tumours from children. Altogether, 121 samples from 46 paediatric patients with brain tumours were profiled with EPIC methylation arrays. The methylation-based classification was mainly homogeneous for all included tumour types that were successfully classified, which is promising for clinical diagnostics. There were indications of multiple subclasses within tumours and switches in the relapse setting, but not confirmed as the classification scores were below the threshold. Site-specific methylation alterations did occur within the tumours and varied significantly between tumour types for the temporal samples, and as a trend in spatial samples. More alterations were present in high-grade tumours compared to low-grade, and significantly more alterations with longer relapse times. The alterations in the spatial and temporal samples were significantly depleted in CpG islands, exons and transcription start sites, while enriched in OpenSea and regions not affiliated with a gene, suggesting a random location of the alterations in less conserved regions. In conclusion, more DNA methylation changes accumulated over time and more alterations occurred in high-grade tumours. The alterations mainly occurred in regions without gene affiliation, and did not affect the methylation-based classification, which largely remained homogeneous in paediatric brain tumours.
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