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- Gao, Zhihao, et al.
(författare)
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Benchmark of a multi-physics Monte Carlo simulation of an ionguide for neutron-induced fission products
- 2022
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Ingår i: European Physical Journal. - : Springer Nature. - 1286-0042 .- 1286-0050. ; 58:2
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Tidskriftsartikel (refereegranskat)abstract
- To enhance the production of medium-heavy,neutron-rich nuclei, and to facilitate measurements of independentyields of neutron-induced fission, a proton-toneutronconverter and a dedicated ion guide for neutroninducedfission have been developed for the IGISOL facilityat the University of Jyväskylä. The ion guide holds thefissionable targets, and the fission products emerging fromthe targets are collected in helium gas and transported to thedownstream experimental stations.Acomputer model, basedon a combination of MCNPX for modeling the neutron production,the fission code GEF, and GEANT4 for the transportof the fission products, was developed. The model willbe used to improve the setup with respect to the productionand collection of fission products. In this paper we benchmarkthe model by comparing simulations to a measurementin which fission products were implanted in foils located atdifferent positions in the ion guide. In addition, the productsfrom neutron activation in the titanium foil and the uraniumtargets are studied. The result suggests that the neutron fluxat the high-energy part of the neutron spectrum is overestimatedby approximately 40%.However, the transportation offission products in the uranium targets agrees with the experimentwithin 10%. Furthermore, the simulated transportationof fission products in the helium gas achieves almost perfectagreement with the measurement. Hence, we conclude thatthe model, after correction for the neutron flux, is well suitedfor optimization studies of future ion guide designs.
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| 2. |
- Gao, Zhihao, et al.
(författare)
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Fission studies at IGISOL/JYFLTRAP : Simulations of the ion guide for neutron-induced fission and comparison with experimental data
- 2020
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Ingår i: ND 2019. - : EDP Sciences. - 9782759891061
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Konferensbidrag (refereegranskat)abstract
- For the production of exotic nuclei at the IGISOL facility, an ion guide for neutron-induced fission has been developed and tested in experiments. Fission fragments are produced inside the ion guide and collected using a helium buffer gas. Meanwhile, a GEANT4 model has been developed to simulate the transportation and stopping of the charged fission products. In a recent measurement of neutron-induced fission yields, implantation foils were located at different positions in the ion guide. The gamma spectra from these foils and the fission targets are compared to the results from the GEANT4 simulation.In order to allow fission yield measurements in the low yield regions, towards the tails and in the symmetric part of the mass distribution, the stopping and extraction efficiency of the ion guide has to be significantly improved. This objective can be achieved by increasing the size while introducing electric field guidance using a combination of static electrodes and an RF-carpet. To this end, the GEANT4 model is used to optimise the design of such an ion guide.
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| 5. |
- Weghuber, D., et al.
(författare)
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A 6-month randomized, double-blind, placebo-controlled trial of weekly exenatide in adolescents with obesity
- 2020
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Ingår i: Pediatric Obesity. - 2047-6302 .- 2047-6310. ; 15:7
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Pharmacological treatment options for adolescents with obesity are very limited. Glucagon-like-peptide-1 (GLP-1) receptor agonist could be a treatment option for adolescent obesity.OBJECTIVE: To investigate the effect of exenatide extended release on body mass index (BMI)-SDS as primary outcome, and glucose metabolism, cardiometabolic risk factors, liver steatosis, and other BMI metrics as secondary outcomes, and its safety and tolerability in adolescents with obesity.METHODS: Six-month, randomized, double-blinded, parallel, placebo-controlled clinical trial in patients (n = 44, 10-18 years, females n = 22) with BMI-SDS > 2.0 or age-adapted-BMI > 30 kg/m2 according to WHO were included. Patients received lifestyle intervention and were randomized to exenatide extended release 2 mg (n = 22) or placebo (n = 22) subcutaneous injections given once weekly. Oral glucose tolerance tests (OGTT) were conducted at the beginning and end of the intervention.RESULTS: Exenatide reduced (P < .05) BMI-SDS (-0.09; -0.18, 0.00), % BMI 95th percentile (-2.9%; -5.4, -0.3), weight (-3 kg; -5.8, -0.1), waist circumference (-3.2 cm; -5.8, -0.7), subcutaneous adipose tissue (-552 cm3 ; -989, -114), 2-hour-glucose during OGTT (-15.3 mg/dL; -27.5, -3.1), total cholesterol (11.6 mg/dL; -21.7, -1.5), and BMI (-0.83 kg/m2 ; -1.68, 0.01) without significant change in liver fat content (-1.36; -3.12, 0.4; P = .06) in comparison to placebo. Safety and tolerability profiles were comparable to placebo with the exception of mild adverse events being more frequent in exenatide-treated patients.CONCLUSIONS: Treatment of adolescents with severe obesity with extended-release exenatide is generally well tolerated and leads to a modest reduction in BMI metrics and improvement in glucose tolerance and cholesterol. The study indicates that the treatment provides additional beneficial effects beyond BMI reduction for the patient group.
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