| 1. |
- Chauhan, B C, et al.
(författare)
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Practical Recommendations for Measuring Rates of Visual Field Change in Glaucoma
- 2008
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Ingår i: British Journal of Ophthalmology. - : BMJ. - 1468-2079 .- 0007-1161. ; 92, s. 569-573
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Tidskriftsartikel (refereegranskat)abstract
- Statement of Interest Assessment of visual field damage is the major index of the functional impact of glaucoma with direct relevance to quality of life measures. Visual field change was used as a primary endpoint for progression in the recent glaucoma trials and its measurement is the cornerstone of glaucoma management influencing therapeutic decisions. The objective of this perspective is to provide practical recommendations for measuring clinically relevant rates of glaucomatous visual field progression to help identify patients at risk for visual impairment. They focus on the frequency of examinations required for detecting various amounts and rates of visual field change.
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| 2. |
- Nath, Swapan K., et al.
(författare)
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A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus
- 2008
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 40:2, s. 152-154
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Tidskriftsartikel (refereegranskat)abstract
- We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1.7 x 10(-17), odds ratio = 1.78). We further replicated this association in two independent samples of individuals of African descent (P = 0.0002 and 0.003; overall meta-analysis P = 6.9 x 10(-22)). The genetic association between ITGAM and SLE implicates the alpha(M)beta2-integrin adhesion pathway in disease development.
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| 3. |
- Vijh, G., et al.
(författare)
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Solid freeform fabrication of aluminum alloy components : Numerical simulations
- 2009
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Ingår i: Transactions of the Indian Institute of Metals. - : Springer Science and Business Media LLC. - 0019-493X .- 0972-2815 .- 0975-1645. ; 62:4-5, s. 291-294
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Tidskriftsartikel (refereegranskat)abstract
- A heat transfer model has been developed to simulate the evolution of temperature during semi-solid metal (SSM) solid freeform fabrication (SFF) process. The governing equations were solved numerically using finite difference method. Deposition of simple cubic components of A356 (Al-7%Si-0.45%Mg) aluminum alloy have been simulated. The effect of process parameters such as deposition pattern, deposition velocity, slurry cross-section and slurry temperature on the transient temperature distribution in these components have been studied. Out of the three deposition patterns studied, i.e. rotating, alternating and unidirectional, the alternating pattern enabled depositing larger interfacefree components. Increasing the slurry flow rate resulted in the deposition of larger interface-free components
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| 4. |
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| 5. |
- Chaudhury, Asim, et al.
(författare)
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Low silicon non-grain-oriented electrical steel: Linking magnetic properties with metallurgical factors
- 2007
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Ingår i: Journal of Magnetism and Magnetic Materials. - : Elsevier BV. - 0304-8853 .- 1873-4766. ; 313:1, s. 21-28
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Tidskriftsartikel (refereegranskat)abstract
- Commercial supply, from several steel manufacturers, of low-silicon non-grain-oriented electrical steel was monitored over a span of several years. A total of 51 samples were selected-selected from many hundreds on the basis of large differences in magnetic properties, but absence of significant variations in chemistry (other than differences in silicon percentage). The selected samples were analyzed for crystallographic texture and for grain size. The data were carefully analyzed to bring out the effects of metallurgical variables, namely silicon %, grain size and crystallographic texture, on the magnetic properties using explicit functional relationships as well as artificial neural network (ANN). Among the explicit relationships, power law relationship appears to offer a best fit between magnetic properties and the metallurgical factors. ANN approach to the relationship, however, brought out predicted values with least error
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| 6. |
- Han, Shizhong, et al.
(författare)
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Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE)
- 2009
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 18:6, s. 1171-1180
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Tidskriftsartikel (refereegranskat)abstract
- We recently identified a novel non-synonymous variant, rs1143679, at exon 3 of the ITGAM gene associated with systemic lupus erythematosus (SLE) susceptibility in European-Americans (EAs) and African-Americans. Using genome-wide association approach, three other studies also independently reported an association between SLE susceptibility and ITGAM or ITGAM-ITGAX region. The primary objectives of this study are to assess whether single or multiple causal variants from the same gene or any nearby gene(s) are involved in SLE susceptibility and to confirm a robust ITGAM association across nine independent data sets (n = 8211). First, we confirmed our previously reported association of rs1143679 (risk allele 'A') with SLE in EAs (P = 1.0 x 10(-8)) and Hispanic-Americans (P = 2.9 x 10(-5)). Secondly, using a comprehensive imputation-based association test, we found that ITGAM is one of the major non-human leukocyte antigen susceptibility genes for SLE, and the strongest association for EA is the same coding variant rs1143679 (log(10)Bayes factor=20, P = 6.17 x 10(-24)). Thirdly, we determined the robustness of rs1143679 association with SLE across three additional case-control samples, including UK (P = 6.2 x 10(-8)), Colombian (P = 3.6 x 10(-7)), Mexican (P = 0.002), as well as two independent sets of trios from UK (P(TDT) = 1.4 x 10(-5)) and Mexico (P(TDT) = 0.015). A meta-analysis combing all independent data sets greatly reinforces the association (P(meta) = 7.1 x 10(-50), odds ratio = 1.83, 95% confidence interval = 1.69-1.98, n = 10 046). However, this ITGAM association was not observed in the Korean or Japanese samples, in which rs1143679 is monomorphic for the non-risk allele (G). Taken together along with our earlier findings, these results demonstrate that the coding variant, rs1143679, best explains the ITGAM-SLE association, especially in European- and African-derived populations, but not in Asian populations.
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