| 1. |
- Callaway, EM, et al.
(författare)
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A multimodal cell census and atlas of the mammalian primary motor cortex
- 2021
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 598:7879, s. 86-102
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Tidskriftsartikel (refereegranskat)abstract
- Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties and cellular resolution input–output mapping, integrated through cross-modal computational analysis. Our results advance the collective knowledge and understanding of brain cell-type organization1–5. First, our study reveals a unified molecular genetic landscape of cortical cell types that integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a consensus taxonomy of transcriptomic types and their hierarchical organization that is conserved from mouse to marmoset and human. Third, in situ single-cell transcriptomics provides a spatially resolved cell-type atlas of the motor cortex. Fourth, cross-modal analysis provides compelling evidence for the transcriptomic, epigenomic and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types. We further present an extensive genetic toolset for targeting glutamatergic neuron types towards linking their molecular and developmental identity to their circuit function. Together, our results establish a unifying and mechanistic framework of neuronal cell-type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.
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| 2. |
- Vu, Tung T., et al.
(författare)
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Energy-Efficient Massive MIMO for Serving Multiple Federated Learning Groups
- 2021
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Ingår i: 2021 IEEE GLOBAL COMMUNICATIONS CONFERENCE (GLOBECOM). - : IEEE. - 9781728181042
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Konferensbidrag (refereegranskat)abstract
- With its privacy preservation and communication efficiency, federated learning (FL) has emerged as a learning framework that suits beyond SG and towards 6G systems. This work looks into a future scenario in which there are multiple groups with different learning purposes and participating in different FL processes. We give energy-efficient solutions to demonstrate that this scenario can be realistic. First, to ensure a stable operation of multiple FL processes over wireless channels, we propose to use a massive multiple-input multiple-output network to support the local and global FL training updates, and let the iterations of these FL processes be executed within the same large-scale coherence time. Then, we develop asynchronous and synchronous transmission protocols where these iterations are asynchronously and synchronously executed, respectively, using the downlink unicasting and conventional uplink transmission schemes. Zero-forcing processing is utilized for both uplink and downlink transmissions. Finally, we propose an algorithm that optimally allocates power and computation resources to save energy at both base station and user sides, while guaranteeing a given maximum execution time threshold of each FL iteration. Compared to the baseline schemes, the proposed algorithm significantly reduces the energy consumption, especially when the number of base station antennas is large.
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