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Circulating Tumor C...
Circulating Tumor Cell Kinetics and Morphology from the Liquid Biopsy Predict Disease Progression in Patients with Metastatic Colorectal Cancer Following Resection
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- Kolenčík, Drahomir (författare)
- Charles University in Prague
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- Sachin, Narayan (författare)
- University of Southern California
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- Thiele, Jana-Aletta (författare)
- Charles University in Prague
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- McKinley, Dillon (författare)
- University of Southern California
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- Sandström Gerdtsson, Anna (författare)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,LUCC: Lund University Cancer Centre,Other Strong Research Environments,University of Southern California
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- Welter, Lisa (författare)
- University of Southern California
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- Hošek, Petr (författare)
- Charles University in Prague
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- Ostašov, Pavel (författare)
- Charles University in Prague
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- Vyčítal, Ondrej (författare)
- Charles University in Prague
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- Brůha, Jan (författare)
- Charles University in Prague
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- Fiala, Ondrej (författare)
- Charles University in Prague
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- Šorejs, Ondrej (författare)
- Charles University in Prague
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- Liska, Vaclav (författare)
- Charles University in Prague
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- Pitule, Pavel (författare)
- Charles University in Prague
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- Kuhn, Peter (författare)
- University of Southern California
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- Shishido, Stephanie (författare)
- University of Southern California
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(creator_code:org_t)
- 2022-01-27
- 2022
- Engelska.
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 14:3
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.mdpi.com...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
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- The liquid biopsy has the potential to improve current clinical practice in oncology byproviding real-time personalized information about a patient’s disease status and response to treatment. In this study, we evaluated 161 peripheral blood (PB) samples that were collected aroundsurgical resection from 47 metastatic colorectal cancer (mCRC) patients using the High-DefinitionSingle Cell Assay (HDSCA) workflow. In conjunction with the standard circulating tumor cell (CTC)enumeration, cellular morphology and kinetics between time-points of collection were considered inthe survival analysis. CTCs, CTC-Apoptotic, and CTC clusters were found to indicate poor survivalwith an increase in cell count from pre-resection to post-resection. This study demonstrates thatCTC subcategorization based on morphological differences leads to nuanced results between thesubtypes, emphasizing the heterogeneity within the CTC classification. Furthermore, we show thatfactoring in the time-point of each blood collection is critical, both for its static enumeration and forthe change in cell populations between draws. By integrating morphology and time-based analysisalongside standard CTC enumeration, liquid biopsy platforms can provide greater insight into thepathophysiology of mCRC by highlighting the complexity of the disease across a patient’s treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
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Cancers
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Till lärosätets databas
- Av författaren/redakt...
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Kolenčík, Drahom ...
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Sachin, Narayan
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Thiele, Jana-Ale ...
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McKinley, Dillon
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Sandström Gerdts ...
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Welter, Lisa
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visa fler...
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Hošek, Petr
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Ostašov, Pavel
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Vyčítal, Ondrej
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Brůha, Jan
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Fiala, Ondrej
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Šorejs, Ondrej
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Liska, Vaclav
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Pitule, Pavel
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Kuhn, Peter
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Shishido, Stepha ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Cancers
- Av lärosätet
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Lunds universitet