| 1. |
- Andreasson, Björn, et al.
(författare)
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The measurement of venous haematocrit in patients with polycythaemia vera.
- 1999
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Ingår i: Journal of internal medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 246:3, s. 293-7
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: In clinical practice, patients with polycythaemia vera (PV) are monitored by measurement of venous packed cell volume (PCV). However, whereas treatment recommendations are still based upon studies in which the results were obtained with the centrifuged microhaematocrit, currently in most instances automated blood cell counters are used to calculate PCV. In a group of patients with polycythaemia we therefore compared the results obtained by the microhaematocrit method with PCV calculated by haematology analysers. DESIGN: The study was carried out on a prospective basis. Duplicate venous blood samples were collected. The centrifuged microhaemotocrit was obtained by using an IEC Micro-MB Centrifuge. Depending on different routine methods used in the participating hospitals, the blood cell counter PCV was calculated using Coulter STKS, Bayer Technicon H2 or H3. SETTING: Patients were included from four Swedish university hospitals: Akademiska (Uppsala), Huddinge and Karolinska (Stockholm) and Sahlgrenska (Göteborg). SUBJECTS: Seventy-four patients with PV and 10 patients with secondary polycythaemia were included and a total of 150 duplicate blood samples were analysed from these subjects. RESULTS: In the 150 measurements the mean blood cell counter calculated PCV was 0.448 +/- 0.037; the mean for centrifuged microhaematocrit was 0.467 +/- 0. 037 and the difference between means was highly significant (P = 6.8 x 10-25). The means for centrifuged haematocrit and calculated PCV differed significantly in the groups of PV patients treated with phlebotomy only, hydroxyurea or radiophosphorous (P < 0.0001, respectively). In PV patients treated with alpha-interferon and in patients with secondary polycythaemia the difference in means did not reach statistical significance (P = 0.07 and P = 0.13, respectively). The groups of patients with MCV <80 fL and >/=80 fL both presented significant differences between means for calculated PCV and centrifuged haematocrit. CONCLUSIONS: If PV patients are monitored with blood cell counter calculated PCV it appears that the therapeutic goal should be to maintain the calculated PCV below 0.43, provided the local differences in calculated PCV and centrifuged haematocrit are of the same magnitude as in this study.
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| 2. |
- Borgstrom, S, et al.
(författare)
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Time-resolved x-ray spectroscopy of optical-field-ionized plasmas
- 1995
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Ingår i: Laser and Particle Beams. - 0263-0346. ; 13:4, s. 459-468
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Tidskriftsartikel (refereegranskat)abstract
- The time-dependent soft X-ray emission of helium and nitrogen plasmas generated by optical-field ionization is reported. The experiments were carried out by focusing pulses of the high-power Ti:sapphire laser of the Lund Institute of Technology (lambda = 796 nm, pulse duration 150 fs, pulse energy 150 mJ) to a 50-mu m diameter spot close to a nozzle, using He and N-2 as target gases. The emission on He+, N4+, and N3+ resonance lines was recorded by means of a flat-field grating spectrometer coupled to an X-ray streak camera. A pronounced difference in the temporal shape of the emission of the Lyman-alpha line of hydrogen-like helium and of the 2p-3d resonance lines of lithium-like and beryllium-like nitrogen was observed. The helium line exhibited an initial spike followed by a slow revival of the emission, whereas the nitrogen lines showed a slow decay after a fast initial rise. These observations are explained with the help of simulations.
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| 3. |
- Carlsson, J, et al.
(författare)
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Time-resolved Studies of Light-propagation In Paper
- 1995
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Ingår i: Applied Optics. - 2155-3165. ; 34:9, s. 1528-1535
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Tidskriftsartikel (refereegranskat)abstract
- A method for time-resolved recording of light scattering in thin, highly scattering media is described. Subpicosecond pulses from a high-power Ti:sapphire laser are used, and single-shot recordings of the scattered light are made with a fast streak camera. The method is applied to the study of light scattering in paper, and a 1-ps resolution is demonstrated. The dependence of the light scattering on the basis of weight and density of the paper has been studied. A white-light continuum generated from the high-power pulses by the use of self phase modulation in water is used to study the wavelength dependence of the scattering process. A model for the propagation of light in paper has been developed and used in Monte Carlo simulations. The experimental results are used for testing this model, and absorption and scattering parameters are determined from that comparison.
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| 4. |
- Enlund, Fredrik, 1968, et al.
(författare)
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Psoriasis susceptibility locus in chromosome region 3q21 identified in patients from southwest Sweden
- 1999
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Ingår i: Eur J Hum Genet. ; 7:7, s. 783-90
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Tidskriftsartikel (refereegranskat)abstract
- We have performed a pair-wise linkage study in the search for psoriasis susceptibility regions. A preliminary scan was performed on 20 families. In this set we obtained indications of linkage on chromosome 3q21. This region was further investigated using material from a total of 104 families (set 1B) resulting in a non-parametric linkage (NPL) of 1.77. The material was stratified in families whose parental origin is in southwest Sweden (set 1C). A maximum NPL value of 2.77 was obtained in this group. A transmission disequilibrium test (TDT) was performed on the stratified material (set 1C) and a significant P value of 0.005 was obtained, at marker D3S1269. The locus was confirmed with TDT in replicate material consisting of 148 families in which a single member was affected (P value 0.0007) at marker D3S1551. Thus, we have observed a significant P value using TDT in the vicinity of markers D3S1269/D3S1551, suggesting a novel psoriasis susceptibility region.
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| 5. |
- Li, Z. S, et al.
(författare)
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Radiative properties of neutral germanium obtained from excited-state lifetime and branching-ratio measurements and comparison with theoretical calculations
- 1999
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Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 60:1, s. 198-208
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Tidskriftsartikel (refereegranskat)abstract
- Using time-resolved UV laser-induced fluorescence from a laser-produced plasma, natural radiative lifetimes have been measured for 21 levels of Ge I belonging to the odd-parity 4p4d, 4p5d, and 4p6s configurations. Stimulated Brillouin scattering in water has allowed us to compress Nd:YAG laser pulses pumping a dye laser (where YAG denotes yttrium aluminum garnet), thus yielding 1-ns tunable laser pulses to enable accurate measurements of short lifetimes. Branching ratios of Ge I have been measured by inductively coupled plasma emission spectrometry, the intensity calibration being performed by means of Ar lines emitted by a hollow-cathode lamp. The experimental lifetimes and branching ratios have been combined in order to provide a set of accurate transition probabilities for the 4p-5s and 4p-4d transitions. A relativistic Hartree-Fock; calculation, taking configuration-interaction and polarization effects into account, has been combined with a least-squares optimization procedure of the Slater and spin-orbit integrals in order to test the ability of this approach to correctly predict radiative properties of the group-IV elements. Good agreement between experimental and theoretical transition probability values has been achieved for most of the transitions considered.
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| 6. |
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