| 1. |
- Grunewald, Johan, et al.
(författare)
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T-cell receptor-HLA-DRB1 associations suggest specific antigens in pulmonary sarcoidosis
- 2016
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Ingår i: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 47:3, s. 898-909
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Tidskriftsartikel (refereegranskat)abstract
- In pulmonary sarcoidosis, CD4(+) T-cells expressing T-cell receptor V alpha 2.3 accumulate in the lungs of HLA-DRB1*03(+) patients. To investigate T-cell receptor-HLA-DRB1*03 interactions underlying recognition of hitherto unknown antigens, we performed detailed analyses of T-cell receptor expression on bronchoalveolar lavage fluid CD4(+) T-cells from sarcoidosis patients. Pulmonary sarcoidosis patients (n=43) underwent bronchoscopy with bronchoalveolar lavage. T-cell receptor alpha and beta chains of CD4(+) T-cells were analysed by flow cytometry, DNA-sequenced, and three-dimensional molecular models of T-cell receptor-HLA-DRB1*03 complexes generated. Simultaneous expression of V alpha 2.3 with the V beta 22 chain was identified in the lungs of all HLA-DRB1*03(+) patients. Accumulated V alpha 2.3/V beta 22-expressing T-cells were highly clonal, with identical or near-identical V alpha 2.3 chain sequences and inter-patient similarities in V beta 22 chain amino acid distribution. Molecular modelling revealed specific T-cell receptor-HLA-DRB1*03-peptide interactions, with a previously identified, sarcoidosis-associated vimentin peptide, (Vim)(429-443) DSLPLVDTHSKRTLL, matching both the HLA peptide-binding cleft and distinct T-cell receptor features perfectly. We demonstrate, for the first time, the accumulation of large clonal populations of specific V alpha 2.3/V beta 22 T-cell receptor-expressing CD4(+) T-cells in the lungs of HLA-DRB1*03(+) sarcoidosis patients. Several distinct contact points between V alpha 2.3/V beta 22 receptors and HLA-DRB1*03 molecules suggest presentation of prototypic vimentin-derived peptides.
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| 2. |
- Jönsson, Sten, 1940, et al.
(författare)
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Learning Banks
- 2015
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Ingår i: HRM Workshop, Personal- och ledningsfrågor i en global värld. Handelshögskolan vid Göteborgs universitet, 4-5 mars 2015.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 3. |
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| 4. |
- Oliva Palau, Jonàs, et al.
(författare)
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Pathogen-induced defoliation of Pinus sylvestris leads to tree decline and death from secondary biotic factors
- 2016
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Ingår i: Forest Ecology and Management. - : Elsevier BV. - 0378-1127 .- 1872-7042. ; 379, s. 273-280
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Tidskriftsartikel (refereegranskat)abstract
- The contribution of non-lethal pathogenic attacks to tree death is still unclear. Manion's theory of the spiral of decline predicts that tree decline and death occurs because of a sequence of predisposing, inciting and contributing events. To understand whether pathogens can act as predisposing or inciting factors, we tested whether a sequence of non-lethal pathogen attacks causing crown defoliation could lead to a chronic decline in tree health and predispose trees to die. Scots pine (Pinus sylvestris) trees predisposed or escaping (non-predisposed) a first outbreak by the pathogen Gremmeniella abietina (predisposing event) were compared in terms of survival and susceptibility to secondary pests (contributing event) after a second G. abietina outbreak (inciting event). Four years after the inciting event, mortality among predisposed trees was up to five times higher than among trees escaping the first epidemic. Predisposed trees were twice as susceptible to secondary attacks by the common pine shoot beetle (Tomicus piniperda). Ten years after the inciting event, severely predisposed trees had not been able to restore their crowns and still showed stagnated growth. This study showed that pathogen-induced defoliation can act as predisposing and inciting factors for tree death, reducing the capacity of trees to survive short- or long-term stressing events, such as bark beetle attacks. We also showed that tree decline can result from a combination of predisposing and inciting events caused by pathogens. (C) 2016 Elsevier B.V. All rights reserved.
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| 5. |
- Wahlström Johnsson, Inger, 1973-, et al.
(författare)
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High birth weight was not associated with altered body composition or impaired glucose tolerance in adulthood
- 2019
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 108:12, s. 2208-2213
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Tidskriftsartikel (refereegranskat)abstract
- Aim To investigate whether a high birth weight was associated with an increased proportion of body fat or with impaired glucose tolerance in adulthood.Methods Our cohort comprised 27 subjects with birth weights of 4,500 g or more, and 27 controls with birth weights within ±1 SDS, born at Uppsala University Hospital 1975-1979. The subjects were 34-40 years old at the time of study.Anthropometric data was collected, and data on body composition was obtained by air plethysmography and bioimpedance and was estimated with a three compartment model. Indirect calorimetry, blood sampling for fasting insulin and glucose as well as a 75 g oral glucose tolerance test were also performed. Insulin sensitivity was assessed using homeostasis model assessment 2 (HOMA2) and Matsuda index. Areas under the curves were calculated for insulin and glucose.Results There were no differences in body mass index, body composition or insulin sensitivity between subjects with a high birth weight and controls.Conclusion Adult subjects, born with a moderately high birth weight, did not differ from those with birth weights within ±1 SDS regarding body composition or glucose tolerance
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| 6. |
- Wandell, Per, et al.
(författare)
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Depression or anxiety and all-cause mortality in adults with atrial fibrillation : A cohort study in Swedish primary care
- 2016
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Ingår i: Annals of Medicine. - : Informa UK Limited. - 0785-3890 .- 1365-2060. ; 48:1-2, s. 59-66
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Tidskriftsartikel (refereegranskat)abstract
- Objective Our aim was to study depression and anxiety in atrial fibrillation (AF) patients as risk factors for all-cause mortality in a primary care setting.Methods The study population included adults (n=12283) of 45 years and older diagnosed with AF in 75 primary care centres in Sweden. The association between depression or anxiety and all-cause mortality was explored using Cox regression analysis, with hazard ratios (HRs) and 95% confidence intervals (95% CIs). Analyses were conducted in men and women, adjusted for age, educational level, marital status, neighborhood socio-economic status (SES), change of neighborhood status and anxiety or depression, respectively, and cardiovascular co-morbidities. As a secondary analysis, background factors and their association with depression or anxiety were explored.Results The risk of all-cause mortality was higher among men with depression compared to their counterparts without depression even after full adjustment (HR=1.28, 95% CI 1.08-1.53). For anxiety among men and anxiety or depression among women with AF, no associations were found. Cerebrovascular disease was more common among depressed AF patients.Conclusions Increased awareness of the higher mortality among men with AF and subsequent depression is called for. We suggest a tight follow-up and treatment of both ailments in clinical practice.
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