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- Akner, Gunnar, 1953-, et al.
(författare)
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Glucocorticoid receptor inhibits microtubule assembly in vitro.
- 1995
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Ingår i: Molecular and cellular endocrinology. - : Elsevier BV. - 0303-7207 .- 1872-8057. ; 110:1-2, s. 49-54
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Tidskriftsartikel (refereegranskat)abstract
- The effect of glucocorticoid hormones, purified glucocorticoid receptor (GR) and purified heat shock protein M(r) 90,000 (hsp90) on microtubule (MT) assembly in vitro was tested by a spectrophotometric MT assembly assay and electron microscopy. GR significantly prolonged the nucleation phase, slowed down the assembly rate and reduced the maximal amplitude of MT assembly compared with control. The effects were partially reversed by the addition of glucocorticoid hormone. GR associated with MTs. These results indicate that GR affects MT assembly in vitro, which may be a functional correlate to the structural association of GR with MTs. This implies that factors affecting GR may affect MT assembly in vivo.
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| 2. |
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| 3. |
- Mårtensson, Lena, et al.
(författare)
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Labour pain treated with cutaneous injections of sterile water : a randomised controlled trial
- 1999
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Ingår i: British Journal of Obstetrics and Gynecology. - : Wiley-Blackwell. - 1470-0328 .- 1471-0528. ; 106:7, s. 633-637
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Tidskriftsartikel (refereegranskat)abstract
- Objective To evaluate the relief of pain in labour with subcutaneous and intracutaneous injections of sterile water, compared with placebo.Design Randomised controlled trial.Setting Labour ward with approximately 3000 deliveries annually in a suburban area near Gothenburg, Sweden.Participants Ninety-nine pregnant women at term, requiring pain relief for severe lower back pain during the first stage of labour. The women were randomised to receive four injections of 0.1 mL sterile water (without salt) intracutaneously ( n= 33 ), four injections of 0.5 mL sterile water subcutaneously ( n= 33 ) or placebo treatment ( n= 33 ).Main outcome measures Reduction of labour pain measured by visual analogue scale.Results The median visual analogue scale pain score for labour pain was significantly lower compared with initial values in the two study groups and compared with placebo at 10 and 45 minutes after treatment. The median reductions in visual analogue scores after 10 minutes were 5.0 cm and 4.5 cm in the intracutaneous and subcutaneous injection groups, respectively; women in the placebo group scored a median reduction of 1.7 cm. After 45 minutes the median reductions in the visual analogue scores were 4.9 cm and 4.0 cm in the intracutaneous and subcutaneous injection groups, respectively, compared with 1.0 cm for women in the placebo group. No significant differences in analgesic effect or pain experienced during administration were found between the two study groups.Conclusion The new subcutaneous method of administering sterile water, as well as the earlier described intracutaneous injection method, were effective for the relief of pain in labour.
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| 5. |
- Schneider, Gisbert, et al.
(författare)
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Feature-extraction from endopeptidase cleavage sites in mitochondrial targeting peptides
- 1998
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Ingår i: Proteins. - 0887-3585 .- 1097-0134. ; 30:1, s. 49-60
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Tidskriftsartikel (refereegranskat)abstract
- Cleavage sites in nuclear-encoded mitochondrial protein targeting peptides (mTPs) from mammals, yeast, and plants have been analysed for characteristic physicochemical features using statistical methods, perceptrons, multilayer neural networks, and self-organizing feature maps, Three different sequence motifs were found, revealing loosely defined arginine motifs with Arg in positions -10, -3, and -2. A self-organizing feature map was able to cluster these three types of endopeptidase target sites but did not identify any species-specific characteristics in mTPs, Neural networks were used to define local sequence features around precursor cleavage sites.
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| 6. |
- Wallin, Gunnar B, 1936, et al.
(författare)
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Two neural mechanisms for respiration-induced cutaneous vasodilatation in humans?
- 1998
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Ingår i: The Journal of physiology. - : Wiley. - 0022-3751. ; 513 ( Pt 2), s. 559-69
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Tidskriftsartikel (refereegranskat)abstract
- 1. In humans, a deep breath is known to induce cutaneous vasoconstriction in the warm state, and vasodilatation in the cold state. To investigate whether vasodilatation in the cold state is related to reduction of sympathetic vasoconstrictor nerve traffic, we studied the effect of a deep breath on vascular resistance in a skin area on the dorsum of the hand, in which release of noradrenaline from sympathetic nerves was blocked by iontophoretic pretreatment with bretylium tosylate. Simultaneous measurements were made in two control areas. In eight healthy subjects, data were obtained from deep breaths taken before bretylium in the warm state, after general cooling to a finger skin temperature below 25 C and after rewarming to above 32 C. 2. In the warm state before bretylium pretreatment, the deep breath evoked short-lasting vasoconstrictions at all sites. In the cold state there was no change of vascular resistance in the bretylium-pretreated area, whereas in the control areas an initial tendency towards vasoconstriction was followed by a significant transient vasodilatation. After rewarming, transient vasoconstrictions reappeared at the control sites, whereas only a transient vasodilatation occurred at the bretylium-pretreated site. 3. In six healthy subjects we also monitored the effects of a deep breath on skin sympathetic nerve activity (recorded by microneurography in the peroneal nerve), and skin vascular resistance within the innervation zone of the impaled nerve fascicle in the foot. Data from thirty deep breaths per subject were averaged. 4. In the cold state, the deep breath induced a strong increase in neural discharge, followed by a transient reduction of nerve traffic lasting approximately 15 s and associated with a subsequent reduction of vascular resistance. 5. We conclude that the deep breath-induced vasodilatation in the cold state is due to reduction of sympathetic vasoconstrictor nerve traffic. The vasodilatation after bretylium treatment in the warm state raises the possibility that a deep breath induces two simultaneous neural reactions, a vasoconstrictor and an active vasodilator component, the latter being weaker and normally masked by the strong vasoconstrictor component.
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| 7. |
- Wallin, Gunnar, 1923-, et al.
(författare)
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Makthavare i fokus : attityder och verklighetsuppfattningar hos toppskikten inom politik och förvaltning
- 1999
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Redan för 30 år sedan tog ett antal amerikanska statsvetare initiativ till ett forskningsprojekt där man utgick från iakttagelsen att skilda länder på olika sätt och med olika framgång förmått möta och hantera de krav som allt snabbare samhällsförändringar ställt dem inför.Under senare delen av 1980-talet togs nytt initiativ till en upprepning av undersökningen, nu med större utrymme för länderspecifika studier. Författarna till denna bok har utgjort den svenska forskargruppen. De har i sin undersökning velat beskriva politikers och tjänstemäns attitydmönster och, i viss mån, beteenden samt att utröna likheter och olikheter mellan de bägge grupperna.
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