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- Hoogewijs, D., et al.
(författare)
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From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia
- 2007
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Ingår i: Integrative and Comparative Biology. - : Oxford University Press (OUP). - 1557-7023 .- 1540-7063. ; 47:4, s. 552-577
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this symposium at the First International Congress of Respiratory Biology (ICRB) was to enhance communication between comparative biologists and cancer researchers working on O-2 sensing via the HIF pathway. Representatives from both camps came together on August 13-16, 2006, in Bonn, Germany, to discuss molecular adaptations that occur after cells have been challenged by a reduced (hypoxia) or completely absent (anoxia) supply of oxygen. This brief "critters-to-cancer" survey discusses current projects and new directions aimed at improving understanding of hypoxic signaling and developing therapeutic interventions.
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| 2. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
- 2008
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Ingår i: Autophagy. - : Landes Bioscience. - 1554-8627 .- 1554-8635. ; 4:2, s. 151-175
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Forskningsöversikt (refereegranskat)abstract
- Research in autophagy continues to accelerate,1 and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring macroautophagy in different organisms. Recent reviews have described the range of assays that have been used for this purpose.2,3 There are many useful and convenient methods that can be used to monitor macroautophagy in yeast, but relatively few in other model systems, and there is much confusion regarding acceptable methods to measure macroautophagy in higher eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers of autophagosomes versus those that measure flux through the autophagy pathway; thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from fully functional autophagy that includes delivery to, and degradation within, lysosomes (in most higher eukaryotes) or the vacuole (in plants and fungi). Here, we present a set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes. This set of guidelines is not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response.
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| 3. |
- Brunnström, K, et al.
(författare)
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VQEG Validation and ITU Standardisation of Objective Perceptual Video Quality Metrics
- 2009
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Ingår i: IEEE signal processing magazine (Print). - 1053-5888 .- 1558-0792. ; 26:3, s. 96-101
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Tidskriftsartikel (refereegranskat)abstract
- For industry, the need to access accurate and reliable objective video metrics has become more pressing with the advent of new video applications and services such as mobile broadcasting, Internet video, and Internet Protocol television (IPTV). Industry-class objective quality- measurement models have a wide range of uses, including equipment testing (e.g., codec evaluation), transmission- planning and network-dimensioning tasks, head-end quality assurance, in- service network monitoring, and client-based quality measurement. The Video Quality Experts Group (VQEG) is the primary forum for validation testing of objective perceptual quality models. The work of VQEG has resulted in International Telecommunication Union (ITU) standardization of objective quality models designed for standard- definition television and for multimedia applications. This article reviews VQEG's work, paying particular attention to the group's approach to validation testing.
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