| 1. |
- Scheitz, Jan F, et al.
(författare)
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Cohort profile: Thrombolysis in Ischemic Stroke Patients (TRISP): a multicentre research collaboration.
- 2018
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Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 8:9
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Tidskriftsartikel (refereegranskat)abstract
- The ThRombolysis in Ischemic Stroke Patients (TRISP) collaboration aims to address clinically relevant questions about safety and outcomes of intravenous thrombolysis (IVT) and endovascular thrombectomy. The findings can provide observational information on treatment of patients derived from everyday clinical practice.TRISP is an open, investigator-driven collaborative research initiative of European stroke centres with expertise in treatment with revascularisation therapies and maintenance of hospital-based registries. All participating centres made a commitment to prospectively collect data on consecutive patients with stroke treated with IVT using standardised definitions of variables and outcomes, to assure accuracy and completeness of the data and to adapt their local databases to answer novel research questions.Currently, TRISP comprises 18 centres and registers >10000IVT-treated patients. Prior TRISP projects provided evidence on the safety and functional outcome in relevant subgroups of patients who were excluded, under-represented or not specifically addressed in randomised controlled trials (ie, pre-existing disability, cervical artery dissections, stroke mimics, prior statin use), demonstrated deficits in organisation of acute stroke care (ie, IVT during non-working hours, effects of onset-to-door time on onset-to-needle time), evaluated the association between laboratory findings on outcome after IVT and served to develop risk estimation tools for prediction of haemorrhagic complications and functional outcome after IVT.Further TRISP projects to increase knowledge of the effect and safety of revascularisation therapies in acute stroke are ongoing. TRISP welcomes participation and project proposals of further centres fulfilling the outlined requirements. In the future, TRISP will be extended to include patients undergoing endovascular thrombectomy.
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| 2. |
- Wegener, Konrad, et al.
(författare)
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Recent developments in grinding machines
- 2017
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Ingår i: CIRP Annals - Manufacturing Technology. - : Elsevier BV. - 1726-0604 .- 0007-8506. ; 66:2, s. 779-802
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Tidskriftsartikel (refereegranskat)abstract
- Grinding is often the final step in the process/manufacturing chain, meaning that no subsequent post-grinding correction of the surface and geometry is performed. This imposes strong requirements on grinding-machine technology and on the understanding of this finalising process. While grinding has unique capabilities it is nevertheless in competition with other machining processes. The evolution of grinding machines is driven by process requirements like accuracy, MRR, and subsurface integrity. The regeneration of the tool on the machine with dressing devices is to be regarded as unique for grinding machines, hence a grinding machine always runs two separate processes. The high accuracy of grinding has, in fact, been an obstacle to simply adopting developments from other machining processes. Also, a lack of experienced machinists and a general trend towards individualized products and one-piece flow has required a transition from an experience-based approach to a science-based approach. Development is further driven by market demands, such as cost-reduction in terms of CAPEX, footprint, TCO versus quality, and throughput, which affect business models and the machine's design and construction. Moreover, the current mega-trends – such as resource efficiency, individualization, ergonomics and Industry 4.0 – are changing the appearance of grinding machines, which is also affected by the availability of new technologies, especially sensors, actuators and the control or machine intelligence. This paper reviews the most-relevant technologies, assesses their impact and the readiness of industry to adopt them, identifies the still-open issues, and concludes with future research requirements.
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