| 1. |
- Chalmers, J. R., et al.
(författare)
-
Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)
- 2016
-
Ingår i: British Journal of Dermatology. - : Oxford University Press (OUP). - 0007-0963 .- 1365-2133. ; 175:1, s. 69-79
-
Tidskriftsartikel (refereegranskat)abstract
- This article is a report of the fourth meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in Malmo, Sweden on 23-24 April 2015 (HOME IV). The aim of the meeting was to achieve consensus over the preferred outcome instruments for measuring patient-reported symptoms and quality of life for the HOME core outcome set for atopic eczema (AE). Following presentations, which included data from systematic reviews, consensus discussions were held in a mixture of whole group and small group discussions. Small groups were allocated a priori to ensure representation of different stakeholders and countries. Decisions were voted on using electronic keypads. For the patient-reported symptoms, the group agreed by vote that itch, sleep loss, dryness, redness/inflamed skin and irritated skin were all considered essential aspects of AE symptoms. Many instruments for capturing patient-reported symptoms were discussed [ including the Patient-Oriented SCOring Atopic Dermatitis index, Patient-Oriented Eczema Measure (POEM), Self-Administered Eczema Area and Severity Index, Itch Severity Scale, Atopic Dermatitis Quickscore and the Nottingham Eczema Severity Score] and, by consensus, POEM was selected as the preferred instrument to measure patient-reported symptoms. Further work is needed to determine the reliability and measurement error of POEM. Further work is also required to establish the importance of pain/soreness and the importance of collecting information regarding the intensity of symptoms in addition to their frequency. Much of the discussion on quality of life concerned the Dermatology Life Quality Index and Quality of Life Index for Atopic Dermatitis; however, consensus on a preferred instrument for measuring this domain could not be reached. In summary, POEM is recommended as the HOME core outcome instrument for measuring AE symptoms.
|
|
| 2. |
- Warr, N., et al.
(författare)
-
The Miniball spectrometer
- 2013
-
Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 49:3
-
Tidskriftsartikel (refereegranskat)abstract
- The Miniball germanium detector array has been operational at the REX (Radioactive ion beam EXperiment) post accelerator at the Isotope Separator On-Line facility ISOLDE at CERN since 2001. During the last decade, a series of successful Coulomb excitation and transfer reaction studies have been performed with this array, utilizing the unique and high-quality radioactive ion beams which are available at ISOLDE. In this article, an overview is given of the technical details of the full Miniball setup, including a description of the.-ray and particle detectors, beam monitoring devices and methods to deal with beam contamination. The specific timing properties of the REX-ISOLDE facility are highlighted to indicate the sensitivity that can be achieved with the full Miniball setup. The article is finalized with a summary of some physics highlights at REX-ISOLDE and the utilization of the Miniball germanium detectors at other facilities.
|
|
| 3. |
- Chalmers, J. R., et al.
(författare)
-
Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)
- 2018
-
Ingår i: British Journal of Dermatology. - : John Wiley & Sons. - 0007-0963 .- 1365-2133. ; 178:5, s. E332-E341
-
Tidskriftsartikel (refereegranskat)abstract
- This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12-14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus over the definition of the core domain of long-term control and how to measure it and (ii) to prioritize future areas of research for the measurement of the core domain of quality of life (QoL) in children. Moderated whole-group and small-group consensus discussions were informed by presentations of qualitative studies, systematic reviews and validation studies. Small-group allocations were performed a priori to ensure that each group included different stakeholders from a variety of geographical regions. Anonymous whole-group voting was carried out using handheld electronic voting pads according to pre-defined consensus rules. It was agreed by consensus that the long-term control domain should include signs, symptoms, quality of life and a patient global instrument. The group agreed that itch intensity should be measured when assessing long-term control of eczema in addition to the frequency of itch captured by the symptoms domain. There was no recommendation of an instrument for the core outcome domain of quality of life in children, but existing instruments were assessed for face validity and feasibility, and future work that will facilitate the recommendation of an instrument was agreed upon.
|
|
| 4. |
- Akkoyun, S., et al.
(författare)
-
AGATA - Advanced GAmma Tracking Array
- 2012
-
Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002 .- 0167-5087 .- 1872-9576. ; 668, s. 26-58
-
Tidskriftsartikel (refereegranskat)abstract
- The Advanced GAmma Tracking Array (AGATA) is a European project to develop and operate the next generation γ-ray spectrometer. AGATA is based on the technique of γ-ray energy tracking in electrically segmented high-purity germanium crystals. This technique requires the accurate determination of the energy, time and position of every interaction as a γ ray deposits its energy within the detector volume. Reconstruction of the full interaction path results in a detector with very high efficiency and excellent spectral response. The realisation of γ-ray tracking and AGATA is a result of many technical advances. These include the development of encapsulated highly segmented germanium detectors assembled in a triple cluster detector cryostat, an electronics system with fast digital sampling and a data acquisition system to process the data at a high rate. The full characterisation of the crystals was measured and compared with detector- response simulations. This enabled pulse-shape analysis algorithms, to extract energy, time and position, to be employed. In addition, tracking algorithms for event reconstruction were developed. The first phase of AGATA is now complete and operational in its first physics campaign. In the future AGATA will be moved between laboratories in Europe and operated in a series of campaigns to take advantage of the different beams and facilities available to maximise its science output. The paper reviews all the achievements made in the AGATA project including all the necessary infrastructure to operate and support the spectrometer. © 2011 Elsevier B.V. All rights reserved.
|
|
| 5. |
|
|
| 6. |
- Ekström, Andreas, et al.
(författare)
-
Electric quadrupole moments of the 2(1)(+) states in Cd-100,Cd-102,Cd-104
- 2009
-
Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 80:5
-
Tidskriftsartikel (refereegranskat)abstract
- Using the REX-ISOLDE facility at CERN the Coulomb excitation cross sections for the 0(gs)(+)-> 2(1)(+) transition in the beta-unstable isotopes Cd-100,Cd-102,Cd-104 have been measured for the first time. Two different targets were used, which allows for the first extraction of the static electric quadrupole moments Q(2(1)(+)) in Cd-102,Cd-104. In addition to the B(E2) values in Cd-102,Cd-104, a first experimental limit for the B(E2) value in Cd-100 is presented. The data was analyzed using the maximum likelihood method. The provided probability distributions impose a test for theoretical predictions of the static and dynamic moments. The data are interpreted within the shell-model using realistic matrix elements obtained from a G-matrix renormalized CD-Bonn interaction. In view of recent results for the light Sn isotopes the data are discussed in the context of a renormalization of the neutron effective charge. This study is the first to use the reorientation effect for post-accelerated short-lived radioactive isotopes to simultaneously determine the B(E2) and the Q(2(1)(+)) values.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Kester, O., et al.
(författare)
-
Accelerated radioactive beams from REX-ISOLDE
- 2003
-
Ingår i: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. - 0168-583X. ; 204, s. 20-20
-
Konferensbidrag (refereegranskat)abstract
- In 2001 the linear accelerator of the Radioactive beam EXperiment (REX-ISOLDE) delivered for the first time accelerated radioactive ion beams, at a beam energy of 2 MeV/u. REX-ISOLDE uses the method of charge-state breeding, in order to enhance the charge state of the ions before injection into the LINAC. Radioactive singly-charged ions from the on-line mass separator ISOLDE are first accumulated in a Penning trap, then charge bred to an A/q
|
|
| 10. |
- Kröll, Th, et al.
(författare)
-
Quadrupole Collectivity of neutron-rich nuclei around 132Sn
- 2008
-
Ingår i: Frontiers in Nuclear Structure, Astrophysics, and Reactions, FINUSTAR 2007. - : AIP. - 9780735405325 ; 1012, s. 296-299
-
Konferensbidrag (refereegranskat)abstract
- We report on the "safe" Coulomb excitation of neutron-rich Cd, Xe, and Ba isotopes in the vicinity of the doubly-magic nucleus 132Sn. The radioactive nuclei have been produced by ISOLDE at CERN and postaccelerated by the REX-ISOLDE facility. The γ-decay of excited states has been detected by the MINIBALL array. The presented preliminary results for the B(E2) values are consistent with expectations from phenomenological systematics and will be compared with theoretical calculations.
|
|
| 11. |
- Niedermaier, O., et al.
(författare)
-
"Safe" Coulomb excitation of Mg-30
- 2005
-
Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 94:17, s. 172501 (artno)-
-
Tidskriftsartikel (refereegranskat)abstract
- We report on the first radioactive beam experiment performed at the recently commissioned REX-ISOLDE facility at CERN in conjunction with the highly efficient γ spectrometer MINIBALL. Using Mg-30 ions accelerated to an energy of 2.25 MeV/u together with a thin Ni-nat target, Coulomb excitation of the first excited 2(+) states of the projectile and target nuclei well below the Coulomb barrier was observed. From the measured relative deexcitation γ-ray yields the B(E2;0(gs)(+)→ 2(1)(+)) value of Mg-30 was determined to be 241(31)e(2) fm(4). Our result is lower than values obtained at projectile fragmentation facilities using the intermediate-energy Coulomb excitation method, and confirms the theoretical conjecture that the neutron-rich magnesium isotope Mg-30 resides outside the "island of inversion."
|
|
| 12. |
- Niedermaier, O., et al.
(författare)
-
The neutron-rich Mg isotopes: first results from MINIBALL at REX-ISOLDE
- 2005
-
Ingår i: Nuclear Physics A. - : Elsevier BV. - 0375-9474. ; 752, s. 273-273
-
Tidskriftsartikel (refereegranskat)abstract
- We report on the first radioactive beam experiment performed at the recently commissioned REX-ISOLDE facility at CERN in conjunction with the highly efficient γ spectrometer MINIBALL. Using Mg-30 ions accelerated to an energy of 2.25 MeV/u together with a thin Ni-nat target, Coulomb excitation of the first excited 2(+) states of the projectile and target nuclei well below the Coulomb barrier was observed. From the measured relative deexcitation γ-ray yields the B(E2;0(gs)(+)→ 2(1)(+)) value of Mg-30 was determined to be 241(31)e(2) fm(4). Our result is lower than values obtained at projectile fragmentation facilities using the intermediate-energy Coulomb excitation method, and confirms the theoretical conjecture that the neutron-rich magnesium isotope Mg-30 resides outside the "island of inversion."
|
|
| 13. |
- Pereira, M. P., et al.
(författare)
-
Position Statement : Linear prurigo is a subtype of chronic prurigo
- 2019
-
Ingår i: Journal of the European Academy of Dermatology and Venereology. - : Wiley. - 0926-9959 .- 1468-3083. ; 33:2, s. 263-266
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Chronic prurigo (CPG) is a distinct disease characterized by chronic pruritus, history and/or signs of prolonged scratching and multiple pruriginous lesions. It may present with various clinical manifestations, including papules, nodules, plaques or umbilicated lesions. Some patients with chronic pruritus show pruriginous linear and scaring scratch lesions (LSSL) and it is unclear whether these lesions belong to the spectrum of CPG. Objective: To achieve a consensus on the classification of pruriginous LSSL and establish criteria to differentiate them from similar appearing conditions of different nature. Methods: Members of the Task Force Pruritus (TFP) of the European Academy of Dermatology and Venereology participated in the consensus conference, discussing representative clinical cases. Using the Delphi method, consensus was reached when ≥75% of members agreed on a statement. Results: Twenty-one members of the TFP with voting rights participated in the meeting. It was consented that LSSL occurs due to chronic pruritus and prolonged scratching, and share common pathophysiological mechanisms with CPG. LSSL were thus considered as belonging to the spectrum of CPG and the term ‘linear prurigo’ was chosen to describe this manifestation. Conclusion: Considering linear prurigo as belonging to the spectrum of CPG has important clinical implications, since both the diagnostic and therapeutic approach of these patients should be performed as recommended for CPG. Importantly, linear prurigo should be differentiated from self-inflicted skin lesions as factitious disorders or skin picking syndromes. In the latter, artificial manipulation rather than pruritus itself leads to the development of cutaneous lesions, which can show clinical similarities to linear prurigo.
|
|
| 14. |
- Petri, M., et al.
(författare)
-
Structure of C-16: Testing shell model and ab initio approaches
- 2012
-
Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 86:4, s. Art. no. 044329-
-
Tidskriftsartikel (refereegranskat)abstract
- Excited states in C-16 were populated via the Be-9(N-17,C-16+gamma)X one-proton knockout reaction. The lifetime of the 2(1)(+) state in C-16 was measured using the recoil distance method. The extracted lifetime of tau(+)(21) = 11.4(-0.9)(+0.8)(stat) +/- 0.7(syst(B rho))(-1.5)(+0.0)(syst(feeding)) ps yields a deduced B(E2;2(1)(+) -> 0(1)(+)) = 4.21(-0.26)(+0.34)(stat)(-0.24)(+0.28)(syst(B rho))(-0.00)(+0.64)(syst(feeding)) e(2)fm(4) value in good agreement with a previous measurement. The one-proton knockout cross section is used to extract the proton amplitude of the C-16 2(1)(+) state, which confirms the neutron dominant character of this state. Gamma-ray branching ratios between the 2(2)(+) state and the 2(1)(+) and ground states were also determined. The results are compared with p-sd shell model and no-core shell model (with NN and NN + NNN) calculations. The inclusion of three-body forces are essential in order for the no-core shell model calculations to reproduce the experimental findings on the gamma-ray branching ratios.
|
|
| 15. |
- Petts, A., et al.
(författare)
-
Lifetime measurements and coulomb excitation of light Hg nuclei
- 2009
-
Ingår i: Capture Gamma-Ray Spectroscopy and Related Topics. - : American Institute of Physics (AIP). - 9780735406230 ; , s. 414-418
-
Konferensbidrag (refereegranskat)abstract
- Two complementary experimental programs have taken place to investigate the origin and evolution of shape coexistence in the light mercury region. Recoil Distance Doppler-shift measurements were performed at the University of Jyväskylä utilizing the Köln plunger device in conjunction with the JUROGAM + RITU + GREAT setup. In addition, Coulomb excitation measurements of 184,186,188Hg were performed at REX-ISOLDE using the MINIBALL Ge-detector array. The results of the lifetime measurements of the yrast states up to Iπ = 10+ in 182Hg are reported. Preliminary analysis of the Coulomb excitation data is also discussed.
|
|
| 16. |
- Scheit, H., et al.
(författare)
-
Coulomb excitation of neutron-rich beams at REX-ISOLDE
- 2005
-
Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-601X .- 1434-6001. ; 25:Suppl. 1, s. 397-402
-
Konferensbidrag (refereegranskat)abstract
- After the successful commissioning of the radioactive beam experiment at ISOLDE (REX-ISOLDE) - an accelerator for exotic nuclei produced by ISOLDE - in 2002 and the promotion to a CERN user facility in 2003, first physics experiments using these beams were performed. Initial experiments focused on the region of deformation in the vicinity of the neutron-rich Na and Mg isotopes. Preliminary results on the neutron-rich Na and Mg isotopes show the high potential and physics opportunities offered by the exotic isotope accelerator REX in conjunction with the modern Germanium gamma spectrometer MINIBALL.
|
|
| 17. |
- Stefanescu, I., et al.
(författare)
-
Coulomb Excitation of 68,70Cu: First Use of Postaccelerated Isomeric Beams
- 2007
-
Ingår i: Physical Review Letters. ; 98
-
Tidskriftsartikel (refereegranskat)abstract
- We report on the first low-energy Coulomb excitation measurements with radioactive Ipi=6- beams of odd-odd nuclei 68,70Cu. The beams were produced at ISOLDE, CERN and were post-accelerated by REX-ISOLDE to 2.83 MeV/nucleon. gamma rays were detected with the MINIBALL spectrometer. The 6- beam was used to study the multiplet of states (3-, 4-, 5-, 6-) arising from the pi2p3/2nu1g9/2 configuration. The 4- state of the multiplet was populated via Coulomb excitation and the B(E2;6--->4-) value was determined in both nuclei. The results obtained illustrate the fragile stability of the Z=28 shell and N=40 subshell closures. A comparison with large-scale shell-model calculations using the 56Ni core shows the importance of the proton excitations across the Z=28 shell gap to the understanding of the nuclear structure in the neutron-rich nuclei with N[approximate]40.
|
|
| 18. |
- Voss, P., et al.
(författare)
-
Excited-state transition-rate measurements in C-18
- 2012
-
Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 86:1
-
Tidskriftsartikel (refereegranskat)abstract
- Excited states in C-18 were populated by the one-proton knockout reaction of an intermediate energy radioactive N-19 beam. The lifetime of the first 2(+) state was measured with the Koln/NSCL plunger via the recoil distance method to be tau (2(1)(+)) = 22.4 +/- 0.9(stat)(-2.2)(+3.3)(syst) ps, which corresponds to a reduced quadrupole transition strength of B(E2; 2(1)(+) -> 0(1)(+)) = 3.64(-0.14)(+ 0.15)(stat)(-0.47)(+0.40)(syst) e(2)fm(4). In addition, an upper limit on the lifetime of a higher-lying state feeding the 2(1)(+) state was measured to be tau
|
|
| 19. |
|
|
| 20. |
- Cederkäll, Joakim, et al.
(författare)
-
REX-ISOLDE - experiences from the first year of operation
- 2004
-
Ingår i: Nuclear Physics A. - : Elsevier BV. - 0375-9474. ; 746, s. 17-17
-
Konferensbidrag (refereegranskat)abstract
- The Radioactive beam EXperiment (REX) at CERN-ISOLDE has been commissioned and the first experiments successfully completed during 2002 and 2003. The concept used for post-acceleration has proven to be flexible and the experimental program has therefore been extended during the past year. This paper relays some experiences drawn from using the machine in the current program and also conveys some plans for the future.
|
|
| 21. |
- Chalmers, J. R., et al.
(författare)
-
Report from the third international consensus meeting to harmonise core outcome measures for atopic eczema/dermatitis clinical trials (HOME)
- 2014
-
Ingår i: British Journal of Dermatology. - : Oxford University Press (OUP). - 1365-2133 .- 0007-0963. ; 171:6, s. 1318-1325
-
Tidskriftsartikel (refereegranskat)abstract
- This report provides a summary of the third meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in San Diego, CA, U.S.A., 6-7 April 2013 (HOME III). The meeting addressed the four domains that had previously been agreed should be measured in every eczema clinical trial: clinical signs, patient-reported symptoms, long-term control and quality of life. Formal presentations and nominal group techniques were used at this working meeting, attended by 56 voting participants (31 of whom were dermatologists). Significant progress was made on the domain of clinical signs. Without reference to any named scales, it was agreed that the intensity and extent of erythema, excoriation, oedema/papulation and lichenification should be included in the core outcome measure for the scale to have content validity. The group then discussed a systematic review of all scales measuring the clinical signs of eczema and their measurement properties, followed by a consensus vote on which scale to recommend for inclusion in the core outcome set. Research into the remaining three domains was presented, followed by discussions. The symptoms group and quality of life groups need to systematically identify all available tools and rate the quality of the tools. A definition of long-term control is needed before progress can be made towards recommending a core outcome measure.
|
|
| 22. |
- de Walle, J. V., et al.
(författare)
-
Coulomb excitation of the N=50 nucleus Zn-80
- 2008
-
Ingår i: AIP Conference Proceedings. - 1551-7616 .- 0094-243X. ; 1012, s. 291-295 453
-
Konferensbidrag (refereegranskat)abstract
- Neutron rich Zinc isotopes, including the N=50 nucleus Zn-80, were produced and post-accelerated at the Radioactive Ion Beam (RIB) facility REX-ISOLDE (CERN). Low-energy Coulomb excitation was induced on these isotopes after post-acceleration, yielding B(E2) strengths to the first excited 2(+) states. For the first time, an excited state in Zn-80 was observed and the 2(1)(+) state in Zn-78 was established. The measured B(E2,2(1)(+) -> 0(1)(+)) values are compared to two sets of large scale shell model calculations. Both calculations reproduce the observed B(E2) systematics for the full Zinc isotopic chain. The results for N=50 isotones indicate a good N=50 shell closure and a strong Z=28 proton core polarization. The new results serve as benchmarks to establish theoretical models, predicting the nuclear properties of the doubly magic nucleus Ni-78.
|
|
| 23. |
- Gao, B., et al.
(författare)
-
New Fe-59 Stellar Decay Rate with Implications for the Fe-60 Radioactivity in Massive Stars
- 2021
-
Ingår i: Physical Review Letters. - : American Physical Society (APS). - 0031-9007 .- 1079-7114. ; 126:15
-
Tidskriftsartikel (refereegranskat)abstract
- The discrepancy between observations from gamma-ray astronomy of the Fe-60/Al-26 gamma-ray flux ratio and recent calculations is an unresolved puzzle in nuclear astrophysics. The stellar beta-decay rate of Fe-59 is one of the major nuclear uncertainties impeding us from a precise prediction. The important Gamow-Teller strengths from the low-lying states in Fe-59 to the Co-59 ground state are measured for the first time using the exclusive measurement of the Co-59(t, He-3 + gamma) Fe-59 charge-exchange reaction. The new stellar decay rate of Fe-59 is a factor of 3.5 +/- 1.1 larger than the currently adopted rate at T = 1.2 GK. Stellar evolution calculations show that the Fe-60 production yield of an 18 solar mass star is decreased significantly by 40% when using the new rate. Our result eliminates one of the major nuclear uncertainties in the predicted yield of Fe-60 and alleviates the existing discrepancy of the Fe-60/Al-26 ratio.
|
|
| 24. |
- Lieder, R M, et al.
(författare)
-
Gamma-ray tracking arrays
- 2001
-
Ingår i: PROGRESS IN PARTICLE AND NUCLEAR PHYSICS, VOL 46. ; , s. 399-407
-
Konferensbidrag (refereegranskat)abstract
- The next generation of 4 pi arrays for high-precision gamma -ray spectroscopy will involve "gamma -ray tracking front-end on digital signal processing techniques, which allows to extract energy, timing and spatial information on the interactions of a gamma -ray in the Ge detector by pulse shape analysis of its signals. Utilizing the information on the positions of the interaction points and the energies released at each point the tracks of the gamma -rays in a Ge shell can be reconstructed in three dimensions.
|
|
| 25. |
- Pereira, M. P., et al.
(författare)
-
European academy of dermatology and venereology European prurigo project : Expert consensus on the definition, classification and terminology of chronic prurigo
- 2018
-
Ingår i: Journal of the European Academy of Dermatology and Venereology. - : Wiley. - 0926-9959. ; 32:7, s. 1059-1065
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The term prurigo has been used for many decades in dermatology without clear definition, and currently used terminology of prurigo is inconsistent and confusing. Especially, itch-related prurigo remains unexplored regarding the epidemiology, clinical profile, natural course, underlying causes, available treatments and economic burden, although burdensome and difficult to treat. Objective: To address these issues, the multicentre European Prurigo Project (EPP) was designed to increase knowledge on chronic prurigo (CPG). In the first step, European experts of the EADV Task Force Pruritus (TFP) aimed to achieve a consensus on the definition, classification and terminology of CPG. Additionally, procedures of the cross-sectional EPP were discussed and agreed upon. Methods: Discussions and surveys between members of the TFP served as basis for a consensus conference. Using the Delphi method, consensus was defined as an agreement ≥75% among the present members. Results: Twenty-four members of the TFP participated in the consensus conference. Experts consented that CPG should be used as an umbrella term for the range of clinical manifestations (e.g. papular, nodular, plaque or umbilicated types). CPG is considered a distinct disease defined by the presence of chronic pruritus for ≥6 weeks, history and/or signs of repeated scratching and multiple localized/generalized pruriginous skin lesions (whitish or pink papules, nodules and/or plaques). CPG occurs due to a neuronal sensitization to itch and the development of an itch-scratch cycle. Conclusion: This new definition and terminology of CPG should be implemented in dermatology to harmonize communication in the clinical routine, clinical trials and scientific literature. Acute/subacute forms of prurigo are separated entities, which need to be differentiated from CPG and will be discussed in a next step. In the near future, the cross-sectional EPP will provide relevant clinical data on various aspects of CPG leading to new directions in the scientific investigation of CGP.
|
|
| 26. |
- Recchia, F, et al.
(författare)
-
Position resolution of the prototype AGATA triple-cluster detector from an in-beam experiment
- 2009
-
Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 604:3, s. 555-562
-
Tidskriftsartikel (refereegranskat)abstract
- AGATA belongs to a new generation of gamma-ray detector arrays for nuclear spectroscopy at present in its final stage of development. The detectors of these new arrays will be based on 36-fold electronically segmented coaxial germanium diodes operated in position sensitive mode. An in-beam test of the AGATA prototype triple cluster detector was carried out with the purpose of demonstrating the feasibility of such detectors and in order to measure the most sensitive parameters for their overall performance. An inverse kinematics reaction was performed, using a Ti-48 beam at an energy of 100MeV, impinging on a deuterated titanium tat-get. The results from the analysis of the experimental data, compared with the predictions of Monte Carlo Simulations, give an estimation of the position sensitivity of these detectors of about 5 mm FWHM, consistent with the specifications required. (C) 2009 Elsevier B.V. All rights reserved.
|
|
| 27. |
- Stefanova, E. A., et al.
(författare)
-
Four-quasiparticle alignments in Ge-66
- 2003
-
Ingår i: Acta Physica Polonica B. - 0587-4254 .- 1509-5770. ; 34:4, s. 2237-2240
-
Tidskriftsartikel (refereegranskat)abstract
- Above angular momentum 10(+), we found two positive-parity sequences, connected by energetically staggered DeltaI = 1 M1 transitions. The total Routhian surface calculations predict a strong triaxial deformation for them. To our knowledge, this is the first observation of staggered M1 transitions in a deformed four-quasiparticle pi(g(9/2)(2))v(g(9/2)(2)) regime.
|
|
| 28. |
- Stefanova, E. A., et al.
(författare)
-
Four-quasiparticle alignments in Ge-66
- 2003
-
Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 67:5
-
Tidskriftsartikel (refereegranskat)abstract
- The neutron-deficient nucleus Ge-66 was populated at high spin in two experiments using the reaction Ca-40(S-32,alpha2p) at beam energies of 105 and 95 MeV. In the first experiment, a self-supporting Ca-40 target was used, while a gold-backed target of similar thickness was used in the second experiment. gamma rays were detected with the EUROBALL array, combined with the charged-particle detector array EUCLIDES and the Neutron Wall. The level scheme of Ge-66 was extended up to Eapproximate to18 MeV and I-pi=(23(-)). Above angular momentum 10(+), we found two sequences, connected by energetically staggered DeltaI=1 M1 transitions. The total Routhian surface calculations describe Ge-66 at lower spins as a gamma-soft nucleus having a moderate deformation of beta(2)approximate to0.23, while a triaxial deformation is predicted for the band structures above I-pi=10(+). To our knowledge, this is the first observation of staggered M1 transitions in a deformed four-quasiparticle pi(g(9/2)(2))nu(g(9/2)(2)) structure.
|
|
| 29. |
- Stefanova, E. A., et al.
(författare)
-
Observation of negative-parity high-spin states of As-68
- 2005
-
Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 24:1, s. 1-4
-
Tidskriftsartikel (refereegranskat)abstract
- The neutron-deficient nucleus As-68 was populated at high spin in two experiments using the reaction Ca-40(S-32, 3pn) at beam energies of 105 and 95 MeV. A self-supporting and a gold-backed, highly enriched Ca-40 target were used. Gamma rays were detected with the EUROBALL array, combined with the charged-particle detector array EUCLIDES and the Neutron Wall. The As-68 level scheme was considerably extended, especially at negative parity and many previous spin-parity assignments were confirmed or rejected. The total-Routhian-surface (TRS) calculations find shape coexistence and γ softness for the negative- and positive-parity states, respectively.
|
|
| 30. |
- Van de Walle, J., et al.
(författare)
-
Coulomb excitation of neutron-rich Zn isotopes: First observation of the 2(1)(+) state in Zn-80
- 2007
-
Ingår i: Physical Review Letters. - 1079-7114. ; 99:14
-
Tidskriftsartikel (refereegranskat)abstract
- Neutron-rich, radioactive Zn isotopes were investigated at the Radioactive Ion Beam facility REX-ISOLDE (CERN) using low-energy Coulomb excitation. The energy of the 2(1)(+) state in Zn-78 could be firmly established and for the first time the 2(+)-> 0(1)(+) transition in Zn-80 was observed at 1492(1) keV. B(E2,2(1)(+)-> 0(1)(+)) values were extracted for Zn-74,Zn-76,Zn-78,Zn-80 and compared to large scale shell model calculations. With only two protons outside the Z=28 proton core, Zn-80 is the lightest N=50 isotone for which spectroscopic information has been obtained to date. Two sets of advanced shell model calculations reproduce the observed B(E2) systematics. The results for N=50 isotones indicate a good N=50 shell closure and a strong Z=28 proton core polarization. The new results serve as benchmarks to establish theoretical models, predicting the nuclear properties of the doubly magic nucleus Ni-78.
|
|
| 31. |
- Van de Walle, J., et al.
(författare)
-
Low-energy Coulomb excitation of neutron-rich zinc isotopes
- 2009
-
Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 79:1
-
Tidskriftsartikel (refereegranskat)abstract
- At the radioactive ion beam facility REX-ISOLDE, neutron-rich zinc isotopes were investigated using low-energy Coulomb excitation. These experiments have resulted in B(E2, 2(1)(+)-> 0(1)(+)) values in Zn74-80, B(E2, 4(1)(+)-> 2(1)(+)) values in Zn-74,Zn-76 and the determination of the energy of the first excited 2(1)(+) states in Zn-78,Zn-80. The zinc isotopes were produced by high-energy proton- (A = 74, 76, 80) and neutron-(A = 78) induced fission of U-238, combined with selective laser ionization and mass separation. The isobaric beam was postaccelerated by the REX linear accelerator and Coulomb excitation was induced on a thin secondary target, which was surrounded by the MINIBALL germanium detector array. In this work, it is shown how the selective laser ionization can be used to deal with the considerable isobaric beam contamination and how a reliable normalization of the experiment can be achieved. The results for zinc isotopes and the N = 50 isotones are compared to collective model predictions and state-of-the-art large-scale shell-model calculations, including a recent empirical residual interaction constructed to describe the present experimental data up to 2004 in this region of the nuclear chart.
|
|
| 32. |
- Walle, J. Van de, et al.
(författare)
-
Coulomb Excitation of Neutron-Rich Zn Isotopes: First Observation of the 2[sub 1][sup +] State in [sup 80]Zn
- 2007
-
Ingår i: Physical Review Letters. ; 99:14, s. 142501-
-
Tidskriftsartikel (refereegranskat)abstract
- Neutron-rich, radioactive Zn isotopes were investigated at the Radioactive Ion Beam facility REX-ISOLDE (CERN) using low-energy Coulomb excitation. The energy of the 21+ state in 78Zn could be firmly established and for the first time the 2+-->01+ transition in 80Zn was observed at 1492(1) keV. B(E2,21+-->01+) values were extracted for 74,76,78,80Zn and compared to large scale shell model calculations. With only two protons outside the Z=28 proton core, 80Zn is the lightest N=50 isotone for which spectroscopic information has been obtained to date. Two sets of advanced shell model calculations reproduce the observed B(E2) systematics. The results for N=50 isotones indicate a good N=50 shell closure and a strong Z=28 proton core polarization. The new results serve as benchmarks to establish theoretical models, predicting the nuclear properties of the doubly magic nucleus 78Ni.
|
|
| 33. |
|
|
