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- Meinander, K., et al.
(författare)
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Pseudopeptides with a centrally positioned alkene-based disulphide bridge mimetic stimulate kallikrein-related peptidase 3 activity
- 2013
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Ingår i: Medchemcomm. - : Royal Society of Chemistry (RSC). - 2040-2503 .- 2040-2511. ; 4:3, s. 549-553
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Tidskriftsartikel (refereegranskat)abstract
- Pseudopeptides based on the kallikrein-related peptidase 3 (KLK3) activating bicyclic peptide “C-4” comprising hydrocarbon-based disulphide bridge mimetics have been synthesized. After investigating different synthetic approaches, the pseudopeptides were successfully cyclized from two L-allylglycine side chains via an alkene ring-closing metathesis reaction during the peptide synthesis. The alkene-linker was formed in a 1 : 1 E/Z isomer ratio. The resulting pseudopeptides were almost as potent as the parent peptide, increasing the activity of KLK3 over four-fold at 200 μg ml−1 (130–140 μM) concentrations.
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| 3. |
- Jerkeman, A., et al.
(författare)
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Treatment for chronic hepatitis C in a cohort of opiate substitution therapy recipients in three Swedish cities - completion rates and efficacy
- 2014
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Ingår i: European Journal of Gastroenterology & Hepatology. - : Ovid Technologies (Wolters Kluwer Health). - 0954-691X. ; 26:5, s. 523-531
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Tidskriftsartikel (refereegranskat)abstract
- Objectives Opiate substitution treatment (OST) programs could provide opportunities for management of comorbidities, such as hepatitis C virus (HCV) infection, in people who inject drugs. We aimed to prospectively evaluate the real-life feasibility of interferon/ribavirin-based HCV treatment in OST recipients, with a special focus on psychiatric status and health-related quality of life. Patients from a cohort of OST recipients from three cities in Sweden were selected for HCV treatment on the basis of structured investigation for HCV-related liver disease. Therapy was delivered in collaboration between infectious disease and OST clinics, with monitoring for completion and adherence, treatment response, adverse events, health-related quality of life (HRQoL) (SF-36) and signs of depression (MADRS-S), or relapse into drug abuse. The primary endpoint was completion of prescribed treatment; the secondary endpoints were sustained virological response (SVR), adherence, and incidence of depression. Among 69 patients with an indication for antiviral therapy, 41 initiated treatment; 34/41 (83%) completed treatment and 19/41 (46%) achieved SVR. Adequate adherence was observed in 29/41 patients (71%). Two serious adverse events occurred, including one death because of liver failure. Baseline scores for self-assessed health were low, with a significant reduction during treatment. Seventy-one percent of patients (29/41) fulfilled the criteria for clinically significant depression at some time point during treatment. Baseline scores for HRQoL/MADRS-S were associated with treatment completion, SVR, and depression during treatment. Despite the low HRQoL and the high occurrence of depression, HCV treatment was feasible and showed satisfactory rates of completion in this cohort of unselected OST recipients.
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| 4. |
- Brändström, U., et al.
(författare)
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Results from the intercalibration of optical low light calibration sources 2011
- 2012
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Ingår i: Geoscientific Instrumentation, Methods and Data Systems. - : Copernicus GmbH. - 2193-0856 .- 2193-0864. ; 1:1, s. 43-51
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Tidskriftsartikel (refereegranskat)abstract
- Following the 38th Annual European Meeting onAtmospheric Studies by Optical Methods in Siuntio in Finland,an intercalibration workshop for optical low light calibrationsources was held in Sodankyl¨a, Finland. The mainpurpose of this workshop was to provide a comparable scalefor absolute measurements of aurora and airglow. All sourcesbrought to the intercalibration workshop were compared tothe Fritz Peak reference source using the Lindau CalibrationPhotometer built by Wilhelm Barke and Hans Lauche in1984. The results were compared to several earlier intercalibrationworkshops. It was found that most sources were fairlystable over time, with errors in the range of 5–25 %. To furthervalidate the results, two sources were also intercalibratedat UNIS, Longyearbyen, Svalbard. Preliminary analysis indicatesagreement with the intercalibration in Sodankyl¨a withinabout 15–25 %.
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