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- Malmberg, Daniel, et al.
(författare)
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Close encounters in young stellar clusters: implications for planetary systems in the solar neighbourhood
- 2007
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Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 1365-2966 .- 0035-8711. ; 378:3, s. 1207-1216
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Tidskriftsartikel (refereegranskat)abstract
- The stars that populate the solar neighbourhood were formed in stellar clusters. Through N-body simulations of these clusters, we measure the rate of close encounters between stars. By monitoring the interaction histories of each star, we investigate the singleton fraction in the solar neighbourhood. A singleton is a star which formed as a single star, has never experienced any close encounters with other stars or binaries, or undergone an exchange encounter with a binary. We find that, of the stars which formed as single stars, a significant fraction is not singletons once the clusters have dispersed. If some of these stars had planetary systems, with properties similar to those of the Solar System, the planets' orbits may have been perturbed by the effects of close encounters with other stars or the effects of a companion star within a binary. Such perturbations can lead to strong planet-planet interactions which eject several planets, leaving the remaining planets on eccentric orbits. Some of the single stars exchange into binaries. Most of these binaries are broken up via subsequent interactions within the cluster, but some remain intact beyond the lifetime of the cluster. The properties of these binaries are similar to those of the observed binary systems containing extrasolar planets. Thus, dynamical processes in young stellar clusters will alter significantly any population of Solar System-like planetary systems. In addition, beginning with a population of planetary systems exactly resembling the Solar System around single stars, dynamical encounters in young stellar clusters may produce at least some of the extrasolar planetary systems observed in the solar neighbourhood.
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| 2. |
- Malmberg, Daniel, et al.
(författare)
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The Singleton Fraction of Stars Formed in Stellar Clusters
- 2008
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Ingår i: Extreme Solar Systems (Astronomical Society of the Pacific Conference Series). - 9781583816660 - 9781583816677 ; 398, s. 75-76
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Konferensbidrag (refereegranskat)abstract
- Most stars form in some sort of stellar cluster or association. In such clusters the number density of stars can be very high. Thus, single stars in such clusters may undergo frequent close encounters with other stars and exchange encounters with binary systems. The perturbation caused by the other star in a close encounter or by the companion star in a binary can have significant effects on the evolution of any planetary system around the initially single star. If the planetary system which formed around the single star was originally solar-system-like, planet-planet interactions, induced by the perturbation from other stars, may change it significantly and leave it more like some of the planetary systems which are observed around other stars. Only if the host star of an initially solar-system-like planetary system never undergoes any encounters with other stars and is never exchanged into a binary may the planetary system remain solar-system like. We define such a star to be a SINGLETON.
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| 3. |
- Villa, Luisa L., et al.
(författare)
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Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
- 2007
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 356:19, s. 1915-1927
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the prevention of high-grade cervical lesions associated with HPV-16 and HPV-18. METHODS: In this randomized, double-blind trial, we assigned 12,167 women between the ages of 15 and 26 years to receive three doses of either HPV-6/11/16/18 vaccine or placebo, administered at day 1, month 2, and month 6. The primary analysis was performed for a per-protocol susceptible population that included 5305 women in the vaccine group and 5260 in the placebo group who had no virologic evidence of infection with HPV-16 or HPV-18 through 1 month after the third dose (month 7). The primary composite end point was cervical intraepithelial neoplasia grade 2 or 3, adenocarcinoma in situ, or cervical cancer related to HPV-16 or HPV-18. RESULTS: Subjects were followed for an average of 3 years after receiving the first dose of vaccine or placebo. Vaccine efficacy for the prevention of the primary composite end point was 98% (95.89% confidence interval [CI], 86 to 100) in the per-protocol susceptible population and 44% (95% CI, 26 to 58) in an intention-to-treat population of all women who had undergone randomization (those with or without previous infection). The estimated vaccine efficacy against all high-grade cervical lesions, regardless of causal HPV type, in this intention-to-treat population was 17% (95% CI, 1 to 31). CONCLUSIONS: In young women who had not been previously infected with HPV-16 or HPV-18, those in the vaccine group had a significantly lower occurrence of high-grade cervical intraepithelial neoplasia related to HPV-16 or HPV-18 than did those in the placebo group.
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